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All Journal Lantanida Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal SainHealth Justek : Jurnal Sains Dan Teknologi Pharmed: Journal of Pharmaceutical Science and Medical Research AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Inovasi Farmasi Indonesia Borneo Journal of Medical Laboratory Technology Jumat Ekonomi: Jurnal Pengabdian Masyarakat Jumat Informatika: Jurnal Pengabdian Masyarakat Jumat Pendidikan: Jurnal Pengabdian Masyarakat Jurnal Pengabdian dan Pemberdayaan Nusantara (JPPNu) Journal of Experimental and Clinical Pharmacy (JECP) Indonesian Journal of Chemistry and Environment Jurnal Pijar MIPA Borneo Journal of Pharmacy
Khoirul Ngibad
Universitas Maarif Hasyim Latif
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Effectiveness of Ethanol Extract Dosage of Arabian Bidara Leaf (Zizphus spina-christi (L.) Desf.) on Reduction of Hypercholesterolemia in Mus musculus Valenata Valenata; Gaby Ayu Patricia; Khoirul Ngibad
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1449

Abstract

Hypercholesterolemia is one of the main risk factors for cardiovascular disease, which is characterized by increased cholesterol levels in the blood. The leaves of Ziziphus spina-christi (Arabian bidara) are known to contain flavonoids, saponins, tannins, and alkaloids that have the potential to provide antihypercholesterolemia effects. This study aimed to evaluate the effectiveness of ethanol extract of Z. spina-christi leaves on the reduction of total cholesterol in hypercholesterolemia mice. Extraction is carried out by the maceration method using 96% ethanol and produces a yield of 3.8%. A total of 36 male mice were divided into six groups (n=6): negative control, positive control (propylthiouracil induction), drug control (simvastatin), and three extract treatment groups with doses of 14, 28, and 56 mg/20 g BB. The treatment was given orally for four days, then cholesterol levels were analyzed using the enzymatic method CHOD-PAP. The results showed that the positive control cholesterol levels increased significantly (189.3 ± 6.2 mg/dL) compared to the negative control (112.7 ± 10.3 mg/dL). The administration of the extract lowered cholesterol levels gradually: 170.4 ± 6.3 mg/dL (10%), 159.6 ± 7.6 mg/dL (15.7%), and 147.3 ± 11.7 mg/dL (22.2%). Simvastatin decreased more (117.7 ± 12.5 mg/dL; 37.8%). It was concluded that bidara arabic leaf extract has antihypercholesterolemia potential with a multifactorial mechanism, although its effectiveness is lower than that of simvastatin.
Co-Authors Adrian Wahyu Adi Saputra Afisa Asmaanis Agustina Wulandari Ahmad Rizal Tohari Ajeng Setya Apriolivia Alfin Setya Ningrum Allifa Hanna Rizki Anita Firdaus Anton Yuntarso Asma'ul Fadlillah Brilliant Margalin Cakra Haryo Wibowo Cicik Wijayanti Dane Prastio Datin An Nisa Sukmawati David Khalik Arrafi Munandar Dendi Rinaldi Dheasy Herawati Dwi Nur Qoiriyah Elis Dwi Nuryani Erfin Erfin Erfin Essy Oktarina Evinia Eka Novem Fahlia Nirmala Firda Inayah Firdania Firdaus Rosyida Gaby Ayu Patricia Galuh Anggun Oktaviani Halik Wijaya Hanifah Delima Nuardani Ika Widya Ardhyani Khairil Anam Kholifatuz Zumaroh Khotmil Ula Lisa Savitri M Farkhan Moch Lazuardi Imani Moh. Mustofa Moh. Zakaria Zakki Mouza Sutra Karmelia Putri Vito Muh Sungging Pradana Muhamad Agung Laksono Muhammad Sungging Pradana Muji Harsini Mukti Ali Nevita Lexia Nilam Maghfiroh Novia Afriani Donatomo Nurisma Fadhila Putri Alifia Arofah Putri Yoggy Mayssa Kisdiati Rafika Destiana Wardani Ragil Tri Sutrisno Raymond F Runtu Reza Ichsan Mashuda Risma Wanda Putri Rizky Dwi Nur Faizi Sembilu, Nambi Setyo Dwi Santoso Sholikudin Sholikudin Siti Nur Husnul Yusmiati Sofia Ayu Fernanda Subagyo Subagyo Sulthan Al Akbar Tarisatus Syahlum Mukarromah Titik Sundari Valenata Valenata Vega Permadani Veronica Nindi Rihi Violya Desta Prananda Wahyu Adi Setiawan Wahyu Ningsih Wildan Sam Aden Yosi Nur Susilawati Yusanti Ervina Zelika Nur Jannah