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Methisoprinol (Inosine Pranobex) for Mumps During a Local Outbreak: Findings from a Descriptive Single-Center Study Mujayanto, Rochman
Jurnal Medali Vol 7, No 2 (2025): Media Dental Intelektual August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.2.103-108

Background: Mumps is an acute infectious disease caused by the paramyxovirus, commonly found in many countries. In 2024, mumps outbreaks were reported globally, with significant cases in India (18,158), the USA (328), the Netherlands (578), and Indonesia (413). The current treatment guidelines for mumps are paracetamol or ibuprofen for pain relief. Purpose: To describe clinical profiles and outcomes of mumps patients treated with methisoprinol in a single-center cross-sectional study. Methods: A descriptive cross-sectional study of mumps patients treated with methisoprinol was conducted at the Islamic Dental Hospital Sultan Agung, Semarang, using retrospective data from August to December 2024. Mumps was defined by the WHO's clinical definition of parotid gland swelling. Results: Among 35 mumps patients, there was an almost equal gender distribution, with most being under 18. The majority had a history of febrile illness, used symptomatic medication, and lacked MMR vaccination history. There was a significant difference in the duration of parotitis before and after methisoprinol medication. Factors like sex, age, parotitis location, and MMR vaccination history did not significantly affect recovery time. Conclusion: Methisoprinol significantly reduced the duration of parotitis, while sex, age, parotitis location, and MMR vaccination history did not significantly influence recovery time.

EKSTRAK DAUN SALAM DALAM MENINGKATKAN EKSPRESI FIBROBLAST GROWTH FACTOR PADA ULKUS TRAUMATIK RONGGA MULUT Rosada, Amrina; Mujayanto, Rochman; Poetri, Adisty Restu
Odonto : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Traumatic ulcers are lesions of the oral mucosa caused by mechanical, chemical, and temperature trauma. Traumatic ulcer treatment aims to reduce inflammation, accelerate the healing process, and reduce pain. Bay leaf has anti-inflammatory pharmacological activities. This study aims to determine the effect of bay leaf extract on the expression of fibroblast growth factor in traumatic ulcer oral mucosa in Wistar rats.Method: This is an experimental research with a post-test only control group design, consisting of four groups with 20 sample of male Wistar rats. All animals were injured using a hot burnisher attached to the labial mucosa for 1 second. The gel was applied twice daily until the 3rd and 5th day after the ulcer has formed. Rat mucosal tissues were analyzed by immunohistochemical staining for FGF expressions. Statistical analysis using SPSS Mann-Whitney test.Result: The results showed the mean of cells expressing FGF in the bay gel extract group on the 3rd and 5th days were 8.4 Â± 0.8, and 13.6 Â± 0.5. Mann Whitney test results showed P<0.05 there is a significant differential expression of FGF traumatic ulcer oral mucosa of experimental animals on days 3 and 5 compared control group.Conclusion: Bay leaf extract increased FGF expression on days 3 and 5

BAY LEAF (SYZYGIUM POLYANTHUM) EXTRACT EFFECT ON IL-10 EXPRESSION IN ORAL ULCER Shafia, Arina; Mujayanto, Rochman; Feranisa, Anggun
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

GEOGRAPHIC TONGUE WITH BURNING MOUTH SYNDROME (CASE REPORT) Sari, Nendika Dyah Ayu Murika; Mujayanto, Rochman
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

ABSTRACTBackground: Geographic tongue is a condition that involves the dorsal surface of the tongue. This condition is usually painless, but in some cases, it may be accompanied by a burning sensation.The cause is unknown, but it is thought to be related to heredity, hormonal imbalances, allergies, and anemia. The aim of this study is to describe the geographic tongue, which is associated with burning mouth syndrome. Procedure: A 23-year-old woman came to RSIGM Sultan Agung Semarang with the chief complaint of fissure front tongue and moving spots, which made her sore when eating spicy food. According to the findings of the investigations, the MCV and MCH values were low, while the total IgE level was higher than normal. Geographic tongue with burning mouth syndrome et causa allergy and iron deficiency were the diagnoses in this case. The treatment for this condition is iron containing vitamins. Conclusion: More investigation is required to determine the correct diagnosis, etiology, and treatment. Iron supplements can support to reduce the complaints. As a follow-up management of allergic conditions and iron deficiency, some more examinations by dermatologist and internist are required.

