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All Journal Medicina journal of internal medicine Majalah Kedokteran Bandung The Indonesian Biomedical Journal Universa Medicina Indonesian Journal of Rheumatology Jurnal Penyakit Dalam Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Kidney and Hypertension Neurologico Spinale Medico Chirurgico Bali Anatomy Journal Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA)
Yenny Kandarini
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana, Denpasar, Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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High Incidence of Hepatitis B Virus Infection in Hemodialysis Patients at Sanglah General Hospital and It’s Risk Factors Cokorda Agung Wahyu Purnamasidhi; I Ketut Mariadi; I Dewa Nyoman Wibawa; Yenny Kandarini
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 3 (2016): VOLUME 17, NUMBER 3, December 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.387 KB) | DOI: 10.24871/1732016155-161

Abstract

Background: Patients receiving maintenance hemodialysis (HD) are at higher risk for Hepatitis B Virus (HBV) infections than in general population. Strict infection control is essential to prevent nosocomial transmission. We aimed to investigate the incidence of HBV infection in the HD population in Sanglah General Hospital as well as risk factors acquired HBV infection.Method: All adult patients receiving maintenance HD (n=267) in 3 dialysis units at Sanglah Hospital were studied between March to June 2016. In this study, medical record of patients on maintenance hemodialysis were reviewed and the patients were interviewed by the researchers to collect data regarding the serology status of these patients before and during HD, and potential risk factors which could be associated with HBV acquisition.Results: Participant mean age was 54.07 ± 0.80 years and 154 (57.7%) were male.We found 21 patients (7.8%) were sero-positive for HBV (HBsAg positive) with mean titer was 9.26±1.85. Of the sero-positive patients,1 patient (4.8%) were known to be infected before the initiation of HD and 20 patients (95.2%) were infected during HD. Incidence of HBV infection during  HD was 7.5% (20/266). Sero-positive patients were younger with mean age was 51.81±2.76 years, had longer time on dialysis and had previous blood transfusions. Risk factors, which significant associated with hepatitis B infection were history of transfusion (p0.01; OR: 2.49; 95%CI: 1.29-8.18) and duration of hemodialysis (p 0.01; OR: 1.07; 95% CI: 1.03-3.74).Conclusion: Patients on maintenance HD in Sanglah General Hospital have a high incidence of HBV infection. The factors associated with HBV infection are highly suggestive of nosocomial transmission within HD units. History of transfusion and duration of hemodialysis were significant risk factors for HBV infection in patients receiving maintenance HD.
DIAGNOSIS DAN TATALAKSANA RENAL TUBULAR ASIDOSIS TIPE 1 PADA PASIEN DENGAN LUPUS ERITEMATOSUS SISTEMIK Elim Jusri; Yenny Kandarini; Gede Wira Mahadita
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 6, No 1 (2023): EFFECTS OF CORONA VIRUS 2019
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v6i1.10733

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease affecting several body systems with a variety of clinical manifestations, course of disease, and prognosis. Its clinical manifestations can involve almost all organ systems including musculoskeletal, skin and mucosa, kidney, neuropsychiatry, lung, heart, blood vessels, gastrointestinal, ocular, obstetric, endocrine, and haematology. SLE can occur with a variety of degrees of tubular abnormalities. Tubular inflammation, tubular atrophy, interstitial inflammation and fibrosis are reported in 50-70% of patients with SLE. We have reported a case of a 27-year-old female with renal tubular acidosis (RTA) type 1 who has systemic lupus erythematosus. RTA is a group of abnormalities of the renal function, characterized by renal impairment in the reabsorption of HCO3- and excreting acid (H+). The administration of corticosteroids and immunosuppressants, correction of metabolic acidosis with sodium bicarbonate, and potassium supplementation are the main modalities of therapy in patients with SLE with RTA type-1
Contrast media induced nephropathy: case series and review of the literature focusing on management Marciyasa, Putu Agus; Kandarini, Yenny; Mahadita, Gede Wira; Ayu, Nyoman Paramita
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.252-261

Abstract

BackgroundContrast media administration during diagnostic and invasive procedures in high risk patients for nephrotoxicity is a common problem in clinical practice. Radiological procedures using intravascular iodinated contrast injection media have been widely used for therapeutic purposes. Contrast-induced nephropathy (CIN) is a serious complication of angiographic procedures and results from administration of contrast media (CM), which increases morbidity and mortality rates. Case Description                                                                                                                                                                                                               We present these 10 cases with high risk of CIN and diverse characteristics. A new generation iso-osmolar CM (iodixanol) was administered in these cases. Three of the cases experienced CIN events, where one patient experienced an improvement in his condition, but two other patients experienced complications and eventually died due to the underlying disease. The other 6 cases did not experience CIN after receiving CM, which was due to better preparation beforehand. One patient with a history of regular hemodialysis, underwent immediate post-operative dialysis with CM, and no evaluation of the incidence of CIN was required. Conclusion Of the 10 cases observed, 3 of them experienced CIN which was caused by the severity of the patient’s condition and lack of preparation time before the CM procedure. Management of CIN is complex, starting from the pre-treatment evaluation until 72 hours or more after the CM procedure. This case series suggests that even new generation CM (including iodixanol) may be severely nephrotoxic, when administered to high risk patients. The amount of CM given must be below the maximum limit and adjusted to the patient’s condition. Additionally, we review the complex mechanisms involved in management of CM nephrotoxicity.
Exploring Meditation Influence on Stem Cell: A Review of Current Evidence Santosa, I Gusti Ngurah Putra Eka; Jawi, I Made; Bakta, I Made; Yasa, I Wayan Putu Sutirta; Wirawan, I Made Ady; Lesmana, Cokorda Agung Bagus Jaya; Kandarini, Yenny; Purnamawati, Susy
Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Vol. 7 (2024): PROSIDING SINTESA
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/snts.v7i.3716

