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All Journal ACTA VETERINARIA INDONESIANA Althea Medical Journal Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Global Medical and Health Communication Jurnal Manajemen Kesehatan Indonesia MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Lelly Yuniarti
Department Of Biochemistry, Nutrition And Biomolecular, Faculty Of Medicine, Universitas Islam Bandung
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Bandung Conference Series : Medical Science

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Rasio Cycle Threshold (CT) Internal Control (IC)/CT Gen N Sars-Cov-2 dan Ekspresi Gen N Sars-Cov-2 Berhubungan dengan Tingkat Keparahan Pasien Covid-19 Gibran Bramasta Dirgavansya; Umar Islami; Lelly Yuniarti
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1212

Abstract

Abstract. Introduction: COVID-19 is a disease caused by a virus called SARS-CoV-2, COVID-19 cases in Indonesia reached 4.2 million in October 2021. The standard for diagnosis of COVID-19 is RT-PCR because of its high specificity and sensitivity, RT -PCR produces a CT value that can describe the amount of nucleic acid and viral load of SARS-CoV-2. This study aims to analyze the relationship between the expression of SARS-CoV-2 gene N and the ratio of CT internal control/CT gene N SARS-CoV-2 with the severity of illness in COVID-19 patients. Methods: This study was an observational study with a cross-sectional approach to inpatients at Cideres Majalengka Hospital, the data was taken in the form of medical records and the results of the RT-PCR examination were CT values. The expression of the SARS-CoV-2 N gene was calculated using the saliva formula (Formula 2-ΔΔCT), while the ratio was obtained by comparing the CT values internal control /CT gene N SARS-CoV-2. The relationship of gene expression and CT ratio with severity was analyzed using the correlation test Spearman at a 95% confidence level. Results: The correlation test Spearman showed a relationship between the expression of SARS-CoV-2 Gene N (r=0.31; p=0.015) and the ratio of CT internal control/CT gene N SARS-CoV-2 (r= 0.28; p = 0.03) with the severity of COVID-19 patients. Severity is classified according to the COVID-19 Management Guidelines into mild, moderate, severe, critical. Conclusion: The conclusion of this study is that there is a relationship between the expression of SARS-CoV-2 gene N and the ratio of CT internal control/CT gene N SARS-CoV-2 with the severity of COVID-19 patients, the greater the gene expression ratio value, the severity of the patient Heavier. The ratio of CT internal control /CT gene N SARS-CoV-2 and high gene expression indicate a high viral load that can increase the severity of the patient. Abstrak. Pendahuluan: COVID-19 adalah penyakit yang diakibatkan oleh virus bernama SARS-CoV-2, kasus COVID-19 di Indonesia mencapai 4,2 juta pada Oktober 2021. Standar baku diagnosis COVID-19 adalah RT-PCR karena spesifisitas dan sensitivitasnya tinggi, RT-PCR menghasilkan CT value yang dapat menggambarkan jumlah asam nukleat dan viral load SARS-CoV-2. Penelitian ini bertujuan menganalisis hubungan ekspresi gen N SARS-CoV-2 dan rasio CT internal control/CT gen N SARS-CoV-2 dengan tingkat keparahan penyakit pasien COVID-19. Metode: Penelitian ini merupakan penelitian observasional dengan pendekatan potong lintang pada pasien rawat inap RSUD Cideres Majalengka, data diambil berupa rekam medik dan hasil pemeriksaan RT-PCR berupa CT value. Ekspresi gen N SARS-CoV-2 dihitung menggunakan rumus Livak (Rumus 2-ΔΔCT), sementara rasio didapatkan dengan membandingkan nilai CT internal control/CT gen N SARS-CoV-2. Hubungan dari ekspresi gen dan rasio CT dengan tingkat keparahan dianalisa dengan menggunakan uji korelasi spearman pada tingkat kepercayaan 95%. Hasil: Uji korelasi spearman menunjukkan adanya hubungan antara ekspresi gen N SARS-CoV-2 (r=0,31; p=0,015) dan rasio CT internal control/CT gen N SARS-CoV-2 (r= 0,28; p=0,03) dengan tingkat keparahan pasien COVID-19. Tingkat keparahan diklasifikasikan berdasar Pedoman Tatalaksana COVID-19 menjadi ringan, sedang, berat, kritis. Kesimpulan: Kesimpulan dari penelitian ini adalah terdapat hubungan antara ekspresi gen N SARS-CoV-2 dan rasio CT internal control/CT gen N SARS-CoV-2 dengan tingkat keparahan pasien COVID-19, semakin besar nilai ekspresi gen rasio maka tingkat keparahan pasien semakin berat. Rasio CT internal control/CT gen N SARS-CoV-2 dan ekspresi gen yang tinggi menunjukkan viral load yang tinggi sehingga dapat meningkatkan tingkat keparahan pasien.
Analisis In Sillico Mekanisme Cell Survival Zat Aktif Daun Sirsak (Annona Muricata Linn) pada Kanker Kolorektal Hur'iynazzahra Kariima Romli; Lelly Yuniarti; Julia Hartati
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1316

