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All Journal El-Hayah : Jurnal Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Biogenerasi Community Development Journal: Jurnal Pengabdian Masyarakat IJORER : International Journal of Recent Educational Research Jurnal Pijar MIPA
Kuki, Agustina Dua
Universitas Nusa Nipa
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Physics Public Health Other

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Prediksi Asam Kuinat Sebagai Anti-Inflamasi Terhadap COX-2 Secara Virtual Bare, Yohanes; Kuki, Agustina Dua; Rophi, Apriani Herni; Krisnamurti, Gabriella Candrakirana; Lorenza, Margaretha Rika Wahyu Gabrella; Sari, Dewi Ratih Tirto
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 4, No 3 (2019): October 2019
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.212 KB) | DOI: 10.24002/biota.v4i3.2516

Abstract

Inflamasi merupakan mekanisme pertahanan tubuh terhadap terhadap rangsangan berbahaya, seperti patogen, sel-sel yang rusak, senyawa beracun, atau iradiasi. Selama inflamasi dalam tubuh terdapat COX-2 mediator inflamasi yang peran meningkatkan inflamasi.  Sistem imun anti-inflamasi yang mengalami mutasi menyebabkan inflmasi meningkat. Oleh karena itu untuk menurnkannya menggunakan bioaktif alam. Asam kuinat memiliki toksisitas yang sangat rendah dan tidak memberikan efek negatif terhadap organ tubuh manusia. Asam kuinat memiliki potensi yang besar sebagai kandidat obat tertinggi dalam terapi. Akan tetapi kurangnya kajiannya. Penelitian ini bertujuan unutk memprediksi potensi serta menganalisis asam kuinat sebagai agen inflamasi dengan cara menghambat COX-2. Metode yang digunakan terdiri atas pengunduhan protein COX-2 dari protein data bank (PDB) dan asam kuinat diperoleh dari database PubChem, persiapan protein (COX-2) dan ligan (asam Kuinat) dengan program PyRx, analisis interaksi protein dan ligan menggunakan program Hex 8.0.0 dan Discovery Studio client 4.  Interaksi antara protein dan ligan menunjukan hasil positif dengan ditemukan 2 domain protein yang berikatan dengan asam kuinat. Protein domain A (GLU140, ASN144, SER143, dan TRP139) dan protein domain B (GLU236, THR237, LYS333, GLN241, GLN330, PHE329, dan LEU238). Ikatan yang terbentuk ada ikatan hidrogen dengan energi sebesar -198.95cal/mol. Asam kuinat diprediksi memiliki potensi sebagai terapi anti-inflamasi, hal ini ditunjukan karena ada ikatan yang terbentuk antara ligan dan 11 residu asam amino.
In Silico Study: Prediction the Potential of Caffeic Acid As ACE inhibitor Bare, Yohanes; Kuki, Agustina Dua; Daeng Tiring, Sri Sulistyaningsih Natalia; Rophi, Apriani Herni; Krisnamurti, Gabriella Candrakirana; Tirto Sari, Dewi Ratih
El-Hayah : Jurnal Biologi Vol 7, No 3 (2019): EL-HAYAH (VOL 7, NO 3 SEPTEMBER 2019)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v7i3.10053

Abstract

Hypertension is an abnormal increase in blood pressure. Regulating blood and cardiovascular function have correlated with the ACE pathway. To decrease blood pressure can use the ACE inhibitor. This paper aims to predict potential of Caffeic Acid as anti-hypertension by blocking the ACE pathway. The method in this research used in silico study. The protein was obtained from Protein Data Bank (PDB) and the ligand was obtained from PubChem. Molecular docking was performed by using HEX and visualization analysis was analyzed by using Discovery Studio. The interaction of caffeic acid and ACE has a functional as anti-hypertension roles. The evidence by twelve amino acid, which bind with the caffeic acid (ASP377, ASN277, ASN285, GLU376, ALA170, ASN167, ASN374, THR372, THR166, CYS370, GLU162 and PRO163). The chemistry bond was formed are hydrogen bond, van der Waals and electrostatics in amino residue ASP377. This binding could stop the synthesis of AT-I to AT-II which pathway to hypertension. Caffeic acid has a potential role as anti-hypertension by inhibiting ACE.
Effect of the Type of Organic Waste and Retention Time on Biogas Production from Cow Dung Mago, Oktavius Yoseph Tuta; Nirmalasari, M A Yohanita; Kuki, Agustina Dua; Bunga, Yohanes Nong; Misa, Aljefridus
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 5, No 3 (2020): October 2020
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v5i3.3682

