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All Journal e-Journal Pustaka Kesehatan Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) UNEJ e-Proceeding Science and Technology Indonesia Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Journal of Agropharmacy
Lusia Oktora Ruma Kumala Sari
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Optimasi Kecepatan dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida Menggunakan Polimer Etil Selulosa (Optimization of Stirring Speed and Time on Preparation of Metformin Hydrochloride Microspheres Using Ethyl Cellulose Polymer) Amalia Fadila; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Metformin hydrochloride (MH) is a first line therapy in the treatment of noninsulin-dependent diabetes mellitus. However, MH has a very short half-life, relatively low bioavailability, and gastrointestinal adverse effects. Controlled released formulations can overcome this problem by increasing gastro retention time (GRT). Drug delivery systems aimed at improving GRT can be designed in a single units (eg, tablets) and multiple unit (eg, microspheres). Stirring speed and time affect several aspects such as shape, size, and particle size distribution, the release rate, and entrapment efficiency (EE) of the microspheres.. This research was aimed to find the stirring speed and time to produce MH microspheres having high EE. The result showed that the microspheres stirred at 1,000 rpm for 2 hours produced the highest EE, 84.792 ± 0.975 %; had the drug loading of 12.067 ± 0.0649 %; and yield of 99.44 ± 0.123 % with the particle size 157.5 ± 1.007 μm, has the spheres shape and a relatively smooth and bright surface morphology. FTIR analysis results indicated that there were no changes in the functional groups on MH as an active ingredient. Keywords: metformin hydrochloride-ethyl cellulose microspheres, non-aquoeous solvent evaporation, stirring speed, stirring time, factorial design
Optimasi Formula Tablet Effervescent Dispersi Padat Meloksikam Menggunakan Desain Faktorial Lusia Oktora Ruma Kumala Sari; Tiara Berlianti; Eka Deddy Irawan
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7571

