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Journal : Journal of Agropharmacy

Formulasi Krim Ekstrak Daun Kersen (Muntingia calabura L.) dan Seng Oksida Sebagai Sediaan Tabir Surya Rosyidi, Viddy Agustian; Ameliana, Lidya; maarif, safirul
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Sunscreen has two types of working mechanisms, namely chemical absorber and physical blocker. Sunscreens are usually made from synthetic chemicals, but currently there are many natural ingredients that have potential as sunscreens and are believed to have little negative effect compared to synthetic chemicals. One example of a natural ingredient that has potential as a sunscreen is kersen leaves. Kersen leaves contain quite a lot of flavonoid and polyphenol compounds, therefore cherry leaves have the potential to be an antioxidant and natural sunscreen. The effectiveness of cherry leaf sunscreen can be optimized by adding a physical blocker sunscreen ingredient, namely zinc oxide. Based on research results, the in vitro effectiveness value of sunscreen cream preparations provides the best results with an SPF value of 2.193 ± 0.152 which is included in the minimal protection category with a reduction in the percentage transmission value of erythema (%TE) of 1.513 ± 0.523 which is included in the sunblock category. and the percent pigmentation transmission (%TP) value was 1,378 ± 0.325, which is included in the sunblock category.
Optimasi Moringa Gum dan Hidroksi Propil Metil Selulosa dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida Sari, Lusia Oktora Ruma Kumala; Hanif, Mohammad Ainul Fakhruddin; Irawan, Eka Deddy; Winarti, Lina; Barikah, Kuni Zu’aimah; Rosyidi, Viddy Agustian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Moringa gum is a natural polymer obtained from Moringa oleifera plant and has been used as a stabilizer, binder, disintegrant, and controlled release matrix. Moringa gum has a polyuronide group, which can potentially be a mucoadhesive agent. This study used moringa gum as a mucoadhesive agent in diltiazem HCl mucoadhesive buccal film. This research aimed to determine the effect of the combination of moringa gum and HPMC on surface pH, swelling index, and in-vitro mucoadhesive residence time. Mucoadhesive buccal films were evaluated for weight and thickness uniformity, folding resistance, drug content, surface pH, swelling index, in-vitro mucoadhesive residence time, and characterization in the form of FTIR and release studies. All formulations met the tests of uniformity of weight and thickness, folding resistance, and drug content. The results showed FB as the optimum formula with a surface pH of 5.803±0.101, a swelling index of 7.031±0.134, and a residence time of 505.67±4.51 minutes. FTIR showed no interaction, and the release study showed 82.197±1.178% release at 480 minutes. In conclusion, a combination of moringa gum and HPMC mucoadhesive buccal film has been successfully prepared with moringa gum as a mucoadhesive agent that increases the residence time.