Abstract

Abstract. Colorectal cancer (CRC) is a malignancy of the colon which is the second leading cause of cancer death. The first-line treatment for CRC consists of chemotherapy and monoclonal antibodies that target cell survival. The efficacy of chemotherapy drugs in most cases of CRC still needs to be improved because the cancer cells show that they still have a defense mechanism. In several studies, the active compounds of soursop leaves have several anticancer effects such as cell survival. The drug discovery process requires time, several stages of clinical trials, and large funds so we need a method that can help make them more efficient, one of which is in sillico method. This study used the in sillico method by looking for the active compound of soursop leaves from published scientific articles and also looking for three-dimensional structures, predicting, and analysis of target proteins using several databases. The results of this study found 18 target proteins of soursop leaf active compound is involved in cell survival mechanism of CRC by regulating cell cycle regulation, miRNA transcription regulation, decreasing cell proliferation, triggering apoptosis, decreasing cell invasion and metastasis. The conclusion of this study is that the active substances of soursop leaves have some target proteins that can have some anticancer mechanism, one of which is by suppressing cell survival in CRC. Abstrak. Kanker kolorektal (KKR) merupakan keganasan pada usus besar yang menjadi kanker kedua penyebab kematian tertinggi akibat kanker. Pengobatan lini pertama KKR diantaranya kemoterapi dan antibodi monoklonal yang memiliki target salah satunya mekanisme cell survival. Efikasi obat kemoterapi pada sebagian besar kasus KKR masih perlu ditingkatkan karena sel kanker menunjukkan masih memiliki mekanisme pertahanan. Pada beberapa penelitian, zat aktif daun sirsak memiliki efek sebagai antikanker seperti melalui cell survival. Proses penemuan obat memerlukan waktu, beberapa tahap uji klinis, dan dana yang besar sehingga perlu metode yang membantu agar lebih efisien, salah satunya in sillico. Penelitian ini menggunakan metode in sillico dengan melakukan penelusuran zat aktif daun sirsak dari artikel ilmiah yang terpublikasi dan dilakukan pencarian stuktur tiga dimensi, prediksi, serta analisis protein target menggunakan beberapa database. Hasil dari penelitian ini yaitu ditemukan 18 protein target zat aktif daun sirsak yang terlibat pada mekanisme cell survival KKR dengan mengatur regulasi siklus sel, regulasi transkripsi miRNA, memicu apoptosis, menurunkan proliferasi sel, kemampuan invasi, dan metastasis sel. Kesimpulan pada penelitian ini yaitu zat aktif daun sirsak memiliki protein target yang dapat memiliki mekanisme antikanker salah satunya dengan menekan cell survival pada KKR.
Hubungan Komorbid Hipertensi dengan Gejala Long Covid-19: Studi Pada Pasien Covid-19 yang Pernah di Rawat Inap di RSUD Al-Ihsan Provinsi Jawa Barat dan RSUD Cideres Majalengka Althaafvashti Trixie Niadi; Lelly Yuniarti; Abdul Hadi Hassan
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6267

