Article Per Year (5 Year)
p-Index From 2021 - 2026
2.386
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Urology Jurnal Kesehatan Andalas Global Medical and Health Communication Jurnal Jamu Indonesia Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Integrasi Kesehatan dan Sains Bandung Conference Series : Medical Science Indonesian Journal of Jamu
Yuktiana Kharisma
Department Of Anatomical Pathology, Faculty Of Medicine Universitas Islam Bandung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

Published : 28 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 28 Documents
Search

 1   2   3 
Karakteristik Kuantitas Konten Seluler Apus Mukosa Bukal Antara Perokok dan Non Perokok Azlia Salsabila Rahadian Putri; Kharisma, Yuktiana; Rachmawati, Meike
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10688

Abstract

Abstract. Cigarettes are a health problem that is the main focus in Indonesia, Indonesia is still in 3rd place with the highest number of smokers in the world. The habit of consuming cigarettes can cause serious problems such as stroke, cancer and coronary heart disease. Long-term exposure to dangerous compounds in cigarettes such as tar, nicotine, bensopyrene can cause dysplasia that occurs in the mucosal epithelium of the oral cavity. This study aims to see differences in the quantity of cellular content of buccal mucosal smears between smokers and non-smokers. This research uses an analytical observational method through an approachcross sectional which was carried out on 20 people in the work environment of Bandung Islamic University. Data were obtained from the results of buccal mucosal swabs stained with dyepap smear(Pap) and observed under a light microscope. Data were analyzed using univariate and bivariate tests and tests were carried outT Independent andmann whitney. This research found that the characteristics of non-smokers were an average age of 46 years, a bachelor's degree, married with a middle income. Characteristics of smokers, the average age is 38 years, high school education, married with low income, Ujit independent get no difference in cell numbers between smokers and non-smokers, testmann whitney shows that there is a difference in the number of lymphocyte cells between the two populations with a P value of 0.009 (<0.05). Smoking does not cause changes in the quantity of cellular content of the buccal mucosa, but smoking can cause chronic inflammation and lead to mutations and malignancy in buccal mucosal cells. Abstrak. Rokok merupakan masalah kesehatan yang menjadi fokus utama di Indonesia, Indonesia masih menempati posisi ke 3 dengan angka perokok tertinggi di dunia. Kebiasaan mengkonsumsi rokok dapat menyebabkan masalah serius seperti stroke, kanker, dan penyakit jantung koroner. Paparan jangka panjang terhadap senyawa berbahaya dalam rokok seperti tar, nikotin, bensopiren dapat menimbulkan displasia yang terjadi pada epitel mukosa rongga mulut. Penelitian ini bertujuan untuk melihat perbedaan kuantitas konten selular apus mukosa bukal antara perokok dan non perokok. Penelitian ini menggunakan metode observasional analitik melalui pendekatan cross sectional yang dilakukan pada 20 orang di lingkungan kerja Universitas Islam Bandung. Data diperoleh dari hasil swab mukosa bukal yang diwarnai oleh pewarna papanicolaou (Pap) dan diamati dibawah mikroskop cahaya. Data dianalisis dengan uji univariat dan bivariat dan dilakukan uji T Independent dan mann whitney. Penelitian ini didapatkan karakteristik non perokok berusia rata rata 46 tahun, berpendidikan S1, sudah menikah dengan penghasilan menengah. Karakteristik perokok rata-rata berusia 38 tahun, berpendidikan SMA, sudah menikah dengan pendapatan rendah, Uji t independent mendapatkan tidak adanya perbedaan jumlah sel antara perokok dan non perokok, uji mann whitney menunjukan adanya perbedaan jumlah sel linfosit antara kedua populasi dengan nilai P sebesar 0.009 (<0.05). Merokok tidak menyebabkan perubahan kuantitas konten selular mukosa bukal, namun merokok dapat menyebabkan inflamasi kronis dan mengarah ke mutasi dan berujung keganasan pada sel mukosa bukal.
Hubungan Derajat Merokok dengan Gambaran Manifestasi Inflamasi Kronik pada Rongga Mulut Perokok Raissa Khais Azmi; Kharisma, Yuktiana; Damayanti, Meta Maulida
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10847

