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All Journal Lantanida Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal SainHealth Justek : Jurnal Sains Dan Teknologi Pharmed: Journal of Pharmaceutical Science and Medical Research AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Inovasi Farmasi Indonesia Borneo Journal of Medical Laboratory Technology Jumat Ekonomi: Jurnal Pengabdian Masyarakat Jumat Informatika: Jurnal Pengabdian Masyarakat Jumat Pendidikan: Jurnal Pengabdian Masyarakat Jurnal Pengabdian dan Pemberdayaan Nusantara (JPPNu) Journal of Experimental and Clinical Pharmacy (JECP) Indonesian Journal of Chemistry and Environment Jurnal Pijar MIPA Borneo Journal of Pharmacy
Khoirul Ngibad
Universitas Maarif Hasyim Latif
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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In Vitro Antioxidant Activity, Flavonoid and Phenolic Contents of 70% Methanol Extract from Purple and Yellow Passion Fruit Peel Khoirul Ngibad; Siti Nur Husnul Yusmiati; Setyo Dwi Santoso; Firda Inayah; Rizky Dwi Nur Faizi
Indonesian Journal of Chemistry and Environment Vol 6, No 2 (2023): DECEMBER 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i2.57725

Abstract

Peel of purple and yellow passion fruit has the potential to be an antioxidant. The flavonoid and total phenol compound groups are two examples of natural antioxidant compounds that can potentially be antioxidants. Many studies have used 70% methanol solvent to extract flavonoids and total phenolics from plants. The aim of this study is to analyze the potential of 70% methanol extract from the peel of purple and yellow passion fruit as an in vitro antioxidant using the DPPH method, total flavonoid, and phenolic levels. The passion fruit peel powder was macerated with 70% methanol for four days. The total flavonoid contents were determined using quercetin, and total phenols were determined using gallic acid. The 2.2-diphenyl-1-picrylhydrazyl (DPPH) was used for in vitro antioxidant activity by determining the percent inhibition of DPPH radicals. The flavonoid content in the 70% methanol extract of purple and yellow passion fruit peel is 1.2824 and 1.9775 mg QE/g extract, respectively. In contrast, the total phenolic content in 70% methanol extract of purple and yellow passion fruit peel is 15.8 and 3.6 mg GAE/g extract, respectively. The 70% methanol extract of purple passion fruit peel at a concentration of 80 mg/L resulted in a more significant percent inhibition of DPPH free radicals (72.80 %) than yellow passion fruit (64.91 %). In conclusion, the results suggest that 70 % methanol extract from purple and yellow passion fruit peel can decrease free radicals and be a natural antioxidant.Keyword: Antioxidant activity, Flavonoid, Methanol extract, Passion fruit peel, Total phenol
Antihypercholesterolemic Potential of Ethanolic Leaf Extracts of Santalum album L., Calotropis gigantea, Ziziphus spina-christi L. Khoirul Ngibad; Elis Dwi Nuryani; Tarisatus Syahlum Mukarromah; Nurisma Fadhila
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.11499

Abstract

Hyperlipidemia, especially elevated Low-Density Lipoprotein (LDL) cholesterol, is a global health problem that increases the risk of cardiovascular disease. Conventional treatment with statins is effective, but it often causes side effects. This study aims to evaluate the potential of sandalwood (Santalum album L.) leaf, biduri (Calotropis gigantea) leaf, and arabic bidara (Ziziphus spina-christi L.) leaf as an antihypercholesterolemia agent using ethanol extract to lower cholesterol levels in mice.  Extraction is carried out through maceration with 96% ethanol for 3 x 24 hours, then evaporated to produce a thick extract.  The samples used in the antihyperocholesterolterol test were extracts of Santalum album L., Calotropis gigantea, and Ziziphus spina-christi L. Six groups, six mice each, consisted of: negative control (I), positive control (II), simvastatin drug control (III), and three test dose groups (IV: 3.5 mg/20 g BW, V: 7 mg/20 g BW, VI: 14 mg/20 g BW). Cholesterol levels were measured by the Point of Care Testing (POCT) Method using a cholesterol strip test after a blood draw.  The results showed that simvastatin can lower cholesterol by 59 mg/dl. Moreover, Santalum album L. leaf extracts provided the most significant reduction in cholesterol (33 mg/dl), followed by Ziziphus spina-christi L. (31 mg/dl) and Calotropis gigantea (28 mg/dl).  Although simvastatin showed a greater decrease, the plant extract still exerted significant effects as an alternative to antihypercholesterolemia therapy. This decrease in cholesterol is related to the content of active compounds, such as flavonoids and phenolics, that reduce LDL oxidation. These findings suggest that Santalum album L. has promising potential as an herbal antihypercholesterolemic agent
Peningkatan Inovasi dan Penjualan UMKM SINOM SI MANIES CAK ENDUT melalui Strategi Pemasaran Digital Wildan Sam Aden; Erfin Erfin; Ahmad Rizal Tohari; Reza Ichsan Mashuda; Moh. Zakaria Zakki; Anita Firdaus; Moh. Mustofa; Adrian Wahyu Adi Saputra; Alfin Setya Ningrum; Ika Widya Ardhyani; Khoirul Ngibad
Jumat Ekonomi: Jurnal Pengabdian Masyarakat Vol. 3 No. 3 (2022): Desember
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas KH. A. Wahab Hasbullah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32764/abdimasekon.v3i3.3230

