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All Journal Medical Journal of Indonesia Sari Pediatri Jurnal Respirologi Indonesia
Wahyuni Indawati
Dr. Cipto Mangunkusumo National General Hospital, Faculty Of Medicine, Universitas Indonesia, Department Of Pediatrics
Health Professions Medicine & Pharmacology

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Penggunaan MgSO4 pada Asma Serangan Berat: laporan kasus Bambang Supriyatno; Rismala Dewi; Wahyuni Indawati
Sari Pediatri Vol 11, No 3 (2009)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.453 KB) | DOI: 10.14238/sp11.3.2009.155-8

Abstract

Derajat serangan asma dibagi dalam tiga kelompok yaitu serangan ringan, sedang, dan berat, untuk membedakan tata laksananya. Kadang-kadang dengan tata laksana yang sudah sesuai standar pada serangan berat kurang memberikan respons sehingga perlu tata laksana alternatif. Salah satu terapi alternatif adalah penggunaan MgSO4 yang masih menjadi kontroversi efektivitasnya dibandingkan dengan pemberian inhalasi beta-2 agonis dan ipratropium bromida. Di sisi lain pernah dilaporkan keberhasilan penggunaan MgSO4 pada asma serangan berat setelah gagal dengan tata laksana standar. Dilaporkan dua anak dengan asma serangan berat yang tidak responsif dengan terapi standar seperti pemberian oksigen, cairan rumatan, inhalasi dengan dengan beta-2 agonis dan kortikosteroid intravena. dengan penambahan MgSO4 didapatkan respons yang sangat baik. Sebagai kesimpulan MgSO4 dapat digunakan sebagai terapi alternatif pada asma serangan berat.
Infeksi Influenza A dan B pada Anak dengan Influenza Like Illness (ILI) atau Pneumonia di Jakarta Wahyuni Indawati; Darmawan B Setyanto; Nastiti Kaswandani
Sari Pediatri Vol 16, No 2 (2014)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.593 KB) | DOI: 10.14238/sp16.2.2014.136-42

Abstract

Latar belakang Secara global, influenza merupakan salah satu penyebab utama morbiditas dan mortalitas pada anak serta menimbulkan beban ekonomi yang cukup besar. Manifestasi infeksi ini secara klinis sulit dibedakan dengan penyebab lain pada pasien dengan Influenza Like Illness (ILI) atau pneumonia.Tujuan. Menilai proporsi infeksi influenza A dan B pada anak dengan ILI dan pneumonia, mengetahui karakteristik subjek dengan infeksi influenza serta faktor yang memengaruhinya.Metode. Penelitian potong lintang dilakukan di RS Cipto Mangunkusumo dan Puskesmas Kecamatan Pulo Gadung sejak Januari 2010 hingga Oktober 2010. Pada anak berusia 0-14 tahun dengan diagnosis ILI atau pneumonia sesuai kriteria WHO dilakukan rapid test untuk influenza dengan menggunakan bahan usapan nasofaring. Data karakteristik klinis, demografi, dan lingkungan dicatat dalam formulir penelitian.Hasil. Didapatkan proporsi infeksi influenza A dan B pada anak dengan ILI dan pneumonia 14/167 (8,3%). Sebagian besar menderita infeksi influenza B (12/14 subjek). Usia >5 tahun berhubungan dengan kejadian infeksi influenza yang lebih tinggi dibandingkan kelompok usia ≤5 tahun (p=0,012). Selain demam, gejala lain berupa batuk, sakit kepala, nyeri otot, lesu, dan nyeri tenggorok lebih banyak didapatkan pada subjek dengan infeksi influenza.Kesimpulan. Pada anak dengan ILI dan pneumonia, proporsi infeksi influenza 8,3%, terutama didapatkan infeksi Influenza B. Usia merupakan faktor yang memengaruhi infeksi influenza. Karakterustik klinis subjek dengan infeksi influenza sesuai dengan manifestasi klasik penyakit tersebut.
Faktor - Faktor yang Memengaruhi Terjadinya Laringomalasia pada Anak dengan Penyakit Refluks Gastroesofageal Lina Ninditya; Wahyuni Indawati; Yogi Prawira; Pramita Gayatri
Sari Pediatri Vol 23, No 6 (2022)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp23.6.2022.383-9

