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All Journal Medical Journal of Indonesia Berkala Kedokteran CRJIM (Clinical and Research Journal in Internal Medicine) Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Nanang Miftah Fajari
University Of Lambung Mangkurat
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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HUBUNGAN ANTARA INDEKS MASSA TUBUH DENGAN KEJADIAN STROKE PADA PASIEN DIABETES MELITUS DI RSUD ULIN BANJARMASIN Widi Aurelia Mirmaningtyas; Nanang Miftah Fajari; Mohammad Bakhriansyah; Wiwit Agung Sri Nur Cahyawati; Dona Marisa
Homeostasis Vol 6, No 2 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i2.10016

Abstract

Diabetes melitus (DM) merupakan penyakit metabolik yang dapat mengakibatkan beberapa komplikasi salah satunya berupa stroke. Indeks massa tubuh (IMT) diduga dapat meningkatkan risiko terjadinya stroke pada pasien DM. Tujuan penelitian ini adalah untuk mengetahui hubungan antara IMT dengan kejadian stroke pada pasien DM. Penelitian ini bersifat observasional analitik dengan pendekatan potong lintang pada 52 data pasien stroke yang dipilih menggunakan metode total sampling dan 52 data pasien tidak stroke yang dipilih menggunakan metode simple random sampling. Data pasien diperoleh dari pangkalan data Borneo Wetland Study on Diabetes 2 (BEST-DIAB 2) milik Poliklinik Endokrin RSUD Ulin Banjarmasin. Data dianalisis menggunakan uji Chi-square dengan perangkat lunak SPSS versi 26. Hasil analisis menunjukan bahwa tidak terdapat hubungan yang bermakna secara statistik antara IMT dengan kejadian stroke pada pasien DM di RSUD Ulin Banjarmasin (p=0,377).
HUBUNGAN ANTARA KADAR HbA1c DENGAN KEJADIAN STROKE PADA PASIEN DIABETES MELITUS Merdayana Merdayana; Nanang Miftah Fajari; Mohammad Bakhriansyah; Nanik Tri Wulandari; Siti Wasilah
Homeostasis Vol 6, No 2 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i2.9987

Abstract

Diabetes melitus (DM) adalah penyakit kronis yang ditandai dengan peningkatan kadar gula darah yang melebihi batas normal. Komplikasi DM timbul karena kadar glukosa tidak terkendali dan tidak tertangani dengan baik sehingga menyebabkan timbulnya komplikasi stroke. Semakin tinggi kadar HbA1c maka risiko komplikasi stroke akan mudah terjadi. Tujuan penelitian ini adalah untuk mengetahui hubungan antara kadar HbA1c dengan kejadian stroke pada pasien DM. Penelitian observasional analitik ini merupakan penelitian potong lintang dengan menggunakan data pasien yang tercatat di pangkalan data Borneo Wetland Study on Diabetes 2 (BEST-DIAB 2) milik Poliklinik Endokrin RSUD Ulin Banjarmasin tahun 2019-April 2022. Pasien stroke dipilih sebanyak 49 orang dengan menggunakan metode total sampling dan 49 data pasien tidak stroke dipilih menggunakan metode simple random sampling (rasio 1:1). Data dianalisis menggunakan uji Chi square dengan perangkat lunak SPSS versi 26 pada tingkat kepercayaan 95% (α=0,05). Penelitian ini menunjukan bahwa tidak terdapat hubungan yang bermakna secara statistik antara kadar HbA1c dengan kejadian stroke pada pasien DM di RSUD Ulin Banjarmasin (p=0,110).
HUBUNGAN ANTARA LAMA MENDERITA DIABETES MELITUS DENGAN KEJADIAN STROKE DI RSUD ULIN BANJARMASIN Munirah, Nida; Fajari, Nanang Miftah; Bakhriansyah, Mohammad; Cahyawati, Wiwit Agung Sri Nur; Marisa, Dona
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11463

