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Hubungan Karakteristik, Hiperglikemi, dan Kerusakan Saraf Pasien Neuropati Diabetik di RSMH Palembang Periode 1 Januari 2013 Sampai Dengan 30 November 2014 Suri, Muthiah Hasnah; Haddani, Hasnawi; Sinulingga, Sadakata
JURNAL KEDOKTERAN DAN KESEHATAN Vol 2, No 3 (2015): OKTOBER 2015
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Neuropati diabetik merupakan komplikasi tersering dari penyakit diabetik. Faktor risiko yang mempengaruhi timbulnya neuropati diabetik adalah lamanya menderita DM, pertambahan usia, jenis kelamin, dan hiperglikemi. Kerusakan saraf pada neuropati diabetik dapat diketahui dengan pemeriksaan ENMG. Tujuan penelitian ini untuk menganalisis hubungan karakteristik, hiperglikemi, dan kerusakan saraf pada pasien neuropati diabetik berdasarkan pemeriksaan ENMG. Metode penelitian adalah analitik observasional dengan desain cross sectional. Sebanyak 63 sampel diambil dari rekam medis dan hasil pemeriksaan ENMG pasien neuropati diabetik di RSMH Palembang periode tahun 2013-2014. Hasil didapatkan penderita neuropati diabetik perempuan 32 orang (50,8%), laki-laki 31 orang (49,2%), usia <55 tahun 25 orang (39,7%), usia >55 tahun 38 orang (60,3%), lama menderita DM <5 tahun 13 orang (20,63%), lama menderita DM >5 tahun 50 orang (79,37%), kadar HbA1C <8 31 orang (49,21), dan kadar HbA1C >8 32 orang (50,79%). Kerusakan saraf tipe axonal-demyelinating 44 orang (69,8%) dan tipe demyelinating 19 orang (30,2%). Tidak ada hubungan antara usia dan kerusakan saraf (p=0,796). Tidak ada hubungan antara jenis kelamin dan kerusakan saraf (p=0,066). Tidak ada hubungan antara lama menderita DM dan kerusakan saraf (p=0,169). Ada hubungan antara kadar HbA1C dan kerusakan saraf (p=0,045; OR 3,13; CI95% 1,002-9,774). Kesimpulan didapatkan tidak ada hubungan antara usia, jenis kelamin, lamanya menderita DM dan kerusakan saraf. Ada hubungan hiperglikemi dan kerusakan saraf.

Hubungan Karakteristik, Hiperglikemi, dan Kerusakan Saraf Pasien Neuropati Diabetik di RSMH Palembang Suri, Muthiah Hasnah; Haddani, Hasnawi; Sinulingga, Sadakata
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 4, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.V4I1.7957

Neuropati diabetik merupakan komplikasi tersering dari penyakit diabetik. Faktor risiko yang mempengaruhi timbulnya neuropati diabetik adalah lamanya menderita DM, pertambahan usia, jenis kelamin, dan hiperglikemi. Kerusakan saraf pada neuropati diabetik dapat diketahui dengan pemeriksaan ENMG. Tujuan penelitian ini untuk menganalisis hubungan karakteristik, hiperglikemi, dan kerusakan saraf pada pasien neuropati diabetik berdasarkan pemeriksaan ENMG. Metode penelitian adalah analitik observasional dengan desain cross sectional. Sebanyak 63 sampel diambil dari rekam medis dan hasil pemeriksaan ENMG pasien neuropati diabetik di RSMH Palembang periode tahun 2013-2014. Hasil didapatkan penderita neuropati diabetik perempuan 32 orang (50,8%), laki-laki 31 orang (49,2%), usia <55 tahun 25 orang (39,7%), usia >55 tahun 38 orang (60,3%), lama menderita DM <5 tahun 13 orang (20,63%), lama menderita DM >5 tahun 50 orang (79,37%), kadar HbA1C <8 31 orang (49,21), dan kadar HbA1C >8 32 orang (50,79%). Kerusakan saraf tipe axonal-demyelinating 44 orang (69,8%) dan tipe demyelinating 19 orang (30,2%). Tidak ada hubungan antara usia dan kerusakan saraf (p=0,796). Tidak ada hubungan antara jenis kelamin dan kerusakan saraf (p=0,066). Tidak ada hubungan antara lama menderita DM dan kerusakan saraf (p=0,169). Ada hubungan antara kadar HbA1C dan kerusakan saraf (p=0,045; OR 3,13; CI95% 1,002-9,774). Kesimpulan didapatkan tidak ada hubungan antara usia, jenis kelamin, lamanya menderita DM dan kerusakan saraf. Ada hubungan hiperglikemi dan kerusakan saraf.

