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The proportion and characteristics of hypertension outpatients in productive age at Selemadeg Public Health Center, Tabanan in 2020 Made Dyah Vismita Indramila Duarsa Duarsa; Hanik Nuryanti; Yenny Kandarini; Gede Wira Mahadita; Putu Aryani; Bagus Juniada
Bali Anatomy Journal Vol 3 No 2 (2020): Bali Anatomy Journal (BAJ)
Publisher : Department of Anatomy, Medical Faculty, Universitas Udayana, Bali-Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/baj.v3i2.46

Abstract

Background: Selemadeg Public Health Center (PHC) had reported, in 2018, hypertension is still included as the top 10 diseases within its community care area. The last registration data showed that mostly hypertension cases was still related to productive age population. Aims: This study aims to assess the incidence of hypertension in preventing the risk factors of hypertension. Method: This research was conducted at Selemadeg PHC, Tabanan in the period of time between February-March 2020, using a descriptive study form with a consecutive sampling technique. Results: It indicated that 33.3% from all patients had experienced hypertension. Based on gender, more in female respondents, on the rate of 41.7%. Based on the family history, it was found that 50.0% of them have had a family history of hypertension. Based on the obesity status, 55.6% with a BMI> 25. Based on high salt consumption was found 50.0% and based on low physical activity was 37,9% on smoking habits 44.4% indicated that the patient was a smoker. Conclusion: The proportion of hypertension involved productive age patients as well as it was found more in the female gender group, with a family history of hypertension, high salt consumption, smokers, obesity and has a low physical activity pattern.
Effect of Vitamin D Supplementation in Disease Activity, Activity-Related Markers, Inflammatory Marker and Serum Calcium of Systemic Lupus Erythematosus Patiens: A Systematic Review and Meta-Analysis G Kambayana; Dwijo Anargha Sindhughosa; Pande Ketut Kurniari; Wira Gotera; Yenny Kandarini
Indonesian Journal of Rheumatology Vol. 13 No. 1 (2021): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v13i1.168

Abstract

Background: Effect of additional supplementation of vitamin D toward Systemic lupus erythematosus (SLE) disease activity still differ in results obtained between studies being conducted. The current meta-analysis systematically analyzed the effect of vitamin D supplementation on SLE disease activity with updated literature, also its effect toward other parameters. Material and Methods: Relevant literatures were obtained from PubMed database and Google Scholar. The obtained studies were analyzed using fixed effect model or random effect model. Results: Five eligible studies with a total of 318 participants were included. Vitamin D supplementation did not affect the total SLEDAI score in SLE patients with pooled mean difference of -0.96 (p =0.09; 95% CI: -2.06 to 0.14). Serum vitamin D level increased after administration of vitamin D with pooled mean difference of 12.67 (p =0.001; 95% CI: 5.04 to 20.29). vitamin D supplementation increase serum calcium levels, with pooled difference of 0.07 (p = 0.006; 95% CI: 0.02 to 0.12). Pooled results from two studies obtained vitamin D supplementation did not affect ESR, C3 and C4. Conclusions: Current meta-analysis obtained no significant changes in SLEDAI scores due to vitamin D supplementation. In contrast, serum vitamin D and serum calcium levels were increased.
Protein and Phosphate Intakes are Associated with Hyperphosphatemia in Hemodialysis Patients at Sanglah Hospital, Bali, Indonesia Made Dyah Vismita Indramila Duarsa; Yenny Kandarini; Gede Wira Mahadita; Ni Nyoman Shinta Prasista Sari
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2656