Abstract

Abstract. Smoking is a major health problem that is considered the leading cause of preventable death in many countries. Tooth loss, periodontal disease, oral soft tissue changes, excessive tooth wear, halitosis, implant failure, oropharyngeal cancer, stomatitis, gingivitis, and dental caries are some of the negative effects on oral health that smoking can cause. Aim of this study was to determine how the degree of smoking correlates with symptoms of chronic inflammation in the oral cavity of people who smoke. This research was designed quantitatively using a cross-sectional approach. Focus of the research is young adults who actively smoke who work at the Bandung Islamic University (UNISBA) in 2023. The total number of respondents for this research is 60 respondents. The instrument used is a questionnaire that shows the degree of smoking and signs of chronic inflammation. Data obtained were analyzed using the Pearson correlation test. Results of this study show that among young adult active smokers working at Bandung Islamic University, there is a significant correlation between the degree of smoking and dental caries (respectively p=0.015 and p=0.002), but there is no correlation between stomatitis (p=0.152). Conclusion of this study is that chronic inflammatory manifestations of dental caries and gingivitis are associated with the degree of smoking. Cigarette smoke remaining in the mouth for a long time reduces the amount of saliva, making the oral cavity and teeth more susceptible to caries. In addition, cigarette ingredients can affect the connective tissue and gingival epithelium, increasing the likelihood of gingivitis. Abstrak. Kebiasaan merokok adalah masalah kesehatan utama yang dianggap sebagai penyebab utama kematian yang dapat dicegah di berbagai negara. Kehilangan gigi, penyakit periodontal, perubahan jaringan lunak oral, keausan gigi yang berlebihan, halitosis, kegagalan implan, kanker orofaringeal, stomatitis, gingivitas, dan karies gigi adalah beberapa efek negatif pada kesehatan mulut yang dapat disebabkan oleh kebiasaan merokok. Tujuan penelitian ini adalah untuk mengetahui bagaimana derajat merokok berkorelasi dengan gejala inflamasi kronis pada rongga mulut orang yang merokok. Penelitian ini dirancang secara kuantitatif dengan menggunakan pendekatan cross-sectional. Fokus penelitian adalah orang dewasa muda yang aktif merokok yang bekerja di Universitas Islam Bandung (UNISBA) pada tahun 2023. Jumlah total responden penelitian ini 60 responden. Instrument yang digunakan adalah kuesioner yang menunjukkan derajat merokok serta tanda inflamasi kronik. Data yang diperoleh dianalisis dengan uji korelasi Pearson. Hasil penelitian ini menunjukkan bahwa pada individu perokok aktif dewasa muda tenaga kerja di Universitas Islam Bandung, terdapat korelasi signifikan antara derajat merokok dan karies gigi (berturut-turut p=0,015 dan p=0,002), tetapi tidak ada korelasi antara stomatitis (p=0,152). Simpulan dari penelitian ini, manifestasi inflamasi kronik karies gigi dan gingivitis dikaitkan dengan derajat merokok. Asap rokok menetap di mulut selama waktu yang lama mengurangi jumlah saliva, membuat rongga mulut dan gigi lebih rentan terhadap karies. Selain itu, kandungan rokok dapat mempengaruhi jaringan ikat dan epitel gingiva, meningkatkan kemungkinan gingivitis.
Karakteristik Klinis pada Pasien Limfadenitis Granulomatus Non-Tuberkulosis di RS Muhammadiyah Bandung Fasyah Rizki Putri; Kharisma, Yuktiana; Rachmawati, Meike
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.12531