Abstract

Latar belakang. Penyakit refluks gastroesofageal (PRGE) merupakan komorbiditas tersering pada pasien dengan laringomalasia. Banyak studi yang sudah membuktikan adanya hubungan antara PRGE dengan laringomalasia. Namun, sejauh ini belum ada studi yang mempelajari faktor-faktor yang memengaruhi terjadinya laringomalasia pada pasien dengan PRGE. Tujuan. Mengetahui proporsi laringomalasia pada anak dengan PRGE dan faktor-faktor yang memengaruhi (prematuritas, orang tua dengan riwayat dispepsia, pola makan dan disfungsi neurologis) terjadinya laringomalasia pada anak dengan PRGE. Metode. Merupakan studi prognostik dengan desain potong lintang pada 88 anak dengan diagnosis PRGE yang diambil dari rekam medis RSCM mulai dari tahun 2017 hingga 2020. Analisis data menggunakan chi-square/Fisher and logistic regression.Hasil. Proporsi laringomalasia didapatkan 12,5%. Tidak ada faktor yang memengaruhi terjadinya laringomalasia pada anak dengan PRGE. Namun, penelitian ini melihat adanya kecenderungan terjadinya laringomalasia pada subyek dengan pajanan asap rokok, adanya asupan makanan/minuman tengah malam, palsi serebral, dan pola makan yang tidak sesuai dengan feeding rule. Kesimpulan. Adanya kecenderungan terjadinya laringomalasia pada subyek dengan pajanan asap rokok, adanya asupan makanan/minuman tengah malam, dan pola makan yang tidak sesuai dengan feeding rule.
Co-Infection of Tuberculosis and COVID-19 in Children: A Case Report Madeleine Ramdhani Jasin; Talitha Rahma Ayuningtyas; Achmad Rafli; Irawan Mangunatmadja; Wahyuni Indawati; Nastiti Kaswandani
Jurnal Respirologi Indonesia Vol 44, No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.323

Abstract

Background: Coinfection of TB and COVID-19 might occur, yet few evidence has been reported. Current COVID-19 pandemic also results in disruption at TB management in the community.Case: A 5-month-old boy came with recurrent seizure, with history of persistent cough and fever for 1 month prior, also positive possible TB contact. He was diagnosed with disseminated TB, involving miliary appearance in chest Xray also meningitis, coinfected with COVID-19.Discussion: During COVID-19 pandemic, TB service in the community is disrupted, resulting in delay in TB diagnosis, as observed in this patient, leading to severe manifestation. Coinfection of TB and COVID-19 can occur and may lead to more severe symptoms in either both diseases. Management of TB COVID-19 coinfected children is similar to those without COVID-19. Our patient received treatment consisting of 2 RHZE then 10 RH. Monitoring of symptoms and possible sequelae is necessary.Conclusion: Coinfection TB and COVID-19 may occur in children, and both can lead to more severe manifestation of each condition, particularly if diagnosis is delayed. Strengthening TB care in the community is essential so that there will be no delay in diagnosis, also no disruption in treatment and monitoring.
Safety and immunogenicity of the CoV2-Bio in a healthy population aged 18 years and older in Indonesia Maria, Suzy; Olfriani, Ciho; Koesnoe, Sukamto; Sekartini, Rini; Soedjatmiko; Medise, Bernie Endyarni; Yuniar, Irene; Indawati, Wahyuni; Wirahmadi, Angga; Sari, Rini Mulia; Adi, Nuri Purwito; Retnaningdyah, Windri
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247476