Abstract

Increased chronic kidney disease (CKD) mortality rate is significantly associated with increased blood phosphate levels. Hyperphosphatemia control is one of the main focuses in the management of hemodialysis (HD) patients. A high protein diet has been suggested to prevent malnutrition in hemodialysis patients. However, a high protein and phosphorus diet has the risk of increasing the phosphate level in the blood circulation, leading to a higher mortality rate of hemodialysis patients. This study aimed to prove that the level of protein and phosphate intake is associated with hyperphosphatemia in CKD patients with routine HD. This was cross-sectional analytical study conducted from September to October 2020 on 66 CKD patients who underwent hemodialysis. Subject characteristics and phosphorus and protein intake data were obtained from a questionnaire food recall adapted from the Food and Agriculture Organization of the United Nations. Data consumption patterns were processed using the nutritional survey software to obtain the nutritional values. Data were analyzed using the Chi-Square test to identify the relationship and risk between hyperphosphatemia and diet protein, phosphorus, and protein-phosphorus ratio. The confidence level in this study was 95%. There was a significant relationship between protein and phosphorus intake in hyperphosphatemia in CKD patients. The risk factors for hyperphosphatemia were high phosphorus intake (p=0.018; OR=3.886;95% CI: 1.212–12.460) and adequate protein intake (p=0.035; OR=3.674; 95% CI: 1.049-12.865). This study showed no significant relationship between phosphorus-protein ratio, protein-phosphorus ratio, and hyperphosphatemia incidence. In conclusion, high protein intake and excessive phosphorus intake provide a significant relationship to the incidence of hyperphosphatemia in CKD patients undergoing routine hemodialysis.
Factors that influence peritonitis events on patients with continuous ambulatory peritoneal dialysis in Sanglah General Hospital, Denpasar-Bali, Indonesia Gede Wirya Kusuma Duarsa; Oka Udrayana; Yeni Kandarini; Raka Widiana; Marleen
Neurologico Spinale Medico Chirurgico Vol 3 No 3 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i3.105

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Background. To determine risk factors that influence peritonitis event on patients with Continuous Ambulatory Peritoneal Dialysis (CAPD) in Sanglah Hospital, thus, we can prevent the occurrence of peritonitis in CRF patients with CAPD. Methods. This is a retrospective cohort study, which was conducted at the Sanglah Hospital in Denpasar from August to September 2016. All data are processed using SPSS 17.0 for Windows, data analysis by using the Kaplan Meier (K-M) curves, hypothesis using the log-rank test, while for the survival is by using the median or mean survival. The significance is determined by the value of p < 0.05 with 95% CI. Results. A total of 78 people (46 men and 32 women) who meet the inclusion criteria of this study. Thirteen people (16.7%) are experiencing peritonitis. K-M Survival Curves between in CRF patients with CAPD, with Age ≥ 50 years (51.36 months survival rates, 95% CI 44.79 until 57.93) with < 50 years (56.1 months Survival rates, 95% CI 51.41 until 60.78) with RR 2.54 log-rank p 0.084. K-M Survival Curves between in CRF patients with CAPD, with DM (mean 52.63 months survival rates, 95% CI 47.21 until 58.06) with No DM (56.88 months survival rates, 95% CI 52.89 until 60.88) with RR 4.16 and 0.037 log-rank p. Conclusion. There is a correlation between DM and the incidence of peritonitis in CRF patients with CAPD at Sanglah Hospital. However, age and education level are not related.
Correlation of total ischemic time to creatinine serum level and resistive index value in kidney transplant Putu Astri Novianti; Gede Wirya Kusuma Duarsa; Gede Andi Aditya; Anak Agung Gde Oka; Kadek Budi Santosa; I Wayan Yudiana; Pande Made Wisnu Tirtayasa; Ida Bagus Putra Pramana; Yenny Kandarini; Wayan Sudana; Djodi Sidartha; Raka Widiana
Neurologico Spinale Medico Chirurgico Vol 3 No 2 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i2.109

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Background: The transient period when the kidney donor was extracted until being anastomosed (total ischemic time) will aggravate many putative molecular ischemic-reperfusion injury mechanisms. Several studies have reported the risk of delayed graft function development, which can be reflected by creatinine serum (Cr) level and resistive index (RI) value. This study aims to determine the correlation of total ischemic time to Cr levels reduction in one-month post-transplantation and RI value. Methods: This was a cross-sectional retrospective study involving subjects who underwent kidney transplantation in Sanglah General Hospital. In this study, the primary parameters were total ischemic time, Cr level, and RI value. The total ischemic time is calculated using a stopwatch intraoperatively. Cr level was obtained from blood examination, and RI value was obtained from the ultrasonography test. Data analysis was analyzed statistically using SPSS 24.0, and p < 0.05 was considered significant. Results: About 17 kidney transplant subjects were included in this study. The mean total ischemic time was 105 minutes and 43 seconds. There was an insignificant negative correlation between Cr level reduction and total ischemia time (r = -0.36; p = 0.89). An analysis of the correlation of total ischemic time and RI value, there was a linear correlation, but statistically insignificant (r = 0.11; p = 0.66). Conclusion: Total ischemic time has a negative correlation with post-transplant creatinine serum level and a positive correlation with the post-transplant resistive index value, but these results are not statistically significant.
Assessment of quality of life among chronic kidney disease patients undergoing hemodialysis in Sanglah General Hospital, Denpasar from April-May 2017 using EQ-5D-5L questionnaire Ni Putu Rani Apsari Dewi; Yenny Kandarini; I Gde Ketut Sajinadiyasa; Triharnoto Triharnoto
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (533.318 KB) | DOI: 10.15562/ism.v11i1.172

