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Christina Salaki
Universitas Sam Ratulangi
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Dual anti-inflammatory and antimicrobial effects of stingless bee propolis on second-degree burns Manginstar, Christian O.; Tallei, Trina E.; Salaki, Christina L.; Niode, Nurdjannah J.; Jaya, Hendra K.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2359

Abstract

Propolis, a natural resinous product from stingless bees, is widely recognized for its anti-inflammatory and antimicrobial properties. However, its combined effects in addressing both inflammation and infection in second-degree burns have remained insufficiently explored. The study aimed to investigate the dual role of propolis in modulating inflammation and preventing bacterial infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in a second-degree burn model. Propolis was collected from stingless bees in Gowa, South Sulawesi, Indonesia, and extracted using methanol. Second-degree burns were induced in male Rattus norvegicus, which were then divided into three groups: one treated with propolis, another silver sulfadiazine (positive control), and third with NaCl (negative control). After seven days of treatment, the expression of tumor necrosis factor-alpha (TNF-α) and vascular endothelial growth factor (VEGF) proteins in wound samples was analyzed using immunohistochemistry. The antimicrobial activity of the propolis extract was assessed using the disc diffusion assay, followed by minimum inhibitory concentration (MIC) testing. Network pharmacology analysis was also conducted to assess the anti-inflammatory activity of propolis. Results showed that propolis significantly reduced TNF-α expression and increased VEGF expression, which might enhance VEGF-mediated angiogenesis, leading to improved wound healing compared to controls. The antimicrobial tests demonstrated strong activity against MRSA and P. aeruginosa, with inhibition zones correlating with higher extract concentrations. The MIC value of the propolis extract was 198.66 µg/µL against MRSA and 212.06 µg/µL against P. aeruginosa. Network pharmacology analysis revealed key proteins, including Jun proto-oncogene (JUN), estrogen receptor 1 (ESR1), signal transducer and activator of transcription 3 (STAT3), and proto-oncogene tyrosine-protein kinase Src (SRC), involved in the regulation of TNF-α and VEGF, further supporting the synergistic effects of propolis. This study demonstrates that stingless bee propolis effectively promotes tissue regeneration and prevents infection in second-degree burns, highlighting its potential as an alternative to conventional treatments for wound care.
PKM Pengendalian Hama pada Tanaman Cabai dengan Pestisida yang Ramah Lingkungan di Kelurahan Rurukan Kecamatan Tomohon Timur Montong, Vivi B.; Salaki, Christina L.; Rondonuwu, Frans. B.; Makal, Henny V.
Jurnal Lentera: Penelitian dan Pengabdian Masyarakat Vol. 6 No. 1 (2025): Jurnal Lentera: Penelitian dan Pengabdian Masyarakat
Publisher : Yayasan Bina Lentera Insan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57207/tp0drx17

Abstract

Budidaya cabai secara intensif selama puluhan tahun memunculkan dampak pestisida antara lain terjadinya penurunan produktivitas karena aplikasi pestisida sintetik secara terus-menerus mengakibatkan organisme pengganggu tanaman (OPT) menjadi resisten sehingga serangan OPT semakin meningkat. Solusi yang perlu dilakukan ialah bagaimana memberikan pengetahuan, keterampilan dan pengalaman dengan cara penyuluhan kepada petani cabai di Kelurahan Rurukan untuk mengendalikan OPT cabai dengan menggunakan strategi dan taktik pengendalian yang ramah lingkungan. Informasi dari hasil analisis sebagai berikut: (1) peserta sangat antusias mengikuti kegiatan, menyimak, merespon, dan menanggapi secara positif terhadap pemaparan materi oleh narasumber, dan (2) terjadi peningkatan pengetahuan peserta dan penguasaan materi penyuluhan, ditandai dengan 16 orang peserta yang memahami dari 20 peserta, dan terjadi kenaikan pemahaman peserta dari nilai pra kegiatan (pre-test) ke akhir kegiatan (post-test) sebesar 65%.
Co-Authors Anggreini Kilala Anggreini Kilala, Anggreini Ariyane O.S. Siwu Assa, Berty Bastian P. Wowiling Bastian P. Wowiling, Bastian P. Betsy A.N. Pinaria Carla F. Kairupan Caroulus S. Rante Christian F.A. Rumende Christian L. Kaparang Daisy S. Kandowangko Dantje T Sembel Dantje Tarore Elisabet R.M. Meray Emmy Senewe Erwin G Kristanto Evie Paendong Gladys M. Tumanduk Guntur S.J. Manengkey Hans Huijbregts Henny Makal Henny Makal, Henny Henny V Makal Henny V.G. Makal Herlina I. S. Wungouw Herlina Wungouw Inri Wowor Ir. Caroulus S. Rante, MS Jackson Fraky Watung Jackson Watung Jackson Watung James B. Kaligis Jantje H. Manangka Jantje Pelealu Jantje Pelealu Jaya, Hendra K. Jesmandt Situmorang Jesmandt Situmorang Jimmy Rimbing Juliet E.M. Mamahit Juliet M.E. Mamahit Juliet M.E. Mamahit Krisen, Jeane Krisen Kumolontang, Geyby ., Langkah Sembiring LANGKAH SEMBIRING Makal, Henny V Makal, Henny V. Makkiah, Makkiah Manginstar, Christian O. Max ., Tulung Max Tulung Montong, Vivi B Montong, Vivi B. Moulwy F. Dien Natalia Samba Niken Handayani Niken Handayani Niken Satut Nur Handayani Noni N. Wanta Nurdjannah J. Niode Oddi R Pinontoan Odi R. Pinontoan Rafel S. Saroinsong Redsway Maramis Rivo Manopo Rondonuwu, Frans. B. Sammy S.N. Rori Sherlij Dumalang Threis Umboh Trina E. Tallei, Trina E. Tuldenigsri H. Gigir Tulung, Max ., Vera E. Tangkilisan Washliyah, Sitti Waywind Soewarno Yukiko Susandi Zainudin Limbanadi