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All Journal Biomedical Engineering Global Medical and Health Communication Science and Technology Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kedokteran Meditek
Fanny Rahardja
Departemen Mikrobiologi Fakultas Kedokteran, Universitas Kristen Maranatha, Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Efek Jus Gel Lidah Buaya (Aloe vera L.) dalam Menghambat Penyerapan Glukosa di Saluran Cerna pada Manusia Christian, Evan; Jasaputra, Diana Krisanti; Rahardja, Fanny
Global Medical & Health Communication (GMHC) Vol 2, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak Diabetes melitus (DM) merupakan penyakit kronis yang ditandai dengan peningkatan kadar glukosa darah. Prevalensi DM di Indonesia menduduki peringkat ke-4 dunia. Pencegahan dan penatalaksanaannya menjadi sangat penting, sehingga diperlukan terapi komplementer alternatif yang salah satunya adalah lidah buaya. Tujuan penelitian ini untuk menilai efek jus gel lidah buaya (Aloe vera L.) dalam menghambat penyerapan glukosa di saluran cerna pada manusia. Penelitian dilaksanakan di laboratorium Farmakologi Unversitas Kristen Maranatha Bandung selama Desember 2011 sampai Desember 2012. Penelitian ini merupakan penelitian kuasi eksperimental dengan desain penelitian cross over. Penelitian dilakukan pada 10 orang subjek penelitian dan masing-masing memperoleh 3 perlakuan yaitu pemberian akuades, acarbose, dan jus gel lidah buaya yang diberikan saat makan. Kadar glukosa darah diukur pada saat puasa dan 2 jam post prandial. Uji analisis statistik dilakukan dengan menggunakan metode analysis of varians (ANOVA), dengan α = 0,05 dengan Uji lanjut Fisher LSD. Hasilnya menunjukkan adanya kenaikan kadar glukosa darah 2 jam post prandial oleh jus gel lidah buaya sebesar 14,35%, sedangkan akuades 23,91%. Hal ini menunjukkan perbedaan bermakna (p<0,05) yang berarti jus gel lidah buaya menghambat penyerapan glukosa pada saluran cerna. Potensi jus gel lidah buaya ini setara dengan acarbose yang menaikkan kadar glukosa darah 2 jam post prandial sebesar 12,31 % (p>0,05). Simpulan dari penelitian ini adalah jus gel lidah buaya menghambat penyerapan glukosa di saluran cerna pada manusia. Kata kunci: Lidah buaya (Aloe vera L.), penyerapan glukosa The Effect of ALOE VERA L Gel Juice  as Glucose Absorption Inhibitors in Gastrointestinal Tract on Humans Abstract Diabetes mellitus (DM) is a chronic disease characterized by elevated blood glucose levels. The prevalence of DM in Indonesia ranks fourth in the world. Prevention and management are very important, that the necessary complementary alternative such as aloe vera is encouraged. This study aim to assess the effect of aloe vera gel juice in inhibiting the absorption of glucose in the gastrointestinal tract on humans. The study was a quasi experimental study with cross over study design conducted on 10 subjects during December 2011 to December 2012 in laboratory Department of Pharmacology Maranatha Christian University Bandung. Treatments given into 3 categories that are distilled water, acarbose, and the juice of aloe vera gel in meal time. FastingBlood glucose levels and after 2 hours post prandialswere measured. The data was analyzed using analysis of varians  (ANOVA), with α = 0.05 and the Fisher LSD test. The results showed that an increase in blood glucose levels after 2 hours post prandials was 14.35% in subjects given aloe vera gel juice, and 23.91% for distilled water and show significant differences (p<0.05. It means that aloe vera gel juice inhibited glucose absorption in the gastrointestinal tract. The potential of aloe vera gel juice is equivalent to acarbose which increases blood glucose levels 2 hours post prandials at 12.31% (p>0.05). The conclusion of this study is aloe vera gel juice inhibit glucose absorption in the gastrointestinal tract on humans. Key words: Aloe vera (Aloe vera L.), glucose inhibition 
Phytochemical assay, potential of antimalarial and antioxidant activities of green tea extract and its fractions Fanny Rahardja; Rita Tjokropranoto; Wahyu Widowati; Siska Lusiana; Adrian Suhendra; Susy Tjahjani; Iwan Budiman; Maesaroh Maesaroh; Nurul Fauziah
Biomedical Engineering Vol 1, No 1 (2014)
Publisher : Biomedical Engineering

