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Bawon Triatmoko
Fakultas Farmasi Universitas Jember
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Molecular Docking Analysis of Anti-malarial Compounds as Plasmepsin IV Inhibitor from Targeted Indonesian Medicinal Plants Arthur Hariyanto Prakoso; Muhammad Habiburrohman; Wilda Nur Rohmatillah; Bawon Triatmoko; Ari Satia Nugraha
Nusantara Science and Technology Proceedings International Conference on Life Sciences and Biotechnology (ICOLIB)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0801

Abstract

Malaria is one of the major causes of death in tropical and sub-tropical countries, caused by the infection of the protozoan parasite (Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium knowlesi). As the prevalence of parasite drug-resistant strains increasing, alternative medicine to eliminate malaria is needed. In this study, a molecular docking protocol was employed to predict and select natural compounds from Indonesian medicinal plants as an antimalarial drug candidate. The docking protocol was validated by the RMSD value of crystal versus docking calculation. From 43 species of plants, 238 total compounds were collected and docked into Plasmepsin IV (PMIV) enzyme which plays a role in the nutrition uptake of Plasmodium in human blood circulation. This enzyme was collected from a protein database with codename 5I70. The protocol was produced an acceptable RMSD value of 1.435 ?. The docking experiment resulted in AM202 (Cassiamin B) from Cassia siamea as the best potent Plasmepsin IV inhibitor. This compound has the potential candidate for future anti-malarial drugs. Cassiamin B had an affinity value of -11.2 kcal/mol which was higher than PMIV’s native ligand (-3.8 kcal/mol).
Ethnopharmacology and Computer-Aided Tandem Protocol to Search for Antimalarial Agents from Indonesian Medicinal Plants: HAP Inhibitor Adinda Kusuma Pertiwi; Muhammad Habiburrohman; Yoshinta Debby; Bawon Triatmoko; Ari Satia Nugraha
Nusantara Science and Technology Proceedings International Conference on Life Sciences and Biotechnology (ICOLIB)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0802

Abstract

The anti-malarial potency of Indonesian medicinal plants was evaluated through computational study. From 43 Indonesian medicinal plants, 238 previously reported compounds were carefully docked into HAP (histo-aspartic protease) with codename 3FNT in which the enzyme plays an important catalytic role in Plasmodium falciparum innate metabolism. Exhaustive docking experiments produced 6 best hits molecules including AM210 (4-hydroxy- 3-methoxy strychnine), AM213 (protostrychnine), and AM216 (pseudostrychnine) which have less free energy compared to HAP native ligand, 1,2-ethanediol. This study revealed the potency of Strychnos nux-vomica L. as a source for antimalaria and support its traditional claims.
The Virtual Screening to Search Proplasmepsin II Inhibitor from Indonesian Medicinal Plant Phytochemicals: Anti-Malaria Muhammad Habiburrohman; Wilda Nur Rohmatilah; Arthur Hariyanto Prakoso; Bawon Triatmoko; Ari Satia Nugraha
Nusantara Science and Technology Proceedings International Conference on Life Sciences and Biotechnology (ICOLIB)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0804

Abstract

The indigenous people of Indonesia have used medicinal plants to survive infectious diseases, including malaria. The knowledge has been passed through the generation and a limited number of the plants have been studied properly. Malaria infection has been an endemic and complicated problem in the archipelago where drug-resistant cases worsen the situation. Natural product study without pharmacological information has been a drawback to the development of natural-based antimalarial. Computational chemistry protocol gives lower cost facilitation to later a conventional in vitro bioassay. In this study, virtual screening was deployed to find a Proplasmepsin II enzyme inhibitor, in which the enzyme plays an important in this parasite metabolism. The enzyme (1PFZ) was collected from the PDB database followed by docking validation before exhaustive docking calculation of 238 compounds from 43 Indonesian medicinal plants. The docking protocol was valid as indicated by rmsd value of 1.275 Å. One top hit molecule, AM56, was gained with its free energy of binding value of 10.8 kcal/mol which is better than the interaction of the native ligand, propane-1,2,3-Triol, with the free energy of binding ( G) score of 3.9 kcal/mol. AM56 was a secondary metabolite of Borassus flabellifer and its anti-plasmodium was previously studied. However, the mechanism of action of AM56 was never been reported. This study was able to discover a molecular scaffold of proplasmepsin II enzyme inhibitor and can be used as a pathway to QSAR study of AM56 semi-synthetic derivatives.
Virtual Screening the Interaction of Various Compound from Indonesian Plants with the HGXPRT Enzyme to Find a Novel Antimalarial Drug Wilda Nur Rohmatillah; Naura Bathari Winarto; Arthur Hariyanto Prakoso; Bawon Triatmoko; Ari Satia Nugraha
Nusantara Science and Technology Proceedings International Conference on Life Sciences and Biotechnology (ICOLIB)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0805

