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All Journal Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Health Sains INDRA: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Masyarakat Medika QISTINA: Jurnal Multidisiplin Indonesia Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry

Adriani Susanty

Sekolah Tinggi Ilmu Farmasi Riau

Author-ID : 396110

Religion Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Ekstrak Etanol Daun Tampa Badak (Voacanga foetida (Bl.) K Schum) Terhadap Klirens Kreatinin Mencit Putih (Mus musculus L.) Jantan Susanty, Adriani; Sandi, Nofri Hendri; M, Wewen Sista
Jurnal Penelitian Farmasi Indonesia Vol 1, No 2 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

A research on effect of ethanol extract of tampa badak (Voacanga foetida) to renal function of male white mice at doses 100, 200 and300mg/kgBW of weight has been studied. The employed parameter was measuring creatinine clearence and the kidney weight ratio of malewhite mice in the 61st day. In this study, four group of male white mice, each of which consisted of five mice, were utilized. Three groups weregiven suspension of ethanol extract of tampa badak and the other group as a control was simply given suspension of NaCMC 1% orally. Themeasurement method used was the method of chemical reaction with using reagent Diasys and by using ultraviolet-visible spectrophotometry(Microlab 200) at wavelength 505 nm. The result showed that application of ethanol extract of tampa badak did not give significant effect(p>0,05) to 24 hour urine volume, urinary creatinie quantity, serum creatinine, cretinine clearance as well as kidney weight ratio of malewhite mice.

Sosialisasi pencegahan dan pengendalian Infeksi Saluran Nafas Akut di Wilayah XIII Koto Kampar Rahmayati Rusnedy; Adriani Susanty; Rickha Octavia; Nofri Hendri Sandi; Ferdy Firmansyah; Armon Fernando
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Acute Respiratory Infection (ARI) is one of the highest infectious diseases in Indonesia that can cause death. The public knowledge about the prevention and control of ARI is inadequate, so prevention efforts are needed to reduce the transmission of this infection disease. The purpose of this community service activity is to increase the knowledge of the people of Gunung Bungsu Village, Kec. XIII Koto Kampar on preventing the transmission of ARIs through preventive measures by providing education on how to use masks and proper ethics when coughing/sneezing. The method used was an interactive and participatory model by involving the community at Gunung Bungsu Village, Kec. XIII Koto Kampar. This socialization activity increased the community knowledge, showed by the enthusiasm of community at Gunung Bungsu Village, Kec. XIII Koto Kampar who actively interacts through the questions they ask to increase their understanding of ARI. Beside that, the results of the questionnaire assessment showed that the community was satisfy with the socialization of ARI prevention. This service can be useful for the prevention and control of ARI around the neighborhood.

Aktivitas Sitotoksik Ekstrak Etil Asetat Daun Tampa Badak (Voacanga foetida (Bl.)K.Schum) pada Kanker Kolon HTB-38 Adriani susanty; Dachriyanus Dachriyanus; Yanwirasti Yanwirasti; Fatma Sri Wahyuni; Haiyul Fadhli; Pedro Anugrah Aswan
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Kanker kolon merupakan penyakit yang ditandai oleh perkembangan sel yang tidak terkendali di lapisan epitel pada usus besar. Salah satu tumbuhan yang memiliki aktivitas sebagai antikanker yaitu tumbuhan tampa badak (Voacanga foetida (Bl.) K.Schum). Tumbuhan tampa badak adalah keluarga apocynaceae yang memiliki aktivitas antikanker terhadap sel kanker darah (L1210 dan K256), sel kanker paru (A549) dan sel kanker serviks (HeLa). Penelitian ini bertujuan untuk mengetahui efek sitotoksik ekstrak etil asetat daun tampa badak terhadap sel kanker kolon HTB-38. Metode yang digunakan pada pengujian ini adalah metode MTT Assay pada waktu 24, 48 dan 72 jam. Parameter yang digunakan adalah IC50. Hasil penelitian menujukkan bahwa nilai IC50 ekstrak etil asetat daun tampa badak terhadap sel kanker kolon HTB-38 pada waktu 24, 48 dan 72 jam masing-masing sebesar 0,0287, 0,0776 dan 0.0415 μg/mL. Hasil penelitian ini menunujukkan bahwa ekstrak etil asetat daun tampa badak mempunyai efek sitotoksik kuat terhadap sel kanker kolon HTB-38. Hasil uji ANOVA menyatakan bahwa terdapat perbedaan persen viabilitas antara konsentrasi 0,1 μg/mL, konsentrasi 0,5 μg/mL dan konsentrasi 1 μg/mL (p<0,05) tetapi lama waktu inkubasi tidak memiliki pengaruh terhadap nilai persen viabilitas (p>0,05).

