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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian The Journal of Pure and Applied Chemistry Research UNEJ e-Proceeding AcTion: Aceh Nutrition Journal Jurnal Kimia Terapan Indonesia Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research JFIOnline Pharmaceutical Sciences and Research (PSR) Jurnal Natural Jurnal Tumbuhan Obat Indonesia
Yuni Retnaningtyas
Fakultas Farmasi Univesitas Jember
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Journal : e-Journal Pustaka Kesehatan

 1 
Validasi dan Penetapan Kadar Rhodamin B pada Lipstik yang Beredar di Sekitar Universitas Jember dengan Metode KLT-Densitometri (Validation TLC-densitometry method for determination of Rhodamine B in Lipstick at Jember University Area) Risa Wahyu Ananda; Nia Kristiningrum; Yuni Retnaningtyas
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Rhodamine B is one of the synthetic dyes that forbidden in cosmetics. The study was conducted to validate TLC-densitometry method for determination Rhodamin B in lipstick at Jember University area. Samples was taken by purposive sampling method. The analyte were dissolved with ethanol 70% and cromatographed on silica Gel GF 254 TLC plate using etil asetat : metanol : amoniak in the ratio (15:3:3) (v/v/v). Then, validation and determination sample can be done using TLC-densitometry with maximum wavelength 554 nm. Method was found linear over the concentration range of 6 – 32 ng with correlation coefficient of 0,9965. Spesificity showed calculation of purity and identity more than 0.99. The limits of detection and quantitation limits obtained 0.558 and 1.86 ng/spot. The precision test which includes precision repeatability and intermediate precision, amounting to RSD 6.57% and test accuracy , resulting % recovery and RSD value of 97.74 % ± 2.54% . Based on these results lipstick sample purposively sampled none containing rhodamine B and safe consumer use. Keywords: TLC - densitometry , lipstick , rhodamine B , the validation method of analysis
Deteksi Gelatin Babi pada Sampel Permen Lunak Jelly Menggunakan Metode Fourier Transform Infra Red (FTIR) dan Kemometrik (Detection of Porcine Gelatin in Jelly Soft Candy Sample Using Fourier Transform Infra Red and Chemometrics) Annisa Rahmawati; Bambang Kuswandi; Yuni Retnaningtyas
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Gelatin is widely used in some food products as gelling agent, including jelly soft candy. Most of commercial gelatin is derived from pork skin. Islam prohibits their followers to consume any food products containing pig derivates, including porcine gelatin. Therefore, it is necessary to develop some rapid and reliable methods for detection of porcine gelatin in jelly soft candy. FTIR method combined with chemometrics were chosen because it is rapid, easy and reliable. The purpose of this study was to classify of porcine gelatin in jelly soft candy using FTIR method combined with multivariate statistical methods (chemometrics). The classification method of chemometrics used to test porcine gelatin in commercial product of jelly soft candy was succesful and also in a good assessment with Xematest Pork. Keywords: bovine gelatin, jelly soft candy, porcine gelatin, FTIR, chemometrics.
Penetapan Kadar Inulin dalam Ekstrak Air Umbi Bengkuang (Pachyrhizus erosus L.) dari Gresik Jawa Timur dengan Metode KLT Densitometri (Inulin Determination of Yam Bean Tuber (Pachyrhizus erosus L.) from Gresik East Java using TLC Densitometry) Marizka Wimala; Yuni Retnaningtyas; Lestyo Wulandari
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Yam bean is one of tubers group that has many benefits because of its chemical constituents named inulin. Yam bean are produced in several regions in Indonesia such as Tegal, Bogor, Prembun, and Madura. In this research, inulin determination in yam bean tuber from Gresik East Java as one of yam bean production center, performed to obtain the plant source in Indonesia which is potential to produce inulin. Inulin determination was conducted using TLC Densitometry method that has been validated. Based on a standard curve that meets the requirements of linearity (r=0,997; Vxo=3,847%; Xp=355,407ng), the results showed that levels of inulin in yam bean tuber derived from Gresik was 12,322%±1,733% and mean recovery was 100,08% ± 1,142%. This result meet the requirements for the actual analyte concentration ≥10%: coefficient of variation is
Determinasi Inulin dalam Sampel Ekstrak Umbi Dahlia (Dahlia spp L.) yang Ditamam pada Media Tanah dan Polybag dengan Metode KLT- Densitometri Arrofita Ani Sandiya; Yuni Retnaningtyas; Lestyo Wulandari
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Inulin is a polysaccharide , which is composed of fructose units. Inulin is generally found in plants family Compositae, Amirilidaceae, and Poaceae. Benefits inulin is as bifidogenic body, stimulate the immune system , relieve constipation , reduce the risk of osteoporosis . Inulin can be consumed alone as a prebiotic supplement. The purpose of this study was to develop a method for determination of inulin TLC-Densitometry in dahlia tuber extract samples (Dahlia spp L.) grown in soil media and polybag . Determination of inulin as a method of TLC densitometry using the stationary phase TLC plates Silica Gel F254, mobile phase = acetic acid glacial p.a: methanol p.a: aquabides sterille (v/v/v/v) (0,5:7,5:2) , solvent = Aquabides sterille: Ethanol 96 % p.a (3:1) v/v, apparition stains is mixed aniline in acetone 1% v/v:diphenylamine in acetone 10% b/v:phosphoric acid (5:5:1), and the wavelength () 380 nm . Validation of the method showed that the research procedures performed has had good linearity with a coefficient correlation 0.996 and Vx0 value 4.850%. This method also gives good accuracy and precision that is the percent recovery of inulin at 99,96%±0,39%. and the value of repeatability = 0,993% < 2,7% and intermediate precision RSD = 0,554% < 2,7% with limits of detection (LOD) and limit of quantitation (LOQ), respectively, 71,03 ng/spot and 236.76 ng/spot. The results showed levels of inulin in the dahlia tuber extract soil planted mediated by 86.256%±0.669% (%b/b±RSD%), and dahlia tubers grown polybag mediated by 76.146%±1.657% (%b/b±RSD%).
Penetapan Kadar Inulin dalam Ekstrak Umbi Dahlia variabilis dan Dahlia pinnata dengan Metode KLT Densitometri (Determination of Inulin Content in Dahlia variabilis and Dahlia pinnata Tuber Extract by TLC Densitometry Method) Khoirun Nisa'; Yuni Retnaningtyas; Nia Kristiningrum
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Inulin is a polymer which have many benefits for health and used widely for food. The absence of research on determination of inulin content in dahlia tuber extract from different species, made this study very important to do. The purpose of this study was to determine the inulin content in dahlia tuber extract from different species. So it can be known the most effective type of dahlia to be the major source of inulin production. The method used in this study was TLC densitometry. The result showed that the inulin content in Dahlia variabilis tuber extract was 73.93 ± 1.209%, and the inulin content in Dahlia pinnata tuber extract was 66.76 ± 0.572%. The inulin content in Dahlia variabilis and Dahlia pinnata tuber extract were significantly different. Keywords: inulin, dahlia tuber, Dahlia variabilis, Dahlia pinnata, TLC densitometry
Penentuan Kadar Flavonoid pada Ekstrak Daun Tanaman Menggunakan Metode NIR dan Kemometrik (Determination of Flavonoid in Leave Extracts Using NIR and Chemometric) Hilmia Lukman; Lestyo Wulandari; Yuni Retnaningtyas
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Flavonoids are a group of natural compounds with variety phenolic structures and are found in plants. The aim of this research was to study whether NIR and chemometric methods could be used to determine the flavonoid content. These methods were compared to UV-Vis spectrofotometry. Flavonoid was extracted from plant leaves by ultrasonic and maceration. NIR spectral data of selected leave extracts were correlated with flavonoid content using chemometric. In this study, the chemometric method that used for quantitative and qualitative analysis were Partial Least Square (PLS) and Linear Discriminant Analysis (LDA), respectively. The PLS R2 calibration was 0.9916499 and RMSEC was 2.1521897. In addition, the R2 of LOOCV and 2-Fold-Cross-Validation were 0.9986664 and 0.9823225, respectively. Furthermore, LDA gave accuracy of 100%. The significance of flavonoid content that have been measured by NIR and UV-Vis spectrofotometry was evaluated with paired samples t-test. In conclusion, flavonoid content that have been measured with both methods gave no significant difference. Keywords: flavonoid, chemometric, LDA, NIR, PLS
Sintesis 1-(4-metoksibenzoiloksimetil)-5-fluorourasil sebagai Agen Antikanker . Ifada; Ayik Rosita Puspaningtyas1; Ika Oktavianawati; Yuni Retnaningtyas; Nia Kristiningrum
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5-fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4-methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid. Keywords: 5-fluorouracil derivates, anticancer, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil, benzoylation.
Pengujian Aktivitas Antioksidan Kombinasi Ekstrak Metanol Daun Mangga Gadung (Mangifera indica L. var. gadung) dan Ekstrak Etanol Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) (Antioxidant Activity Assay of Methanolic Extract of Gadung Mango Leaves (Mangifera indica L. var. gadung) and Ethanolic Extract of Pandan Leaves (Pandanus amaryllifolius Roxb.) Combination) Dewi Kusumaningrum Pamungkas; Yuni Retnaningtyas; Lestyo Wulandari
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.3949