Abstract

Abstract. Tuberculosis disease caused by the bacterium Mycobacterium tuberculosis is a global health problem with more than 10 million cases reported by the World Health Organization (WHO) throughout the world. Indonesia also has a significant prevalence rate, especially pulmonary TB, which is ranked fourth highest globally. This study aims to gain a comprehensive understanding of the clinical characteristics of non-tuberculous granulomatous lymphadenitis patients at the Muhammadiyah Hospital in Bandung. This research uses a descriptive method, with research time from January-December 2022. The sample for this research is medical record data from patients with non-tuberculous granulomatous lymphadenitis at Muhammadiyah Hospital in Bandung who meet the inclusion criteria using total sampling. The results of this research were 46 people, but only 40 people met the inclusion criteria. This study discusses the clinical characteristics of patients with non-tuberculous granulomatous lymphadenitis. From this research, it can be concluded that the clinical characteristics based on age are 22-31 years, based on gender the majority are women, the most frequent location of the KGB is the right neck and the symptoms that often appear are pain in the lump, fever and shortness of breath. Abstrak. Penyakit tuberkulosis yang disebabkan oleh bakteri Mycobacterium tuberculosis merupakan masalah kesehatan global dengan lebih dari 10 juta kasus dilaporkan oleh World Health Organization (WHO) di seluruh dunia. Indonesia juga memiliki tingkat prevalensi yang signifikan, terutama TBC paru yang menduduki peringkat global tertinggi keempat. Penelitian ini bertujuan untuk mendapatkan pemahaman menyeluruh tentang karakteristik klinis pada pasien limfadenitis granulomatus non-tuberkulosis di Rumah Sakit Muhammadiyah Bandung. Penelitian ini menggunakan metode descriptive, dengan waktu penelitian dari Januari-Desember 2022. Sampel penelitian ini adalah data rekam medis pasien limfadenitis granulomatous non tuberkulosis di RS Muhammadiyah Bandung yang memenuhi kriteria inklusi dengan menggunakan total sampling. Hasil penelitian ini didapatkan 46 orang, namun hanya 40 orang yang sesuai dengan kriteria inklusi. Penelitian ini mendiskusikan tentang karakteristik klinis pada pasien limfadenitis granulomatus non-tuberkulosis. Dari penelitian ini, dapat disimpulkan bahwa karakteristik klinis berdasarkan usia adalah 22-31 tahun, berdasarkan jenis kelamin yang paling banyak yaitu perempuan, letak KGB yang paling sering adalah leher kanan dan gejala yang sering muncul yaitu nyeri pada benjolan, demam, dan sesak nafas.
Insidensi Bayi Berat Lahir Rendah pada Spektrum Plasenta Akreta di Rumah Sakit Dr Hasan Sadikin Bandung Kharisma, Yuktiana; Agustina, Hasrayati; Suryanti, Sri; Dewayani, Birgitta Maria; Hernowo, Bethy Suryawati
Jurnal Kesehatan Andalas Vol. 11 No. 2 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.2063

Abstract

Low birth weight (LBW) babies are closely related to infant morbidity, stunted growth and cognitive development, and chronic diseases. Placenta accreta spectrum (PAS) is a condition that complicates pregnancy and is closely related to low birth weight. Objectives: To determined the incidence of LBW in mothers with SPA at the hospital Dr. Hasan Sadikin Bandung. Methods: A descriptive observational study involving 71 cases of SPA in hospitals  Dr. Hasan Sadikin Bandung, period 2016-2020, which has met the inclusion and exclusion criteria. SPA cases were divided into three groups: placenta accreta, increta, and percreta. In each SPA group, the incidence of LBW was evaluated. Results: 46.5% (33/71 cases of PAS) had low birth weight, while 53.5% (38/71 cases of PAS) had normal birth weight babies. The placenta accreta and percreta groups were dominated by normal birth weight infants [(18/31 cases), (5/9 cases)], while the placenta increta group was dominated by low birth weight infants (16/31 cases). The LBW category is divided into Extremely Low Birth Weight (ELBW), Very Low Birth Weight (VLBW), and LBW. In placenta accreta, there were 2 ELBW and VLBW infants, and 9 LBW infants. In the placenta increta, there are 3 ELBW and VLBW, and 10 LBW. In the placenta percreta, there were 1 ELBW and 3 LBW, while VLBW was not found in the placenta percreta. Conclusion: The incidence of LBW is found in almost half the population of SPA cases in hospitals. DR. Hasan Sadikin in the 2016-2020 period.Keywords:  low birth weight, placenta accreta spectrum
Can Purple Sweet Potato Water Extract (Ipomoea batatas L.) Induce Steatosis at Toxic Doses in Rat? Hikmatussalam, Gemila; Kharisma, Yuktiana; Romadhona, Nurul
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2172