Abstract

Abstract. Long COVID-19 is a prolonged symptom in patients who have recovered from COVID-19 which incidence increases along with the increasing cases of COVID-19. One of the risk factors for long COVID-19 is comorbid hypertension. This study aimed to discover the relationship between comorbid hypertension and long COVID-19 symptoms. The subjects of this study were COVID-19 inpatients at Al-Ihsan and Cideres Hospital from December 2020–February 2022. This analytical study used a case-control design conducted from December 2021–December 2022. Primary data was gained through interviews and questionnaires. Secondary data was acquired from medical records. The total subjects were 120 patients (65 subjects as cases and 55 subjects as controls) who met the inclusion criteria and were selected using the purposive sampling technique. The results showed that most COVID-19 patients aged 56–65 years and the number was comparable between men and women, most long COVID-19 patients aged 56–65 years and are female, more subjects did not have comorbid hypertension (54.2%), more subjects experienced long COVID- 19 symptoms (54.2%), and the most common long COVID-19 symptoms were fatigue, coughing, and dyspnea. Most COVID-19 patients with comorbid hypertension (41.7%) experienced long COVID-19 symptoms, while most COVID- 19 patients without comorbid hypertension did not experience long COVID-19 symptoms. The conclusion of this study, based on bivariate analysis using Fisher’s exact test with a 95% confidence level, is that there is a correlation between comorbid hypertension and long COVID-19 symptoms (p<0.05). COVID-19 patients with comorbid hypertension are more at risk of experiencing long COVID-19 symptoms. Abstrak. Long COVID-19 merupakan gejala berkepanjangan pada pasien yang telah pulih dari COVID-19 yang kejadiannya meningkat seiring dengan meningkatnya kasus COVID-19. Salah satu faktor risiko terjadinya long COVID-19 adalah komorbid hipertensi. Tujuan penelitian ini adalah mengetahui hubungan komorbid hipertensi dengan gejala long COVID-19. Subjek penelitian adalah pasien COVID- 19 yang pernah dirawat inap di RSUD Al-Ihsan dan Cideres pada Desember 2020– Februari 2021. Penelitian analitis ini menggunakan desain case-control dan dilaksanakan pada Desember 2021–Desember 2022. Data primer diperoleh melalui wawancara dan pengisian kuesioner serta data sekunder diperoleh dari rekam medis. Total subjek penelitian berjumlah 120 pasien yaitu didapatkan 65 kasus dan 55 kontrol yang memenuhi kriteria inklusi dan dipilih dengan teknik purposive sampling. Hasil penelitian menunjukkan bahwa pasien COVID-19 paling banyak berusia 56–65 tahun dan sebanding jumlahnya antara laki-laki dan perempuan, pasien long COVID-19 paling banyak berusia 56–65 tahun dan lebih banyak yang berjenis kelamin perempuan, lebih banyak pasien COVID-19 yang tidak memiliki komorbid hipertensi (54,2%), lebih banyak pasien COVID-19 yang mengalami gejala long COVID-19 (54,2%), dan gejala long COVID-19 yang paling sering dialami adalah fatigue, batuk, dan dyspnea. Sebagian besar pasien COVID-19 dengan komorbid hipertensi (41,7%) mengalami gejala long COVID-19, sedangkan sebagian besar pasien COVID-19 tanpa komorbid hipertensi tidak mengalami gejala long COVID- 19. Kesimpulan penelitian ini, berdasarkan analisis bivariat menggunakan Fisher’s exact test dengan tingkat kepercayaan 95%, adalah terdapat hubungan antara komorbid hipertensi dan gejala long COVID-19 (p<0,05). Pasien COVID-19 dengan komorbid hipertensi lebih berisiko mengalami gejala long COVID-19.
Efek Antikanker dan Ko-Kemoterapi Nanopartikel Alginat Ekstrak Etanol Daun Sirsak (Annona Muricata) dengan Doxorubicin pada Kultur Sel Kanker Serviks Uteri (HeLa) Revina Mayra Salsabila Hasyim; Lelly Yuniarti; Yuke Andriane
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5741