Abstract

Diabetes mellitus (DM) is a metabolic disorder that if it is left untreated for a long period could lead to various complications such as stroke. The longer duration of DM is predicted to increase the risk of stroke. The purpose of this study was to determine the relationship between the duration of DM with the risk of stroke. This was an analytic observational study with a cross-sectional approach. This study involved 54 DM patients with stroke selected by using total random sampling method and 54 DM patients without stroke selected by using simple random sampling method. Data were obtained from the Borneo Wetland Study on Diabetes 2 (BEST-DIAB 2) database owned by Poliklinik Endokrin RSUD Ulin Banjarmasin. Data were then analyzed by using Chi-square test in a statistical software the SPSS version 26 with 95% of confidence interval.  The results showed that no significant relationship (p=0.501) between the duration of DM with the risk of stroke for patients with DM at RSUD Ulin Banjarmasin.  
Correlation Of Albumin Levels With Glucose Levels in Hypoglycemic Patients After The Use Of Insulin Therapy Fajari, Nanang Miftah; Kholifah, Rika; Rosida, Azma
Clinical and Research Journal in Internal Medicine Vol. 5 No. 1 (2024): Volume 5 No 1, May 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.01.04

Abstract

Background: Most of the incidence of hypoglycemia in hospital (11.29%) is caused by administering insulin therapy as a therapeutic modality in diabetes mellitus patients during hospitalization. The bond between albumin and insulin using the help of fatty acids makes insulin control the body's glycemic levels. Aim: The purpose of this study was to determine and analyze the correlation between albumin levels and glucose levels in hypoglycemia patients after the administration of insulin therapy at the Ratu Zalecha General Hospital. Methods: This study was an analytic observational study with a cross-sectional approach. A total of 32 samples were obtained by purposive sampling Results: The patient's mean glucose level was 48.95 ± 11.5 mg/dL and the patient's mean albumin level was 2.4 ± 0.6 g/dL. Bivariate analysis using Pearson's correlation test showed a correlation between albumin levels and glucose levels (p = 0.045 <0.05; r = 0.356). Conclusion: The conclusion is that there is a significant correlation between albumin levels and blood glucose levels, the direction of the positive correlation with the strength of the weak correlation in the endocrine internal medicine ward of the Ratu Zalecha Martapura Hospital.
The Effect of Wetland Geography on the Prevalence of Diabetes Mellitus in South Kalimantan Fajari, Nanang Miftah; Nur’amin, Hendra Wana
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17387

Abstract

Diabetes mellitus (DM) is a high-burden disease in Indonesia especially in South Kalimantan Province. South Kalimantan province lies in mostly wetlands areas. Identification of risk factors related to DM is necessary to prevent the disease. We conducted this study to assess the prevalence of DM in the South Kalimantan people, the impact of a wetlands area on DM prevalence, and other significant risk factors. A cross-sectional study approach was used to identify significant risk factors. We used adjusted multiple logistic regression to assess the association between risk factors and DM prevalence. There were 4612 subjects more than 18 years old in this study with 6.5% of them diagnosed as DM. Most of the subjects live in wetlands area (79.1%) and most of them >40 years old. Several important risk factors associated with DM were identified. Subjects in wetlands have a lower risk of DM compared to non-wetlands area (OR 0.73, CI 95%; 0.43-0.71, p<0.001). Age >40 years old increase the risk of DM (OR 2.24, CI 95 % 1.61-3.10, p<0.001), hypertension (OR 1.65, CI 95% 1.23-2.21, p<0,001), waist circumference >90 cm (OR 2.12, CI 95%. p<0.001), cholesterol level (>200 mg/dl) with DM prevalence (OR 1.38, CI 95% 1.02-1.87, p<0.04) and family history of DM (OR 10.28, CI 95% 7.67-13.76, p<0.001). This study found that wetlands areas may reduce the DM prevalence and other risk factors may increase the prevalence of DM. Further research is necessary to establish the relationship between wetlands area and DM.
The Relationship Between C-Reactive Protein and Hemoglobin Levels with The Death of Chronic Kidney Disease Patients Undergoing Routine Hemodialysis Confirmed to Covid 19 at Ulin Hospital, Banjarmasin Syahputra, Harry Andhika; Rudiansyah, Mohammad; Fajari, Nanang Miftah; Abimanyu, Abimanyu; Djallalludin, Djallalludin
Berkala Kedokteran Vol 20, No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i2.20565