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Abstract

Objective : The research objective was to evaluate the phytochemical compounds, the antioxidant and anti-malarial activity of green tea extract and its fraction. Methods: The antioxidant activity were measured by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity used in vitro laboratories prospective experimental design and completely randomized design, using ethanol extract, hexane, ethyl acetate, butanol fraction, and water fraction ofgreen tea in 7 levels of concentration compared to epicatechin (EC). The data were analyzed using linear regression analysis, and were continued by determined Inhibitory Concentration). The anti-malarial activity of green tea fractions were compared to artemisinin. The data were analyzed using probit analysis, and were continued by determined IC. Results: The results showed that the highest antioxidant activity (IC50) was the fraction of ethyl acetate 2,184 µg/ml. The anti-malarial activity IC50 50 of water and ethyl acetate fraction, ethanol extract and butanol fraction were 0,000090 µg/mL,0,003 µg/mL, 0,006 µg/mL, 0,011 µg/ml respectively.Conclusion: Extract and fractions of green tea have potential anti-malarial and antioxidant properties. Key Words: antioxidant; anti-malarial; green tea; free radicals
Phytochemical assay, potential of antimalarial and antioxidant activities of green tea extract and its fraction Fanny Rahardja
Biomedical Engineering Vol 1, No 1 (2015): BIOMEDICAL ENGINEERING
Publisher : Biomedical Engineering

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.267 KB)

Abstract

Objective : The research objective was to evaluate the phytochemical compounds, the antioxidant and anti-malarial activity of green tea extract and its fraction. Methods : The antioxidant activity were measured by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity used in vitro laboratories prospective experimental design and completely randomized design, using ethanol extract, hexane, ethyl acetate, butanol fraction, and water fraction of green tea in 7 levels of concentration compared to epicatechin (EC). The data were analyzed using linear regression analysis, and were continued by determined Inhibitory Concentration50 (IC50). The anti-malarial activity of green tea fractions were compared to artemisinin. The data were analyzed using probit analysis, and were continued by determined IC50 .Result: The results showed that the highest antioxidant activity (IC50) was the fraction of ethyl acetate 2,184 µg/ml. The anti-malarial activity IC50of water and ethyl acetate fraction, ethanol extract and butanol fraction were 0,000090 µg/mL,0,003 µg/mL, 0,006 µg/mL, 0,011 µg/ml respectively.Conclusion : Extract and fractions of green tea have potential anti-malarial and antioxidant properties.
Efek Jus Gel Lidah Buaya (Aloe vera L.) dalam Menghambat Penyerapan Glukosa di Saluran Cerna pada Manusia Diana Krisanti Jasaputra; Fanny Rahardja; Evan Christian
Global Medical & Health Communication (GMHC) Vol 2, No 1 (2014)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2113.669 KB) | DOI: 10.29313/gmhc.v2i1.1523