Abstract

Nowadays, the demand on fossil energy is increasing in number whereas its availability is decrease. People are still reckoned on it, despite of its rareness. Fossil energy utilized must be banned due to its negative effect. It is time for us to use renewable and eco-friendly energy (biofuel). Biogas is one of biofuel produced from anaerobic decomposition of organic matter by microorganisms. Organic waste as a by-product of our daily activities can be used as raw material to produce biogas. To use waste, means to decrease the environmental pollution problem. This research is aim to study the type of organic waste as a raw material to produce biogas through anaerobic digestion and its retention time. Organic wastes that were used in this research are domestic waste (food waste), agriculture waste (corn leaves) and industrial waste (solid and liquid waste of tofu). All of these wastes were mixed with cow dung as the starter/inoculum. As a control, the starter was used without organic waste addition. The testable retention times were 1st week until 9th week. The experimental design was Factorial Complete Randomized Design with confidence level 95%. The result showed that all the type of organic waste can be used to produce biogas through anaerobic digestion. Statistically, the average volume of biogas produced from industrial waste per week, 5794,3 ml was significantly different from any other organic waste (P=0,000). The best retention time was found on 8th week with the average volume of biogas was 3675,6 ml (P=0,006). There was no interaction between these two factors (P=0,1). This research is expected to open the people’s awareness about the management of useable organic waste as a raw material to produce biogas.
Prediksi Asam Kuinat Sebagai Anti-Inflamasi Terhadap COX-2 Secara Virtual Yohanes Bare; Agustina Dua Kuki; Apriani Herni Rophi; Gabriella Candrakirana Krisnamurti; Margaretha Rika Wahyu Gabrella Lorenza; Dewi Ratih Tirto Sari
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 4, No 3 (2019): October 2019
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v4i3.2516

Abstract

Inflamasi merupakan mekanisme pertahanan tubuh terhadap terhadap rangsangan berbahaya, seperti patogen, sel-sel yang rusak, senyawa beracun, atau iradiasi. Selama inflamasi dalam tubuh terdapat COX-2 mediator inflamasi yang peran meningkatkan inflamasi.  Sistem imun anti-inflamasi yang mengalami mutasi menyebabkan inflmasi meningkat. Oleh karena itu untuk menurnkannya menggunakan bioaktif alam. Asam kuinat memiliki toksisitas yang sangat rendah dan tidak memberikan efek negatif terhadap organ tubuh manusia. Asam kuinat memiliki potensi yang besar sebagai kandidat obat tertinggi dalam terapi. Akan tetapi kurangnya kajiannya. Penelitian ini bertujuan unutk memprediksi potensi serta menganalisis asam kuinat sebagai agen inflamasi dengan cara menghambat COX-2. Metode yang digunakan terdiri atas pengunduhan protein COX-2 dari protein data bank (PDB) dan asam kuinat diperoleh dari database PubChem, persiapan protein (COX-2) dan ligan (asam Kuinat) dengan program PyRx, analisis interaksi protein dan ligan menggunakan program Hex 8.0.0 dan Discovery Studio client 4.  Interaksi antara protein dan ligan menunjukan hasil positif dengan ditemukan 2 domain protein yang berikatan dengan asam kuinat. Protein domain A (GLU140, ASN144, SER143, dan TRP139) dan protein domain B (GLU236, THR237, LYS333, GLN241, GLN330, PHE329, dan LEU238). Ikatan yang terbentuk ada ikatan hidrogen dengan energi sebesar -198.95cal/mol. Asam kuinat diprediksi memiliki potensi sebagai terapi anti-inflamasi, hal ini ditunjukan karena ada ikatan yang terbentuk antara ligan dan 11 residu asam amino.
Effect of the Type of Organic Waste and Retention Time on Biogas Production from Cow Dung Oktavius Yoseph Tuta Mago; M A Yohanita Nirmalasari; Agustina Dua Kuki; Yohanes Nong Bunga; Aljefridus Misa
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 5, No 3 (2020): October 2020
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v5i3.3682