Karakteristik Penderita Polineuropati Akibat Penggunaan Fenitoin di Poliklinik Saraf RSUP Dr. Mohammad Hoesin Palembang Handayani, Sri; Veny, Veny; Haddani, Hasnawi; Marisdina, Selly; Bahar, Erial
Sriwijaya Journal of Medicine Vol. 2 No. 1 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Fenitoin merupakan antikonvulsi yang sering digunakan untuk mengobati kejang umum tonik-klonik, kejang parsial, dan status epileptikus. Salah satu efek samping dari penggunaan fenitoin adalah polineuropati. Di Indonesia sendiri, belum ada data mengenai kejadian polineuropati akibat penggunaan fenitoin. Penelitian ini bertujuan untuk mengetahui karakteristik penderita polineuropati secara klinis maupun elektrofisiologi pada pengguna fenitoin yang berobat ke Poliklinik Saraf RSMH Palembang periode Januari 2017 sampai Maret 2017. Penelitian ini merupakan penelitian deskriptif dengan metode cross sectional pada 23 sampel yang memenuhi kriteria inklusi dari bulan Januari 2017 â€“ Maret 2017. Dilakukan analisis univariat untuk melihat distribusi sampel penelitian, analisis bivariat chi-squareuntuk menilai hubungan antara polineuropati dengan variabel independen, dan untuk melihat faktorâ€“faktor yang berhubungan dengan terjadinya polineuropati secara terintegrasi dilakukan analisis logistik regresi. Proporsi kejadian polineuropati secara klinis pada pengguna fenitoin di Poliklinik RSUP Dr. Mohammad Hoesin Palembang sebesar 26,1%, sedangkan proporsi kejadian polineuropati secara elektrofisiologi sebesar 30,4%. Penelitian ini menunjukkan bahwa banyaknya antikonvulsi yang digunakan dan durasi penggunaan fenitoin berhubungan dengan kejadian polineuropati.

Hubungan Karakteristik, Hiperglikemi, dan Kerusakan Saraf Pasien Neuropati Diabetik di RSMH Palembang Muthiah Hasnah Suri; Hasnawi Haddani; Sadakata Sinulingga
Biomedical Journal of Indonesia Vol. 4 No. 1 (2018): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Neuropati diabetik merupakan komplikasi tersering dari penyakit diabetik. Faktor risiko yang mempengaruhitimbulnya neuropati diabetik adalah lamanya menderita DM, pertambahan usia, jenis kelamin, dan hiperglikemi.Kerusakan saraf pada neuropati diabetik dapat diketahui dengan pemeriksaan ENMG. Tujuan penelitian ini untukmenganalisis hubungan karakteristik, hiperglikemi, dan kerusakan saraf pada pasien neuropati diabetikberdasarkan pemeriksaan ENMG. Metode penelitian adalah analitik observasional dengan desain cross sectional.Sebanyak 63 sampel diambil dari rekam medis dan hasil pemeriksaan ENMG pasien neuropati diabetik di RSMHPalembang periode tahun 2013-2014. Hasil didapatkan penderita neuropati diabetik perempuan 32 orang (50,8%),laki-laki 31 orang (49,2%), usia <55 tahun 25 orang (39,7%), usia >55 tahun 38 orang (60,3%), lama menderita DM<5 tahun 13 orang (20,63%), lama menderita DM >5 tahun 50 orang (79,37%), kadar HbA1C <8 31 orang (49,21),dan kadar HbA1C >8 32 orang (50,79%). Kerusakan saraf tipe axonal-demyelinating 44 orang (69,8%) dan tipedemyelinating 19 orang (30,2%). Tidak ada hubungan antara usia dan kerusakan saraf (p=0,796). Tidak adahubungan antara jenis kelamin dan kerusakan saraf (p=0,066). Tidak ada hubungan antara lama menderita DM dankerusakan saraf (p=0,169). Ada hubungan antara kadar HbA1C dan kerusakan saraf (p=0,045; OR 3,13; CI95%1,002-9,774). Kesimpulan didapatkan tidak ada hubungan antara usia, jenis kelamin, lamanya menderita DM dankerusakan saraf. Ada hubungan hiperglikemi dan kerusakan saraf.