Abstract

Abstract. Uterine cervical cancer ranks fourth in the world and Asia and second in Indonesia. Cervical uteri cancer chemotherapy with doxorubicin still has high side effects. To reduce these side effects, combination therapy can be carried out between standard drugs and drugs from natural ingredients, one of which is soursop leaf in the form of nanoparticles which can increase the delivery of compounds. The purpose of this study was to analyze the anticancer effect of alginate nanoparticles of soursop leaf ethanol extract and its combination with doxorubicin on cervical uteri cancer (HeLa) cells. This research is a pure in vitro experimental study on cervical uteri cancer cell culture (HeLa). The cytotoxicity test was carried out using the microtetrazolium method and analyzed using the SPSS software probit regression. The combination test was carried out with concentrations of 1/2 IC50, 3/8 IC50, 1/4 IC50, 1/8 IC50 and analyzed using CompuSyn software to obtain a CI value indicating the synergy of the preparations. This study had an IC50 of soursop leaf extract nanoparticles of 52.0825 (±24.26) µg/mL (moderate effect) and doxorubicin which had an IC50 of 4.8 (±0.10) µg/mL (strong effect). The lowest CI value obtained was 0.04106. The conclusion of this study is that soursop leaf extract nanoparticles have a moderate anticancer effect and are highly synergistic with eight combinations of doxorubicin. Abstrak. Kanker serviks uteri menempati urutan keempat di dunia dan Asia serta kedua di Indonesia. Kemoterapi kanker serviks uteri dengan doxorubicin masih memiliki efek samping yang tinggi. Untuk menurunkan efek samping tersebut, dapat dilakukan terapi kombinasi antara obat standar dengan obat dari bahan alam, salah satunya adalah daun sirsak dalam bentuk nanopartikel yang dapat meningkatkan penghantaran senyawa. Tujuan penelitian ini adalah untuk menganalisis efek antikanker sediaan nanopartikel alginat ekstrak etanol daun sirsak dan kombinasinya dengan doxorubicin pada sel kanker serviks uteri (HeLa). Penelitian ini merupakan penelitian eksperimental murni in vitro pada kultur sel kanker serviks uteri (HeLa). Uji sitotoksisitas dilakukan menggunakan metode microtetrazolium dan dianalisis melalui regresi probit software SPSS. Uji kombinasi dilakukan dengan konsentrasi 1/2 IC50, 3/8 IC50, 1/4 IC50, 1/8 IC50 dan dianalisis menggunakan software CompuSyn hingga didapatkan nilai CI yang menunjukkan sinergitas sediaan. Penelitian ini memiliki hasil IC50 nanopartikel ekstrak daun sirsak sebesar 52,0825 (±24,26) µg/mL (efek sedang) dan doxorubicin yang memiliki IC50 sebesar 4,8 (±0,10) µg/mL (efek kuat). Nilai CI terendah yang didapatkan adalah sebesar 0,04106. Kesimpulan penelitian ini adalah nanopartikel ekstrak daun sirsak memiliki efek antikanker sedang dan bersifat sinergis sangat kuat dengan doxorubicin sebanyak delapan kombinasi.
Terdapat Hubungan Antara Jenis dan Frekuensi Olahraga dengan Tingkat Stres pada Mahasiswa Kedokteran di Bandung Azmi Putri Azzahra; Lelly Yuniarti; Julia Hartati
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6934