Abstract

The selected KKNT-KWU UMAHA partner is the traditional drink business "Sinom Si Manies Cak Endut" which was founded five years ago and is located on Jl. Raya Semambung No. 409 Lopang Hamlet, Driyorejo District, Gresik Regency. The partner's problems include the following: sinom products are only marketed by word of mouth, and through social media, sinom production is only carried out according to consumer demand. This KKNT-KWU UMAHA activity aims to help overcome partner problems in marketing using social media "Instagram". KKNT-KWU UMAHA activities include observation and discussion with partners to analyze the problems experienced by partners, assistance to partners to start marketing products through social media "Instagram" and assistance to partners to make Instagram feeds to be more attractive and modern to attract the attention of social media users "Instagram". The KKNT-KWU UMAHA activities result in partners having excellent and attractive product photos. In addition, the KKNT-KWU UMAHA activities are able to improve the MSME management process so that there is an increase in turnover and quality of partner products.
Peningkatkan Kuantitas dan Kualitas Hasil Produk Jamu tradisional Ibu Eni di Desa Sidodadi Mijen Moch Lazuardi Imani; Dendi Rinaldi; Wahyu Adi Setiawan; Nilam Maghfiroh; Afisa Asmaanis; Sulthan Al Akbar; Putri Alifia Arofah; Risma Wanda Putri; Khoirul Ngibad; Titik Sundari
Jumat Ekonomi: Jurnal Pengabdian Masyarakat Vol. 3 No. 3 (2022): Desember
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas KH. A. Wahab Hasbullah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32764/abdimasekon.v3i3.3232

Abstract

Jamu adalah obat tradisional berbahan alami warisan budaya yang telah diwariskan secara turun-temurun dari generasi ke generasi untuk kesehatan. Salah satu industri rumah tangga yang saat ini masih memproduksi jamu tradisional adalah Jamu Mbak Konik yang sudah beridiri sejak tahun 1990-an. Jamu mbak konik masih diproduksi secara tradisional dan pengemasannya masih seadanya. Tujuan kegiatan KKNT-KWU UMAHA ini adalah untuk membantu Ibu Eni selaku pemilik usaha dalam meningkatkan produksi baik secara kualitas maupun kuantitas. Metode yang dilakukan pada program KKNT-KWU UMAHA ini adalah metode kualitatif, survey, edukasi dan diskusi serta pendampingan dalam mencapai tujuan tersebut. Hasil dari kegiatan ini adalah jamu Mbak Konik dapat memiliki NIB, brand, logo, dan pembukuan keuangan. Selain itu, pemasaran yang dilakukan mitra lebih luas menggunakan media sosial.
Effectiveness Ethanol Extract of Tinospora crispa L, Cymbopogon citratus, Alpinia purpurata K Schum, and Alpinia galanga L in Lowering Mouse Cholesterol Levels Khoirul Ngibad; Dane Prastio; Evinia Eka Novem; Ragil Tri Sutrisno; Agustina Wulandari; Gaby Ayu Patricia; Cicik Wijayanti
Justek : Jurnal Sains dan Teknologi Vol 9, No 2 (2026): June
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v9i2.38814