Abstract

Nowadays, the demand on fossil energy is increasing in number whereas its availability is decrease. People are still reckoned on it, despite of its rareness. Fossil energy utilized must be banned due to its negative effect. It is time for us to use renewable and eco-friendly energy (biofuel). Biogas is one of biofuel produced from anaerobic decomposition of organic matter by microorganisms. Organic waste as a by-product of our daily activities can be used as raw material to produce biogas. To use waste, means to decrease the environmental pollution problem. This research is aim to study the type of organic waste as a raw material to produce biogas through anaerobic digestion and its retention time. Organic wastes that were used in this research are domestic waste (food waste), agriculture waste (corn leaves) and industrial waste (solid and liquid waste of tofu). All of these wastes were mixed with cow dung as the starter/inoculum. As a control, the starter was used without organic waste addition. The testable retention times were 1st week until 9th week. The experimental design was Factorial Complete Randomized Design with confidence level 95%. The result showed that all the type of organic waste can be used to produce biogas through anaerobic digestion. Statistically, the average volume of biogas produced from industrial waste per week, 5794,3 ml was significantly different from any other organic waste (P=0,000). The best retention time was found on 8th week with the average volume of biogas was 3675,6 ml (P=0,006). There was no interaction between these two factors (P=0,1). This research is expected to open the people’s awareness about the management of useable organic waste as a raw material to produce biogas.
Analysis of Effectiveness Argument-Driven Inquiry to Improve Students’ Argumentation Skill and Conceptual Understanding Agustina Dua Kuki; Rudiana Agustini; Utiya Azizah
IJORER : International Journal of Recent Educational Research Vol. 4 No. 3 (2023): May
Publisher : Faculty of Teacher Training and Education Muhammadiyah University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46245/ijorer.v4i3.316

Abstract

Objective: This study examined the effectiveness of the Argument-Driven Inquiry learning model in science learning in improving students' argumentation skills and conceptual understanding. Method: The techniques used are 1) searching articles on Scopus and Google Scholar using the keyword Argument-Driven Inquiry in science learning, 2) articles were selected focus on increasing conceptual understanding and argumentation skills, 3) the metadata was selected limited to 2015-2023, and 4) conducting the in-depth review. Results: The ADI model was able to improve students' argumentation skills. In general, students' argumentation levels are in levels 3-4. The quality of the arguments developed by students shows the understanding of the concepts possessed by students. Students can reach the cognitive level created (C6) by writing scientific reports. Novelty: This study reinforces previous research regarding the effectiveness of the ADI model in improving argumentation skills and conceptual understanding taken from recent articles. Therefore, this article can be the basis for developing learning tools for the ADI model.
KETERAMPILAN PROSES SAINS PADA PRAKTIKUM BIOKIMIA BERBASIS LINGKUNGAN Dua Kuki, Agustina; Yohanita Nirmalasari, M.A.
Jurnal Biogenerasi Vol. 9 No. 2 (2024): Volume 9 Nomor 2 tahun 2024 periode (Juni 2024 - September 2024)
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v9i2.4296

Abstract

This research aims to describe students' science process skills during the Biochemistry practicum. This research is a type of qualitative descriptive research that is applied to Chemistry Education students at Nusa Nipa University. Determination of the sample using purposive sampling technique. The data collection technique uses a science process skills observation sheet. The observation data was analyzed to obtain an average score for each aspect, then classified according to the categories very good, good, poor and very poor. Based on the research results, it shows that the science process skills in the aspect of categorizing and drawing conclusions obtained a score of 3-3.7, which is in the very good category.
The Development of Learner Activity Sheets Based on Argument Driven Inquiry Model With Socioscientific Issues Context to Improve Students Argumentation Skills Kuki, Agustina Dua; Wea, Kristiana Nathalia; Susanty, Petronela Ivoni
Jurnal Pijar Mipa Vol. 20 No. 5 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i5.9567