Abstract

COVID-19 mortality is much higher in members of the population with multiple co-morbidities. Anemia is independently associated with all-cause mortality in patients hospitalized with COVID-19. C-Reactive Protein (CRP) levels are increased in patients with renal failure and are an independent predictor of cardiovascular mortality. This study used an observational case-control method. Data were taken consecutively using medical records of patients who died as a case group and lived as a control group with chronic kidney disease who underwent routine HD confirmed with COVID-19 at Ulin General Hospital, Banjarmasin. The number of subjects in this study was 92 patients. High CRP levels (>30 mg/L) significantly increased the risk of death by 4 times (OR 4.330; 95% CI 1.800-10.416; p = 0.001). Low hemoglobin levels (<10 g/dl) did not affect mortality in routine hemodialysis patients infected with COVID-19 (OR 0.643; 95% CI 0.281-1.471; p = 0.294). An increased CRP in COVID-19 patients is thought to indicate extensive inflammation in the infected lungs, then the condition of CKD patients undergoing routine hemodialysis with compromised immunity increases the risk of severity and mortality in this population. There is an effect of CRP levels on death from COVID-19 in Chronic Kidney Disease patients undergoing routine hemodialysis at Ulin General Hospital, Banjarmasin.
Correlation among Blood Sugar Levels, C-Reactive Protein, Total Lymphocyte Count with SOFA Score on Sepsis COVID-19 Patients Fajari, Nanang Miftah; Hartono, Ivan; Rudiansyah, Mohammad; Agung SNC, Wiwit; Yasmina, Alfi
Clinical and Research Journal in Internal Medicine Vol. 5 No. 2 (2024): Volume 5 No 2, November 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.02.06

Abstract

Background: COVID-19 is a caused a pandemic since early January 2020. Sequential Organ Failure Assessment (SOFA) score can assess organ dysfunction in the state of Sepsis MODS. Aim: This study aims to determine the relationship between Blood Sugar Levels, C-Reactive Protein (CRP), and Total Lymphocyte Count (TLC) with SOFA score in COVID-19 patients with Sepsis. Methods: An observational study using the cross-sectional method was carried out in 2020-2021 at Ulin Hospital Banjarmasin with a total sample of 87 participants. Results: Based on the Spearman test, there were a positive correlation between Random Blood Sugar levels and SOFA with the scores r = 0.778 (p = 0.000); significant negative correlation between TLC and SOFA with the score r = -0.409 (p = 0.000); and no significant correlation between CRP and SOFA with the score r = -0.077 (p = 0.507). The multivariate test showed that the correlation value for each Random Blood Sugar with a SOFA score is R=0.664 (p=0.000), and the Total Lymphocyte Count with a SOFA score is R=-0.270 (p=0.001). The statistical analysis model revealed that Blood Sugar Levels and Total Lymphocyte Count could predict SOFA scores of as much as 60.9%. Conclusion: Blood sugar levels can be a marker of poor prognosis in COVID-19 patients with Sepsis. Hyperglycemia can be caused by pancreatic cell damage due to SARS-CoV2 invasion, acute insulin resistance, and inflammation caused by Sepsis and COVID-19. Total Lymphocyte Count is one of the many factors contributing to organ dysfunction caused by Sepsis in COVID-19. Keywords: COVID-19, Sepsis, SOFA Score, Prognosis
Risk Factors Analysis of Diabetes Prevalence in Wetland Area: A Study from Borneo Wetland Study on Diabetes Fajari, Nanang Miftah; Hariyanto, Felix; Nur'amin, Hendra; Hasrianti, Nuvita
Clinical and Research Journal in Internal Medicine Vol. 5 No. 2 (2024): Volume 5 No 2, November 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.02.04

