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Kajian Penggunaan Antidiabetik dan Hubungannya Dengan Kontrol Glikemik Pada Pasien Diabetes Mellitus Tipe II Dengan Nefropati Diabetik Oktaviani, Emy; Indriani, Lusi; Kholilah , Siti
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art5

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by increased blood sugar levels (> 200 mg/dL). It occurs due to impaired insulin secretion, decreased insulin sensitivity, or a combination of both factors. DM is a chronic degenerative disease that necessitates long-term treatment and can significantly impact kidney function, particularly in patients with diabetic nephropathy. Objective: This study aims to examine the profile of antidiabetic medications, glycemic control, and the correlation between the pattern of antidiabetic use and glycemic control.Methods: This study employed a cross-sectional design with retrospective data derived from medical records.Results: Among the 104 patients who met the inclusion criteria, the most predominant age group was over 44 years (94.2%), with a slight female predominance (51%). A majority of the patients exhibited normal nutritional status, with a body mass index (BMI) ranging from 18.5 to 24.9 (52.9%). The most common complications were macrovascular, including hypertension, stroke, coronary heart disease, diabetic ketoacidosis, dyslipidemia, and gangrene, affecting 75% of the patients. Conclusion: Statistical analysis using the chi-square test revealed no significant relationship between the pattern of antidiabetic and the glycemic control (p-value = 0.558). This finding suggests that the use of Glycuidone alone, as well as the combination of insulin glargine and aspart, demonstrates good efficacy in achieving glycemic control.