Efek Analgetik Ekstrak Etanol Daun Tampa Badak (Voacanga foetida (Bl.) K. Schum) Pada Mencit Putih Jantan Adriani Susanty; Armon Fernando; Ivona Adelin
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

A study on the analgesic activity ethanolic extract of Voacanga foetida leaves has been conducted on male mice by using Writhing test. The mice were induced with 0.1 mL of glacial acetic acid 1%. The extract was administered orally in the doses of 250, 500, and 1000 mg/kg, suspended with NaCMC 1%, while 65 mg/kg acetosal was used as positive control. The data was analyzed with two way ANOVA. The study revealed that the extract exhibited analgesic effect insignificantly different with acetosal at the doses of 250, 500, and 1000 mg/kg. This effect was different with negative control (p<0.05).

In Vitro Cytotoxic Activity Test of Tampa Badak (Voacanga foetida (Blume) Leaves on L1210 Leukemia Adriani Susanty
Jurnal Sains Farmasi & Klinis Vol 8, No 3 (2021): J Sains Farm Klin 8(3), Desember 2021
Publisher : Fakultas Farmasi Universitas Andalas

The Voacanga foetida (Blume) Rolfe leaves have cytotoxic activity based on our previous research, namely the Brine Shrimps Lethality Test on ethanol extract. This study tested the anticancer activity of the extract and leaf fraction of Voacanga foetida in vitro on L1210 leukemia cells using the direct cell count method and doxorubicin positive control. The results showed that the methanol extract, butanol, ethyl acetate, and hexane fractions, as well as isolated compounds Tb1, Tb2, and Tb3 leaves from Voacanga foetida, had IC50 values of 4.4; 9; 8.4; 16.8; 0.9; 1.8; and 1.1 ppm, compared with doxorubicin with an IC50 value of 0.2 ppm. Based on the IC50 value, it showed that the extract, fraction and isolated compounds of Voacanga foetida had a strong cytotoxic effect, as evidenced by the IC50 value < 30 ppm for each test concentration.

Sosialisasi Protokol Kesehatan dalam Mencegah Penularan Covid-19 di Kelurahan Bina Widya Kota Pekanbaru Rickha Octavia; Denni Anggraini; Adriani Susanty; Rahma Dona; Melzi Octaviani
Jurnal Health Sains Vol. 2 No. 7 (2021): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v2i7.226

COVID-19 cases in Riau Province are still showing a significant increase in numbers. This is due to the activities and mobility of the people of Riau Province who are very much outside the house. Problems in the community, among others, are still many who do not understand the prevention of COVID-19 transmission, including the importance of using masks when out of the house, the importance of personal hygiene, hand washing with soap, and pyshical distancing. The habit of implementing clean and healthy living behaviors is not easy, it requires understanding and motivation from individuals so that each individual is more disciplined in applying them. The purpose of this research is to increase people's knowledge about COVID-19 through leafleat media. The method used is qualitative method. Pretest the community to get an early overview of the understanding of health protocols in preventing the transmission of COVID-19. The results of the posttest questionnaire showed an increase in people's knowledge from not understanding to understanding and very understanding. This is because the measurement of knowledge is done by providing complete information about COVID-19 and its prevention through leaflet media that is very effective in improving one's knowledge. The conclusion of socialization research that has been conducted on November 29, 2020 at RW 09 RT 03 Bina Widya Village, Panam Pekanbaru Riau can be seen that there is an increase in public knowledge after this activity, thus adding to the public's insight on how to prevent the transmission of covid-19 and what foods can be consumed during the current pandemic in order to improve the immune system or immune system.