Abstract

BACKGROUND According to the WHO Target Product Profiles for COVID-19 Vaccines, vaccine development should be indicated for active immunization in all populations, in conjunction with other control measures to curtail the pandemic. Several RBD-based COVID-19 vaccines are being evaluated and have shown advantages. CoV2-Bio was developed based on the wild-type SARS-CoV-2 RBD amino acid sequence, representing residues of the spike protein of the Wuhan-Hu-1 isolate. This study aimed to evaluate the safety and immunogenicity of CoV2-Bio when compared to CoronaVac. METHODS This was an observer-blinded, randomized controlled prospective study of safety and immunogenicity of the CoV2-Bio in healthy adult population. A total of 54 healthy participants were randomized to receive either 3 doses of CoV2-Bio or 2 doses of CoronaVac, and 1 dose of placebo, administered 28 days apart. Participants were followed up for safety and immunogenicity. IgG antibody titers (ELISA) and neutralization assay against Wuhan and Delta strains were evaluated at baseline, Days 28, 56, and 84. We assessed seropositive rate, seroconversion, and GMT as parameters. RESULTS Both vaccines were well tolerated and induced good antibody response. The incidence rate and intensity of local and systemic adverse events did not differ between vaccine and control groups. The vaccine group showed a larger proportion of seroconversion (4-fold increase antibody) (87.5% versus 46.2%, p = 0.001) and higher GMT (305.9 AU/ml versus 102.4 AU/ml, p<0.001) when compared to control group. CONCLUSIONS 3 doses of the CoV2-Bio are safe and immunogenic in healthy adult population. 3 doses of the CoV2-Bio COVID-19 vaccine produce a better immunogenicity profile compared to CoronaVac.
Co-Infection of Tuberculosis and COVID-19 in Children: A Case Report Jasin, Madeleine Ramdhani; Ayuningtyas, Talitha Rahma; Rafli, Achmad; Mangunatmadja, Irawan; Indawati, Wahyuni; Kaswandani, Nastiti
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.323

Abstract

Background:Coinfection TB and COVID-19 might occur, yet few evidence has been reported. Current COVID-19 pandemic also results in disruption at TB management in the community. Case: A 5-month-old boy came with recurrent seizure, with history of persistent cough and fever for 1 month prior, also positive possible TB contact. The diagnosis was disseminated TB (miliary and meningitis), coinfected with COVID-19.Discussion: During COVID-19 pandemic, TB service in the community is disrupted resulting in delay in TB diagnosis, as observed in this patient, leading to severe manifestation. Coinfection of TB and COVID-19 can occur and may lead to more severe symptoms in either both diseases. Management of TB COVID-19 coinfected children is similar to those without COVID-19. Our patient received treatment consisting of 2 RHZE then 10 RH. Monitoring of symptoms and possible sequelae is necessary.Conclusion: Coinfection TB and COVID-19 may occur in children, and both can lead to more severe manifestation of each condition, particularly if diagnosis is delayed. Strengthening TB care in the community is essential so that there will be no delay in diagnosis, also no disruption in treatment and monitoring.Keywords COVID-19, tuberculosis, coinfection, children
Co-Authors Ayuningtyas, Talitha Rahma Bambang Supriyatno Bernie Endyarni Medise Darmawan B Setyanto Harningtyas Jasmin Irawan Mangunatmadja Irene Yuniar, Irene Jasin, Madeleine Ramdhani Kuntjoro Harimurti Lina Ninditya Muhammad Aini Nastiti Kaswandani Nuri Purwito Adi Olfriani, Ciho Pramita Gayatri, Pramita Rafli, Achmad Retnaningdyah, Windri Rini Mulia Sari Rini Sekartini Rismala Dewi Soedjatmiko Sukamto Koesnoe Suzy Maria Talitha Rahma Ayuningtyas Wirahmadi, Angga Yogi Prawira