Abstract

Diabetes melitus (DM) merupakan penyakit kronis yang ditandai dengan peningkatan kadar glukosa darah. Prevalensi DM di Indonesia menduduki peringkat ke-4 dunia. Pencegahan dan penatalaksanaannya menjadi sangat penting, sehingga diperlukan terapi komplementer alternatif yang salah satunya adalah lidah buaya. Tujuan penelitian ini untuk menilai efek jus gel lidah buaya (Aloe vera L.) dalam menghambat penyerapan glukosa di saluran cerna pada manusia. Penelitian dilaksanakan di laboratorium Farmakologi Unversitas Kristen Maranatha Bandung selama Desember 2011 sampai Desember 2012. Penelitian ini merupakan penelitian kuasi eksperimental dengan desain penelitian cross over. Penelitian dilakukan pada 10 orang subjek penelitian dan masing-masing memperoleh 3 perlakuan yaitu pemberian akuades, acarbose, dan jus gel lidah buaya yang diberikan saat makan. Kadar glukosa darah diukur pada saat puasa dan 2 jam post prandial. Uji analisis statistik dilakukan dengan menggunakan metode analysis of varians (ANOVA), dengan α = 0,05 dengan Uji lanjut Fisher LSD. Hasilnya menunjukkan adanya kenaikan kadar glukosa darah 2 jam post prandial oleh jus gel lidah buaya sebesar 14,35%, sedangkan akuades 23,91%. Hal ini menunjukkan perbedaan bermakna (p<0,05) yang berarti jus gel lidah buaya menghambat penyerapan glukosa pada saluran cerna. Potensi jus gel lidah buaya ini setara dengan acarbose yang menaikkan kadar glukosa darah 2 jam post prandial sebesar 12,31 % (p>0,05). Simpulan dari penelitian ini adalah jus gel lidah buaya menghambat penyerapan glukosa di saluran cerna pada manusia. THE EFFECT OF ALOE vera L GEL JUICE AS GLUCOSE ABSORPTION INHIBITORS IN GASTROINTESTINAL TRACT ON HUMANSDiabetes mellitus (DM) is a chronic disease characterized by elevated blood glucose levels. The prevalence of DM in Indonesia ranks fourth in the world. Prevention and management are very important, that the necessary complementary alternative such as aloe vera is encouraged. This study aim to assess the effect of aloe vera gel juice in inhibiting the absorption of glucose in the gastrointestinal tract on humans. The study was a quasi experimental study with cross over study design conducted on 10 subjects during December 2011 to December 2012 in laboratory Department of Pharmacology Maranatha Christian University Bandung. Treatments given into 3 categories that are distilled water, acarbose, and the juice of aloe vera gel in meal time. FastingBlood glucose levels and after 2 hours post prandialswere measured. The data was analyzed using analysis of varians (ANOVA), with α=0.05 and the Fisher LSD test. The results showed that an increase in blood glucose levels after 2 hours post prandials was 14.35% in subjects given aloe vera gel juice, and 23.91% for distilled water and show significant differences (p<0.05. It means that aloe vera gel juice inhibited glucose absorption in the gastrointestinal tract. The potential of aloe vera gel juice is equivalent to acarbose which increases blood glucose levels 2 hours post prandials at 12.31% (p>0.05). The conclusion of this study is aloe vera gel juice inhibit glucose absorption in the gastrointestinal tract on humans.
Evaluasi Efektivitas Sambiloto (Andrographis paniculata) sebagai Hepatoprotektor terhadap Jejas Hati Imbas Obat Mariska Elisabeth; Gerardo Vico Fernando Budiono; Fanny Rahardja; Julia Windi Gunadi
Jurnal Kedokteran Meditek Vol 28 No 3 (2022): SEPTEMBER-DESEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i3.2457

Abstract

Jejas hati imbas obat ditandai dengan peningkatan kadar enzim hati dan kerusakan jaringan hati. Jejas hati imbas obat sering disebabkan oleh konsumsi beberapa obat seperti parasetamol dan rifampisin. Jejas hati imbas obat dapat dibagi menjadi jejas hati imbas obat tipe intrinsik dan jejas hati imbas obat tipe idiosinkratik. Penatalaksanaan jejas hati imbas obat adalah dengan menghentikan konsumsi obat terkait. Salah satu obat herbal asli Indonesia adalah tanaman sambiloto (Andrographis paniculata) yang memiliki banyak manfaat salah satunya sebagai hepatoprotektor dan agen antiinflamasi. Pemberian sambiloto (Andrographis paniculata) pada mencit maupun tikus yang mengalami jejas hati imbas obat menyebabkan penurunan kadar enzim hati di dalam darah dan memperbaiki gambaran histologis hati sehingga sambiloto dapat menjadi salah satu terapi adjuvant untuk mengatasi jejas hati imbas obat.
STUDI LITERATUR: EFEK STENT GRAFT PADA PASIEN DENGAN EMERGENSI AORTA Octavallen, Andri; Tanuwijaya, Farrell; Gunadi, Julia Windi; Rahardja, Fanny; Sanjaya, Ardo
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 12 (2023): Volume 10 Nomor 12
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i12.12961

