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All Journal Majalah Kedokteran Bandung Althea Medical Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Global Medical and Health Communication MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Medika Malahayati Jurnal Kedokteran Meditek
Julia Windi Gunadi
Departemen Fisiologi Fakultas Kedokteran Universitas Kristen Maranatha Bandung-Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Effects of Moderate-Intensity Treadmill Training on Cardiac Mitochondrial Mitophagy and Dynamics in Young and Aged Wistar Rats Julia Windi Gunadi; Difa Hidayat Ramadhan; Bernike Tirsa Safira; Andra Alifya Ramadhan; Roro Wahyudianingsih; Yenni Limyati; Hanna Goenawan; Ronny Lesmana
Althea Medical Journal Vol 13, No 1 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n1.4553

Abstract

Background: Cardiac aging is closely associated with mitochondrial dysfunction and impaired quality control mechanism. Exercise has been shown to modulate mitochondrial homeostasis, however, its effects on cardiac mitophagy and mitochondrial dynamics during aging remain unclear. This study investigated the effects of moderate-intensity treadmill training on mitochondrial maintenance-related gene expression in the hearts of young and aged Wistar rats.Methods: Young and aged rats were divided into four groups: young control, young exercise, aged control, and aged exercise (n=6 per group). Exercise groups performed treadmill running at 20 m/min for 30 minutes/day, 5 days/week for 8 weeks. Cardiac gene expression levels of Pink1, Parkin, Mfn1, Mfn2, Opa1, Drp1, and Fis1 were analyzed using semi-quantitative polymerase chain reaction (PCR). Data were analyzed using one-way ANOVA or Kruskal–Wallis test followed by appropriate post hoc analyses.Results: Exercise significantly increased Mfn2 expression in aged exercise rats compared with aged controls (p=0.029), suggesting partial restoration of age-related decline. Expression of Mfn1 and Drp1 varied among groups but showed no significant pairwise differences. Expression levels of Opa1, Fis1, Pink1, and Parkin remained unchanged. These results indicate that moderate exercise selectively enhances mitochondrial fusion capacity while maintaining balanced fission and basal mitophagy activity.Conclusion: Moderate-intensity treadmill training promotes mitochondrial  fusion-related adaptation in aging cardiac tissue. Regular moderate exercise may represent a potential non-pharmacological strategy to support mitochondrial function and mitigate cardiovascular aging.  
Clinical Outcome of Autologous Hematopoietic Stem Cell Transplantation in Stiff Person Syndrome: A Literature Review Dedeh Supantini; Fellicia Meiliana Fransisca; Ardo Sanjaya; Julia Windi Gunadi; Sylvia Tanumihardja
Jurnal Medika Malahayati Vol 10, No 1 (2026): Volume 10 Nomor 1
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v10i1.25044

Abstract

Stiff person syndrome (SPS) is a rare immune-mediated neurological disorder characterized by progressive muscle stiffness and painful spasms that significantly impair functional ability. Although symptomatic and immunomodulatory therapies are commonly used, some patients remain refractory to standard treatments. Autologous hematopoietic stem cell transplantation (aHSCT) has been proposed as a potential therapeutic option for severe or treatment-resistant cases. This literature review aims to evaluate the clinical outcomes and safety of aHSCT in patients with SPS. A narrative literature review was conducted using published studies reporting the use of  aHSCT in SPS, including clinical trials, cohort, case series, and case reports. Relevant articles were identified through PubMed and Google Scholar, limited to studies published within the last ten years. A total of 134 articles were initially identified, followed by a selection process, and five eligible articles were included in this review. The reviewed studies demonstrated that aHSCT may lead to clinical improvement in selected patients with refractory SPS. Autologous HSCT reduced muscle stiffness and improved functional status. Treatment responses varied, and some non-responders were reported; however, overall clinical outcomes were favorable with acceptable safety profiles. In conclusion, aHSCT may be considered a potential therapeutic option for severe or treatment-resistant SPS, although further prospective studies are needed to confirm its efficacy and safety.
Co-Authors . SETIAWAN Abraham Adiwidjaja Sutjiono Abraham Adiwidjaja Sutjiono Alfred Tri Susanto Alissa Amelia Santoso Andra Alifya Ramadhan Ardo Sanjaya Ardo Sanjaya Astrid Feinisa Khairani Bela Ita Karina Bernike Tirsa Safira Cherry Azaria Cliff Aaron Sutiono Dedeh Supantini Dedeh Supantini Diana Krisanti Jasaputra Diana Krisanti Jasaputra Difa Hidayat Ramadhan Dimpuulina Erna Mariati Fanny Rahardja Fellicia Meiliana Fransisca Fen Tih Firsty Tasya Evitasari Gerardo Vico Fernando Budiono Hanna Goenawan Hanna Goenawan Jeremi Christianto Jalil Tanggulungan Jeremi Christianto Jalil Tanggulungan Katherine Marcella Mariska Elisabeth Penny Setyawati Martioso Pinkan Al Shabrina Rizna Tyrani Rumanti Ronny Lesmana Ronny Lesmana Ronny Lesmana Roro Wahyudianingsih Sunarjati Sudigdoadi Sylvia Tanumihardja Sylvia Tanumihardja Tiodora Arimenda Br. Subekti Titing Nurhayati Unang Supratman Vita Murniati Tarawan Wahyu Widowati Yenni Limyati