Abstract

Hypercholesterolemia is a lipid metabolism disorder that increases the risk of cardiovascular disease. Although statins are effective, long-term use may cause side effects, prompting the exploration of natural alternatives that contain bioactive flavonoids, phenolics, and terpenoids with hypocholesterolemic activity. This study aimed to evaluate the cholesterol-lowering effects of ethanol extracts of Brotowali (Tinospora crispa L.), Lemongrass Stem (Cymbopogon citratus), Red Galangal (Alpinia purpurata K. Schum.), and White Galangal (Alpinia galanga L.) in hypercholesterolemia-induced male mice. A true experimental study was conducted using 36 male mice divided into six groups: Negative Control (I), Positive Control (II), Drug Control (Simvastatin) (III), and three extract groups (IV–VI) receiving doses of 14, 28, and 56 mg/20 g BW. After a seven-day adaptation period, the animals were administered propylthiouracil for 14 days to induce hypercholesterolemia, which was confirmed by blood cholesterol measurement on Day 15. Subsequently, simvastatin or the extracts were administered for three days, and cholesterol levels were measured on Day 18 using a spectrophotometric method. The results showed that all extracts reduced cholesterol levels compared to the Positive Control (194.65 ± 8.26 mg/dL), but were less effective than simvastatin (103.15 ± 15.54 mg/dL). Brotowali reduced levels to 140.90 ± 10.10 mg/dL; Lemongrass Stem to 143.47 ± 21.65 mg/dL. Red Galangal reached 138.79 ± 10.69 mg/dL and White Galangal 139.03 ± 16.53 mg/dL at the highest dose (56 mg/20 g BW). In conclusion, the four ethanol extracts showed potential as natural antihypercholesterolemic agents, with Red and White Galangal demonstrating the greatest cholesterol-lowering effects at a dose of 56 mg/20 g BW, although their efficacy remained lower than simvastatin.
ANTIHYPERLIPIDEMIA EFFECT OF SAGA TREE LEAF ETHANOL EXTRACT (Adenanthera pavonina L.) ON MENCIT (Mus musculus) Sofia Ayu Fernanda; Khoirul Ngibad
Indonesian Journal of Chemistry and Environment Vol. 8 No. 2 (2025): DECEMBER 2025
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v8i2.85364

Abstract

There is no consensus on the optimal dosage and mechanism of action of saga leaf ethanol extract in lowering cholesterol levels in test animals; therefore, further research is needed to understand the effectiveness and optimal dose of this plant as a hyperlipidemia therapy. This study aims to determine the optimal dose of ethanol extract from the leaves of the saga tree (Adenanthera pavonina L.) in reducing cholesterol levels in hyperlipidemic mice. The study was conducted on 36 male mice that were acclimatized for 7 days and induced hyperlipidemia using Propylthiouracil. The test animals were divided into six treatment groups, including a negative control, a positive control, a drug control (simvastatin), and three treatment groups with extract doses of 14, 28, and 56 mg/20 g body weight (BW). Cholesterol levels were measured using the spectrophotometry method, and the data were analyzed using the ANOVA test. The results of the ANOVA test showed a significance value of 0.000 (p < 0.05), indicating a difference in cholesterol levels between groups. A dose of 56 mg/20 g BW showed the highest reduction in cholesterol levels of 57.87 mg/dL. It was concluded that the ethanol extract of the leaves of the saga tree was effective in reducing the cholesterol levels of hyperlipidemic mice at an optimal dose of 56 mg/20 g BW. These results show the potential of the extract as a natural antihyperlipidemia agent that can be developed into an alternative cholesterol-lowering therapy.
POTENTIAL OF ETHANOL EXTRACT OF TURMERIC LEAVES (Curcuma longa) ON THE REDUCTION OF CHOLESTEROL LEVELS IN MICE (Mus musculus) HYPERCHOLESTEROLEMIA MODEL Putri Yoggy Mayssa Kisdiati; Khoirul Ngibad
Indonesian Journal of Chemistry and Environment Vol. 8 No. 2 (2025): DECEMBER 2025
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v8i2.85430

Abstract

Tests on the dosage and effectiveness of turmeric leaf ethanol extract in lowering cholesterol levels in animal models have never been conducted to explore its therapeutic potential. This study aims to determine the effect of turmeric leaf ethanol extract (Curcuma longa) in reducing hypercholesterolemia levels in mice. This study employed an experimental design, dividing 36 mice into six treatment groups. The treatment group consisted of a negative control, a positive control, a drug control, and three doses of turmeric leaf ethanol extract (14 mg/20 g body weight, 28 mg/20 g body weight, and 56 mg/20 g body weight). Cholesterol levels were measured using a spectrophotometer, and the results were analyzed with the ANOVA test. The results showed a significance value of 0.000, indicating a significant difference in the reduction of cholesterol levels between treatment groups (p < 0.05). Turmeric leaf ethanol extract at a dose of 56 mg/20 g body weight resulted in a reduction of 33.6 mg/dL in mouse cholesterol levels, which is higher than that observed with other doses. Turmeric leaf ethanol extract can lower cholesterol levels in mice, with a dose of 56 mg/20 g body weight providing the most significant reduction. This study demonstrates that turmeric leaf ethanol extract has the potential to serve as a natural therapeutic alternative for managing hypercholesterolemia.
Kadar Fenolik, Flavonoid Total dan Aktivitas Antioksidan Ekstrak Etanol Daun Calathea Silver Plate: Total of Phenolic, Flavonoid Content and Antioxidant Activity of Calathea Silver Plate Leaves Extract Datin An Nisa Sukmawati; Lisa Savitri; Firdania Firdaus Rosyida; Khoirul Ngibad; Hanifah Delima Nuardani
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 7 No. 1 (2025): Volume 7 No 1 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v7i1.7316