Abstract

Medicinal plants have been a notable source for antimalarial agents. This study was aimed to investigate the antimalarial potency of Indonesian medicinal plants used traditionally in malarial fever therapy. A total of 238 compounds derived from 43 plants traditionally used to alleviate malarial fever were collected and loaded into molecular docking protocol. The compounds were screened against Hypoxanthine-Guanine-XanthinePhosphoribosyltransferase (HGXPRT, 3OZF) using the AutoDock Vina software 1.1.2. The compound is important for the purine synthesis of the parasite. The experiment resulted in AM125 (20-isoveratramine) from Cyanthillium patulum to possess the highest affinity with free energy (?G)-11 kcal/mol, which is better than HGXPRT native ligands (-6.4kcal/mol). This suggested Cyanthillium patulum was a potential source for antimalarial agents in which its constituents, 20-isoveratramine might responsible for the claims.
In Silico Study of Histo-aspartic Protease (HAP) Inhibitor from Indonesian Medicinal Plants: Anti-malarial Discovery Dinar Mutia Rani; Muhammad Habiburrohman; Yoshinta Debby; Bawon Triatmoko; Ari Satia Nugraha
Nusantara Science and Technology Proceedings International Conference on Life Sciences and Biotechnology (ICOLIB)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0803

Abstract

Malaria is an infectious disease caused by Plasmodium sp with the highest clinical incidence of 12.07% in Indonesia. New anti-malaria compounds are needed to replace antimalarial drugs that are already resistant nowadays. One of the efforts to find a new anti-malaria drug is through research on traditional medicinal plants used by Indonesian tribes from the ethnopharmacology database. In silico studies provide saving solutions in the process of computer-aided drug design. Histo-aspartic protease (HAP) is essential for the growth of Plasmodium falciparum and has been validated as an antimalarial drug target. Therefore, molecular docking was used to provide new insights into the development of drugs by targeting HAP protease. There are 238 compounds from 43 medicinal plants used as targeting ligand in this study prepared by Autodock Vina for an automated docking tool. The comprehensive docking protocol was valid showed by the RMSD value of 1,275 Å. The result obtained that AM50 (borrasosides A) from Borassus flabellifer was found to have the least affinity score of -10.1 kcal/mol higher compared to the native ligand. In conclusion, we are assuming that the mechanism of borrasosides A compound might get involved with HAP. Further protocols are required to prove the HAP inhibition towards Plasmodium falciparum.
Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak dan Fraksi Daun Senggugu (Rotheca serrata (L.) Steane & Mabb.) terhadap Staphylococcus aureus Nimas Ayu Amanda Putri; Bawon Triatmoko; Ari Satia Nugraha
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.4809

Abstract

Indonesia merupakan salah satu negara berkembang yang masih memiliki banyak permasalahan di bidang kesehatan, salah satu diantaranya adalah penyakit infeksi. Pencarian atau penelusuran agen antibakteri baru perlu dilakukan untuk mendapatkan alternatif antibiotik yang memiliki aktivitas terhadap mikroorganisme patogen. Salah satu cara untuk mendapatkan antibiotik baru adalah dengan memanfaatkan agen antibakteri yang bersumber dari tanaman seperti senggugu (Rotheca serrata (L.) Steane & Mabb.). Penelitian ini dilakukan untuk mengetahui kandungan golongan senyawa kimia dan aktivitas anibakteri yang ada pada daun senggugu. Daun senggugu diekstraksi dengan menggunakan metanol. Ekstrak dari daun senggugu kemudian difraksinasi dengan metode fraksinasi bertingkat menggunakan pelarut heksana, diklorometana dan etil asetat. Skrining fitokimia dilakukan dengan menggunakan metode KLT (Kromatografi Lapis Tipis) untuk melihat secara kualitatif adanya kandungan alkaloid, terpenoid, polifenol dan flavonoid. Uji aktivitas antibakteri dilakukan dengan metode mikrodilusi untuk mendapatkan nilai IC50 ekstrak dan fraksi daun senggugu terhadap Staphylococcus aureus ATCC 25923. Uji aktivitas antibakteri ekstrak dan fraksi daun senggugu menunjukkan bahwa fraksi heksana (323,729±2,025 µg/mL) memiliki aktivitas yang paling besar dengan kandungan senyawa kimia berupa terpenoid.
Skrining Fitokimia dan Uji Aktivitas Antibakteri Tumbuhan Jelutong Pipit (Kibatalia arborea (Blume) G.Don) terhadap Escherichia coli Ita Husnul Chotimah; Bawon Triatmoko; Ari Satia Nugraha
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.4806

