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All Journal Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Respirasi (JR) MEDICINUS
Saroyo, Yudianto Budi
Department Of Obstetrics And Gynecology, Universitas Indonesia, Jakarta, Indonesia.
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Placental Vitamin D, Oxidative Stress, and Senescence Markers in Spontaneous Preterm Birth: A Comparative Cross-Sectional Study Saroyo, Yudianto Budi; Wibowo, Noroyono; Prasmusinto, Damar; Purwosunu, Yuditiya; Irwinda, Rima; Dilmy, Mohammad Adya Firmansha; Putri, Atikah Sayogo; Mahendra, Arya Ivan; Putri, Lysandra Olivia Prasanti
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2928

Abstract

AbstractObjective: To evaluate the associations between vitamin D metabolism markers and biomarkers of oxidative stress and placental senescence among women with spontaneous preterm labor compared with those with term labor. Methods: We conducted a comparative cross-sectional study between 2017 and 2019 in two hospitals in Jakarta, Indonesia. Maternal serum and placental samples were collected from women with term labor and spontaneous preterm labor. Markers of the vitamin D pathway 25-hydroxyvitamin D (25[OH]D), 1,25-dihydroxyvitamin D? (1,25[OH]?D?), vitamin D receptor (VDR), and CYP27B1 along with oxidative stress (8-hydroxy-2--deoxyguanosine [8-OHdG]) and placental senescence markers (GLB1 and HMGB), were measured using ELISA, LC–MS/MS, and ICP–MS. Between-group comparisons were performed using parametric or nonparametric tests, as appropriate, and correlations were assessed using Pearson’s or Spearman’s correlation coefficients. Results: A total of 67 women were included (term labor, n = 34; spontaneous preterm labor, n = 33), and both groups were vitamin D deficient. Placental 1,25(OH)?D? levels were significantly lower in the preterm group than in the term group (4.58 ± 2.90 vs 5.57 ± 3.50 pg/ng, p = 0.037). Placental VDR levels also differed significantly between groups {21.70 (6.06–73.40) vs 16.48 (1.87–74.67), p = 0.041}. Across all participants, 8-OHdG and placental senescence markers were negatively correlated with placental 25(OH)D and 1,25(OH)?D? levels and positively correlated with placental CYP27B1 and VDR expression. Conclusion: In this comparative cross-sectional cohort, placental vitamin D metabolites were associated with lower levels of oxidative stress and placental senescence biomarkers, whereas VDR and CYP27B1 showed positive associations with these biomarkers. These patterns may reflect compensatory regulatory mechanisms in the context of maternal vitamin D deficiency. These findings are hypothesis-generating and warrant confirmation in prospective studies and mechanistic investigations. Keywords: oxidative stress, placental senescence, spontaneous preterm labor, vitamin D.
Co-Authors Allan Taufiq Rivai Amien, Bagus Radityo Arya Ady Nugroho Banunaek, Diana Budiman, Jenica Xaviera Chelsea, Edelyne Damar Prasmusinto Damar Prasmusinto Dilmy, Mohammad Adya Firmansha Dwiana Ocviyanti Fairuz, Vycka Fikriyani Faisal Yunus Firmansha Dilmy, Mohammad Adya Fita Maulina Hanny Nilasari Islamah, Rachelya Nurfirdausi Mahendra, Arya Ivan Manurung, Edward Sugito Menaldi Rasmin Mohammad Adya Firmansha Dilmy Noroyono Wibowo Noroyono Wibowo Purwosunu, Yuditiya Putri, Atikah Sayogo Putri, Lysandra Olivia Prasanti Putri, Ruth Widhiati Raharjo Raymond Surya Rima Irwinda Rima Irwinda, Rima Rinawati Rohsiswatmo Rumondang, Amanda Salsabila Putri, Cut Tisya Sandhy Prayudhana Yuditiya Purwosunu Yuditiya Purwosunu Zulhadji, Harry Agustio