Abstract

Abstract. Stress is one of the physiological reactions in an individual where various defense mechanisms occur to face situations that are considered threatening or increased demands. One of the ways to reduce stress levels is to exercise. Exercise will stimulate the production of beta-endorphin hormones which will have the effect of restoring mood and lowering cortisol levels. This research aims to analyze the relationship between the type and frequency of sports and the stress level of Faculty of Medicine students in Bandung. The research method used is descriptive comparative with cross-sectional. The subjects of this research are 135 students of the Faculty of Medicine in the City of Bandung, with simple random sampling. The type and frequency of sports were taken using the Godin Leisure-Time Exercise questionnaire, while the stress level was assessed using the Perceived Stress Scale. Data were analyzed with Fisher's Exact Test with a confidence level of 95% (α=0,05). The results of the research on the relationship between the type of sport and the level of stress obtained p=0.024 and the relationship between the frequency of sport and the level of stress obtained p=0.004. The conclusion of this research is that there is a relationship between the type and frequency of sports and the level of stress. Abstrak. Stres merupakan salah satu reaksi fisiologis pada suatu individu di mana terjadi mekanisme pertahanan yang beragam untuk menghadapi situasi yang dianggap mengancam atau tuntutan yang meningkat. Salah satu cara untuk menurunkan tingkat stres adalah berolahraga. Olahraga akan merangsang pengeluaran hormon beta-endorfin yang akan memberikan efek memulihkan suasana hati dan menurunkan kadar kortisol. Penelitian ini bertujuan untuk menganalisis hubungan jenis dan frekuensi olahraga dengan tingkat stres Mahasiswa Fakultas Kedokteran di Bandung. Metode penelitian yang digunakan adalah deskriptif comparative dengan cross-sectional. Subjek pada penelitian ini adalah Mahasiswa Fakultas Kedokteran di Kota Bandung berjumlah 135 orang, dengan pengambilan sampel secara simple random sampling. Jenis dan frekuensi olahraga diambil menggunakan kuisioner Godin Leisure-Time Exercise sedangkan tingkat stres dinilai menggunakan Perceived Stres Scale. Data dianalisis dengan uji Fisher’s Exact Test dengan tingkat kepercayaan 95% (α=0,05). Hasil penelitian hubungan jenis olahraga dengan tingkat stres didapatkan p=0.024 dan hubungan frekuensi olahraga dengan tingkat stres didapatkan p=0.004. Simpulan pada penelitian ini terdapat hubungan jenis dan frekuensi olahraga dengan tingkat stres.
Komorbid Diabetes Melitus Bukan Merupakan Faktor Risiko Long COVID-19 Muhamad Rizky Pratama Kurniawan Rizky; Lelly Yuniarti Lelly; Umar Islami Umar
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6220

Abstract

Abstract. As many as 30% of COVID-19 patients have comorbid diabetes mellitus. Diabetes is suspected to cause worsening of symptoms and a prolonged duration of symptoms known as long COVID-19. The high number of COVID-19 cases in Indonesia will probably be directly proportional to the long incidence of COVID-19, in Indonesia there are as many as 63.5% of COVID-19 patients experiencing symptoms of long COVID-19. The purpose of this study was to analyze the relationship between comorbid diabetes mellitus and symptoms of long COVID-19. The method used in this research is case control analysis. The research subjects were 91 COVID-19 patients who had been hospitalized at SMC Tasikmalaya Hospital and Cideres Majalengka Hospital and had been declared cured, selected by purposive sampling technique. Processing data using fisher's exact test. The results showed that 50 subjects were male and 41 subjects were female. 51 subjects had a history of comorbid diabetes mellitus. There were 46 subjects experiencing symptoms of long COVID-19 with the most age range experiencing symptoms of long COVID-19 at the age of 41-60 years as many as 53 subjects and the least at age >60 years as many as 18 subjects. There was no significant relationship between co-morbid diabetes mellitus and symptoms of long COVID-19 with a p-value of 0.240 (>0.05). It was concluded that comorbid diabetes mellitus in COVID-19 patients is not a risk factor for the appearance of long-term symptoms of COVID-19. Keywords: COVID-19, diabetes mellitus, long COVID-19
Literature Riview: Analisis Capaian KB Aktif dan Kontrasepsi pada Masa Pandemik Covid-19 Anggit Yanuaristi; Dean Wahjudi Satyaputra; Lelly Yuniarti
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6460