CORRELATION BETWEEN CHRONIC PAIN WITH DEPRESSION AND ANXIETY DISORDERS IN PATIENTS AT RSUP DR MOHAMMAD HOESIN PALEMBANG Henry Sugiharto; Hasnawi Haddani; Yusril Yusril; Nia Elisa Ginting; Erial Bahar
Majalah Kedokteran Sriwijaya Vol 52, No 2 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i2.11970

The International Association for the Study of Pain defines pain as an unpleasant sensory and emotional experience related to the actual or potential damage to a tissue. Recent research reports 30% - 60% of the incidence of pain in depression and anxiety. Both of these conditions affect the quality and function of life of patients with chronic pain. This study was observational analytic research with a cross-sectional study. The subject of this study was the patien with chronic pain treated at Dr. Moh. Hoesin Palembang. Determination of pain level was assessed by Numeric Pain Rating Scale (NPRS) and Functional Pain Scale (FPS). Determination of depression is valued by Beck Depression Inventory II (BDI II) and determination of anxiety with the Beck Anxiety Inventory (BAI). Statistical analysis using a correlation test, is a method to find relationships between variables with a confidence level of 95%, significant if p <0.05. In this study there were 78 patients with chronic pain where the correlation between NPRS scores and depression disorders with a correlation of 35.3% and a p-value of 0.002 showed significant. The correlation between NPRS scores and anxiety disorders with a correlation was 43.5% with and p-value 0,000 which showed a significant correlation. Correlation between FPS score and depression disorders was 33.1% and p-value of 0.003 which showed a significant correlation. Correlation between FPS score and anxiety disorders was 20.8% with a p-value of 0.068 showed not significant correlation. There was a significant correlation between chronic pain with depression and anxiety disorders.

PROFIL PENDERITA KEMOTERAPI YANG MENDERITA POLINEUROPATI DI RSUP MOHAMMAD HOESIN PALEMBANG PERIODE 01 JANUARI 2017 SAMPAI DENGAN 30 MARET 2017 Muhammad Hasnawi Haddani; Nursaenah Karindang
Majalah Kedokteran Sriwijaya Vol 51, No 3 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i3.9192

Polineuropati adalah suatu keadaan yang ditandai dengan gangguan fungsi dan atau struktur yang mengenai banyak saraf tepi, bersifat simetris dan bilateral ditandai dengan gejala seperti rasa kesemutan, mati rasa dan nyeri terbakar. Salah satu faktor yang diduga berhubungan dengan timbulnya polineuropati antara lain penggunaan obat tertentu. Penelitian ini bertujuan untuk mengetahui profil penderita kemoterapi yang menderita polineuropati di RSUP Mohammad Hoesin Palembang periode 01 januari 2017 sampai dengan 31 maret 2017. Penelitian cross sectional dengan menggunakan data primer berbasis rumah sakit dari penderita yang diperiksa dipoli ENMG RSUP Dr.Mohammad Hoesin Palembang dalam rentang waktu 1 januari 2017 hingga 31 maret 2017. Dari 52 subyek yang mendapatkan kemoterapi didapatkan 32 subyek yang menderita polineuropati akibat kemoterapi, Proporsi angka kejadian polineuropati sebesar 60,1%. Prevalensi penderita polineuropati pada pasien kemoterapi paling besar pada penggunaan obat kemoterapi kombinasi (84.5%). Penelitin ini didapatkan gambaran 12 subyek dengan TCSS ringan yang menggunakan obat kombinasi, 2 subyek dengan TCSS ringan yang menggunakan obat anti metabolit, 1 subyek dengan TCSS ringan yang menggunakan obat Targeting terapi. 13 subyek dengan TCSS sedang yang menggunakan obat kombinasi, 2 subyek dengan TCSS sedang yang menggunakan obat platinum, dan 2 subyek dengan TCSS berat yang menggunakan obat kombinasi. Dua belas subyek dengan TCSS ringan yang menderita polineuropati axonal demielinating dan 3 subyek normal. Empat belas subyek dengan TCSS sedang yang menderita polineuropati axonal demielinating dan 1 subyek normal. Dua subyek dengan TCSS berat semua menderita polineuropati axonal demielinating.

