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All Journal HAYATI Journal of Biosciences Nurse Media Journal of Nursing Sari Pediatri Paediatrica Indonesiana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Archives of Pediatric Gastroenterology, Hepatology, and Nutrition The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Nina Dwi Putri
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Medicine & Pharmacology Neuroscience Nursing

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The Impact of Cycle Threshold Value in Influencing the Performance of COVID-19 Antigen Rivaldi Febrian; July Kumalawati; Nina Dwi Putri; Linny Luciana; Aria Kekalih
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2217

Abstract

COVID-19 antigen is an alternative test for detecting SARS-CoV-2 infection. Viral load represented by the Cycle Threshold (CT) in the Real-Time Reverse Transcriptase Polymerase Chain Reaction (rRT-PCR) affects the diagnostic performance of the test. Higher CT values result in reduced sensitivity of the SARS-CoV-2 antigen. The main objective of this study was to determine the highest CT value in rRT-PCR that still yielded reactive results in the COVID-19 antigen test. This cross-sectional study was conducted at the Fever Outpatient Clinic in Dr. Cipto Mangunkusumo Hospital from July 2020 to June 2021. Two hundred and thirty-five naso-oropharyngeal swabs were taken from patients with confirmed and suspected COVID-19 diagnoses. About 24.7% of subjects were tested positive. The median highest CT value giving reactive COVID-19 antigen results was 28.22 (13.33-39.16), while the median CT value for non-reactive antigen results was 34.45 (26.08-39.65). At a CT value < 40, the COVID-19 antigen test demonstrated 63.8% sensitivity, 99.4% specificity, 89.3% Negative Predictive Value (NPV), and 97.4% Positive Predictive Value (PPV). At the CT value < 25, the test showed 92.3% sensitivity, 99.4% specificity, 99.4% NPV, 92.3% PPV, 163.4 LR+, and 0.1 LR-. The identified cut-off point for the CT value was 29.82, with a sensitivity of 64.9% and specificity of 81%. In conclusion, COVID-19 antigen is a valuable test for screening patients with symptoms of SARS-CoV-2 infection. Understanding the influence of cycle threshold can enhance the interpretation and reliability of the antigen test.
Gut Microbiota Profile of Infants with Breastfeeding and Mixed Feeding Patterns Kusumaningrum, Tina; Tafroji, Wisnu; Gultom, Septiani Madonna; Putri, Nina Dwi; Hafifah, Cut Nurul; Safari, Dodi
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.530-538

Abstract

We explore the gut microbiota profiles of 103 stool samples collected from infants at the age of 4 and 6 months in Jakarta, Indonesia. We performed 16S rRNA gene sequencing with Illumina MiSeq to identify the diversity, structure, and composition of the gut microbiota from those stool samples. Among 103 stool samples, 55 and 48 samples were collected from infants with breastfeeding and mixed feeding patterns, respectively. We found that the most abundant bacteria were Bifidobacteriales from the phylum of Actinobacteria (43.05%), Lactobacillales from the phylum of Firmicutes (28.39%), and Enterobacterales from the phylum of Proteobacteria (13.75%). The alpha and beta diversity analysis showed that the association between feeding patterns and differences in the microbial communities was not statistically significant (p-value >0.05). Our study did not show a difference in the gut microbiota pattern between the two feeding pattern groups. This result contributed to the variety of the world gut microbiota profile data in infants.
Challenges and opportunities to improve tuberculosis care for Indonesian children Graham, Stephen M.; Dwihardiani, Bintari; Felisia, Felisia; Koesoemadinata, Raspati Cundarani; Putri, Nina Dwi; Alisjahbana, Bachti; Lestari, Trisasi; Yani, Finny Fitry; Triasih, Rina
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.1-9

Abstract

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Risk Factors of Stunted Children Aged 0-23 Months at Jatibaru Public Health Center Bima, West Nusa Tenggara: A Case Control Study Atmalia, Khafifah Puja; Balfas, Rania Reiza Faris; Aryana, Nurfathonah; Wulandari Hidaya; Putri, Nina Dwi
Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Vol. 4 No. 2 (2025): APGHN Vol. 4 No. 2 May 2025
Publisher : The Indonesian Society of Pediatric Gastroenterology, Hepatology, and Nutrition

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58427/apghn.4.2.2025.51-61

Abstract

Background: Nutritional status in children under-five profoundly affects linear growth, cognitive development, and long-term disease. Stunting, defined as a child being too short for their age, results from prolonged malnutrition, particularly in the first 1000 days. In West Nusa Tenggara (NTB), stunting prevalence is the fourth highest at 32.7%, with 31.2% affected in Bima. This study aims to compare previous exposure between stunted children and non - stunted children in primary health care settings in Bima. Methods: A case-control study was conducted involving children aged 0–23 months who accessed integrated health services, bring a Maternal and Child Health Book (MCH), and had recorded health data at the Jatibaru Primary Health Center. Children with congenital anomalies were excluded. Maternal and child-related risk factors were assessed through anthropometric measurements (WHO standards) and structured interviews with validated questionnaire. Bivariate analysis (Chi-square, p < 0.25) was followed by multivariate logistic regression (p < 0.05). Result: A total of 124 participants were included (62 cases, 62 controls). Multivariate analysis revealed that maternal factors significantly associated with stunted growth in children were poor nutritional status (AOR 7.519, p = 0.000) and low nutrition knowledge (AOR 6.930, p = 0.000). Among child-related factors, stunted children were significantly associated with low birth weight (AOR 17.013, p = 0.000) and inadequate breastfeeding (AOR 7.434, p = 0.006). Conclusion: The mother’s nutritional status and children’s birth weight are the main risk factors of stunted children. Targeted interventions addressing maternal education and perinatal care are recommended to reduce stunting prevalence.
Co-Authors Abram Babakal Amalia Almira Aman B Pulungan Andi Annisa Rusyda Khafiyani Anis Karuniawati Antonius H. Pudjiadi Ari Prayitno Aria Kekalih Aryana, Nurfathonah Aryono Hendarto Atmalia, Khafifah Puja Atut Vebriasa Ayuni Rizka Utami Bachti Alisjahbana Badriul Hegar Badriul Hegar Balfas, Rania Reiza Faris Defi Efendi Delly Chipta Lestari Dwihardiani, Bintari Fatima Safra Alatas Felisia . Finny Fitry Yani Gultom, Septiani Madonna Hafifah, Cut Nurul Hanifah Oswari Hindra Irawan Satari I Dewa Gede Ariputra Irma Annisa Koesoemadinata, Raspati C. Kumalawati, July Kusumaningrum, Tina Linny Luciana Lucyana Alim Santoso Mega Hasanul Huda Merry Angeline Halim Mulya Rahma Karyanti, Mulya Rahma Muzal Kadim Nabila Maudy Salma Nindya Permata Pande Lilik Lestari Partini Pudjiastuti Trihono Pratama Wicaksana Pricilia Mais R. Rr Maria Dyah Kurniasari Raudha Ilmi Farid Rina Triasih Rivaldi Febrian RR Putri Zatalini Sabila Safari, Dodi Shindy Claudya Aprianti Stephen M. Graham, Stephen M. Tafroji, Wisnu Tartila Fathan Tety Nidiawati Titik Ambar Asmarini Trisasi Lestari, Trisasi Wahyu Ika Wardhani Wulandari Hidaya Yogi Prawira Yohanes Andy Rias Yosilia Nursakina