Abstract

An effervescent tablet of meloxicam solid dispersion has been developed for geriatric patients who have difficulty swallowing. The objective of this research was to know the optimum concentration of citric acid and sodium bicarbonate which produce the best effervescent tablet. A 2² factorial design was applied to investigate the effect of two factors: concentration of citric acid and sodium bicarbonate (effervescent materials) on hardness, dissolve time, and %drug released t30. Citric acid (6-18 mg) was used as acid source and sodium bicarbonate (18-105 mg) was used as base source. Software Design Expert trial version 10.0.5. was used to determine the optimum formula. The result showed that all formula satisfied the limit of hardness 2-4 kg/cm2 and friability <1%, but only formula (1), b, and ab that satisfied the limit of dissolve time <300 sec and %drug release t30 >70%. Formula A showed dissolve time 436 sec and %drug release t30 less than 70%. Desirability value of 0.917, which indicated the optimum formula, was obtained from the use of citric acid 6 mg and sodium bicarbonate 105 mg. Keywords: meloxicam, effervescent tablet, solid dispersion, factorial design
Optimasi Komposisi Pelarut Gliserin dan Propilen Glikol terhadap Disolusi Tablet Meloksikam Metode Likuisolid Menggunakan Simplex Lattice Design (Optimization Composition of Glycerin and Propylene Glycol Solvent on Dissolution of Meloxycam Tablet with Li Yudistirawati Khusna; Eka Deddy Irawan; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Meloxicam is Non Steroid Inflammation Drugs (NSAID) that inhibit cyclooxygenase-2 (COX-2). Meloxicam has poor solubility in water. The drug that has poor solubility, need to be modified to increase the solubility. The technique that can increase the solubility is liquisolid technique. The research aim was to develop tablet formulation of meloxicam by increasing the solubility using liquisolid method. This liquisolid tablet used combination of propylene glycol and glycerin as nonvolatile solvent to increase meloxicam release. The liquisolid tablets were evaluated for physical chemical characteristics e.g. homogeneity level, drug content uniformity, friability, hardness, disintegration time and in vitro drug release. Optimization composition of propylene glycol and glycerin used simplex lattice design method with nonvolatile solvent as a factor and dissolution efficiency (DE60) as response. The use of propylene glycol and glycerin will increase drug release. Optimum composition of propylene glycol and glycerin resulting optimum dissolution efficiency (DE60) between 78,88 – 88,48 % was propylene glycol with concentration of 0-15 mg and glycerin with concentration of 0-15 mg in 300 mg of tablet. Keyword: meloxicam, liquisolid, propylene glycol, glycerin, simplex lattice design
Preparasi dan Karakterisasi Nanopartikel Kitosan-Naringenin dengan Variasi Rasio Massa Kitosan-Natrium Tripolifosfat (Preparation and Caracterization of Naringenin-Chitosan Nanoparticles with Various Mass Ratio of Chitosan-Sodium Tripolyphosphat) Helmi Nur Laili; Lina Winarti; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Naringenin has a wide pharmacological activities. Low bioavailability of naringenin caused the under-developed utilization. Preparation of naringenin nanoparticles can improve the bioavailability. Chitosan as polymer for nanoparticles has ideal properties such as nontoxic, biocompatible, biodegradable. Sodium tripolyphosphat (NaTPP) used as an crosslinker to form nanoparticles by ionic gelation method. The aim of this research is to know the optimum formula of chitosan and NaTPP in naringenin-chitosan nanoparticles based on entrapment efficiency (EE) using factorial design. In this research, naringenin-chitosan nanoparticles were prepared with various mass ratio, 6:1, 10:1, 3:1, 5:1 and then EE each formulas measured by UV spectrophotometer. The optimum formula of naringenin-chitosan nanoparticles were characterized by PSA, TEM, and FTIR. The optimum formula (3:1) showed EE >42.12%. The consentration of chitosan and NaTPP to get final optimum formula were 0.06-0.0606777% for chitosan and 0.0970833-0.1% for NaTPP. The result of characterizations showed that size of naringenin-chitosan nanoparticles 13.2 ± 2.6 nm, PDI 0.443, zeta potensial 15.23 mV, complex chitosan-TPP formed. The results demostrated naringenin nanoparticles have successfully prepared. Keywords: naringenin, nanoparticle, chitosan, sodium tripolyphosphat