Abstract

Daun Calatea Silver Plate (CSP) merupakan tanaman hias yang memiliki karakteristik daun berwarna ungu pada bagian atasnya dan perak pada bagian bawahnya yang mengindikasikan adanya potensi bioaktivitas sebagai antioksidan. Sehingga, tujuan penelitian ini adalah untuk mengetahui dan menganalisis kadar fenolik, flavonoid total dan mengukur aktivitas antioksidan ekstrak etanol CSP. Uji kadar fenolik total menggunakan metode folin-ciocalteu dengan menggunakan asam galat sebagai senyawa standar. Sedangkan untuk uji kadar flavonoid total menggunakan metode kolorimetri dengan menggunakan AlCl3 dan senyawa kuersetin sebagai standar. Untuk uji aktivitas antioksidan menggunakan metode DPPH dan ABTS. Adapun hasil dari penelitian ini adalah ekstrak CSP mengandung senyawa fenolik dengan kadar 203,89 mg GEA/g, senyawa flavonoid dengan kadar 446 mg QE/g, memiliki aktivitas antioksidan dengan nilai IC50  75,78±2,1 terhadap DPPH dan nilai IC50 87,75±3,0 terhadap ABTS. Berdasarkan hasil tersebut dapat disimpulkan bahwa ekstrak CSP memiliki potensi sebagai antioksidan alami.
Pengaruh Kombinasi Ekstrak Daun Biduri dan Daun Saga pada Penurunan Kadar Kolesterol Mencit Hiperkolesterolemia David Khalik Arrafi Munandar; Muhammad Sungging Pradana; Khoirul Ngibad
Justek : Jurnal Sains dan Teknologi Vol 8, No 2 (2025): Juni
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v8i2.31362

Abstract

Abstract: Hyperlipidemia is a disorder marked by elevated levels of lipids in the blood, often resulting from excessive dietary fat intake. Biduri and saga leaves are known for their antihyperlipidemic properties. This research aimed to evaluate the effect of a combination of ethanol extracts from biduri (Calotropis gigantea L.) and saga (Adenanthera pavonina L.) leaves in reducing cholesterol levels in hypercholesterolemic mice. The study was conducted using mice divided into six groups: a negative control group without treatment, a positive control group administered propylthiouracil (PTU), a drug control group treated with simvastatin as a standard, and three treatment groups receiving extract combinations in ratios of 1:1, 1:2, and 2:1 at doses of 14 mg/g BW, 28 mg/g BW, and 56 mg/g BW. Cholesterol levels were measured using the spectrophotometry method. The findings demonstrated that the ethanol extract combination effectively reduced cholesterol levels and exhibited potential as a natural antihyperlipidemic agent. The most effective reduction was observed at a dose of 59.80 mg/g BW with a 1:1 ratio. These results suggest that the combination of these plant extracts could serve as a promising herbal alternative for managing hypercholesterolemia and lay the groundwork for further development of safe and accessible herbal medicines.Abstrak: Hiperlipidemia adalah gangguan yang ditandai dengan meningkatnya kadar lemak dalam darah, yang umumnya disebabkan oleh konsumsi lemak secara berlebihan. Daun biduri dan daun saga dikenal memiliki aktivitas sebagai agen penurun lipid. Penelitian ini bertujuan untuk mengkaji pengaruh kombinasi ekstrak etanol daun biduri (Calotropis gigantea L.) dan daun saga (Adenanthera pavonina L.) terhadap penurunan kadar kolesterol pada mencit yang mengalami hiperkolesterolemia. Penelitian dilakukan dengan membagi mencit ke dalam enam kelompok, yaitu kontrol negatif tanpa perlakuan, kontrol positif yang diberikan propiltiourasil (PTU), kontrol obat dengan simvastatin sebagai pembanding, serta tiga kelompok perlakuan yang menerima kombinasi ekstrak dengan rasio 1:1, 1:2, dan 2:1 pada dosis 14 mg/g BB, 28 mg/g BB, dan 56 mg/g BB. Pengukuran kadar kolesterol dilakukan menggunakan metode spektrofotometri. Hasil menunjukkan bahwa kombinasi ekstrak etanol daun biduri dan daun saga mampu menurunkan kadar kolesterol secara signifikan dan memiliki potensi sebagai agen antihiperlipidemik alami. Penurunan paling optimal dicapai pada dosis 59,80 mg/g BB dengan rasio 1:1. Kombinasi ini berpotensi menjadi alternatif pengobatan herbal yang lebih aman dan terjangkau bagi masyarakat, serta menjadi dasar dalam pengembangan fitofarmaka berbasis kombinasi tanaman.
Antihypercholesterolemic Activity of the Ethanol Extract Combination of Leaves Calotropis gigantea L. and Adenanthera pavonina L. Galuh Anggun Oktaviani; Gaby Ayu Patricia; Cicik Wijayanti; Khoirul Ngibad
Justek : Jurnal Sains dan Teknologi Vol 8, No 4 (2025): December
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v8i4.36441

