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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Althea Medical Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Respiratory Science
Haryati Haryati
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine Lambung Mangkurat University, Ulin Regional Hospital, Banjarmasin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Nutritional Status of Hospitalized Tuberculosis Patients in South Kalimantan: A Cross-Sectional Study Mohamad Isa; Ira Nurrasyidah; Elok Hikmatun Nikmah; Desi Rahmawaty; Ali Assagaf; Haryati Haryati; Erna Kusumawardhani
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 2 (2022): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i2.15021

Abstract

The burden of tuberculosis (TB) infection is significant in Indonesia. There is likely a substantial link between TB and malnutrition. Anemia, which is linked to TB patient outcomes and length of hospital stay, is another issue that might aggravate the disease. This study aims to identify how common undernutrition and anemia are among tuberculosis patients at the Ulin Regional Hospital in Banjarmasin. A cross-sectional observational study was conducted using medical record data from 31 hospitalized tuberculosis patients from September to December 2021. Data of weight, height, body mass index (BMI), Hemoglobin (Hb) and blood albumin level at admission were analyzed. The result showed that tuberculosis cases were mostly found in males (61.3%) aged 20-60 years (83.9%). There were 42% of patients with undernutrition (BMI 18.5), 93.5% with anemia, and 71% with hypoalbuminemia. Rifampicin resistance was found in 38.7% of all patients, with 58.3% malnutrition, 100% anemia, and 50% hypoalbuminemia. Thus, there was a possible link between tuberculosis and undernutrition condition. Screening, early diagnosis, and treatment for undernutrition, anemia, and hypoalbuminemia should be encouraged in patients with tuberculosis, whether they are susceptible or resistant to rifampicin, to lower the burden of the disease.
Clinical and Laboratory Features of COVID-19 in Ulin Referral Hospital of South Kalimantan: Predictors of Clinical Outcome Haryati Haryati; Mohamad Isa; Ali Assagaf; Ira Nurrasyidah; Erna Kusumawardhani; Eko Suhartono; Fidya Rahmadhany Arganita
Journal of Tropical Life Science Vol. 11 No. 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.06

Abstract

Corona Virus Disease (COVID-19) is becoming a global pandemic. Indonesia, especially South Kalimantan had recorded increasing cases with a high fatality rate of 3.7%. Information about factors related to outcomes based on clinical and laboratory features in Indonesia is still limited. Identification of the risk is crucial to determine optimal management and reducing mortality. This retrospective study enrolled 455 adults COVID-19 patients, and data were extracted from medical records of Ulin General Hospital Banjarmasin. The latter is COVID-19 referral hospital in South Kalimantan between March-November 2020. Demographic data, comorbidities, and laboratory were all collected. Data were compared between survivors and non-survivors. Fisher’s exact test and chi-square were used to compare categorical variables. The Mann_Whitney U test was used to compare continuous variables. Analysis was continued by multivariate logistic regression then receiver operating characteristic (ROC) curve to determine cut-off value. The multivariate analysis showed that number of comorbidities [odds ratio (OR) 1,339 (95% confidence interval (CI): 1,064-1,685, P = 0,013) was a significant risk factor to the outcome. In laboratory, lactate dehydrogenase (LDH) [OR: 1.001, 95% CI: 1,000-1.002, P = 0.001], Ferritin (OR 1.000, CI: 1,000-1.001, P = 0.013), APTT (OR: 1.045, CI: 1.010-1.082, P = 0.012), and D-dimer (OR: 1.188, CI: 1.064 - 1.327, P = 0.002) were significant predictor factors but only LDH, ferritin, and D- dimer were obtained good AUC 0.731, 0.715, and 0.705, respectively. The cut of the value of LDH was 656.5 U/L, ferritin was 672.18 ng/ml, and D-dimer was 2.28 mg/L. Sensitivity and specificity were 66.7% and 68,0% for LDH, 83,2% and 56,3% for ferritin, and 62,8 and 70,8% for D-dimer. From this research, we revealed that the number of comorbidities was a risk factor for death. Elevated LDH, ferritin, and D-dimer could be good predictive factors for poor outcomes, thereby considering the accelerating management of COVID-19 patients.
Management of Febrile Neutropenia in Lung Cancer Haryati Haryati; Nida Amalia
Respiratory Science Vol. 3 No. 2 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i2.72