Abstract

Abstract: The government established a PSBB policy in 2020 to break the chain of distribution of COVID-19 by limiting people's mobility towards social contact, this has an impact on limited access to health services. This study aims to examine the achievements of active family planning and contraception programs during a pandemik by using the literature review method to identify published literature using relevant keywords. Based on the literature review produced, active KB acceptors decreased during a pandemik, contraceptive methods that experienced a decrease included MOP, pills, injections and MOW. Contraceptives that have increased in IUDs, Implants and Condoms. In conclusion, the results of active family planning decreased due to COVID-19, the distribution of contraceptives was made easier for the community and family planning services were further improved to prevent the "baby boom" at the end of the COVID-19 pandemic. Abstrak: Pemerintah menetapkan kebijakan PSBB pada tahun 2020 utuk memutus mata rantai penyebaran COVID-19 dengan cara membatasi mobilitas masyarakat terhadap kontak sosial, hal tersebut berdampak pada terbatasnya masyarakat mendapatkan layanan kesehatan. Penelitian ini bertujuan untuk meneliti capaian program KB aktif dan kontrasepsi pada masa pandemik dengan menggunakan metode literature review untuk mengidentifikasi literature yang telah dipublish dengan menggunakan kata kunci yang relevan. Berdasarkan dari literature riview dihasilkan, Akseptor KB aktif menurun pada saat pandemik, alat kontrasepsi yang mengalami penurunan diantaranya MOP, Pil, Suntik dan MOW. Alat kontrasepsi yang mengalami peningkatan pada IUD, Implant dan Kondom. Simpulan, capaian KB aktif menurun dipengaruhi oleh COVID-19, distribusi alat kontrasepsi dipermudah untuk masyarakat dan pelayanan KB lebih ditingkatkan untuk mencegah “baby boom” pada akhir masa pandemik COVID-19.
Pengembangan Obat Kanker dari Daun Kelor (Moringa Oleifera) Silmi Hizba Hunafa; Yuke Andriane; Lelly Yuniarti
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6638

Abstract

Abstract. Colon cancer ranks third most common in the world with the second highest mortality rate. Colon cancer therapy, one of which can be through chemotherapy using doxorubicin. Single use of doxorubicin has significant side effects. One effort to reduce side effects and increase its effectiveness is to combine doxorubicin with Moringa leaves (Moringa oleifera). Moringa leaves contain many active ingredients such as flavonoids, D-allose, and eugenol. Another effort that can be made to increase the effectiveness of drugs is by developing nanoparticles. The literature review method was carried out by searching the literature through national and international literature searches as well as data on articles and scientific journals that focused on colon cancer, doxorubicin, the mechanism of action of doxorubicin, the content of Moringa leaves, the anti-cancer effects of Moringa leaves. The results of this study are: There is a cytotoxic effect produced by Moringa leaves (Moringa oleifera) against colon cancer cells and there is a synergistic effect between the combination of doxorubicin and Moringa leaves (Moringa oleifera) against colon cancer cells. Abstrak. Kanker kolon menempati urutan ketiga tersering di dunia dengan tingkat kematian tertinggi kedua. Terapi kanker kolon salah satunya dapat melalui kemoterapi menggunakan doxorubicin. Penggunaan tunggal doxorubicin memiliki efek samping yang signifikan. Salah satu upaya untuk mengurangi efek samping dan meningkatkan efektivitasnya adalah dengan mengkombinasikan doxorubicin dengan daun kelor (Moringa oleifera). Daun kelor memiliki banyak kandungan bahan aktif seperti flavonoid, D-allose, dan eugenol. Upaya lain yang dapat dilakukan untuk meningkatkan efektivitas obat adalah dengan pengembangan nanopartikel. Metode literatur review ini dilakukan dengan pencarian literatur melalui pencarian literatur nasional maupun internasional serta data artikel dan jurnal ilmiah yang berfokus pada kanker kolon, doxorubicin, mekanisme aksi doxorubicin, kandungan daun kelor, efek anti-kanker daun kelor. Hasil dari penelitian ini adalah: Terdapat efek sitotoksik yang dihasilkan daun kelor (moringa oleifera) terhadap sel kanker kolon dan terdapat efek sinergis antara kombinasi doxorubicin dengan daun kelor (Moringa oleifera) terhadap sel kanker kolon.
Efektivitas Pemberian Metformin terhadap Perbaikan Manifestasi Klinis pada Pasien Sindrom Polikistik Ovarium Maulani Nurmuji Atmapratiwi; Lelly Yuniarti; Ariko Rahmat Putra
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10975

