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All Journal Nurse Media Journal of Nursing The Indonesian Journal of Public Health Sari Pediatri The Journal of Educational Development Paediatrica Indonesiana Belitung Nursing Journal Jurnal Gizi Klinik Indonesia Journal of Community Empowerment for Health Berita Kedokteran Masyarakat
Elisabeth Siti Herini
Department Of Child Health, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/ Dr. Sardjito Hospital, Yogyakarta, Central Java
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Paediatrica Indonesiana

 1 
The role of exclusive breastfeeding in prevention of childhood epilepsy Alexander Kurniadi; Elisabeth Siti Herini; Wahyu Damayanti
Paediatrica Indonesiana Vol 55 No 5 (2015): September 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (92.651 KB) | DOI: 10.14238/pi55.5.2015.282-6

Abstract

Background Epilepsy affects 1% of children worldwide. The highest incidence is in the first year of life, and perinatal factors, such as hypoxic-ischemic injury, infection, and cortical malformation may play etiologic roles. Breast milk contains optimal nutrients for human brain in early life. Breastfeeding has been associated with lower risk of infections, better cognitive and psychomotor development. However, the role of breastfeeding in preventing childhood epilepsy remains unclear. Objective To evaluate an association between exclusive breastfeeding and childhood epilepsy. Methods A case-control study conducted from 1 May to 3 July 2013 involving children with epilepsy aged 6 months to 18 years who were attending pediatric outpatient clinic of Dr. Sardjito Hospital, Yogyakarta. Neurologically normal children, individually matched by age and sex, visiting the same clinic were considered as controls. Exclusion criteria were children with structural brain abnormality, history of epilepsy in family, and who had history of neonatal seizure, intracranial infection, febrile seizure, and head trauma before onset of epilepsy. History of breastfeeding was obtained by interviewing the parents. The difference of exclusively breastfeeding proportion between cases and controls was analyzed by McNemar test. Results The total number of participants was 68 cases and controls each. Subjects with epilepsy had lower proportion of exclusively breastfed (48.5%) compared with controls (54.4%), but the difference was not statistically significant (P=0.541). Exclusively breastfeeding showed no statistical significance in decreasing risk of epilepsy (OR=0.71; 95%CI 0.32 to 1.61). Conclusions Exclusive breastfeeding for 4-6 months has no effect against childhood epilepsy.
Postpartum lactation counseling and exclusive breastfeeding: analysis of the 2017 Indonesian Demographic and Health Survey Warantika Rikma Yuniarini; Elisabeth Siti Herini; Abdul Wahab
Paediatrica Indonesiana Vol 61 No 1 (2021): January 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.1.2021.25-33

Abstract

Background The percentage of exclusive breastfeeding in Indonesia on 2018 dropped from 39.8% in infants aged 0 monthsto 15.3% in infants aged 5 months. According to the 2018 Indonesian Basic Health Research Survey (Riskesdas), an average of 37.3% of infants were exclusively breastfed until the age of 6 months. This rate is far from the target of 80% by Ministry of Health of Indonesia. Objective To assess for an association between postpartum counseling and the practice of exclusive breastfeeding in Indonesia. Methods This retrospective cohort study used data from the 2017 Indonesian Demographic and Health Survey (IDHS). The sample comprised 258 infants aged 6 months. Postpartum counseling and other variables were analyzed for possible associations with exclusive breastfeeding by Chi-square test; risk ratios (RR) with 95% confidence intervals (CI) were calculated. Logistic regression test was used to analyze for adjusted odds ratios. Results In 6 months period, the percentage of subjects who received postpartum counseling was 59.7% and who exclusively breastfed was 18.8%. There was no significant association between postpartum lactation counseling and exclusive breastfeeding. However, there were significant associations between exclusive breastfeeding and not using currently as well as maternal residence in rural areas. Conclusion Postpartum counseling on breastfeeding lacks a significant association with exclusive breastfeeding practice at 6 months of age. Therefore, the Ministry of Healthshould reevaluate the implementation of its counseling services.
Potentially predictive factors for hearing function improvement in pediatric cytomegalovirus infection therapy Agung Triono; Elisabeth Siti Herini; Braghmandita Widya; Dian Kesumapramudya Nurputra
Paediatrica Indonesiana Vol 61 No 5 (2021): September 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.5.2021.235-9

Abstract

Background Symptomatic congenital cytomegalovirus (CMV) infection has an impact mainly on neurological sequelae, including sensorineural deafness. Because of the long-term impact, early treatment of CMV infection is mandatory. However, predictive factors for hearing function improvement in CMV infection therapy remain unexamined. Objective To evaluate potential predictive factors for hearing improvement in pediatric CMV infection therapy. Methods All medical record data of patients aged 0-6 years with CMV infection who completed a 6-week course of ganciclovir therapy or a combination of a 4-week course of ganciclovir and a 2-week course valganciclovir from January 2013 to December 2017 were collected. Age at onset of therapy, gender, gestational age, nutritional status, multi-organ involvement, and neurological symptoms were studied as potential predictive factors of hearing improvement in CMV therapy. The effectiveness of CMV infection therapy on improving hearing function was measured with the brainstem evoked response audiometry (BERA) test. Results BERA tests proportion in the right, left, and best ear showed significant improvement after therapy. All variables analyzed were not statistically significant as predictive factors for hearing improvement in CMV infection therapy. Conclusion Ganciclovir/valganciclovir therapy in CMV infection patients accounted for the improvement of hearing impairment. However, none of the assessed factors were considered predictive for improving hearing function in CMV infection therapy.
Predictive factors of advanced chronic kidney disease in children with congenital anomalies of kidney and urinary tract Dea Puspitarini; Elisabeth Siti Herini; Cahya Dewi Satria; Kristia Hermawan
Paediatrica Indonesiana Vol 63 No 2 (2023): March 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.2.2023.96-101