Abstract

Learning by integrating argumentation skills has not been fully implemented in learning.  The purpose of this study was to develop a student activity sheet based on the Argument-Driven inquiry model with a socioscientific issue context. This research integrates the context of socioscientific issues as a stimulus for students in building scientific argumentation. This research method is the 4D model, which includes the define, design, develop, and disseminate stages. However, the stages of this research are limited to the development stage. The results showed that the student activity sheet was developed based on the learning stages of the Argument-Driven inquiry model, which is limited to the scientific argumentation phase. The study of socioscientific issues is adjusted to the learning subtopic of factors that affect the reaction rate. The data from the validation study of the Learner Activity Sheet is classified as a very valid category with a content validity score of 89%; the validity of the layout presentation aspect is 92% and the language aspect is 96%. Meanwhile, the students' response result shows that the level of satisfaction with the activity sheets is 96%, including the category of very satisfied. The improvement of students' argumentation skills was at a moderate level with an N-gain score of 0.64. Statistical test results show there is a significant difference between pretest and posttest scores with a P-value <0.05. Based on these results, it can be concluded that the LAS based on the Argument Driven Inquiry model with a socioscientific Issue context is valid, practical and effective for improving students' argumentation skills.
KETERAMPILAN PROSES SAINS PADA PRAKTIKUM BIOKIMIA BERBASIS LINGKUNGAN Dua Kuki, Agustina; Yohanita Nirmalasari, M.A.
Jurnal Biogenerasi Vol. 9 No. 2 (2024): Volume 9 Nomor 2 tahun 2024 periode (Juni 2024 - September 2024)
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v9i2.4296

Abstract

This research aims to describe students' science process skills during the Biochemistry practicum. This research is a type of qualitative descriptive research that is applied to Chemistry Education students at Nusa Nipa University. Determination of the sample using purposive sampling technique. The data collection technique uses a science process skills observation sheet. The observation data was analyzed to obtain an average score for each aspect, then classified according to the categories very good, good, poor and very poor. Based on the research results, it shows that the science process skills in the aspect of categorizing and drawing conclusions obtained a score of 3-3.7, which is in the very good category.
OPTIMALISASI PENDAMPINGAN PENULISAN KARYA ILMIAH SISWA DI SMA NEGERI 1 TALIBURA Eni, Genoveva Dua; Kuki, Agustina Dua; S, Mansur
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 6 (2024): Vol. 5 No. 6 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i6.37579

Abstract

Menulis merupakan keterampilan yang sering dipelajari oleh siswa dalam proses pembelajaran. Melalui tulisan siswa dapat mengekspresikan gagasan yang tidak dapat disampaikan secara langsung. Tujuan pada kegiatan Pengabdian kepada Masyarakat ini untuk meningkatkan pemahaman dan kemampuan siswa dalam menulis karya ilmiah yang sistematis dan sesuai dengan kaidah penulisan akademis. Metode yang digunakan adalah metode kualitatif dengan pendekatan secara klasikal dan individual. Proses yang dimulai dari pemilihan topik hingga penyusunan laporan penelitian memberikan dampak positif pada keterampilan menulis, berpikir kritis, dan kepercayaan diri siswa.
Co-Authors Aljefridus Misa Apriani Herni Rophi Bare, Yohanes Daeng Tiring, Sri Sulistyaningsih Natalia Dewi Ratih Tirto Sari Eni, Genoveva Dua Gabriella Candrakirana Krisnamurti Krisnamurti, Gabriella Candrakirana Lorenza, Margaretha Rika Wahyu Gabrella M A Yohanita Nirmalasari Margaretha Rika Wahyu Gabrella Lorenza Misa, Aljefridus Nathalia Wea, Kristiana Nirmalasari, M A Yohanita Oktavius Yoseph Tuta Mago Petronela Ivoni Susantya Rudiana Agustini S, Mansur Sari, Dewi Ratih Tirto Utiya Azizah Yohanes Nong Bunga Yohanita Nirmalasari, M.A.