Optimasi Hydroxypropyl Methylcellulose dan Xanthan Gum pada Tablet Floating-Mucoadhesive Gliclazide Metode Desain Faktorial (Optimization of Hydroxypropyl Methylcellulose and Xanthan Gum on Floating-Mucoadhesive Gliclazide Tablet using Factorial Design) Eva Setyorini; Eka Deddy Irawan; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Gliclazide is one of the drugs used for type 2 diabetes mellitus treatment. It requires frequent dosing which is why gliclazide need to be formulated into preparations using a controlled release drug delivery system. This study aimed to determine the optimum composition of hydroxypropyil methylcellulose (HPMC K4M) and xanthan gum polymer combination for gliclazide tablet. Tablets that have been produced were evaluated for tablets physical characterization, homogenity test, dissolution test, floating lag time, and mucoadhesive test. Tablets were optimized using a factorial design and the data were analyzed using design expert trial 9.0.6. The results showed that the optimal formulation for polymer combination in gliclazide tablet was 122.267-140.000 mg for HPMC K4M and 80.659-90.000 mg for xanthan gum.   Keywords: gliclazide, HPMC K4M, xanthan gum, floating-mucoadhesive system, factorial design.
Optimasi Konsentrasi Kitosan dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida (Optimization of Chitosan Consentration and Stirring Time on Preparation of Metformin Hydrochloride Microspheres) Tintia Lintang Pratiwi; Eka Deddy Irawan; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Microspheres is multiple dosage unit controlled drug delivery system with the range of a particle size of 1-1000 µm. Chitosan was used as a polymer and metformin hydrochloride (MH) was used as a drug, and non-aqueous solvent evaporation was chosen for the techniques of microspheres preparation. MH is the first line for treatment of diabetes mellitus type 2. It has relatively low bioavailability and short half-life, therefore it is appropriate to be prepared as microspheres. Many factors affect the result of microspheres preparation, such as chitosan concentration and stirring time which used in preparation. Factorial design optimization used to determine the chitosan concentration and stirring time to produce MH-chitosan microspheres with the highest entrapment efficiency (EE). The result of microspheres preparation used 2250 mg of chitosan and 2 hours stirring time produced 81.191 % EE, and drug loading and yield of 22.673 and 89.602 %, respectively. The microspheres had spheres shape and a relatively smooth and bright surface morphology. The particle size was 653.333 μm. FT-IR analysis indicated that there were no changes in the functional groups on MH as an active ingredient.   Keywords: metformin hydrochloride-chitosan microspheres, non-aquoeous solvent evaporation, factorial design, chitosan concentration, time stirring
FORMULATION AND OPTIMIZATION OF CARBOPOL AND ETHYL CELLULOSE AS FLOATING-MUCOADHESIVE SYSTEM OF DILTIAZEM HYDROCHLORIDE TABLET BY FACTORIAL DESIGN Eka Deddy Irawan; Lusia Oktora Ruma Kumala Sari; Andreas Henry Prasetyo
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Hypertension is a degenerative disease that eachyear has increased the number of patients. Numberof patients in Indonesia is estimated at 15 millionpeople. Nearly 50% of patients suffering fromhypertension are not aware that tends to be severehypertension (Syahrini et al., 2012).Diltiazem Hydrochloride (HCl) is an antihypertensivedrug used 3-4 times a day with doses of 30-60 mg(UBM Medica, 2012). Diltiazem HCl has a half life of3-5 hours (Sweetman, 2009) with the mainabsorption area in the upper stomach (Kapil et al.,2012) that can be formulated into sustained releasedosage gastro retentive system.The system created is a combination of floatingmucoadhesive.The combination of these systems isexpected to overcome the shortcomings of thesystem when used alone. Floating system floats overthe surface of gastric contents when the stomach isfull but at the time stomach is emptied and thetablet reaches the pylorus the bouyancy of thedosage may be decreased. If the stomach is full,mucodhesive dosage form not properly adheres maybe passage the pylorus due to peristalticmovements of the stomach (Gaykar et al., 2013).Polymer is one of the essential ingredients toproduce a floating-mucoadhesive system that meetsthe requirements. The polymer used is acombination of Carbopol and ethyl cellulose. Thecombination of hydrophilic and hydrophobicpolymers proved able to control the rate of drugrelease with high solubility (Nanjwade et al., 2011).
OPTIMASI KOMPOSISI KARBOPOL DAN NATRIUM KARBOKSIMETILSELULOSA SEBAGAI SISTEM BUCCAL MUCOADHESIVE TABLET PROPRANOLOL HIDROKLORIDA Eka Deddy Irawan; Siti Munawaro; Lusia Oktora Ruma Kumala Sari
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 9 No 2 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

