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Journal : journal of internal medicine

PENGARUH HIPERGLEMI TERHADAP PERAN SITOSKELETON (CYTOSKELETON) SEBAGAI JALUR TRANSDUKSI SIGNAL (SIGNAL TRANSDUCTION) Rudijanto, Achmad; Kalim, Handono
journal of internal medicine Vol. 7, No. 3 September 2006
Publisher : journal of internal medicine

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Abstract

Intracellular signal transduction occurs through cascades of reactions involving dozens of proteins that transmit signalsfrom the cell surface, through a crowded cellular environment filled with organelles and a filamentous cytoskeleton, to specifictarget. For most characterized signal transduction pathway, the initial signaling event and the end point are well known. In order tofully understand intracellular signal transduction, it is essential to know the intermediate signaling molecules and to understandhow information flows from one to the next. The cytoskeleton , an interconnected assembly of actin (microfilament), intermediatefilament and microtubule networks that extend throughout the entire cell, is involved in intracellular signal transduction.Individual proteins of the cytoskeleton might participate directly in signal transduction by linking two or more signaling proteinand might also provide a macromolecular scaffold, which spatially organizes components of a signal transduction cascade.Diabetes mellitus is an increasingly common disease. Absolute or relative deficiencies of insulin are common in this disease.Insulin has been suggested to play a key regulatory role in the functional organization of actin filaments. The microtubules are alsothe targets of insulin. A chronic insulin deficiency may could lead to impairment in the organization of the cytoskeleton. Thiscould entail a compromised or slower action of some activated enzymes in cells, affect to intracellular signal transduction.
Co-Authors A Rifa’i Abd. Rasyid Syamsuri Abdurrachman Abdurrachman Achmad Rifa’i, Achmad Achmad Rifa’i Achmad Rudijanto Agustina T Endharti, Agustina T Agustina Tri Endharti Aru W Sudoyo Asri Nugraheni Ati Rastini Atma Gunawan Atma Gunawan Bambang Setyohadi Benny A Pradana, Benny A BP Putra Suryana Dany Farida Deddy Nur Wachid Achadiono Desfryda, Elynca Putri desy wulandari Dewi Purnama Sari Dian Hasanah Djoko W. Soeatmadji Djoko Wahono S Dona Marisa, Dona Dwinadella, Sephia Eko, Mudjiwijono Handaru Elvira Sari Dewi Engli, Katherina Erawati, Dini Rachma fatchiyah . Fatchiyah Fatchiyah Ferdinandus Maria Judajana Fikriah, Ika Firdaningrum, Nimas Eka Hani Susanti, Hani Hani Susianti Hanik Ruliani Harry Isbagio Harun Al Rasyid Harun Al Rasyid I Putu A.S Ibrahim Njoto Ivan A Hartono, Ivan A Joewono Soeroso Joewono Soeroso Kusworini Handono Kusworini Handono Kusworini Handono Kusworini Handono Kusworini Kusworini Laksmi Karunia Tanuwijaya Laksmi Karunia Tanuwijaya Loeki Enggar Fitri M Aris Widodo Mat Suwito Moch Sasmito Djati Mudjiwijono Handaru Eko Muhammad Anshory Muhammad Anshory, Muhammad Muhammad Darwin P Nurdiana Nurdiana Perdana Aditya Rahman Pratama, Mirza Zaka Putri, Choirinnisa Meilia Ayu R.I R.I Rachmat Gunadi Wachjudi Radhitio A Nugroho, Radhitio A Respati Suryanto Dradjat Ria Famuji, Siti Roziah Rifa’i, A Rizky Fachry, Ade Wlidan Rooije R.H. Rumende Sari, Tita Luthfia Solly Aryza Sumarta, Norma Hanifah Supriono Supriono Suryana, Bagus Putu Putra Suwito, Mat Tamaulina Br Sembiring Torajasa Achamar Wahono, Caesarius Singgih Wahono, Cesarius Singgih Wisnu Barlianto Yona One Sidarta, Yona One Zaenal Kusuma