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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Kedokteran Sriwijaya SRIWIJAYA JOURNAL OF MEDICINE Bioscientia Medicina : Journal of Biomedicine and Translational Research Bali Dermatology and Venereology Journal Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal
Yulia Farida Yahya
Dermatology And Venereology Department, Faculty Of Medicine Universitas Sriwijaya. Palembang. Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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KORELASI NILAI AUTOLOGOUS PLASMA SKIN TEST DAN SERUM C-REACTIVE PROTEIN PADA URTIKARIA KRONIS SPONTAN Garfendo, Grady; Husan, Nopriyati; Yahya, Yulia Farida; Bahar, Erial; Thaha, Mohammad Athuf; Kurniawati, Yuli
Media Dermato-Venereologica Indonesiana Vol 51 No 1 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i1.422

Abstract

Urtikaria Kronis Spontan (UKS) berdampak signifikan pada kualitas hidup pasien. Autologous Plasma Skin Test (APST) dan C-reactive protein (CRP) merupakan skrining praktis pada UKS. Hasil positif disebab- kan oleh sitokin inflamatorik saat degranulasi sel mast dan dapat berkorelasi dengan keparahan UKS. Studi analitik observasional dengan desain potong-lintang dilakukan selama bulan Juli-September 2021 melibatkan lima puluh pasien UKS berusia 17-51 tahun. Keparahan penyakit dinilai menggunakan Urticaria Activity Score (UAS7). Hasil APST dinilai berdasarkan kriteria Sabroe. Nilai serum CRP diukur menggunakan high sensitiv- ity CRP (hsCRP). Hasil APST positif ditemukan pada hampir semua pasien (95%) dan hanya empat pasien dengan CRP positif (8%). Keparahan berkorelasi bermakna terhadap diameter urtika (P = 0,038) dan nilai CRP (P = 0,041). Analisis odds ratio (OR) menunjukkan bahwa pasien dengan hasil APST positif memiliki risiko 32 kali mengalami UKS sedang-berat. Tidak ditemukan korelasi bermakna antara nilai APST dan serum CRP pada UKS.
Effectiveness of 5% Channa Striata Extract Gel in Wound Healing: A Double-blind Randomized Controlled Trial Yahya, Yulia Farida; Kurniawati, Yuli; Bahar, Erial; Toruan, Theresia Lumban; Kartowigno, Soenarto; Purwoko, Muhammad Izazi Hari; Octyvani, Tiar Marina
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Snakehead fish (Channa striata, CS) has traditionally been used in Indonesia as a nutrient to promote wound healing. It contains protein highly similar to human protein, which may be involved in wound healing via biological pathways. We aim to determine the effectiveness of the topical 5% CS extract gel in promoting wound healing. Methods: A double-blind, placebo-controlled randomized clinical trial was conducted from June to August 2022 at the Department of Dermatology, Venereology, and Aesthetics of Dr. Mohammad Hoesin Hospital. We allocated 32 post-skin surgery participants with grade I acute superficial wounds on the face, neck, trunk, and extremities into 2 groups with one receiving 5% CS (n=16) and the other receiving placebo (n=16). Both groups applied the treatments twice daily. Assessments of wound healing using modified REEDA (redness, edema, ecchymosis, drainage, approximation) score, wound size, and adverse effects were done at follow-up days 1, 3, and 7. Results: Both groups showed REEDA score improvements on days 1, 3, and 7, with significant difference between both groups identified on day 3 (p=0.038). Wound size improved at each follow-up in all participants, with the 5% CS group being slightly better than the placebo group on day 3 (p>0.05). A mild adverse event was found in only one participant in the 5% CS group (3.1%). Conclusion: Both 5% CS extract gel and placebo had good safety profile and were effective in promoting wound healing. 5% CS extract gel was better at reducing REEDA score.
Association between vitamin D and cholesterol in post-acne hypertrophic scars and keloids: A cross-sectional study Kurniawati, Yuli; Yahya, Yulia Farida; Diba, Sarah; Novriani, Rina; Yusuf, Hasbiallah; Martgaredta, Ekta
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Post-acne hypertrophic scars and keloids result from abnormal wound healing within the pilosebaceous unit. Ruptured microcomedones create wounds that can lead to prolonged inflammation, increased collagen synthesis, and fibrinolysis inhibition, resulting in elevated scar tissue in acne lesions. Vitamin D deficiency can lead to prolonged inflammation and damage to dermal collagen. High total cholesterol levels can lead to excessive sebum production, exacerbating inflammation and fibrosis. This study aimed to determine the association between serum vitamin D and total cholesterol levels with scar severity in patients with post-acne hypertrophic scars and keloids. Methods: This analytical cross-sectional study was conducted at Dr. Mohammad Hoesin General Hospital, Palembang, South Sumatera, Indonesia, among patients who met the inclusion and exclusion criteria. Scar severity was assessed using the Vancouver Scar Scale (VSS). Blood samples were collected for examination of serum vitamin D and total cholesterol. The data were analyzed statistically. Results: Chi-square test of serum vitamin D with VSS scores showed a significant association (p-value = 0.007), while total cholesterol with VSS showed no association (p-value = 1.000). Odd-ratio (OR) for serum vitamin D and VSS was 60, concluding that vitamin D deficiency increased the risk of high VSS by 60-fold in study patients. Conclusion: There was a significant association between serum vitamin D levels and VSS score, while there was no association between total cholesterol and VSS score. Deficiency of serum vitamin D is associated with a higher risk of developing a higher VSS score in patients with post-acne hypertrophic scars and keloids.
Co-Authors Adi Agung Anantawijaya Daryogo Antonius, Cayadi Sidarta aryani, Inda astri Aurelia Stephanie Candra, Nofilia Citra Cyntya Sari Sovianti Damai Trilisnawati Damai Trislinawati Daryago, Adi Agung Anantawijaya Deddy Deddy Diba, Sarah Dimas Ega Wijaya Putra Dwi Handayani Emirzon, M. Afif Baskara Erial Bahar, Erial Fantoni, Odelia Jovita Jusuf Fifa Argentina Findrapase, Riri Puspa Putri Fitriani Fitriani Fitriani Garfendo, Grady Hari Darmawan Husan, Nopriyati Iche Andriyani Liberty, Iche Andriyani Ika Kartika Inda Astri Inda Astri Aryani Indah Astri Aryani Irsan Saleh Jatmiko, Pandu Haryo Kartowigno, Soenarto Kiki Septiafni Martgaredta, Ekta Muhammad Irsan Saleh Mutia Devi Mutia Devi Nabila, Dewa Ayu Bulan Neubrina Raesuky Sukamto Nina Roiana Nina Roiana Nopriyati Nopriyati, Nopriyati Novriani, Rina Nugroho, Suroso Adi Nur Riviati, Nur Octyvani Vani Octyvani, Tiar Marina Purwoko, Izazi Hari Radema A Pranata Radema Maradom Rahmadini, Meirina Rosi Andarina Rusmawardiana Rusmawardiana, Rusmawardiana Saputra, M. Akip Riyan Sarah Diba Sari, Zahra Ayu Lukita Shalini Nadarajah Soenarto Kartowigno Soenarto Kartowigno Stephanie, Aurelia Suprapti Suprapti Thaha, Mohammad Athuf Tiar Marina Toruan, Theresia L Toruan, Theresia Lumban Trilisnawati, Damai Widyastuti Yuli Kurniawati, Yuli Yusuf, Hasbiallah Zahra Ayu Lukita Sari