Abstract

Febrile neutropenia (FN) is defined as an oral temperature of >38.3° C or two consecutive measures >38°C within 2 hours accompanied by an absolute neutrophil count (ANC) of 500/L or a predicted decrease below 500/L in individuals undergoing systemic chemotherapy for cancer. FN is one of the oncological emergencies that can influence cancer patients' outcomes since it can increase morbidity, treatment delays, decrease survival, and expand costs. The incidence of FN is 3.7-28% in lung cancer patients. Mortality associated with FN episodes is 15%. FN risk factors include chemotherapy regimen, age, comorbidities, mucositis, performance status, and previous FN history. Validated predicted instruments such as The Multinational Association for Supportive Care in Cancer (MASCC) or The Clinical Index of Stable Febrile Neutropenia (CISNE) score could assist in the risk assessment of FN and determine advanced management. Effective therapy of FN requires investigation of diagnosis as soon as possible and acknowledging the potential source of infection. The prophylactic granulocyte colony-stimulating factors (G-CSF) and anti-microbial successfully reduced mortality due to FN.
Clinical Characteristic of Different SARS-CoV-2 Variants in South Kalimantan, Indonesia: A Case Study Haryati Haryati; Desi Rahmawaty; Mohamad Isa; Ali Assagaf; Ira Nurrasyidah; Erna Kusumawardhani
Althea Medical Journal Vol 10, No 1 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n1.2810

Abstract

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has undergone various mutations of Corona Virus Disease 2019 (COVID-19). The World Health Organization (WHO) has designated B.1.617.2 (Delta) and B.1.1.529 (Omicron) as variants of concern (VOC). Since clinical features and epidemiological characteristics of patients infected with SARS-CoV-2 variants remain largely unknown, especially in Indonesia, this study aimed to identify the clinical characteristics of COVID-19 patients from South Kalimantan, Indonesia.Methods: Data from medical records of COVID-19 patients at Ulin General Hospital Banjarmasin from June 2021 to February 2022 were randomly extracted, containing demographic data, comorbidities, and laboratory data, as well as the type of virus. Results: In total, 32 patients were included, 9 were infected with delta, 14 with probable omicrons, and 9 with non-VOC. Patients in the probable Omicron group were significantly older than other groups (median age 64 years old, range 54–73 years; p=0.049), had hypertension as the dominant comorbidity (85.7%; p=0.039), the onset appeared slightly earlier (median 3 days; range 2-3 days, p=0.062), with no anosmia symptom (p=0.006). Critical illness predominated and mostly survived in all variants but was not statistically significant (p=0.590 and 0.726, respectively). The three variants showed similarities in laboratory findings; hence, statistical analysis suggested that the leucocytes differed significantly (p=0.020).Conclusions: Patients with the likely Omicron variant are much older, have hypertension as their main comorbidity, do not have any symptoms of anosmia, and have higher leukocyte counts compared to other variants.
Indonesian Society of Respirology (ISR) Consensus Statement on Lung Cancer Screening and Early Detection in Indonesia Sita Andarini; Elisna Syahruddin; Nathaniel Aditya; Jamal Zaini; Ferry Dwi Kurniawan; Sabrina Ermayanti; Noni Novisari Soeroso; Sri Melati Munir; Andreas Infianto; Ana Rima; Ungky Agus Setyawan; Laksmi Wulandari; Haryati Haryati; Ida Ayu Jasminarti; Arif Santoso
Jurnal Respirologi Indonesia Vol 43, No 2 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i2.455

Abstract

Lung cancer is the leading cause of mortality for all cancer globally and in Indonesia. In Indonesia, lung cancer contributes to 12.6% of death of all cancer, making it the number one cause of cancer death, and 8.6% of all cancer incidence in 2018, behind breast, cervical, and colorectal cancer. The total cases per year are expected to almost double from 30,023 in 2018 to 54,983 cases in 2040. Smoking is among the risk factors for lung cancer, after occupational/environmental risk factors, history of lung fibrosis, and family history of cancer. There was a tendency of younger smokers in Indonesia and increased lung cancer incidence and prevalence in the younger population. The median age of lung cancer in Indonesia was younger than in any country, probably due to the younger age of smoking, early onset of carcinogens, asbestos use, and environmental. Lung cancer screening is a voluntary measure to detect lung cancer in the earliest stage, to find cancer at curable disease before symptoms appear in high-risk individuals. Lung cancer early detection is strategies to find cancer earlier after symptoms appear (cough, hemoptysis, dyspnea, chest pain). Low-dose computerized tomography of the thorax (LDCT) screening has been known to reduce lung cancer mortality compared to a chest x-ray (CXR). This Indonesian Society of Respirology consensus statement was aimed to give recommendations on lung cancer screening and early diagnosis in Indonesia.
The Solitary Pulmonary Nodule: Is It Benign or Malignant? Haryati Haryati; Dimas Satrio Baringgo
Respiratory Science Vol. 4 No. 1 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i1.101

