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All Journal Medicina journal of internal medicine Majalah Kedokteran Bandung The Indonesian Biomedical Journal Universa Medicina Indonesian Journal of Rheumatology Jurnal Penyakit Dalam Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA)
Yenny Kandarini
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana, Denpasar, Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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High Incidence of Hepatitis B Virus Infection in Hemodialysis Patients at Sanglah General Hospital and It’s Risk Factors Cokorda Agung Wahyu Purnamasidhi; I Ketut Mariadi; I Dewa Nyoman Wibawa; Yenny Kandarini
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 3 (2016): VOLUME 17, NUMBER 3, December 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.387 KB) | DOI: 10.24871/1732016155-161

Abstract

Background: Patients receiving maintenance hemodialysis (HD) are at higher risk for Hepatitis B Virus (HBV) infections than in general population. Strict infection control is essential to prevent nosocomial transmission. We aimed to investigate the incidence of HBV infection in the HD population in Sanglah General Hospital as well as risk factors acquired HBV infection.Method: All adult patients receiving maintenance HD (n=267) in 3 dialysis units at Sanglah Hospital were studied between March to June 2016. In this study, medical record of patients on maintenance hemodialysis were reviewed and the patients were interviewed by the researchers to collect data regarding the serology status of these patients before and during HD, and potential risk factors which could be associated with HBV acquisition.Results: Participant mean age was 54.07 ± 0.80 years and 154 (57.7%) were male.We found 21 patients (7.8%) were sero-positive for HBV (HBsAg positive) with mean titer was 9.26±1.85. Of the sero-positive patients,1 patient (4.8%) were known to be infected before the initiation of HD and 20 patients (95.2%) were infected during HD. Incidence of HBV infection during  HD was 7.5% (20/266). Sero-positive patients were younger with mean age was 51.81±2.76 years, had longer time on dialysis and had previous blood transfusions. Risk factors, which significant associated with hepatitis B infection were history of transfusion (p0.01; OR: 2.49; 95%CI: 1.29-8.18) and duration of hemodialysis (p 0.01; OR: 1.07; 95% CI: 1.03-3.74).Conclusion: Patients on maintenance HD in Sanglah General Hospital have a high incidence of HBV infection. The factors associated with HBV infection are highly suggestive of nosocomial transmission within HD units. History of transfusion and duration of hemodialysis were significant risk factors for HBV infection in patients receiving maintenance HD.
DIAGNOSIS DAN TATALAKSANA RENAL TUBULAR ASIDOSIS TIPE 1 PADA PASIEN DENGAN LUPUS ERITEMATOSUS SISTEMIK Elim Jusri; Yenny Kandarini; Gede Wira Mahadita
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 6, No 1 (2023): EFFECTS OF CORONA VIRUS 2019
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v6i1.10733

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease affecting several body systems with a variety of clinical manifestations, course of disease, and prognosis. Its clinical manifestations can involve almost all organ systems including musculoskeletal, skin and mucosa, kidney, neuropsychiatry, lung, heart, blood vessels, gastrointestinal, ocular, obstetric, endocrine, and haematology. SLE can occur with a variety of degrees of tubular abnormalities. Tubular inflammation, tubular atrophy, interstitial inflammation and fibrosis are reported in 50-70% of patients with SLE. We have reported a case of a 27-year-old female with renal tubular acidosis (RTA) type 1 who has systemic lupus erythematosus. RTA is a group of abnormalities of the renal function, characterized by renal impairment in the reabsorption of HCO3- and excreting acid (H+). The administration of corticosteroids and immunosuppressants, correction of metabolic acidosis with sodium bicarbonate, and potassium supplementation are the main modalities of therapy in patients with SLE with RTA type-1
Contrast media induced nephropathy: case series and review of the literature focusing on management Marciyasa, Putu Agus; Kandarini, Yenny; Mahadita, Gede Wira; Ayu, Nyoman Paramita
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.252-261