Abstract

Abstract. Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction, hyperandrogenism, and the presence of polycystic ovaries. Metformin, which is an insulin sensitizer agent, is the most widely used therapy in the management of PCOS. This research aims to explore and analyze articles discussing the effectiveness of metformin in improving clinical manifestations in polycystic ovarian syndrome patients. This research is a Scoping Review of articles published in 2012-2022 from the Pubmed, Springer Link, ScienceDirect, and Taylor and Francis databases that meet the criteria of Population (women with PCOS), Intervention (administration of metformin), Comparison (therapy other than metformin), Outcome (improvement of ovarian dysfunction and size of polycystic features, improved fertility, reduced body weight, reduced insulin resistance, improved menstrual cycle, hyperinsulinemia, hyperandrogenism, and abnormal metabolic disorders), Study (randomized controlled trials). The PRISMA diagram method was used in this research. From the four databases, 7,389 articles were obtained, which were then screened according to the inclusion criteria, feasibility test, and critical review according to the Joanna Briggs Institute checklist, resulting in 11 articles. Based on the results of the analysis of 11 articles, 10 articles stated that single metformin therapy was superior in reducing BMI, waist circumference, blood glucose, HOMA index, and improving the menstrual cycle compared to myoinositol therapy, rosiglitazone, letrozole, oral contraceptive pills, clomiphene citrate, cupping fennel seeds, and ovaries. There is 1 article that states that metformin therapy can improve ovulatory dysfunction. Abstrak. Polycystic Ovarian Syndrome (PCOS) merupakan gangguan endokrin umum yang ditandai dengan disfungsi ovulasi, hiperandrogen, dan adanya polikistik pada ovarium. Metformin merupakan agen sensitizer insulin adalah terapi yang paling banyak digunakan dalam penatalaksanaan PCOS. Tujuan dari penelitian adalah untuk mengeksplorasi dan menganalisis artikel yang membahas efektivitas metformin terhadap perbaikan manisfestasi klinis pada pasien polycystic ovarian syndrome. Penelitian ini merupakan Scoping Review artikel yang terbit tahun 2012-2022 dari database Pubmed, Springer Link, SienceDirect, dan Taylor and Francis yang sesuai dengan kriteria dengan Population (wanita penderita PCOS), Intervention (pemberian metformin), Comparison (terapi selain metformin), Outcome (perbaikan disfungsi ovarium dan ukuran gambaran polikistik, perbaikan fertilitas, menurunkan berat badan, mengurangi resistensi insulin, memperbaiki siklus menstruasi, hyperinsulinemia, hiperandrogenisme, dan kelainan metabolisme abnormal), Study (randomized controlled trials). Metode diagram PRISMA digunakan dalam penelitian ini, dari keempat database didapat 7,389 artikel yang kemudian dilakukan skrinning sesuai dengan kriteria inklusi, uji kelayakan, dan telaah kritis sesuai dengan checklist Joanna Briggs Institute dihasilkan 11 artikel. Berdasarkan hasil analisis dari 11 artikel terdapat 10 artikel yang menyatakan bahwa terapi metformin tunggal lebih unggul dalam menurunkan BMI, lingkar pinggang, glukosa darah, HOMA indeks, dan memperbaiki siklus menstruasi dibandingkan dengan terapi myoinositol, rosiglitazone, letrozole, pil kontrasepsi oral, clomiphene citrate, bekam biji adas dan ovarium. Terdapat 1 artikel yang menyatakan bahwa terapi metformin dapat memperbaiki disfungsi ovulasi.
Riwayat Pengobatan Tuberkulosis dan Penyakit Komorbid Sebagai Faktor Risiko Multi-Drugs Resistant Pasien Tuberkulosis Paru Andi Fajri Rahmat; Lelly Yuniarti; Nugraha Sutadipura
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.11565