Abstract

Abstrak: Studi Pustaka: Efek Stent Graft pada Pasien dengan Emergensi Aorta. Emergensi Aorta merupakan suatu kelainan pada aorta yang seringkali menyebabkan kematian. Terapi konvensional dilakukan dengan cara pembedahan terbuka. Seiring dengan berkembangnya zaman, beberapa negara melakukan terapi endovaskuler karena lebih bersifat invasif minimal dan memiliki tingkat morbiditas dan mortalitas yang lebih rendah. Salah satu terapi endovaskular adalah dengan menggunakan stent graft. Stent Graft dalam tatalaksana emergensi aorta merupakan pengobatan yang sederhana, aman, dan cepat, dengan rata – rata tingkat keberhasilan operasi dan kelangsungan hidup pasien >80%. Metode pengumpulan data dan penulisan hasil kajian menggunakan Preferred Reporting Items for Systematic Reviews & Meta Analyses (PRISMA) yang diakses melalui PubMed dan Science Direct. Beberapa studi memaparkan, terapi endovaskular dengan intervensi stent graft menunjukkan tingkat morbiditas dan mortalitas yang lebih rendah yaitu <20% dan <19%. Hal tersebut dipengaruhi oleh berbagai macam faktor seperti usia, kondisi anatomi aorta, skor APACHE. Tujuan dari tinjauan pustaka ini adalah untuk melihat evaluasi atau hasil dari berbagai kasus pasien–pasien yang mengalami emergensi aorta dan diberikan tatalaksana pembedahan secara endovaskular menggunakan stent graft.
Potential of Bitter Melon (Momordica charantia L.) Extract for Chronic Kidney Disease Based on In Vitro Study via TGF/SMADs Signaling, Antioxidant, Antiinflammation, Apoptosis Inducer Activities Prahastuti, Sijani; Rahardja, Fanny; Wargasetia, Teresa Liliana; Zahiroh, Fadhilah Haifa; Sabrina, Adilah Hafizha Nur; Kusuma, Hanna Sari Widya; Azis, Rizal; Hadiprasetyo, Dhanar Septyawan; Ningrum, Siti Ratu Rahayu; Widowati, Wahyu; Sarwono, Sylvie
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.538-551

Abstract

Chronic kidney disease (CKD) is a physiological abnormality in the kidneys whose prevalence is expected to continue to increase. On the other hand, Bitter melon (Momordica charantia L.) is known to have the potential to manage CKD. This study explores the compound content of M. charantia ethanol extract (MCEE) and its potential for CKD based on in vitro assays. To model chronic kidney disease (CKD), SV40 MES-13 (mouse glomerular mesangial) cells were exposed for 3 days to 20 mM glucose. After glucose induction, the cells were subjected with different concentrations of MCEE (Momordica charantia L. ethanolic extract). The chemical profile of MCEE was analyzed using LC/MS-MS. Cell viability was examined through the WST assay, while intracellular ROS and apoptosis levels were measured by flowcytometry. Colorimetry was used to analyze SOD, MDA, and CAT levels. ELISA was used to analyze inflammatory proteins (TGF-β 1, IL-6, TNF-α, IL-1β ) levels. Meanwhile, the relative gene expression of SMAD-2, SMAD-3, SMAD-4, SMAD-7 was examined through qRT-PCR. The results exhibited that MCEE contains cucurbitane p-coumaric, ferulic acid, caffeic acid, gallic acid, chlorogenic acid, and epicatechin. MCEE was also known to be non-toxic to SV40 MES-13 cells. In addition, MCEE reduced intracellular ROS levels, MDA, necrosis levels, and inflammatory proteins, while also regulating SMAD-2, SMAD-3, and SMAD-4 gene expression. MCEE increased levels of CAT, and SOD, and regulated SMAD-7 gene expression in the CKD cells model. The most effective MCEE is MCEE 50 μg/mL. MCEE demonstrated potential as a CKD treatment based on in vitro studies through TGF/SMADs signaling activity, antioxidant, anti-inflammatory, and apoptosis inducer.
Co-Authors Adrian Suhendra Ardo Sanjaya Azis, Rizal Diana Krisanti Jasaputra Evan Christian Evan Christian, Evan Gerardo Vico Fernando Budiono Gunadi, Julia Windi Hadiprasetyo, Dhanar Septyawan Hanna Sari Widya Kusuma, Hanna Sari Widya Iwan Budiman Julia Windi Gunadi Maesaroh Maesaroh Mariska Elisabeth Ningrum, Siti Ratu Rahayu Nurul Fauziah Octavallen, Andri Rita Tjokropranoto Sabrina, Adilah Hafizha Nur Sarwono, Sylvie Sijani Prahastuti Siska Lusiana Susy Tjahjani Tanuwijaya, Farrell Teresa Liliana Wargasetia Wahyu Widowati WAHYU WIDOWATI Zahiroh, Fadhilah Haifa