Abstract

Solitary pulmonary nodules (SPN) are round-shaped opacities with or without firm borders and ≤3 cm in diameter. 40% of solitary pulmonary nodules in high-risk populations are malignant and >10 mm in diameter. With the high incidence of pulmonary cancer, diagnosing pulmonary nodules is essential for clinicians. This review aims to discuss more solitary pulmonary nodules based on multiple recommendations for diagnosis and management. Malignancy probability assessment is the first step in evaluating each patient with new pulmonary nodules, as it significantly affects the prognosis of the disease. The assessment depends on the risk factors present in the patient, which are cigarettes, age, history of cancer, and family history. Radiological evaluation is the second phase in pulmonary nodule evaluation. Predictors of malignant nodules that should be assessed are nodule size, growth rate, nodule morphology, location, and enhancement. Many guidelines have been published regarding treating solitary pulmonary nodules, including the Fleischner Society, ACCP, and BTS guidelines. 
Implementing Palliative and End-of-Life Care in Lung Cancer: When to Start? Haryati Haryati; Desi Rahmawaty; Tenri Ashari Wanahari
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.64-71

Abstract

Lung cancer is among the most prevalent cancers and the primary cause of cancer-related mortality. Despite advances in treatment, patients often have a poor prognosis, with a limited survival period, particularly in advanced stages. Significant morbidity is linked with lung cancer, and symptoms are frequently inadequately controlled, resulting in a considerable symptom burden for patients and their family caregivers. It is typically accompanied by an overall reduction in one's quality of life (QoL). Palliative care is an established therapy paradigm that successfully enhances symptom management and physical and mental health. It can be initiated as soon as the patient develops symptoms (even in the early stage) or is diagnosed with a late stage. Over the past few decades, palliative care has become a vital part of comprehensive care for people, especially those with advanced diseases. Early palliative care (EPC) integration within the oncology setting is more effective than standard care in enhancing the patient's QoL and length of survival, resulting in less intrusive end-of-life care. When caring for lung cancer patients, medical practitioners must remember their duty to cure occasionally, routinely alleviate, and constantly comfort the patient. Treating physical symptoms, illness comprehension, coping, and psychological and spiritual anguish are all vital components. Intervention strategies by multidisciplinary teams concentrating on the patient and their family and dealing with the circumstances are essential. All health providers should prioritize palliative and end-of-life care to enhance care and assist patients and their families in navigating the final period of life.
Neutrophil-Lymphocyte Ratio, Platelet Lymphocyte Ratio, And Carcinoembryonic Antigen Relationship With Survival In Non-Small Cell Lung Cancer Patients Haryati Haryati; Ayudiah Puspita Mayasari; Farida Heriyani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22773

Abstract

Inflammation is crucial to cancer development. A complete blood count is standard patient testing. Thus, inflammatory biomarkers like neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) may predict lung cancer prognosis. Serum carcinoembryonic antigen (CEA) is the main predictive marker of most studies. Elevated NLR, PLR, and CEA levels are frequently associated with poorer overall survival in NSCLC patients. A retrospective cross-sectional study included 50 NSCLC medical records patients from Ulin Regional South Kalimantan Hospital. NLR, PLR, and CEA baseline peripheral blood individuals were investigated for NSCLC overall survival (OS). Patients are separated by OS mean into two groups. Mann-Whitney compared variables. The ROC curve and AUC were used to evaluate the above indicators' prognostic value. The mean of OS was 6 months. NLR, PLR, and CEA patients in ≤ 6 months had higher median values compared to > 6 months groups (8.73 vs. 4.3; 301.23 vs. 217.81; and 106 vs. 27.87). Survival was significantly associated with NLR and CEA (p-values 0.010 and 0.011). NLR >5.90 with AUC 0.725 (sensitivity 63.6%, specificity 29.4%) and CEA >41.39 ng/mL with AUC 0.722 (sensitivity 72.7%, specificity 29.4%). Parallel tests of NLR and CEA testing increased sensitivity and specificity (75.8%, 70.6%). This study revealed that elevated NLR and CEA are associated with patient survival, and monitoring both markers enhances survival prediction accuracy. It can improve insight into disease progression and adjust the therapeutic approach for NSCLC patients.
Co-Authors Aida Hastuti Ali Assagaf Ana Rima Andreas Infianto Anggarda Kristianti Utomo Anisa Anisa Arganita, Fidya Rahmadhany Arif Santoso Ayudiah Puspita Mayasari Ayudiah Puspita Mayasari Brian Pramana Santoso Desi Rahmawaty Desi Rahmawaty Desi Rahmawaty Dimas Satrio Baringgo Eko Suhartono Eko Suhartono Eko Suhartono Elisna Syahruddin Elok Hikmatun Nikmah Emmi Erliyanti Ermayanti, Sabrina Erna Kusumawardhani Farida Heriyani Ferry Dwi Kurniawan Fidya Rahmadhany Arganita Holly Diany Ida Ayu Jasminarti Ira Nurrasyidah Joharman Joharman Laksmi Wulandari Marsheilla Riska Mohamad Isa Muhammad Nor Nathaniel Aditya Nida Amalia Noni Novisari Soeroso Noor Athiyya Sabrina Wahda Utami Setyawan, Ungky Agus Sita Andarini Sri Melati Munir Tenri Ashari Wanahari Widya Ramadhaniati Zaini, Jamal