Abstract

Endogenous stem cells play a critical role in maintaining tissue homeostasis, repair, and regeneration. The interconnectedness of mind and body has long been recognized as influencing physical health, with practices such as yoga and meditation demonstrating positive effects on overall well-being. This review aims to synthesize current evidence on the effects of meditation on stem cell function, focusing on both indirect (telomere-related) and direct pathways. Meditation appears to influence stem cell function through various mechanisms. Indirectly, meditation may impact stem cells by modulating telomere length and activity. This modulation is likely mediated through stress reduction, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, melatonin elevation, immune system modulation, and reduction of oxidative stress. Directly, meditation may influence stem cell trafficking and differentiation. While studies suggest potential benefits of meditation on stem cell function, further research is needed to fully elucidate the underlying mechanisms. Emerging evidence suggests that meditation may positively influence stem cell function through both indirect and direct pathways. Future research should focus on clarifying the precise mechanisms, investigating the role of meditation parameters, and conducting clinical trials to assess the therapeutic potential of meditation in promoting stem cell-mediated tissue regeneration and repair. A multidisciplinary approach involving researchers from various fields is crucial for comprehensively understanding the complex interplay between meditation, stem cells, and overall health.
Mechanical and Technical Complication in Patient with Continous Ambulatory Peritoneal Dialysis (CAPD) with Encapsulated Peritoneal Sclerosis Kandarini, Yenny; Mahadita, Gede Wira; Tedjamartono, Theodore Dharma
Indonesian Journal of Kidney and Hypertension Vol 2 No 3 (2025): Volume 2 No. 3, December 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i3.197

Abstract

Continuous Ambulatory Peritoneal Dialysis (CAPD) relies on an intraperitoneal catheter for the inflow and outflow of dialysate fluid; therefore, mechanical complications are often encountered. Encapsulated peritoneal sclerosis (EPS) is one of the rare complications in CAPD patients, but it has high mortality and morbidity rates. A case of a patient with EPS was reported in a 53-year-old man in the form of a problem with the dwelling of the CAPD. Patients complain of a longer duration of dwelling with a positive fluid balance. There are no complaints of fever or abdominal pain. Abdominal inspection shows symmetrical, no mass, no wound or pus from the CAPD tip. The patient had a history of recurrent peritonitis. CAPD Cuff was released due to laparoscopy findings with grade IV adhesions in the omentum and peritoneum; it also showed omental cakes and peritoneal fluid with debris. Diagnosis of EPS was established based on the presence of clinical symptoms due to intestinal obstruction and structural disorders due to peritoneal fibrosis, like thickening and adhesions of the intra-abdomen, accompanied by findings of fibrous cocoon or omental cakes in the intestine, with laparotomy and/or laparoscopy. CAPD is related to various complications of infections and non-infections. Although complications related to infections are more often found, non-infection complications such as EPS can also occur in CAPD Patients; therefore, clinicians need to be aware of this complication, especially in patients with a history of recurrent peritonitis.
Seroprevalence of CMV and HSV in Kidney Transplant Donor Candidates and Recipients at Ngoerah Hospital, Denpasar Trisnawati, Ni Nyoman Ayu; Somia, I Ketut Agus; Kandarini, Yenny
Indonesian Journal of Kidney and Hypertension Vol 3 No 1 (2026): Vol 3 No 1 (2026): Volume 3 No. 1, April 2026
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Despite significant advancements in solid organ transplantation over recent decades, infections remain a leading cause of morbidity and mortality among transplant recipients. Herpesviruses, particularly Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV), are the most common viral pathogens affecting this patient population. This study aims to evaluate the seroprevalence of CMV and HSV infections among kidney transplant donor and recipient candidates at RS. Ngoerah Denpasar. Methods: This descriptive study involved 66 adult subjects, comprising 33 kidney transplant donor candidates and 33 recipient candidates, all aged over 18 years. The study participants were evaluated for CMV and HSV seroprevalence using serological tests, including IgG and IgM antibodies, to determine the presence of latent or active infections. The study population included patients with chronic kidney disease (CKD) stage V who were candidates for kidney transplantation. Results: Among the 33 donor candidates, 39.4% were found to have both CMV and HSV infections, with 45.5% testing positive for IgG anti-CMV, indicating a latent CMV infection. In the recipient candidate group, 27.3% were infected with both CMV and HSV, with 42.4% showing seropositivity for IgG anti-CMV. Additionally, a small proportion of donor and recipient candidates were found to have reactivated HSV infections, as indicated by the presence of IgM antibodies. The study highlights the significant prevalence of CMV and HSV infections among kidney transplant donor and recipient candidates. Conclusion: These findings underscore the importance of thorough serological screening prior to transplantation to identify latent infections that may influence post-transplant outcomes.
Characteristic of Patients Undergoing Initiation of Emergency Haemodialysis at Ngoerah Hospital Denpasar in 2023 Dwi Saraswati, Kadek Sinta; Kandarini, Yenny
Indonesian Journal of Kidney and Hypertension Vol 3 No 1 (2026): Vol 3 No 1 (2026): Volume 3 No. 1, April 2026
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v3i1.231