Abstract

Infeksi menjadi masalah kesehatan yang serius terutama di negara berkembang seperti di Indonesia.Sejumlah agen antibakteri baru yang berasal dari metabolit sekunder tumbuhan telah banyak diteliti salah satunya adalah Kibatalia arborea (Bl) G.Don.Penelitian ini dilakukan untuk mengetahui aktivitas dan kandungan golongan senyawa yang ada pada daun K. arborea. Daun K. arborea diekstraksi dengan menggunakan metanol. Ekstrak dari daun K. arborea kemudian difraksinasi dengan metode fraksinasi bertingkat menggunakan pelarut n- heksana, diklorometana dan etil asetat. Uji aktivitas antibakteri dilakukan dengan metode mikrodilusi untuk mendapatkan nilai IC50 ekstrak dan fraksi daun K. arborea terhadap Escherichia coli ATCC 25922. Skrining fitokimia dilakukan untuk melihat adanya kandungan golongan senyawa alkaloid, terpenoid, polifenol dan flavonoid. Uji aktivitas antibakteri ekstrak dan fraksi daun K. arborea terhadap E. coli menunjukkan bahwa fraksi etil asetat (516,458±12,073 µg/ml) memiliki aktivitas yang paling besar, diikuti ekstrak (590,665±24,157 µg/ml) dan dua fraksi dengan nilai IC50 yang tidak berbeda secara signifikan yaitu fraksi n-heksana (880,667±22,587 µg/ml) dan fraksi diklorometana (848,616±37,029 µg/ml). Hasil skrining fitokimia ekstrak metanol daun K. arborea menunjukkan bahwa ekstrak mengandung senyawa dari golongan flavonoid, polifenol, terpenoid. Fraksi heksana mengandung alkaloid dan terpenoid. Fraksi diklorometana mengandung alkaloid, terpenoid dan polifenol. Fraksi etil asetat mengandung terpenoid, polifenol dan flavonoid. Sedangkan residu tidak mengandung golongan senyawa flavonoid, polifenol, terpenoid dan alkaloid.
Optimasi Formula Granul Effervescent Kombinasi Ekstrak Kelopak Bunga Hibiscus Sabdariffa L. dan Ekstrak Daun Guazuma Ulmifolia Lam. Dwi Nurahmanto; Marsalita Irine Prabandari; Bawon Triatmoko; Nuri Nuri
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 14 No. 02 Desember 2017
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (839.031 KB) | DOI: 10.30595/pharmacy.v14i2.2031

Abstract

Guazuma ulmifolia Lam. dan Hibiscus sabdariffa L. dapat digunakan untuk menurunkan kadar kolesterol dalam darah. Penelitian ini membuat sediaan granul effervescent dari kombinasi ekstrak daun Guazuma ulmifolia Lam. dan ekstak Kelopak Bunga Hibiscus sabdariffa L. Jamu yang mengandung ekstrak tersebut biasanya memiliki rasa yang pahit. Formulasi dalam bentuk effervescent, dengan asam sitrat dan natrium bikarbonat sebagai sumber asam dan basa, dapat memperbaiki sifat yang kurang menyenangkan tersebut. Penelitian ini bertujuan untuk mengetahui formula optimum yang memiliki sifat fisik granul effervescent yang baik. Penelitian ini dilakukan berdasarkan metode desain faktorial dengan dua faktor dan dua level yang menghasilkan empat formula yaitu formula (1), a, b, dan ab. Sifat fisik granul effervescent yang diuji adalah kelembaban dan waktu larut. Hasil menunjukkan bahwa peningkatan konsentrasi natrium bikarbonat dapat menurunkan kelembaban dan waktu larut. Sedangkan, peningkatan konsentrasi asam sitrat justru sebaliknya. Formula optimum yang diperoleh dalam penelitian ini mengandung asam sitrat 600 mg dan natrium bikarbonat 1440 mg. Formula tersebut memiliki komposisi yang sama seperti formula b.
Isolasi Fungi Tanah Muara Desa Pasir Putih Kabupaten Situbondo serta Penapisan Aktivitas Antibakteri terhadap Staphylococcus aureus Ziyan Nihlatul Millah; Bawon Triatmoko; Ari Satia Nugraha
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1077