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Introduction: Hemodialysis or renal function replacement therapy is routine medical care for chronic kidney disease (CKD) patients. Many problems arise among patients with chronic kidney disease (CKD) undergoing hemodialysis, including physical, psychological, social and family relationships. Those will affect patient’s quality of life (QOL).Method: A cross-sectional study performed from April-May 2017 in Sanglah General Hospital Denpasar using EuroQol 5 (EQ-5D-5L) Questionnaire to assess the Health-Related Quality of Life (HRQOL). All of CKD patients undergoing hemodialysis in Sanglah General Hospital Denpasar that matched the inclusion and exclusion criteria were recruited to this study.Results: There were 46 patients participated in this study. Overall, 37 (86.05%) were male and divided into four age groups. The reported HRQOL as measured by means of EQ-5D-5L Index Value and EQ-VAS (Visual Analog Scale) Score was 0.71 ± 0.22 and 75.7 ± 0.635, respectively. The median of EQ-5D-5L Index Value and EQ-VAS Score was 0.71 [0.63-0.84] and 75 [70-80].Conclusion: This study provided associations between sociodemographic characteristics and their HRQOL. Healthcare providers should be aware of low HRQOL among patients with female gender, elderly patients and unemployed patients to improve their quality of life.
Tatalaksana peritonitis bakteri Staphylococcus Epidermidis pada seorang pasien dengan continuous ambulatory peritoneal dialysis (CAPD) I Gusti Agung Ayu Indira Nirmala Dewi; Yenny Kandarini
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (629.13 KB) | DOI: 10.15562/ism.v11i2.642

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Background: Peritonitis is a common CAPD related infection. It can cause discontinue dyalisis peritoneal and conversion to hemodyalisis.Case description: This article reported a 54-year-old man on 5 years dialysis peritoneal with a complaint of abdominal pain since 1 week before admission. The complaint accompanied by fever and nausea. On abdominal examination there are mild distention, weak of bowel sound, pressure pain, and defans muscular. Dialisat examination found cloudy fluid, effluent white blood cell count 961 cells/mm3 composed of 85% polymorphonuclear leucocytes. Peritoneal dialysis effluent gram stain, routine culture found isolated Staphylococcus epidermidis with methicillin resistant, significant as infectious agent depend on patient’s clinical and infection’s marker. Performed a definitive antibiotic with Linezolid 600 miligram intravena and Gentamicin 40 miligram intraperitoneal during 14 days showed clinical and laboratorium improvement.Conclusion: Peritonitis remains a major cause of technique failure in peritoneal dialysis and affects patient’s morbidity and mortality. Management should be definitive antibiotic as dialysat culture result. Catheter removal indicated if there were refractory peritonitis, relapsing peritonitis, refractory exit-site and tunnel infection, fungal peritonitis. Latar belakang: Peritonitis merupakan komplikasi infeksi pada pasien CAPD yang umum terjadi. Peritonitis dapat menjadi penyebab utama penghentian dialisis peritoneal dan dikonversi ke hemodialisis.Deskripsi kasus: Laporan kasus ini melaporkan laki-laki berusia 54 tahun yang telah menjalani CAPD selama 5 tahun mengeluh nyeri perut sejak 1 minggu yang lalu SMRS. Nyeri perut disertai dengan demam dan mual. Pemeriksaan abdomen didapatkan distensi ringan, bising usus terdengar lemah, adanya nyeri tekan, dan defans muskuler. Pemeriksaan analisis cairan dialisat didapatkan warna keruh/berawan dengan jumlah  961 sel/uL dengan dominan polymononuklear sebesar 85%. Pemeriksaan kultur/ biakan cairan peritoneum didapatkan terisolasi bakteri Staphylococcus epidermidis yang bersifat Methicillin resistant, significan sebagai agen penyebab infeksi tergantung keadaan klinis dan marker infeksi pasien. Dilakukan tatalaksana terapi antibiotik definitif dengan Linezolid 600 miligram setiap 12 jam intravena dan Gentamicin 40 miligram intraperitoneal, intermiten dose saat penggantian cairan malam hari. Pemberian terapi antibiotik definitif dan intraperitoneal dilanjutkan selama 14 hari dan pada pasien didapatkan perbaikan secara klinis dan laboratorium. Simpulan: Peritonitis merupakan penyebab utama kegagalan teknik pada dialisis peritoneal dan mempengaruhi morbiditas serta mortalitas pasien CAPD. Diagnosis peritonitis terkait CAPD sedini mungkin serta pemberian terapi yang cepat dan tepat dapat menghindarkan pasien dari komplikasi yang lebih berat dan kegagalan dialisis peritoneal.
Hemodialisis Sustained Low-Efficiency Dialysis: Indikasi dan Penerapannya Yenny Kandarini; I Made Arya Winangun
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (415.039 KB) | DOI: 10.15562/ism.v12i1.935