The Anti-proliferation Effect of an Isolated Butanol Fraction of Tampa Badak (Voacanga foetida (Bl.) K. Schum) Leaves on Leukemia, Lung, and Cervical Cancer Susanty, Adriani; Dachriyanus, Dachriyanus; Yanwirasti, Yanwirasti; Sri Wahyuni, Fatma; Sekar, Andisyah Putri; Alimin, Nur; Magdazaleni, Magdazaleni; Sofia, Sri Esky; Dewi, Citra Kartika
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Voacanga foetida (Bl.) K.Schum leaves are known to have cytotoxic activity against blood cancer cells. This study was aimed to determine the potential of an isolated butanol fraction of Voacanga foetida (Bl.) K.Schum leaves (Tb3 compound) in inhibiting the proliferation of several cancer cells, including leukemia (K562), lung cancer (A549), and cervical cancer (He-La) using the dye exclusion method. We found that the percentage of anti-proliferation of the Tb3 compound was increased in a dose-dependent manner, where it showed 83% (K562), 72.3% (He-La), and 70.7% (A549) inhibition at higher concentration. These values were relatively higher compared to doxorubicin as a positive control, 77.1%, 63.8%, and 62.7%, respectively. Moreover, the IC50 values of the Tb3 compound were still in the range of active cytotoxic compounds based on NCI classification, which is less than 4 µg/mL; 0.5 μg/mL, 2.4 μg/mL, and 3.6 μg/mL for K562, A549, and He-La, respectively. Therefore, this study indicated the potential anticancer effect of an isolated butanol fraction of the Tb3 compound to inhibit cancer cell proliferation, which provides an alternative for cancer therapy.

KNOWLEDGE ABOUT STORAGE OF SYRUP DRUG ON PATIENT IN PUSKESMAS PEKANBARU CITY Desmariani -; Fintolin Jaya Putri; Seftika Sari; Ratna Sari Dewi; Adriani Susanty; Enda Mora
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.5259

Drug storage is something that must be considered because it can affect the quality of the drug. Storage conditions must adapt to the stability of each drug. This study aims to determine the level of knowledge about the storage of syrup drug preparations in patients in all public health centers in Pekanbaru. The research method is analytic observational with cross sectional design. The research sample was the people who visited all health centers in Pekanbaru city which were selected by purposive sampling technique according to the inclusion and exclusion criteria and obtained a sample of 160 respondents. The instrument is a knowledge questionnaire that has been tested for validation and reliability. The knowledge questionnaire contained 14 valid questions (r=0.818). Presentation of data with bar charts and narrative text. The results of the study revealed that there were 66 respondents (41.25%) in the good knowledge category and 94 respondents (58.75%) in the sufficient knowledge category and none of the respondents had less knowledge in the category. From these results, it can be concluded that most people do not know well how to store syrup drugs, so it is necessary for the role of pharmacists to provide education to the public, especially regarding how to store drugs correctly

Cytotoxic Activity of Ethyl Acetate Extract from Voacanga foetida (Bl.) Rolfe Leaves Against T47D Breast Cancer Cells Adriani Susanty; Mira Febrina; Dian Sanita Putri; Ihsan Ikhtiarudin; Fatma Sri Wahyuni; Dachriyanus Dachriyanus
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.3499

The cytotoxicity of ethyl acetate extract from Tampa badak (Voacanga foetida (Bl.) Rolfe) leaves against Artemia salina leach larvae was determined using the brine shrimp lethality test (BSLT) method and was evaluated against T47D breast cancer cells using MTT assay method. The result of BSLT showed a consistent result with MTT assay, which is the result obtained that ethyl acetate extract is very toxic against A. salina Leach larvae with LC50 value of 8.61 µg/mL and very cytotoxic against T47D breast cancer cells with IC50 values of 0.87; 0.66; and 0.95 µg/mL at the 24, 48 and 72 hours of incubation times, respectively. The MTT assay data were analyzed using a two-way ANOVA statistical method to see the effect of the dependent variable (concentration and time) on the independent variable (% viability). Based on the statistical test result, there is a difference in % viability between concentrations of 0.1; 1; and 10 µg/mL (p <0.05), but the length of incubation does not affect % viability (p >0.05).