Efficacy of Alpha Lipoic Acid Supplementation In Chemotherapy-Induced Peripheral Neuropathy Mediarty Syahrir; Yenny Dian Andayani; Norman Djamaludin; Erty Sundarita Maksudin; Putri Farissa Muharramah; Kgs. M. Rosyidi; Hasnawi Haddani; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.162

Background. Chemotherapy-induced peripheral neuropathy is a side effect of several chemotherapy drugs and a significant cause of chronic pain in cancer patients, which affects patients' long-term quality of life. The neurotoxic chemotherapy agents most reported to cause neuropathic pains are platinum and taxane. This study aimed to determine the efficacy of alpha-lipoic acid supplementation in chemotherapy patients. Methods. This study used a randomized, double-blind clinical trial in the oncology haematology clinic in the Department of Internal Medicine at Mohammad Hoesin General Hospital Palembang from November 2018 to July 2019. Samples were taken from patients who met the inclusion criteria and signed informed consent forms to join the study. This studyused SPSS version 22.0 for Windows to analyze the data. Results. This research studied 30 subjects who were divided into alpha lipoic acid groups and placebo groups with 15 samples each. The alpha-lipoic acid group showed a significant decline in the Toronto Clinical Scoring System (TCSS) after treatment (p = 0.000) compared to the placebo group (p = 0.164). Conclusions. Treatment with a 600 mg single dose each day of alpha-lipoic acid for 12 weeks effectively improved patients condition significantly.

Efficacy of Lidocaine and Ketamine Combination on Reduction of Pain Intensity, Improvement of Functional State and Central Desensitization of Chronic Low Back Pain Henry Sugiharto; Hasnawi Haddani; Yuki Fitria; Rizal Zainal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.167

Abstract Background: Chronic low back pain (LBP) prevalence is approximately 20% of world population. Central and peripheral sensitization are considered as the main mechanism of pain chronification. This study hypothesize that lidocaine and ketamine combination reduces pain intensity, improves functional state and central desensitization of chronic low back pain. It is by modulating central sensitization in sub-anesthetic dose, prolonging inactivation of Na-channel, blocking NMDA-receptor and preventing secondary hyperalgesia. Aim of study: To evaluate the efficacy of lidocaine and ketamine combination on the intensity of pain, functional state and central desensitization of chronic low back pain. Methods:. This double blind randomized control trial study was carried out in Mohammad Hoesin General Hospital, Palembang, Indonesia from May 2018 to January 2019. A total of 20 patients with low back pain that last for more than 3 months, aged >18 years old, of either sex who were willing to be enrolled in this study, were randomly allocated into one of the two groups of 10 each. The treatment group (n=10) received standardized therapy (analgesic and physiotherapy) + intravenous ketamine 0.5 mg/kg + lidocaine 2 mg/kg and the control group (n=10) received standardized therapy + 100 ml Nacl 0.9%. Pain intensity, functional state, and central desensitization were measured before the treatment, day 7 after treatment, and a month after treatment using Numeric Pain Rating Scale (NPRS), Functional Pain Scale (FPS), and Central Sensitization Inventory (CSI). Results: The administration of ketamine 0.5 mg/kg + lidocaine 2 mg/kg resulted in NPRS and CSI changes was effective since the 7th day post intervention (p-value=0.021 and p-value=0.001) while on FPS changes, it was effective since the 30th day post intervention (p-value=0.000) Conclusion: From the result, it could be concluded that the administration of ketamine and lidocaine is effective on decreasing pain intensity and central desensitization in chronic LBP.