Abstract

BackgroundContrast media administration during diagnostic and invasive procedures in high risk patients for nephrotoxicity is a common problem in clinical practice. Radiological procedures using intravascular iodinated contrast injection media have been widely used for therapeutic purposes. Contrast-induced nephropathy (CIN) is a serious complication of angiographic procedures and results from administration of contrast media (CM), which increases morbidity and mortality rates. Case Description                                                                                                                                                                                                               We present these 10 cases with high risk of CIN and diverse characteristics. A new generation iso-osmolar CM (iodixanol) was administered in these cases. Three of the cases experienced CIN events, where one patient experienced an improvement in his condition, but two other patients experienced complications and eventually died due to the underlying disease. The other 6 cases did not experience CIN after receiving CM, which was due to better preparation beforehand. One patient with a history of regular hemodialysis, underwent immediate post-operative dialysis with CM, and no evaluation of the incidence of CIN was required. Conclusion Of the 10 cases observed, 3 of them experienced CIN which was caused by the severity of the patient’s condition and lack of preparation time before the CM procedure. Management of CIN is complex, starting from the pre-treatment evaluation until 72 hours or more after the CM procedure. This case series suggests that even new generation CM (including iodixanol) may be severely nephrotoxic, when administered to high risk patients. The amount of CM given must be below the maximum limit and adjusted to the patient’s condition. Additionally, we review the complex mechanisms involved in management of CM nephrotoxicity.
Exploring Meditation Influence on Stem Cell: A Review of Current Evidence Santosa, I Gusti Ngurah Putra Eka; Jawi, I Made; Bakta, I Made; Yasa, I Wayan Putu Sutirta; Wirawan, I Made Ady; Lesmana, Cokorda Agung Bagus Jaya; Kandarini, Yenny; Purnamawati, Susy
Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Vol. 7 (2025): PROSIDING SINTESA
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/snts.v7i.3716

Abstract

Endogenous stem cells play a critical role in maintaining tissue homeostasis, repair, and regeneration. The interconnectedness of mind and body has long been recognized as influencing physical health, with practices such as yoga and meditation demonstrating positive effects on overall well-being. This review aims to synthesize current evidence on the effects of meditation on stem cell function, focusing on both indirect (telomere-related) and direct pathways. Meditation appears to influence stem cell function through various mechanisms. Indirectly, meditation may impact stem cells by modulating telomere length and activity. This modulation is likely mediated through stress reduction, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, melatonin elevation, immune system modulation, and reduction of oxidative stress. Directly, meditation may influence stem cell trafficking and differentiation. While studies suggest potential benefits of meditation on stem cell function, further research is needed to fully elucidate the underlying mechanisms. Emerging evidence suggests that meditation may positively influence stem cell function through both indirect and direct pathways. Future research should focus on clarifying the precise mechanisms, investigating the role of meditation parameters, and conducting clinical trials to assess the therapeutic potential of meditation in promoting stem cell-mediated tissue regeneration and repair. A multidisciplinary approach involving researchers from various fields is crucial for comprehensively understanding the complex interplay between meditation, stem cells, and overall health.
Renoprotective Effects of Hydroxychloroquine and Folinic Acid via ET-1 and NLRP3 Modulation in Reducing Tubular Injury in A Rabbit Model of Methanol-induced Acute Kidney Injury Prayuda, Prayuda; Widiana, I Gde Raka; Suega, Ketut; Kandarini, Yenny; Winarti, Ni Wayan; Purwanto, Bambang
The Indonesian Biomedical Journal Vol 17, No 4 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i4.3747