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Acute kidney injury (AKI) and chronic kidney disease (CKD) are still a global health burden. The global incidence of AKI reaches 21.6% with a mortality rate of 23.9%. AKI is associated with the need for renal support therapy of 4-5% patients. AKI that persists in a long period can lead to CKD. CKD are associated with increased economic burdens, risk of cardiovascular disease and death. One of treatments to prevent morbidity and death in AKI and CKD is through hemodialysis. Sustained low-efficiency dialysis (SLED) resembles the form of conventional intermittent hemodialysis (IHD) but by slowing down the blood flow and the dialysis flow with the duration being extended to 6-12 hours can reduced the risk of hemodynamic instability compared to IHD. A recent meta-analysis and systematic review stated that there were no differences between SLED and continous renal replacement therapy (CRRT) regarding the recovery of renal function in AKI, days required for recovery and the incidence of hypotension in patients in ICU. SLED provides results that are almost the same as 24 hours continuous hemodialysis of CRRT in patients with unstable hemodynamics but with more affordable cost. Understanding the use and mechanism of SLED is important to manage patients with AKI and CKD in unstable hemodynamic conditions.  Acute kidney injury (AKI) dan penyakit ginjal kronik (PGK) masih menjadi beban kesehatan di dunia. Angka insiden global AKI mencapai 21,6% dengan angka mortalitas 23,9%. AKI diasosiasikan dengan perlunya terapi pendukung ginjal pada 4-5% pasien. AKI yang menetap dalam periode yang lama dapat mengarah ke PGK. PGK diasosiasikan dengan meningkatnya beban ekonomi, risiko penyakit kardiovaskular dan kematian. Salah satu penanganan untuk mencegah morbiditas dan kematian pada AKI dan PGK yaitu melalui hemodialisis. Sustained low-efficiency dialysis (SLED) menyerupai bentuk hemodialisis konvensional intermittent hemodialysis (IHD) namun dengan memperlambat aliran darah dan aliran dialisis dengan durasi yang diperpanjang menjadi 6-12 jam dapat mengurangi risiko instabilitas hemodinamik dibandingkan IHD. Sebuah meta analisis dan review sistematik menyebutkan tidak ada perbedaan antara SLED dan continous renal replacement therapy (CRRT) pada pemulihan fungsi ginjal pada AKI, hari yang diperlukan untuk pemulihan dan kejadian hipotensi pada pasien di ICU. SLED menunjukkan hasil yang hampir sama seperti pada hemodialisis yang dilakukan berkelanjutan selama 24 jam pada CRRT pada pasien hemodinamik yang tidak stabil namun dengan biaya yang lebih terjangkau. Pemahaman mengenai penerapan dan mekanisme SLED menjadi penting untuk menangani pasien AKI dan PGK dengan kondisi hemodinamik yang tidak stabil.
Perbandingan efektivitas dan keamanan antara roxadustat dan epoetin alfa sebagai terapi anemia pada pasien yang menjalani hemodialisis reguler: meta analisis Kadek Wisnu Segara Karya; Ni Luh Parameswari Praptika; Nyoman Yudia Trianadewi Nurbudhi; Yenny Kandarini
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1481.005 KB) | DOI: 10.15562/ism.v12i3.1130