Abstract

Purple sweet potato (Ipomoea batatas L.) has a secondary metabolite that contains a lot of antioxidants. Some of the secondary metabolites in purple sweet potato have a hepatotoxic effect. Objective: To described the toxic effects of purple sweet potato water extract on steatosis in rats. Methods: This descriptive study was conducted on 29‒30 June 2019 in the Biomedical Laboratory of the Faculty of Medicine, Islamic Bandung University, with an in-vivo experimental design with random allocation techniques and using the proposed new method on 11 rats. One of the control rats was not given extract, and ten other rats were given a dose of purple sweet potato water extract 50, 200, 400, 800, 1000, 1500, 2000, 3000, 4000, and 5000 mg/KgBW/PO. The liver organ was harvested after 24 hours, and then slides were made at the Pathology Anatomy Laboratory of Padjajaran University. Results: The histopathological view did not find any steatosis either in macrovesicular or microvesicular, but other features were found in ballooning degeneration, sinusoidal dilation, and inflammation. Conclusion: Steatosis was not found because purple sweet potato contains anthocyanins and tannins.Keywords: purple sweet potato, steatosis, tannin
Nuclear Changes Features in Buccal Mucosa Smear of Adult Male Smokers Using Pappaniculou Staining Kharisma, Yuktiana; Indriyanti, Raden Anita; Yuniarti, Lelly; Noormartany, Noormartany; Nur, Ismet Muchtar; Yenolinsky, Yolanda
Althea Medical Journal Vol 12, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n1.3486

Abstract

Background: Tobacco smoke contains a combination of chemicals that could be harmful to the buccal mucosa as the first part of the body that has been exposed. Damage to the buccal epithelial cells has the potential to become a malignant lesion. This study aimed to describe changes in the nuclear epithelial of the buccal mucosa using Pappaniculou staining as an indicator of mucosal damage in smokers.Methods: This was a descriptive analytical study, involving adult male participants from Bale Endah District, Bandung Regency, Indonesia aged >35 years, who had smoked for ≥10 years. Buccal mucosa smear was taken, and the features of nuclear epithelial changes were observed per 500 cells, each at 400x magnification with Pappaniculou stain to evaluate the features of micronucleus, broken egg, karyorrhexis, karyolysis. Those who did not smoke were recruited as a control group.Results: Smokers were mostly light active smokers or kretek cigarettes, with a smoking duration of ≥15 years. The frequency of micronucleus (p<0.001), broken eggs (p<0.001), karyorrhexis (p=0.001), karyolysis (p=0.003) in the buccal mucosal epithelial was significantly different between the smoker and non-smoker groups.Conclusions: All epithelial nuclear changes have shown significant differences between smoker and non-smoker groups. Nuclear epithelial features in smoker may be associated with future malignancies, therefore, smoking cessation programs are necessary to substantially reduce tobacco use, thus fostering a healthy lifestyle for everyone.
Hubungan Karakteristik dengan Tingkat Pengetahuan Perempuan Usia Reproduktif mengenai Berat Badan Lahir Rendah dan Spektrum Plasenta Akreta pada Salah Satu Komunitas Perguruan Tinggi Swasta di Bandung Agustina, Hasrayati; Dewayani, Birgitta Maria; Suryanti, Sri; Hernowo, Bethy Suryawaty; Kharisma, Yuktiana
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 1 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i1.11816