BAY LEAF (SYZYGIUM POLYANTHUM) EXTRACT GEL EFFECT ON TNF- Î‘ EXPRESSION IN TRAUMATIC ULCERS HEALING PROCESS Savira, Annisha; Mujayanto, Rochman; Amurwaningsih, Musri
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Traumatic ulcers were injuries that occur to the epithelium and basement membrane, due to physical, mechanical, or chemical trauma. The healing process of traumatic ulcers was divided into three main phases, namely inflammatory, proliferation, and maturation phase. TNF-Î± as a proinflammatory mediator worked 2-3 days which later would be replaced by an anti-inflammatory mediator. This research aimed to determine the impact of bay leaf extract gel, which had a very high anti-inflammatory content, on TNF-Î± expression in accelerating the ulcers healing process.Method: This research method was an in vivo experimental laboratory research using a post-test only control design. The sample consists of 20 rats divided into four groups, namely, the control group on day 1, control groups on day 3, treatment groups on 1st day, and treatment groups on 3rd day. Rats were made traumatic ulcers on the lower lip mucosa and were given bay leaf extract gel in the morning and evening. The tissue was then made into a histological preparation and given immunohistochemical staining to see TNF-Î±.Result: The results showed the mean of cells expressing TNF-Î± in the bay leaf gel extract group on the 1st and 3rd days has P> 0.05. Independent T-test on 1st day dan 3rd group showed a significant difference in TNF-Î± expression in the control and treatment groups.Conclusion: The conclusion obtained in this study was bay leaf extract gel had a significant effect on the expression of TNF-Î± in the traumatic ulcers healing process.

BAY LEAF (SYZYGIUM POLYANTHUM) EXTRACT EFFECT ON IL-10 EXPRESSION IN ORAL ULCER Shafia, Arina; Mujayanto, Rochman; Feranisa, Anggun
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.1.53-59

GEOGRAPHIC TONGUE WITH BURNING MOUTH SYNDROME (CASE REPORT) Sari, Nendika Dyah Ayu Murika; Mujayanto, Rochman
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.2.18-24

ABSTRACTBackground: Geographic tongue is a condition that involves the dorsal surface of the tongue. This condition is usually painless, but in some cases, it may be accompanied by a burning sensation.The cause is unknown, but it is thought to be related to heredity, hormonal imbalances, allergies, and anemia. The aim of this study is to describe the geographic tongue, which is associated with burning mouth syndrome. Procedure: A 23-year-old woman came to RSIGM Sultan Agung Semarang with the chief complaint of fissure front tongue and moving spots, which made her sore when eating spicy food. According to the findings of the investigations, the MCV and MCH values were low, while the total IgE level was higher than normal. Geographic tongue with burning mouth syndrome et causa allergy and iron deficiency were the diagnoses in this case. The treatment for this condition is iron containing vitamins. Conclusion: More investigation is required to determine the correct diagnosis, etiology, and treatment. Iron supplements can support to reduce the complaints. As a follow-up management of allergic conditions and iron deficiency, some more examinations by dermatologist and internist are required.

BAY LEAF (SYZYGIUM POLYANTHUM) EXTRACT GEL EFFECT ON TNF- Î‘ EXPRESSION IN TRAUMATIC ULCERS HEALING PROCESS Savira, Annisha; Mujayanto, Rochman; Amurwaningsih, Musri
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.1.25-30

Background: Traumatic ulcers were injuries that occur to the epithelium and basement membrane, due to physical, mechanical, or chemical trauma. The healing process of traumatic ulcers was divided into three main phases, namely inflammatory, proliferation, and maturation phase. TNF-Î± as a proinflammatory mediator worked 2-3 days which later would be replaced by an anti-inflammatory mediator. This research aimed to determine the impact of bay leaf extract gel, which had a very high anti-inflammatory content, on TNF-Î± expression in accelerating the ulcers healing process.Method: This research method was an in vivo experimental laboratory research using a post-test only control design. The sample consists of 20 rats divided into four groups, namely, the control group on day 1, control groups on day 3, treatment groups on 1st day, and treatment groups on 3rd day. Rats were made traumatic ulcers on the lower lip mucosa and were given bay leaf extract gel in the morning and evening. The tissue was then made into a histological preparation and given immunohistochemical staining to see TNF-Î±.Result: The results showed the mean of cells expressing TNF-Î± in the bay leaf gel extract group on the 1st and 3rd days has P> 0.05. Independent T-test on 1st day dan 3rd group showed a significant difference in TNF-Î± expression in the control and treatment groups.Conclusion: The conclusion obtained in this study was bay leaf extract gel had a significant effect on the expression of TNF-Î± in the traumatic ulcers healing process.

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