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Introduction: Chronic kidney disease (CKD) is a global health problem. Hemodialysis (HD) is one of the treatment modalities for end-stage renal disease which is commonly used. A complication that is often found in patients undergoing regular HD is anemia. Roxadustat is a prolyl hydroxylase inhibitor (PHI) which has a potential as an alternative therapy for anemia in patients undergoing regular HD. The aim of this meta-analysis was to compare the efficacy and safety of roxadustat and epoetin alfa as anemia management in patients undergoing regular HD.Methods: We searched the literature sources in the PubMed, MEDLINE, Cochrane, Scopus, Embase, Elsevier, and Proquest databases until June 1, 2021. The search terms used were chronic kidney disease, hemodialysis, dialysis, roxadustat, epoetin alfa, anemia management, incidence of side effects, randomize, and randomization. We excluded the study population with acute kidney injury/dyslipidemia/metabolic syndrome. All analyzes in this meta-analysis were performed using Review Manager version 5.3 (RevMan Cochrane, London, UK).Result: We have found five eligible studies (2777 patients). Funnel plots and p-Egger were examined to assess publication bias. The results showed a statistically significant difference between roxadustat and epoetin alfa with respect to the mean difference of hemoglobin (Hb) (WMD: 0.31; p<0.05), hepcidin (WMD: -18.94; p<0.05), transferrin (WMD: 67.88; p<0.05), transferrin saturation (WMD: 2.78; p<0.05), iron (WMD: 5.02; p<0.05) and risk of adverse events (OR: 1.25; p<0.05) displayed on the forest plot.Conclusion: Based on this meta-analysis, it can be concluded that anemia management with roxadustat is better than epoetin alfa in patients undergoing regular HD. Latar Belakang: Penyakit ginjal kronis (PGK) merupakan masalah kesehatan global. Hemodialisis (HD) merupakan salah satu modalitas terapi PGK stadium akhir yang umum digunakan. Komplikasi yang sering ditemukan pada pasien yang menjalani HD reguler adalah anemia. Roxadustat adalah suatu prolyl hydroxylase inhibitor (PHI) yang memiliki potensi sebagai alternatif terapi anemia pada pasien yang menjalani HD reguler. Tujuan dari meta-analisis ini adalah untuk membandingkan efektivitas dan keamanan antara roxadustat dan epoetin alfa sebagai manajemen anemia pada pasien yang menjalani HD reguler.Metode: Kami mencari sumber literatur pada database PubMed, MEDLINE, Cochrane, Scopus, Embase, Elsevier, dan Proquest hingga 1 Juni 2021. Istilah pencarian yang digunakan yaitu penyakit ginjal kronis, hemodialisis, dialisis, roxadustat, epoetin alfa, manajemen anemia, kejadian efek samping, acak, dan pengacakan. Kami mengeksklusi populasi penelitian dengan cedera ginjal akut/dislipidemia/sindrom metabolik. Semua analisis dalam meta-analisis ini dilaksanakan dengan menggunakan Review Manager versi 5.3 (RevMan Cochrane, London, UK).Hasil: Kami menemukan lima studi yang memenuhi syarat (2777 pasien). Funnel plot dan p-Egger diperiksa untuk menilai bias publikasi. Hasil menunjukkan perbedaan signifikan secara statistik antara roxadustat dan epoetin alfa terhadap perbedaan rerata dari hemoglobin (Hb) (WMD: 0,31; p<0,05), hepsidin (WMD: -18,94; p<0,05), transferin (WMD: 67,88; p<0,05), saturasi transferin (WMD: 2,78; p<0,05), zat besi (WMD: 5,02; p<0,05) dan risiko kejadian efek samping (OR: 1,25; p<0,05) yang ditampilkan pada forest plot.Kesimpulan: Berdasarkan meta-analisis ini, dapat disimpulkan bahwa manajemen anemia dengan roxadustat lebih baik dibandingkan dengan epoetin alfa pada pasien yang menjalani HD reguler.
Focal Segmental Glomerulosclerosis caused by Hepatitis B Infection Comorbid with HIV Infection Nicholas Wijayanto; Yenny Kandarini; IDN Wibawa; Ni Wayan Winarti
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 2 (2022): VOLUME 23, NUMBER 2, August 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (569.031 KB) | DOI: 10.24871/2322022256-260

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Glomerulonephritis is an inflammatory condition on renal glomerulus. These entities can manifest as nephrotic syndrome. One of causes of secondary glomerulonephritis is hepatitis B infection. Glomerulonephritis due to hepatitis B only happens in 0.1 – 25% cases, with the focal segmental glomerulosclerosis (FSGS) is rarely reported. We reported 20 years old male with nephrotic syndrome. He was homosexual with history of unprotected sex and multiple partners. From kidney biopsy, we found focal segmental glomerulosclerosis lesion. Blood examination showed he had both hepatitis B (HBV-DNA 1.7x108 IU/mL) and HIV infection (HIV-RNA 820 copies/mL, CD4 839 cell/uL). We treated this patient with combination of anti-viral drugs which consist of tenofovir, lamivudine and efavirenz. After three weeks of treatment, he showed improvement in the clinical symptoms and urinalysis.