Isolation and Cytotoxic Activity Test of Alkaloids from Dichloromethane Fraction of Bark of Tampa Badak (Voacanga foetida (Blume) Rolfe) Against T47D Cell Line Adriani Susanty; Nurdina Putri; Ihsan Ikhtiarudin; Novia Sinata; Dira Dira; Fatma Sri Wahyuni; Dachriyanus Dachriyanus
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.583

Cancer is a problem in the health sector because this disease has an increasing incidence of morbidity and mortality. While the treatment still leaves some drug side effects, which cause discomfort for cancers sufferers. The arises because most cancer drugs work non-selectively. Because of some of the problems above, it is necessary to encourage the search for alternative drugs treatment of cancer. Voacanga foetida (Blume) Rolfe (Apocynaceae) is a species of plant from the genus Voacanga known as the tampa badak from West Sumatra. This plant is known to be source of indole alkaloids and also bis-indole alkaloids potential as cancer drugs. Therefore, in this study we are interested to explore the potency of this plant as natural product sources with potential cytotoxic activity. The study was started from the isolation process and continued by characterization of the isolated compounds and then testing their cytotoxic activity T47D breast cancer cell line. The isolation process of alkaloid compounds were performed by acid-base extraction, liquid-liquid fractionation, and followed by separation using column chromatography. Then,the potency of cytotoxic activity of the isolates were screened through Brine Shrimp Lethality Test (BSLT) method and evaluated by MTT assay. The structure of three isolated alkaloids (VFB-DB1.1; VFB-DB2.1; and VFB-DB2.2) were charachterized using spectroscopic analyses, including UV and FT-IR. One isolated compound (VFB-DB1.1) was also characterized using 1H NMR spectroscopy. Based on the similarity of 1H NMR spectra of isolated compound when compared with the literature, compound VFB-DB1.1 was identified as voacangine. Then, the BSLT and MTT assay result showed that VFB-DB1.1 exhibited LC50 value of 15.8 µg/mL againt Artemia salina L.and IC50 value of 8.9 µg/mL against T47D breast cancer cells, respectively.

Co-Authors Achdar, Ridza Fitria Adelina, Helmi Rahmah Afridho, Arif Alimin, Nur Arief, Encik Juliansyah Armon Fernando Aulia, Nada Aqilah Cahyani, Astri Dachriyanus Delvi, Kasma Muria Denni Anggraini Desmariani - DEWI FITRIANI Dewi, Citra Kartika Dewi, Irana Dian Sanita Putri Dira Dira Dirmaningsih, Septi Enda Mora Fadhila, Metha Fadhila, Qonita Nur Farisa, Nayla Al Fatma Sri Wahyuni Ferdy Firmansyah Fintolin Jaya Putri Haiyul Fadhli Hasanah, Mitha Husnawati Husnawati Ihsan Ikhtiarudin Indri Aprilia, Indri Ivona Adelin Izrawati, Izrawati Jannati, Nisa Karismawati, Karismawati Kuang, Liau Che Kurniasih, Aminah Lifiani, Rilialita Linda, Rosa Magdazaleni, Magdazaleni Mayrade, Salma Yudhistira Meiriza Djohari, Meiriza Melisa, Eva Melzi Octaviani Meridona, Meridona Mira Febrina Ngazizah, Yeti Nur Nofri Hendri Sandi Nurdina Putri Pedro Anugrah Aswan Putri, Bayzola Ditya Putri, Dhini Fahira Putri, Widia Rahma Ramona, Paula Ratna Sari Dewi Rickha Octavia Rusnedy, Rahmayati Rustam, Muhanifa Safitri, Fasri Dian Sandi, Widya Ari Sari, Seftika Sekar, Andisyah Putri Sinata, Novia Sisca, Sari Kurnia Sofia, Sri Esky Suheri, Wira Noviana Syafutri, Lidiyah Tania, Berla Thamrin Thamrin Ulfa, Rodhia Wewen Sista M Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yuti, Denisyah Fitri

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