Abstract

BACKGROUND: Methanol intoxication is associated with significant morbidity and mortality, particularly when acute kidney injury (AKI) developed. Emerging evidence implicates Endothelin-1 (ET-1) and Nucleotide-binding domain leucine-rich repeat-containing pyrin receptor 3 (NLRP3) inflammasome in renal injury, but their roles in methanol-induced AKI remain unclear. To date, no studies have examined whether hydroxychloroquine or folinic acid, which are known to modulate ET-1 and NLRP3 signaling, could mitigate renal injury in this setting. This study evaluated their therapeutic effects in a rabbit model of methanol-induced AKI.METHODS: The animals subjects were randomly assigned to four groups: control group receiving aquabidest, folinic acid group receiving 2 mg/kg body weight (BW) intraperitoneal folinic acid, hydroxychloroquine group receiving 30 mg/kg BW oral hydroxychloroquine phosphate, and combination group receiving both folinic acid and hydroxychloroquine at the same dosages. Histopathological evaluation of tubular injury scores and immunohistochemical analysis of ET-1 and NLRP3 expression were then conducted.RESULTS: Expressions of ET-1, NLRP3, and tubular injury scores were significantly lower in the hydroxychloroquine, folinic acid, and combination therapy groups compared to the control group (p<0.001). Expression of ET-1 was lowest in folinic acid group (59.38±0.71%), followed by combination group (62.23±1.98%) and hydroxychloroquine group (62.43±1.81%), compared to control group (72.14±1.02%). Expression of NLRP3 was lowest in combination group (58.94±1.05%), followed by folinic acid and hydroxychloroquine group, which showed equal values (60.57±1.38%), compared to control group (72.15±1.02%). Tubular injury scores were also lowest in combination group (27.07±3.16%), followed by hydroxychloroquine group (45.29±1.75%) and folinic acid group (48.38±2.49%), compared to control group (77.15±1.66%).CONCLUSION: Expression of ET-1 and NLRP3, as well as tubular injury scores, are significantly lower in all treatment groups compared to control, suggesting hydroxychloroquine and folinic acid demonstrated renoprotective effects in methanol-induced AKI, likely through modulation of ET-1 and NLRP3 pathways.KEYWORDS: methanol intoxication, acute kidney injury, hydroxychloroquine, folinic acid, endothelin-1, NLRP3 inflammasome, experimental animal models, rabbits
Co-Authors Anak Agung Gde Oka Anak Agung Wiradewi Lestari Ayu, Nyoman Paramita Bagus Juniada Bambang Purwanto Cokorda Agung Wahyu Purnamasidhi Djodi Sidartha Dwijo Anargha Sindhughosa Elim Jusri Elizabeth Haryanti Elysanti Dwi Martadiani Gede Andi Aditya Gede Kambayana Gede Wira Mahadita Gede Wira Mahadita Gede Wirya Kusuma Duarsa Hanik Nuryanti Hendra Koncoro I Dewa Nyoman Wibawa I Gde Raka Widiana I Gede Ketut Sajinadiyasa I Gusti Agung Ayu Indira Nirmala Dewi I Ketut Mariadi I KETUT SUARDANA, I KETUT I Made Ady Wirawan I Made Arya Winangun I Made Bakta I Made Jawi I Wayan Putu Sutirta Yasa I Wayan Yudiana IBN Mahendra Ida Bagus Putra Pramana Jod Loekman Jodhi S Loekman Jodi S Loekman Jodi Sidharta Loekman K Suwitra Kadek Budi Santosa Kadek Wisnu Segara Karya Ketu Suwitra Ketut Suega Ketut Suwitra Lesmana, Cokorda Agung Bagus Jaya Made Dyah Vismita Indramila Duarsa Made Dyah Vismita Indramila Duarsa Duarsa Mahadita, Gede Wira Marciyasa, Putu Agus Marleen Ni Luh Parameswari Praptika Ni Nyoman Shinta Prasista Sari Ni Putu Rani Apsari Dewi Ni Wayan Winarti Nicholas Wijayanto Nyoma Sutarka Nyoman Margian Nyoman Paramita Ayu Nyoman Yudia Trianadewi Nurbudhi Oka Udrayana Ommy Agustriadi Pande Ketut Kurniari Pande Made Wisnu Tirtayasa Prayuda, Prayuda Purnamawati, Susy Putu Aryani Putu Astri Novianti Santosa, I Gusti Ngurah Putra Eka Sianny Herawati Sudjana, Karismayusa Triharnoto Triharnoto W Sudhana Wayan Sudana Wayan Sudhan Wayan Sudhana Wira Gotera Yuriawantini -