Abstract

Background: National Basic Health Survey held by the Ministry of Health Republic of Indonesia shows the prevalence of Diabetes Mellitus increased from 6.9% to 8.5% in 2018. Wetland is an area covered by shallow water on the surface, which represents a unique ecosystem. Aim: This study investigated the association between various risk factors and DM prevalence in South Kalimantan Wetlands, Indonesia. Early identification and management of risk factors may prevent progression into diabetes mellitus. Methods: We conducted the Borneo Wetland Study on Diabetes (Best-Diab 1) with a cross-sectional study approach using the latest health survey data conducted by the South Kalimantan Provincial Health Office from the primary health center visit from January 2020 to March 2022. Using Proportionate Random Sampling, we divided samples into two groups; 6.010 in the DM group, and 6.010 non DM group. Results: Gender, age, BMI, blood pressure, and blood glucose level were significantly correlated with diabetes mellitus prevalence (p<0.001). Family history of DM surprisingly has a significant impact on DM prevalence (PR, 3.16; 95% CI, 2.80-3.57, p<0.001). The prevalence of DM in the smoking group was 0.78 times less than in non-smoking individuals (PR, 0.78; 95% CI, 0.74-0.82; p<0.001). Excess sugar was the greatest risk factor for diabetes mellitus, with the prevalence of DM 4.72 times greater than normal sugar intake (PR, 4.72; 95% CI, 4.29-5.2; p<0.001). Excess salt intake also seemed to be a significant risk factor among DM patients (PR, 1.24; 95% CI, 1.17-1.30, p<0.001. Conclusion: Females, older age, higher BMI, and family history of DM were significant risk factors for diabetes mellitus prevalence in this study. Further studies are needed to determine how those factors impacted diabetes mellitus. Keywords: risk factors, prevalence, diabetes mellitus, wetland, South Kalimantan
Comparison of stingless bee honey and silver sulfadiazine on diabetic wound healing in rat models Fajari, Nanang Miftah; Pranoto, Agung; Perdanakusuma, David Sontani; Prenggono, Muhammad Darwin; Rudiansyah, Mohammad; Nur'amin, Hendra Wana; Syarifa, Yulia; Hasrianti, Nuvita; Saputri, Imelda Nita; Afrianto, Muhammad Irawan; Husna, Annisa Halida
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257974

Abstract

BACKGROUND Diabetic foot ulcers (DFUs) are a major health concern in Indonesia. Adjuvant therapies may improve healing by avoiding secondary infections, promoting angiogenesis, and supporting oxygen circulation. This aimed to evaluate the effect of stingless bee honey (SBH) from Heterotrigona itama on diabetic wound size in rats (Rattus norvegicus), compared to silver sulfadiazine (SSD). METHODS An experimental study was conducted on 13 diabetic wounds in streptozotocin-induced diabetic rats treated with three types of therapies: SSD (n = 5), pure SBH (n = 5), and SBH with 20% water content (n = 3). The study initially involved 21 rats, but eight died during the diabetes modeling and wound observation phases, presumably due to hyperglycemia. Baseline characteristics did not differ significantly across the groups. RESULTS SBH with 20% water content and pure SBH reduced wound size by 95.1% and 92.1%, outperforming SSD (77.4%), with all therapies showing statistically significant improvement (p<0.05). However, the differences between groups were not statistically significant (p = 0.162). CONCLUSIONS Topically applied SBH is a potential natural therapeutic agent for diabetic wounds, in addition to standard treatment such as SSD.
Co-Authors Abimanyu Abimanyu Afrianto, Muhammad Irawan Agung Pranoto Alfi Yasmina Annisa Halida Husna, Annisa Halida Azma Rosida Azma Rosida, Azma Dewi Indah Noviana Pratiwi Dewi Indah Noviana Pratiwi Djallalluddin Djallalluddin Djallalludin, Djallalludin Dona Marisa, Dona Faris Naufal Fauzia Noor Liani Firzatullah Ega Radyastra Franciscus Xaverius Hendriyono Hariyanto, Felix Hartono, Ivan Hasrianti, Nuvita Hendra Wana Nur&#039;amin I Nyoman Suarjana Ira Nurrasyidah Jeremy Eckhart S Parhusip Kholifah, Rika Mahdalena Mahdalena Marcellinus Anthony Raharjo Marwah Hulfah Merdayana Merdayana Mohammad Bakhriansyah Mohammad Bakhriansyah Mohammad Rudiansyah Muhammad Ghaly Maulana Muhammad Ilham Fadillah Munirah, Nida Nanik Tri Wulandari Nur'amin, Hendra Nur'amin, Hendra Wana Nur’amin, Hendra Wana Perdanakusuma, David Sontani Prenggono, Muhamad Darwin Saputri, Imelda Nita Siti Wasilah Syahputra, Harry Andhika Syarifa, Yulia Theresa Tyra Sertani Widi Aurelia Mirmaningtyas Wiwit Agung Sri Nur Cahyawati