Abstract

Abstract. Multidrug Resistant Tuberculosis (MDR-TB) is a type of tuberculosis that is resistant to at least two first-line antibiotics isoniazid (INH) and rifampicin (RMP) with or without resistance to other anti-tuberculosis drugs (OAT). This study aims to explore and analyze articles that discuss the history of tuberculosis treatment as a risk factor for multi-drug resistance in adult pulmonary tuberculosis patients. The research used literature studies between 2012-2022 from the Pubmed, Springer Link, ScienceDirect, Proquest, and Taylor and Francis databases. Based on the results of the analysis and discussion of the descriptions of the research articles reviewed, it can be concluded that a history of previous TB treatment is the main risk factor for increasing the incidence of MDR-TB. Abstrak. Multidrug Resistant Tuberculosis (MDR-TB) merupakan jenis tuberkulosis yang resisten terhadap setidaknya dua antibiotik lini pertama isoniazid (INH) dan rifampisin (RMP) dengan atau tanpa resistensi terhadap obat anti tuberkulosis (OAT) lain. Penelitian ini bertujuan untuk mengeksplorasi dan menganalisis artikel yang membahas riwayat pengobatan tuberkulosis sebagai faktor risiko terjadinya multi-drugs resistant pada pasien tuberkulosis paru dewasa. Penelitian menggunakan studi literatur antara tahun 2012-2022 dari database Pubmed, Springer Link, ScienceDirect, Proquest, dan Taylor and Francis. Berdasarkan hasil analisis dan pembahasan dari uraian artikel penelitian yang di-review dapat disimpulkan bahwa riwayat pengobatan TB sebelumnya menjadi faktor risiko utama dari meningkatnya kejadian MDR-TB.
Co-Authors Abdul Hadi Hassan Agly Adithya Agly Adithya, Agly Ahmad, Sadiah Althaafvashti Trixie Niadi Andi Fajri Rahmat Andriane, Yuke Anggit Yanuaristi Anissha Fitry Oktavianita Anissha Fitry Oktavianita Apen Afgani Ariko Rahmat Putra Athar Fathur Rafi Azmi Putri Azzahra Azri Iskandar Azri Iskandar, Azri Bachti Alisjahbana Batara, Triando Bhatara, Tryando Clara Juniasari Dean Wahjudi Satyaputra Dida Ahmad Gurnida Dika Rifky Fernanda Dika Rifky Fernanda Endang Sutedja Enggar Hestu Enggar Hestu, Enggar Gibran Bramasta Dirgavansya Gibran Bramasta Dirgavansya Herri S. Sastramihardja Herry Garna Heru Haerudin Hilmi Sulaiman Rathomi Hur'iynazzahra Kariima Romli Ida Parwati Ismet Muchtar Nur Julia Hartati Julia Hartati Kharisma, Yuktian Maulani Nurmuji Atmapratiwi Maya Tejasari Miranti Kania Dewi Muhamad Rizky Pratama Kurniawan Rizky Mutia Nana Nadiya Amalia Nanan Sekarwana Noormartany Nugraha Sutadipura Nurizzatun Nafsi Pratama, Ryan Martin Pupung Purnamasari Raden Anita Indriyanti Revina Mayra Salsabila Hasyim Sadeli Masria Sadiah Achmad Salma Nur Afina Samsudin Surialaga Silmi Hizba Hunafa Siti Annisa Devi Trusda, Siti Annisa Devi Suganda Tanuwijaya Suganda Tanuwijaya, Suganda Susan Fitriyana Susanti Dharmmika Tety H. Rahim Titik Respati Tryando Bhatara Uci Ary Lantika Umar Islami Wida Purbaningsih Yani Triyani Yani Triyani Yenolinsky, Yolanda Yuktiana Kharisma Zulmansyah , Zulmansyah