Abstract

Background Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease (CKD) in children. Delayed diagnosis of CAKUT due to lack of universal screening (such as prenatal ultrasound screening or postnatal ultrasound screening in neonates with risk of CAKUT) has led to more cases of advanced CKD in children. CKD has high morbidity and mortality, and early detection is required to prevent the progression of CKD. Objective To determine the factors that predict the development of advanced CKD in children with CAKUT. Methods This retrospective cohort study included children with CAKUT at Dr. Sardjito Hospital, Yogyakarta, Indonesia from January 2016 to February 2021. Patients who were diagnosed with CAKUT were followed up to 5 years or until the onset of advanced CKD. Advanced CKD was defined as a decreased estimated glomerular filtration rate (eGFR) of less than 30mL/min/1.73m2 based on the revised Schwartz formula. CKD progression-free survival was determined with Kaplan-Meier and Cox regression analyses. Results Among 62 subjects with CAKUT, 7 (11.3%) subjects progressed to advanced CKD. The mean time of advanced CKD progression was 52.2 (95%CI 46.9 to 57.5) months. The overall incidence rate was 22 per 1,000 person-years. Based on Kaplan-Meier analysis, children with eGFR <60 mL/min/1.73m2 at the time of diagnosis had more rapid progression to advanced CKD than patients with eGFR ?60 mL/min/1.73m2 [40.2 (95%CI 33.4 to 46.6) months vs. 58.2 95%CI 46.9 to 57.5) months; P=0.02, respectively]. Conclusion Reduced eGFR at the time of diagnosis showed rapid progression to advanced CKD.
Predictors for seizure relapse in children with epilepsy after antiepileptic drug withdrawal: case-control study Triono, Agung; Herini, Elisabeth Siti; Mangunatmaja, Irawan
Paediatrica Indonesiana Vol. 64 No. 2 (2024): March 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.2.2024.120-5

Abstract

Background Epilepsy is defined as a neurologic condition caused by a pathological brain condition. Epilepsy patients who have stopped treatment and are seizure-free for two years are considered to have achieved complete remission. Relapse occurs when seizures return after anti-epileptic drug (AED) withdrawal. Several studies reported that frequent seizures, prolonged duration to control seizures, number of AEDs consumed, and abnormal electroencephalography (EEG) found during AEDs tapered, were reported as predictors of relapse. Methods This retrospective, case-control study was carried out from 2012 – 2016 using multisite medical record evaluation, followed by interviews and EEG examinations. The case group included children with epilepsy who had seizure relapse, while the control group included children with complete remission of epilepsy. Bivariate and multivariate analyses were performed to identify predictors of relapse. Results Relapse predictors in bivariate analysis were symptomatic etiology epilepsy (OR 5.000; 95%CI 2.345 to 10.660; P<0.001), time to seizure control ?1 year (OR 3.689; 95%CI 1.493 to 9.116; P=0.003), and worsened EEG evolution at pre-withdrawal compared to EEG at the time of diagnosis (OR 2.310; 95%CI 1.132 to 4.717; P=0.021). Statistically significant relapse predictors in multivariate analysis were symptomatic etiology epilepsy (OR 4.384; 95%CI 1.985 to 9.681; P<0.001) and slow (?1 year) time to seizure control (OR 4.355; 95%CI 1.753 to 10.817; P 0.002). Conclusion Symptomatic etiology epilepsy and time to seizure control ?1 year are independent predictive factors for seizure relapse in children with epilepsy. Therefore, children with these conditions require a longer period and careful, gradual dose reduction before antiepileptic drugs withdrawal.
Co-Authors Abdul Wahab Adeta Stefianti Isnoor Agung Triono Agung Triono Agung Triono Agung Triono, Agung Albaaza Nuady Alexander Kurniadi Alexandra Widita Swipratami Alifiani Hikmah Putranti Andri Kenti Gayatina Ashadi Prasetyo Avianti Pramastuti Bawono, Kornelius Dandung Braghmandita Widya Braghmandita Widya Indraswari Cahya Dewi Satria Damroni, Rais Aliffandy Dea Puspitarini Diantika, Kania Dwi Yuwono Puji Sugiharto, Dwi Yuwono Puji Fitri Haryanti Hadiyanto, Marissa Leviani Ignatia Rosalia Kirana Indria Laksmi Gamayanti Irawan Mangunatmadja Iskandar, Kristy Kania Diantika Kornelius Dandung Bawono Kristia Hermawan Kristy Iskandar Lestari, Lilis Mangunatmaja, Irawan Maria Martiani Marissa Leviani Hadiyanto Marissa Leviani Hadiyanto Martalena Purba Martiani, Maria Maulina Handayani Mei Neni Sitaresmi Melina Dian Kusumadewi Mooiindie, Khansadhia Hasmaradana Muriana Novariani Nugrahanto, Andika Priamas Nurputra, Dian Kesumapramudya Paramastuti, Avianti Prasetyo, Ashadi Purba, Martalena Ratni Indrawanti Salsabilla Hasna Mutiara Rizki Sari Wardhani Satoshi Takada Setya Wandita Setya Wandita, Setya Sri Hartini Suryono Yudha Patria Timoti, Joshua Totok Sumaryanto Florentinus, Totok Sumaryanto Veronica Wulan Wijayanti Wahyu Damayanti Warantika Rikma Yuniarini Wijayanti, Veronica Wulan Yunika Puspa Dewi Yusmiyati Yusmiyati