The purpose of this study is to provide controlled release dosage by avoiding first pass metabolism and enzymatic degradation. Propranolol hydrochloride mucoadhesive buccal tablets was prepared by direct compression method using carbopol and CMC Na as buccal mucoadhesive polymer. Buccal mucoadhesive strength measured using buccal mucosa of gout. Testing the release of propranolol hydrochloride was determined by dissolution test using phosphate buffer solution pH 6,8 for 8 hours. Dissolution efficiency (DE) was calculated to describe the overall release profiles and used in determining the optimum response. The optimum region is determined using factorial design with the design criteria of response force for 20-40 grams of mucoadhesive buccal and DE480 between 45-55%. The amount of carbopol that can provide the optimum response is between the range of 53,27-55 mg while the amount of CMC Na can provie the optimum response range is between 70-100 mg.
OPTIMASI CROSPOVIDONE DAN POLYVINYL PYRROLIDONE K-30 DALAM FORMULASI ORALLY DISINTEGRATING TABLET (ODT) SALBUTAMOL SULFAT Lusia Oktora Ruma Kumala Sari; Kuni Zu’aimah Barikah; Via Rahmatia
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 1 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i1.19900

Abstract

Abstract. The objective of the present study was to optimize crospovidone as a superdisintegrant and polyvinyl pyrrolidone (PVP) K-30 as a binder in ODT salbutamol sulphate. ODT salbutamol sulphate was made by direct compression technique. Optimization was carried out by the factorial design method using Design Expert 11.0 software with optimized responses, including hardness, friability, and disintegration time. The result showed that crospovidone affected the decrease in the disintegration time of ODT. PVP K-30 affected decreasing friability and increasing hardness and disintegration time of ODT. The interaction of crospovidone and PVP K-30 affected the decrease in ODT's disintegration time. The optimum formula contained 5% crospovidone and 1,5% PVP K-30, resulting in 5,087 kg of hardness, 0,743% friability, and 45,350 seconds of disintegration time. ODT salbutamol sulphate’s optimum formula dissolved 93,082% after 30 minutes. Kata Kunci Orally disintegrating tablet; salbutamol sulphate; crospovidone; pvp k-30
OPTIMASI MORINGA GUM DAN GLISERIN DALAM SEDIAAN MUCOADHESIVE BUCCAL FILM DILTIAZEM HIDROKLORIDA Lusia Oktora Ruma Kumala Sari; Lidya Ameliana; Putri Mustika Nandani
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20866

Abstract

Moringa Gum is a gum derived from the Moringa oleifera tree which can be used as a stabilizer, binder, mucoadhesive, disintegrant, sustained release and controlled release matrix. Diltiazem Hydrochloride is a drug with low bioavailability and has a low plasma half-life (3-4 h). The bioavailability and half-life of Diltiazem Hydrochloride can be improved by buccal film mucoadhesive formulation. In this study, a combination of natural polymers, namely Moringa Gum and glycerin plasticizer, was used to produce a film with swelling, mucoadhesive properties and also good folding resistance. This studi was conducted to optimize Moringa Gum and glycerin to see the release profile of Diltiazem Hydrochloride in the muchoadhesive buccal film. The formulation was carried out using the solvent casting method with optimization using a design expert while verification of the optimum formula was carried out using a one sample t test with a confidence level of 95% with the condition that the significance was p>0,05. The optimum formula obtained from the amount of polymer Moringa Gum is 75 mg and the plasticizer glycerin is 5 mg. The results of the FTIR test showed that there was no interaction between Diltiazem Hydrochloride and the moringa gum polymer. As for the release test results, the release percentage was 99.69% by following the Higuchi release model. This study concludes is that buccal film was successfully prepared using a combination of moringa gum and glycerin with its potential to increase the bioavailability and half-life of Diltiazem Hydrochloride by prolonging the contact time and controlling the release. Kata Kunci Diltiazem Hidroklorida; Mucoadhesive Buccal Film; Moringa Gum; Gliserin
Co-Authors Amalia Fadila Ameliana, Lidya Andreas Henry Prasetyo Barikah, Kuni Zu’aimah Cahyaningrum, Nitta Christyn Novita S Dwi Nurahmanto Eka Deddy Irawan Eka Deddy Irawan Elok Rimadani Eryani, Mikhania Christiningtyas Eunike Aprilianio Eva Setyorini Hanif, Mohammad Ainul Fakhruddin Helmi Nur Laili Hery Diar Febryanto Irsalina Triastutik Kuni Zu’aimah Barikah Kuni Zu’aimah Barikah Lestari, Tirtawati Putri Liananta Fawzia Wulandari Lidya Ameliana Lina Winarti Lubis, Maralodia Almira Muhammad Asrofi, Muhammad Nani Sukmawati Ninda Sukmaningrum Nursatriya, Agne Yuliana Nurul Qomariyah Putri Mustika Nandani Septi Sudianingsih Siti Munawaro Siti Munawaro, Siti Sukmaningrum, Ninda Tiara Berlianti Tintia Lintang Pratiwi Ulfia Dwi Novita Via Rahmatia Viddy Agustian Rosyidi Yudi Wicaksono Yudistirawati Khusna