Abstract

Berat badan lahir rendah (BBLR) dan spektrum plasenta akreta (SPA) merupakan salah satu masalah kesehatan yang menyebabkan morbiditas serta mortalitas ibu dan janin yang signifikan. Pengetahuan tentang kesehatan sangat penting untuk mengurangi efek buruk tersebut. Penelitian bertujuan mengetahui tingkat pengetahuan perempuan usia reproduktif mengenai BBLR dan SPA. Studi potong lintang berbasis masyarakat tersebut dilakukan pada bulan Agustus 2021 pada 65 partisipan komunitas usia reproduktif pada salah satu perguruan tinggi swasta di Bandung melalui pengisian kuesioner yang telah tervalidasi. Analisis data menggunakan uji chi-square melalui perangkat lunak STATA versi 15 untuk mengevaluasi hubungan antara karakteristik partisipan dengan tingkat pengetahuan BBLR dan SPA. Hasil penelitian sebanyak 54% partisipan memiliki pengetahuan BBLR dan SPA itu cukup.  Terdapat hubungan signifikan karakteristik pekerjaan (p=0,02) dengan tingkat pengetahuan BBLR dan SPA, sedangkan karakteristik usia (0,009), status pernikahan (0,24), dan pendidikan (0,2) tidak berhubungan dengan tingkat pengetahuan mengenai BBLR dan SPA. Terdapat beberapa faktor yang memengaruhi pengetahuan, seperti usia, pendidikan, sosial budaya, ekonomi, lingkungan, serta pekerjaan. Simpulan, pemberian stimulus berupa informasi seputar BBLR dan SPA melalui kegiatan sosialisasi yang berkesinambungan diharapkan dapat menjadi salah satu solusi untuk meningkatkan pengetahuan pada komunitas perempuan usia reproduktif AbstractLow birth weight (LBW) and placenta accreta spectrum (PAS) are health problems that cause significant maternal and fetal morbidity and mortality. Health knowledge is very important to reduce these adverse effects. This study aims to determine the level of knowledge of women of reproductive age about LBW and PAS. The cross-sectional community-based study was conducted in August 2021 on 65 participants of the reproductive age community at a private university in Bandung by filling out a validated questionnaire. Data analysis used the Chi-Square test by STATA software version 15 to evaluate the association between participant characteristics and knowledge level of LBW and PAS. The results showed that most of the participants had sufficient knowledge of LBW and PAS (54%). There was a significant relationship between job characteristics (p=0.02) and the level of knowledge of LBW and SPA, while the characteristics of age (0.009), marital status (0.24), and education (0.2) are not related to the level of knowledge of LBW and SPA. Several factors influence knowledge, such as age, education, socio-culture, economy, environment, and work. In conclusion, health education in the form of information about LBW and PAS through continuous counseling is expected to be one of the solutions to increase knowledge in the community.
Penentuan Derajat Toksisitas Akut Ekstrak Air Buah Pepaya (Carica papaya L.) Muda Pada Mencit Menggunakan Purposed New Recommended Method Nadiyah, Laila Dinda; Kharisma, Yuktiana; Yuniarti, Yuniarti
Jurnal Jamu Indonesia Vol. 1 No. 2 (2016): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v1i2.14

Abstract

Papaya (Carica papaya L.) fruit was proven scientifically in having medicinal effects: such as gastroprotective, laxative, galactagogues, and antibacterial effect. Unripe papaya fruit contains saponin, alkaloid, tannin, flavonoid, triterpenoid, and quinone which may reveal toxicities as adverse effect when it consumed in high dose. The aim of this study is to determine the acute toxicity degree of unripe Carica papaya L. fruit aqueous extract in mice using proposed new recommended method. The acute toxicity degree conducted by determination of lethal dose50 (LD50) using new recommended method to 12 female mice. The subjects were divided into three stages and each mouse was given different dose of the extract. LD50 calculated by mean of mortality lowest dose and non mortality highest dose then the result classified into the degree of acute toxicity. The study showed there was no mortality in all groups of the experimental subject. LD50 of unripe Carica papaya L. aqueous extract was found >5000 mg/kg BW and classified as Practically Non Toxic (PNT) substance.
Co-Authors Aaron Tigor Abdul Hadi Hassan Abdul Hadi Hassan Aldri Frinaldi Andriane, Yuke Armaya Ariyoga Astari P. Riani Astri Kania Astri Kania, Astri Ayu Prasetia Azlia Salsabila Rahadian Putri Bethy Suryawati Hernowo Bethy Suryawati Hernowo Bethy Suryawati Hernowo Birgitta Maria Dewayani Birgitta Maria Dewayani Dewayani, Birgitta Maria Eka Hendryanny Eka Nurhayati Ermina Widiyastuti Fajar Awalia Yulianto Faridza, Muhammad Fasyah Rizki Putri Hasrayati Agustina Hasrayati Agustina Hasrayati Agustina Hernowo, Bethy Suryawaty Herri S. Sastramihardja Hikmatussalam, Gemila Ismet Muchtar Nur Laila Dinda Nadiyah Lelly Yuniarti Maya Tejasari Meike Rachmawati Meta Maulida Damayanti Miranti Kania Dewi Mochamad Firdaus Bhuanaputra Muhammad Alief Abdul ‘Aziiz Muhammad Ilham Halim Nadiyah, Laila Dinda Noormartany Putri Anggraini Aswad Raden Anita Indriyanti Rahmi Fathonah Rahmi Fathonah, Rahmi Raissa Khais Azmi Ratna Damailia Romadhona, Nurul Santoso, Shenny Dianathasari Santun Bhekti Rahimah Sri Suryanti Sri Suryanti Titik Respati Uci Ari Lantika Winni Maharani Yenolinsky, Yolanda Yuniarti Yuniarti Yuniarti Yuniarti