Efficacy of Alpha Lipoic Acid Supplementation In Chemotherapy-Induced Peripheral Neuropathy Mediarty Syahrir; Yenny Dian Andayani; Norman Djamaludin; Erty Sundarita Maksudin; Putri Farissa Muharramah; Kgs. M. Rosyidi; Hasnawi Haddani; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.162

Background. Chemotherapy-induced peripheral neuropathy is a side effect of several chemotherapy drugs and a significant cause of chronic pain in cancer patients, which affects patients' long-term quality of life. The neurotoxic chemotherapy agents most reported to cause neuropathic pains are platinum and taxane. This study aimed to determine the efficacy of alpha-lipoic acid supplementation in chemotherapy patients. Methods. This study used a randomized, double-blind clinical trial in the oncology haematology clinic in the Department of Internal Medicine at Mohammad Hoesin General Hospital Palembang from November 2018 to July 2019. Samples were taken from patients who met the inclusion criteria and signed informed consent forms to join the study. This studyused SPSS version 22.0 for Windows to analyze the data. Results. This research studied 30 subjects who were divided into alpha lipoic acid groups and placebo groups with 15 samples each. The alpha-lipoic acid group showed a significant decline in the Toronto Clinical Scoring System (TCSS) after treatment (p = 0.000) compared to the placebo group (p = 0.164). Conclusions. Treatment with a 600 mg single dose each day of alpha-lipoic acid for 12 weeks effectively improved patients condition significantly.

Efficacy of Lidocaine and Ketamine Combination on Reduction of Pain Intensity, Improvement of Functional State and Central Desensitization of Chronic Low Back Pain Henry Sugiharto; Hasnawi Haddani; Yuki Fitria; Rizal Zainal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.167

Abstract Background: Chronic low back pain (LBP) prevalence is approximately 20% of world population. Central and peripheral sensitization are considered as the main mechanism of pain chronification. This study hypothesize that lidocaine and ketamine combination reduces pain intensity, improves functional state and central desensitization of chronic low back pain. It is by modulating central sensitization in sub-anesthetic dose, prolonging inactivation of Na-channel, blocking NMDA-receptor and preventing secondary hyperalgesia. Aim of study: To evaluate the efficacy of lidocaine and ketamine combination on the intensity of pain, functional state and central desensitization of chronic low back pain. Methods:. This double blind randomized control trial study was carried out in Mohammad Hoesin General Hospital, Palembang, Indonesia from May 2018 to January 2019. A total of 20 patients with low back pain that last for more than 3 months, aged >18 years old, of either sex who were willing to be enrolled in this study, were randomly allocated into one of the two groups of 10 each. The treatment group (n=10) received standardized therapy (analgesic and physiotherapy) + intravenous ketamine 0.5 mg/kg + lidocaine 2 mg/kg and the control group (n=10) received standardized therapy + 100 ml Nacl 0.9%. Pain intensity, functional state, and central desensitization were measured before the treatment, day 7 after treatment, and a month after treatment using Numeric Pain Rating Scale (NPRS), Functional Pain Scale (FPS), and Central Sensitization Inventory (CSI). Results: The administration of ketamine 0.5 mg/kg + lidocaine 2 mg/kg resulted in NPRS and CSI changes was effective since the 7th day post intervention (p-value=0.021 and p-value=0.001) while on FPS changes, it was effective since the 30th day post intervention (p-value=0.000) Conclusion: From the result, it could be concluded that the administration of ketamine and lidocaine is effective on decreasing pain intensity and central desensitization in chronic LBP.

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