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All Journal HAYATI Journal of Biosciences Jurnal Tumbuhan Obat Indonesia Jurnal Penelitian Farmasi Indonesia Journal of Mathematical and Fundamental Sciences Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Ensiklopedia of Journal JFIOnline ASEAN Journal on Science and Technology for Development

DAYAR ARBAIN

Faculty Of Pharmacy, University 17 Agustus 1945, Jl. Sunter Raya Permai, Jakarta, 14350

Author-ID : 3284960

Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Kajian Kimia Dari Fraksi Etil Asetat Kulit Batang Kayu Pahit (Picrasma Javanica Bl.) Sri Hainil; Dayar Arbain; Deddi Prima Putra
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

N-1 main compound from ethyl acetate fraction of kayu pahit bark (Picrasma Javanica B1) has been isolated and characterized with colom chromatography and continued with preparative chromatography. According to analized from spectrum data used ultraviolet (UV) spectroscopy, infra red (IR), 1H RMI (Resonansi Magnet Inti), 13 C RMI, Massa , COSY (Correlated Spectroscopy), HSQC (Heteronuclear Single Quantum Correlation), HMBC ( Heteronuclear Multiple Bond Correlation) and literature study showed that the compound of isolation was javanicin A.

The Isolation of Xanthones from Trunk Latex of Garcinia mangostana Linn. and Their Antimicrobial Activities Vivi Anggia; Amri Bakhtiar; Dayar Arbain
Indonesian Journal of Chemistry Vol 15, No 2 (2015)
Publisher : Universitas Gadjah Mada

ɑ-Mangostin (1), β-mangostin (2) and gartanin (3) have been isolated from the trunk latex of Garcinia mangostana Linn. and investigated for their antimicrobial activities against Bacillus subtilis, Enterococcus faecalis, Micrococcus luteus, Salmonella typhosa, Staphylococcus epidermidis, Streptococcus mutans and Vibrio cholerae. The significant antibacterial activity showed by α-mangostin (1) against Bacillus subtilis, Enterococcus faecalis. Staphylococcus epidermidis and Vibrio cholerae, but all compounds showed no activity to inhibit the growth of Micrococcus luteus and Streptococcus mutans.

3,4-DIHYDROXYBENZOIC ACID AND 3,4-DIHYDROXYBENZALDEHYDE FROM THE FERN Trichomanes chinense L.; ISOLATION, ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES Nova Syafni; Deddi Prima Putra; Dayar Arbain
Indonesian Journal of Chemistry Vol 12, No 3 (2012)
Publisher : Universitas Gadjah Mada

3,4-dihydroxybenzoic acid (1) and 3,4-dihydroxybenzaldehyde (2) have been isolated from ethyl acetate fraction of methanolic fractions of leaves, stems and roots of the fern Trichomanes chinense L. (Hymenophyllaceae). These two compounds also showed significant antioxidant using DPPH and antimicrobial activities using the disc diffusion assay.

Senyawa Non-aromatik Herba Centella asiatica menggunakan Metode Baru melalui Karbon Aktif, dan Analisis Farmakologi Jejaring pada Luka Bakar Awaluddin, Rizki; Mustaqim, Rafli Mulkan; Arbain, Dayar; Hayati, Farida; Khaerunnisa, Siti
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.50623