Abstract

Background: Initiation of emergency hemodialysis is associated with higher morbidity and mortality compared to planned hemodialysis. Identifying the characteristics of patients undergoing emergency hemodialysis is essential to improve clinical outcomes. This study aimed to describe the clinical characteristics of patients who initiated emergency hemodialysis at Ngoerah Hospital, Denpasar, in 2023. Methods: This cross-sectional descriptive study used secondary data obtained from the patient registry. Total sampling was applied to include all patients who underwent initiation of emergency hemodialysis at Ngoerah Hospital, between January 1 and March 31, 2023. Data were analyzed descriptively. Results: A total of 70 patients were included. The mean age was 54.54 ± 14.6 years, and 52.3% were male. The most common etiology of CKD) was obstructive nephropathy (32.8%), followed by diabetic kidney disease (21.4%). Major comorbidities included heart disease (35.7%), malignancy (25.8%), and diabetes mellitus (21.4%). The most frequent indications for emergency hemodialysis were metabolic acidosis (71.8%). Temporary jugular vein central venous dialysis catheters were the most commonly used vascular access (67.6%). Only 21.1% of patients had received pre-dialytic monitoring. The median estimated glomerular filtration rate (eGFR) was 5.69 mL/min/1.73 m², median serum creatinine was 8.47 mg/dL, and median serum potassium level was 5.6 mEq/L. Conclusion: Patients initiating emergency hemodialysis at Ngoerah Hospital demonstrated diverse clinical characteristics. The high prevalence of metabolic acidosis along with low rates of pre-dialytic monitoring, highlights the need for improved early detection and management of CKD to reduce emergency hemodialysis initiation. Keywords: emergency hemodialysis, patient characteristics, chronic kidney disease, Ngoerah Hospital Denpasar
Co-Authors Anak Agung Gde Oka Anak Agung Wiradewi Lestari Ayu, Nyoman Paramita Bagus Juniada Cokorda Agung Wahyu Purnamasidhi Djodi Sidartha Dwi Saraswati, Kadek Sinta Dwijo Anargha Sindhughosa Elim Jusri Elizabeth Haryanti Elysanti Dwi Martadiani Gede Andi Aditya Gede Kambayana Gede Wira Mahadita Gede Wira Mahadita Gede Wirya Kusuma Duarsa Hanik Nuryanti Hendra Koncoro I Dewa Nyoman Wibawa I Gde Raka Widiana I Gede Ketut Sajinadiyasa I Gusti Agung Ayu Indira Nirmala Dewi I Ketut Agus Somia I Ketut Mariadi I KETUT SUARDANA, I KETUT I Made Ady Wirawan I Made Arya Winangun I Made Bakta I Made Jawi I Wayan Putu Sutirta Yasa I Wayan Yudiana IBN Mahendra Ida Bagus Putra Pramana Jod Loekman Jodhi S Loekman Jodi S Loekman Jodi Sidharta Loekman K Suwitra Kadek Budi Santosa Kadek Wisnu Segara Karya Ketu Suwitra Ketut Suega Ketut Suwitra Lesmana, Cokorda Agung Bagus Jaya Made Dyah Vismita Indramila Duarsa Made Dyah Vismita Indramila Duarsa Duarsa Mahadita, Gede Wira Marciyasa, Putu Agus Marleen Ni Luh Parameswari Praptika Ni Nyoman Shinta Prasista Sari Ni Putu Rani Apsari Dewi Ni Wayan Winarti Nicholas Wijayanto Nyoma Sutarka Nyoman Margian Nyoman Paramita Ayu Nyoman Yudia Trianadewi Nurbudhi Oka Udrayana Ommy Agustriadi Pande Ketut Kurniari Pande Made Wisnu Tirtayasa Purnamawati, Susy Putu Aryani Putu Astri Novianti Santosa, I Gusti Ngurah Putra Eka Sianny Herawati Sudjana, Karismayusa Tedjamartono, Theodore Dharma Triharnoto Triharnoto Trisnawati, Ni Nyoman Ayu W Sudhana Wayan Sudana Wayan Sudhan Wayan Sudhana Wira Gotera Yuriawantini -