Abstract

Healthcare-Associated Infections (HAIs) is a bacterial infections in Indonesia caused by Staphylococcus aureus. According to the World Health Organization (WHO), the prevalence of HAIs in developing countries varies between 5.7% and 19.1% with a combined prevalence of 10.1%. The prevalence of HAIs in Indonesia is 7.1%. Infections caused by bacteria are a life-threatening disease, which needs to be treated immediately by administering antibacterial agents. One of the natural products with potential as new antibacterial agents, such as soil fungi. This research aims to discover the Antibacterial activity of fungi on estuary land at Pasir Putih village, Situbondo, East Java. This research was initiated by growing the soil on the PDA media to isolate six fungi which were labeled as IS-B1-A1, IS-B1-A2, IS-B1-T1, IS-B1-T2, IS-B1-B1, and IS-B1-B2. All the isolated fungi were separately fermented for 14 d and extracted using ethyl acetate before the microdilution test. The result of antibacterial testing showed all extracts from isolated fungi with code IS-B1-A1, IS-B1-A2, IS-B1-T1, IS-B1-T2, IS-B1-B1, and IS-B1-B2 possessed antibacterial activity against Staphylococcus aureus with percentage inhibition of 51.1±2.6%; 84.6±3.1%; 72.7±7.9%; 82.9±7.6%; 65.6±0.8%; 88.2±2.8% at a concentration of 100 μg/mL.
Pengaruh Metode Ekstraksi terhadap Kadar Fenol dan Flavonoid Total, Aktivitas Antioksidan serta Antilipase Daun Jati Belanda (Guazuma ulmifolia) Nuri, Nuri; Puspitasari, Endah; Hidayat, Mochammad Amrun; Ningsih, Indah Yulia; Triatmoko, Bawon; Dianasari, Dewi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.143-150.2020

Abstract

The leaf of Guazuma ulmifolia has been used traditionally for antiobesity. The activity of antiobesity was affected by the content of bioactive compounds. Extraction is the primary step to obtain bioactive compounds from plant material. The method and solvent used for extraction are crucial factors to produce extracts that have a high amount of active compounds. This study aims to determine the total phenolic and total flavonoids content from ethanolic extracts, water extract, and infusions of G. ulmifolia leaf and to evaluate the antioxidant and antilipase activity. Folin-Ciocalteu method was used to determine the phenolic content, while flavonoid content determination was done using aluminium chloride colorimetric assay. The antioxidant activity was done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and the antilipase activity was quantified using p-nitrophenol release from p-nitrophenyl butyrate (p-NPB) substrate-colorimetric assay. The result of G. ulmifolia leaf extraction showed that the highest yield was obtained from water extraction (10.50%). Whereas, the ethanolic extract was showed the highest total phenolic content (67.761±1.811 mg GAE/g extract) and the highest total flavonoid content (124.643 ± 1.033 mg QE/g extract). The same extract also exhibited the highest antioxidant activity (IC50 = 6.544 ± 0.271 µg/mL) and antilipase activity (IC50 = 307.280 ± 21.430 µg/mL).
Co-Authors Achmad Syarifudin Noor Adinda Kusuma Pertiwi Afif Rifqie Maulana Afrian Rosyadi Agustinus Yuswanto Amrina Rosyada Fajriyanti Ari Satia Nugraha Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Asia Asia Asia, Asia Dewi Dianasari Dewi Dianasari Dianasari, Dewi Dinar Mutia Rani Dita Isnaini Prabawati Dwi Nurahmanto Dwi Nurahmanto Endah Puspitasari Fauzia Ken Nasititi Fawwas Batio Putra Pamungkas Gani Asri Muharam Huda Almuttaqin Ifan Arif Maulana Indah Yulia Ningsih Ita Husnul Chotimah Lestyo Wulandari Mariatul Kibthiyyah Marsalita Irine Prabandari Mochammad Amrun Hidayat Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Muhammad Zainul Arifin Muharram, Gani Asri Nafa Rosyida Zanuba Nasititi, Fauzia Ken Naura Bathari Winarto Nimas Ayu Amanda Putri Nuri Nuri Nuri Nuri Nuri Nuri Saeful Akhmad Tauladani Savitri, Ganevi Resta Tauladani, Saeful Akhmad Triana Hertiani Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yoshinta Debby Zanuba, Nafa Rosyida Ziyan Nihlatul Millah