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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian The Journal of Pure and Applied Chemistry Research UNEJ e-Proceeding AcTion: Aceh Nutrition Journal Jurnal Kimia Terapan Indonesia Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research JFIOnline Pharmaceutical Sciences and Research (PSR) Jurnal Natural Jurnal Tumbuhan Obat Indonesia
Yuni Retnaningtyas
Fakultas Farmasi Univesitas Jember
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Oral glucose tolerance assay of extract from Mangifera foetida l. and Pandanus amaryllifolius roxb. leaves RETNANINGTYAS, YUNI; CRISTIANTY, FRANSISKA MARIA; KRISTININGRUM, NIA; WARDANI, PRAMUDIA
Jurnal Natural Volume 24 Number 1, February 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i1.30982

Abstract

This study examines the potential antidiabetic activity of a combination of Mangifera foetida L. and Pandanus amaryllifolius Roxb. leaves. Mangifera leaves contain a compound called mangiferin, which acts as an antidiabetic and antioxidant. On the other hand, Pandanus leaves, are rich in terpenoids and steroids that also possess anti-diabetic effects. An Oral Glucose Tolerance Test (OGTT) was conducted on male mice of the Babl/c strain to assess the antidiabetic effects. The test involved administering a combination of ethanolic leaf extracts from Mangifera foetida L. and Pandanus amaryllifolius Roxb. in a 1:1 ratio. The study followed a pre-test design with a control group, comprising six treatment groups, each consisting of four male mice. The groups were described as follows: Group 1 was served as the normal group without any treatment. Groups II-IV received single extracts or combinations of extracts at doses of 62.5 mg/200g BW, 125 mg/200g BW, and 250 mg/200g BW. Group V acted as the positive control and was given oral glucose and glibenclamide at a dose of 0.09 mg/200g BW. Group VI was served as the negative control, receiving oral glucose and distilled water. The group that exhibited the highest percentage of decreased blood sugar levels was the one given oral glucose at a dose of 0.078g/20g BW of mice, along with the combination of Mangifera foetida L. and Pandanus amaryllifolius Roxb. leaves extract (1:1) at a dose of 35 mg/20g BW. This group demonstrated a decrease of 71.985 4.858 in blood glucose levels. The ANOVA analysis confirmed that the percentage decrease in blood sugar levels was significantly different from the positive control, indicating a higher effectiveness of the combination treatment in reducing blood glucose levels than the positive control.
AKTIVITAS ANTIOKSIDAN FRAKSI AIR DAN FRAKSI ETER KOMBINASI EKSTRAK METANOL DAUN KOPI ARABIKA (Coffea arabica L.) DAN KULIT BATANG KAYU MANIS (Cinnamomum burmannii Nees ex BI.): Antioxidant Activity of Water and Ether Fraction Combination of Arabica Coffee Leaves (Coffea arabica L.) Extract and Cinnamon burmanii Bark (Cinnamomum burmannii Nees ex Bi.) Retnaningtyas, Yuni; Wulandari, Lestyo; Fauzan Arrozi
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 1 (2023): July 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i1.604

Abstract

Antioxidants are compounds that can inhibit an oxidation reaction, by binding to free radicals that play a role in the emergence of several degenerative diseases. Arabica coffee (Coffea arabica) and cinnamon (Cinnamomum burmannii) are plants that have antioxidant activity so that when combined they have the potential to produce a synergistic effect. The purpose of this study was to test the antioxidant effects of the combination of methanol extract of Arabica coffee leaves and cinnamon bark in both the water and ether fractions. Antioxidant activity was determined using the DPPH method, as a positive control vitamin C was used, and antioxidant activity was expressed in the form of IC50. The results showed a synergistic effect of the two extracts where the antioxidant activity of both the water fraction and the ether fraction in the combined form was greater than the single form. The highest antioxidant activity was shown by the water fraction of the combination of methanol extract of Arabica coffee leaves and cinnamon bark in a ratio (1:2) with an IC50 value of 8.759 ± 0.050 g/mL. This antioxidant activity is lower than the antioxidant activity of vitamin C with an IC50 value of 3.267 ± 0.007 g/mL
Phytosynthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Schleichera oleosa and Their Antioxidant Activity Retnaningtyas, Yuni; Nafisa, Lia Wardatun; Pangaribowo, Dian Agung
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 3 (2025): Edition September-December 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.03.7917

Abstract

Silver nanoparticles (AgNPs) have unique properties and biological activity. It was prepared using the phytosynthesis method with an aqueous leaf extract of Schleichera oleosa in which rich of phenolic compounds and can be applied as a bioreductor. Phytosynthesis, environmentally friendly approach that is biocompatible, cost-effective, and predicted can support large-scale synthesis. This paper report total phenol contents, and the phytosynthesis AgNPs, the characterization and evaluation of antioxidative activity. The total phenolic content was determined using the Folin-Ciocalteu method. The optimum AgNPs have a maximum wavelength of 415 nm. FTIR-ATR characterization shows that the functional groups that act as bioreductors and capping agents are phenolic groups. AgNPs have a Z-average value of 78.5 nm with a PDI of 0.382 and have a spherical morphology. Antioxidant activity test using the DPPH method showed IC50 value of AgNPs is 41.837 ± 0.540 µg mL-1 and included a very strong antioxidant.
Co-Authors . Ifada Annisa Rahmawati Arrofita Ani Sandiya Ayik Rosita Puspaningtyas1 Bambang Kuswandi CRISTIANTY, FRANSISKA MARIA Dewi Dianasari Dewi Kusumaningrum Pamungkas Dian Agung Pangaribowo Diyanul Mustafidah Endah Puspitasari Fauzan Arrozi Gabriella F Punu Hamzah, Muhammad Hafidi Hamzah, Muhammad Hafidi Hilmia Lukman, Hilmia Ika Oktavianawati Indah Purnama Sary, Indah Purnama Karmilasari, Alviani Dwi Khoirun Nisa' Lestyo Wulandari Lestyo Wulandari Lestyo Wulandiri Luna Ivanka Dwi Elavia Mariska Wimala Marizka Wimala Nafisa, Lia Wardatun Nia Kristiningrum Renggani, Hidayah Dwi Risa Wahyu Ananda Ulfatul Munawaroh WARDANI, PRAMUDIA Yodi Setiadi