Abstract

The content of polyphenolic compounds in mango and fragrant pandan leaves has been showed an antioxidant activity and commonly used as traditional treatment of some diseases. The aim of this research was to determine the activity of antioxidant of the gadung mango leaves and fragrant pandan leaves extract combination. The activity of antioxidant was investigated by DPPH method (IC50) with vitamin C as positive control. The results showed that the sample had lower antioxidant activities than vitamin C. The IC50 value of vitamin C was 2.613±0.021 μg/ml, followed by methanolic extract of gadung mango leaves, ratio 1:1 of gadung mango leaves extract and pandan leaves extract combination, and ethanolic extract of fragrant pandan leaves with IC50 value of 3.263±0.009; 13.392±0.157; 39.700±1.003 μg/ml, respectively. Methanolic extract of gadung mango leaves and ethanolic of fragrant pandan leaves combination didn't have higher antioxidant activities compared to the antioxidant activities of the singular methanolic extract of gadung mango leaves itself. Keywords: antioxidant activity, gadung mango, fragrant pandan
Co-Authors . Ifada Annisa Rahmawati Arrofita Ani Sandiya Ayik Rosita Puspaningtyas1 Bambang Kuswandi CRISTIANTY, FRANSISKA MARIA Dewi Dianasari Dewi Kusumaningrum Pamungkas Dian Agung Pangaribowo Diyanul Mustafidah Endah Puspitasari Fauzan Arrozi Gabriella F Punu Hamzah, Muhammad Hafidi Hamzah, Muhammad Hafidi Hilmia Lukman, Hilmia Ika Oktavianawati Indah Purnama Sary, Indah Purnama Karmilasari, Alviani Dwi Khoirun Nisa' Lestyo Wulandari Lestyo Wulandari Lestyo Wulandiri Luna Ivanka Dwi Elavia Mariska Wimala Marizka Wimala Nafisa, Lia Wardatun Nia Kristiningrum Renggani, Hidayah Dwi Risa Wahyu Ananda Ulfatul Munawaroh WARDANI, PRAMUDIA Yodi Setiadi