Prevalensi luka bakar masih menjadi perhatian kaitannya dengan perubahan fisik pasca luka bakar yakni contractures, hypertrophic scar dan keloid yang menurunkan fungsi, kualitas hidup dan estetika kulit. Herba pegagan (Centella asiatica) melalui senyawa triterpen telah dikenal untuk mempercepat luka bakar. Namun, sifat senyawa triterpen yang polar identik dengan keberadaan klorofil dan senyawa lainnya yang sulit dipisahkan. Masih adanya kontroversi terkait protein yang berperan dalam kesembuhan luka bakar membutuhkan kajian untuk menentukan protein potensial. Penelitian ini bertujuan untuk mengeksplorasi metode baru pada ekstraksi herba pegagan menggunakan karbon aktif serja kajian farmakologi jejaring untuk menentukan protein potensial. Herba pegagan diekstraksi menggunakan metode maserasi pada pelarut metanol dan dilanjutkan dengan penambahan karbon aktif. Hasil purifikasi diidentifikasi menggunakan KLT dengan fase gerak kloroform: asam asetat glasial: metanol: akuades (60:32:12:8 v/v) dan pereaksi semprot anisaldehid-asam sulfat. Kajian farmakologi jejaring dilakukan secara in silico untuk mengkaji interaksi protein-protein dan senyawa-protein berkaitan dengan luka bakar. Hasil skrining fitokimia menunjukkan keberadaan asaticoside pada ekstrak terpurifikasi dan maserat dengan nilai Rf yang relatif identik. Senyawa non aromatik berperan dalam mempercepat kesembuhan luka bakar dengan mempengaruhi protein IL1β, IL6, MAPK8, PTGS2, NOX4, IFN-γ, NFKB1, TGFβ1, MMP13, dan TNF.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN GARCINIA MICROCARPA TERHADAP 11 BAKTERI PATOGEN MANUSIA Ningsih, Yozi Fiedya; Arbain, Dayar; Bakhtiar, Amri
Ensiklopedia of Journal Vol 7, No 4 (2025): Vol. 7 No. 4 Edisi 2 Juli 2025
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v7i4.3279

Abstract: Infections caused by pathogenic bacteria remain a significant global health issue, particularly with the growing incidence of antimicrobial resistance. Therefore, the search for new antibacterial sources from medicinal plants has become a promising alternative. Garcinia microcarpa, a species belonging to the Garcinia genus, is known that Garcinia contains bioactive compounds such as xanthones, flavonoids, and tannins, which have potential antibacterial properties. This study aimed to evaluate the antibacterial activity of Garcinia microcarpa leaf extract against 11 human pathogenic bacteria, namely Staphylococcus aureus, Streptococcus mutans, Staphylococcus epidermidis, Enterococcus faecalis, Micrococcus luteus, Bacillus subtilis, Pseudomonas aeruginosa, Vibrio cholerae, Escherichia coli, Salmonella typhii, and Salmonella typhosa. Leaf extraction was performed using the maceration method with methanol as the solvent. Antibacterial activity was assessed using the disk diffusion method. The results showed that Garcinia microcarpa leaf extract exhibited antibacterial activity with varying inhibition zones against the tested bacteria. The highest activity was observed against E. coli and S. epidermidis, with inhibition zone diameters of 13.8 ± 1 mm and 13.0 ± 0.3 mm, respectively, at a concentration of 1 mg/disk. These findings suggest that Garcinia microcarpa has potential as a natural source of antibacterial compounds. Further studies are needed for fractionation, isolation of active compounds, and bioactivity testing.Keywords: Garcinia microcarpa, extract, antibacterial activity.

Co-Authors Amri Bakhtiar Amri Bakhtiar Amri Bakhtiar Amri Bakhtiar Armon Fernando Awaluddin, Rizki Deddi Prima Putra DEDI PRIMA PUTRA DWI SURYANTO Farediah Ahmad Faroliu, Goldha Fitri Suryani Friardi Ismed Ghalib Syukrilah Syahputra GINTA RIO Harry Abrir Effendy Hasnah M. Sirat Hasnirwan Hasnirwan Hayati, Farida Khaerunnisa, Siti KIKI NURTJAHJA Meiridha Mutiara Andania Melvyn V. Sargent Muhammad Taher Mustaqim, Rafli Mulkan Mutiara Ayudia Astuti Nanda Putra Ningsih, Yozi Fiedya Nofrizal Nova Syafni NUNUK PRIYANI Piter Piter Solachuddin Jauhari Arief Ichwan Sri Hainil TATA BINTARA KELANA Vivi Anggia Vivi Anggia, Vivi

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