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All Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Pharmaceutical Journal of Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal of Pharmaceutical (JOP) CERATA Journal of Community Empowerment
Melati Permata Hati
Universitas Muhammadiyah Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengaruh Kombinasi Matriks terhadap Karakter Tablet Metformin HCl Lepas Lambat Sistem Floating Effervescent Hati, Melati Permata
Pharmaceutical Journal of Indonesia Vol. 7 No. 2 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.007.02.3

Abstract

The research aimed to prepare and evaluate of sustained release metformin HCl tablet with floating system. The tablets were prepared by wet granulation using HPMC K4M and chitosan as matrixes with proportions (w/w) 17.78%:4.44%; 14.44%:7.78%; 11.11%:11.11% ;7.78%;14.44%; 4.44%:17.78%. The tablets were evaluated of weight variation, drug content, hardness, friability, and in vitro floating and drug release studies. The dissolution study had been carried out for 6 hours using USP dissolution apparatus II (paddle) in 900 ml HCl pH 3.0 media at 37±0.50C. All tablet formulas showed closed similarity with the requirement physical tablet of United State Pharmacopea (USP) and Farmakope Indonesia reference. The matrixes containing higher HPMC K4M, and lower chitosan showed floating lag time decreased and duration time increased. Meanwhile, tablet disintegration was the lowest. The release test showed that all formulas did not meet the requirements dissolution metformin HCl sustained release tablet. The result of this study is sustained release tablet metformin HCl with matrixes HPMC K4M and chitosan able to float, but it did not form sustained release.
Co-Authors Abdul Rahman Wahid Alvi Kusuma Wardani Anjeli Amalia Anna Pradiningsih Atis Anggraini Baiq Leny Nopitasari Baiq Lenysia Puspita Anjani Baiq Nurbaety Cyntiya Rahmawati Dian Ratna Rianti Dzun Haryadi Ittiqo Dzun Haryadi Ittiqo Furqani, Nur Furqoni, Nur Irjayanti, Nining Irmatika Hendriyani Ittiqo, Dzun Haryadi Ittiqoa, Dzun Haryadi Nadya Silva Rosa Nur Furqani Nur Furqoni Nurbaetya, Baiq Nurul Qiyaam, Nurul Octariana Sofyan Pratama, Rafli Renaldy Putri Jeniti Putu Gede Suriya Gunawan Rafli Adnan Riza Ragil Puspita Megaranu Safwan Safwan Setiawan Dwi Anggoro Shah Iqbal Ikraman Akbar Sugara, Taufan Hadi Taufan Hari Sugara Wahid, Abdul Rahman Yuli Fitriana Yuli Fitriana Yuli Fitriani