Abstract

Hypercholesterolemia is a significant risk factor for cardiovascular disease, and its prevalence continues to increase. Pharmacological therapy using statins is effective but may cause side effects when used long-term. Therefore, exploring natural ingredients as an alternative antihypercholesterolemic therapy is essential. This study aimed to evaluate the activity of a combination of ethanol extracts of Calotropis gigantea L. leaves and Adenanthera pavonina L. on the cholesterol levels of male mice induced with propylthiouracil (PTU). The study was conducted experimentally using a post-test-only control-group design with 36 male mice divided into six groups: negative control, positive control, drug control (simvastatin), and three treatment groups receiving extract combinations at doses of 14, 28, and 56 mg/g BW. The research stages included seven days of animal adaptation, induction of hypercholesterolemia with PTU for 14 days, administration of the extract combination at doses of 14, 28, and 56 mg/g BW for four days, and blood sampling for total cholesterol measurement using an automated chemical spectrophotometer. The results showed a significant increase in cholesterol levels in the positive control group, while simvastatin produced the most significant reduction. The extract combination gradually decreased cholesterol levels with increasing dose, with the highest dose approaching the effect of simvastatin. The paired t-test showed a p-value < 0.05, indicating significant differences between treatments. The combination of Calotropis gigantea L. and Adenanthera pavonina L. leaf extracts has potential as a herbal agent to support antihypercholesterolemic therapy.
Co-Authors Adrian Wahyu Adi Saputra Afisa Asmaanis Agustina Wulandari Ahmad Rizal Tohari Ajeng Setya Apriolivia Alfin Setya Ningrum Allifa Hanna Rizki Anita Firdaus Anton Yuntarso Asma'ul Fadlillah Brilliant Margalin Cakra Haryo Wibowo Cicik Wijayanti Dane Prastio Datin An Nisa Sukmawati David Khalik Arrafi Munandar Dendi Rinaldi Dheasy Herawati Dwi Nur Qoiriyah Elis Dwi Nuryani Erfin Erfin Erfin Essy Oktarina Evinia Eka Novem Fahlia Nirmala Firda Inayah Firdania Firdaus Rosyida Gaby Ayu Patricia Galuh Anggun Oktaviani Halik Wijaya Hanifah Delima Nuardani Ika Widya Ardhyani Khairil Anam Kholifatuz Zumaroh Khotmil Ula Lisa Savitri M Farkhan Moch Lazuardi Imani Moh. Mustofa Moh. Zakaria Zakki Mouza Sutra Karmelia Putri Vito Muh Sungging Pradana Muhamad Agung Laksono Muhammad Sungging Pradana Muji Harsini Mukti Ali Nevita Lexia Nilam Maghfiroh Novia Afriani Donatomo Nurisma Fadhila Putri Alifia Arofah Putri Yoggy Mayssa Kisdiati Rafika Destiana Wardani Ragil Tri Sutrisno Raymond F Runtu Reza Ichsan Mashuda Risma Wanda Putri Rizky Dwi Nur Faizi Sembilu, Nambi Setyo Dwi Santoso Sholikudin Sholikudin Siti Nur Husnul Yusmiati Sofia Ayu Fernanda Subagyo Subagyo Sulthan Al Akbar Tarisatus Syahlum Mukarromah Titik Sundari Valenata Valenata Vega Permadani Veronica Nindi Rihi Violya Desta Prananda Wahyu Adi Setiawan Wahyu Ningsih Wildan Sam Aden Yosi Nur Susilawati Yusanti Ervina Zelika Nur Jannah