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All Journal FORUM STATISTIKA DAN KOMPUTASI Media Statistika Statistika JURNAL MATEMATIKA STATISTIKA DAN KOMPUTASI IPTEK The Journal for Technology and Science CAUCHY: Jurnal Matematika Murni dan Aplikasi Sosioinforma International Journal of Advances in Intelligent Informatics Scientific Journal of Informatics JOIN (Jurnal Online Informatika) Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) Jurnal Penelitian Pertanian Tanaman Pangan BAREKENG: Jurnal Ilmu Matematika dan Terapan SINTECH (Science and Information Technology) Journal MIND (Multimedia Artificial Intelligent Networking Database) Journal Jurnal Aplikasi Statistika & Komputasi Statistik FIBONACCI: Jurnal Pendidikan Matematika dan Matematika Inferensi International Journal of Advances in Data and Information Systems InPrime: Indonesian Journal Of Pure And Applied Mathematics Majalah Ilmiah Matematika dan Statistika (MIMS) Jurnal Lebesgue : Jurnal Ilmiah Pendidikan Matematika, Matematika dan Statistika Enthusiastic : International Journal of Applied Statistics and Data Science Prosiding Seminar Nasional Official Statistics Jurnal Natural Eduvest - Journal of Universal Studies Xplore: Journal of Statistics PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON DATA SCIENCE AND OFFICIAL STATISTICS Parameter: Jurnal Matematika, Statistika dan Terapannya Scientific Journal of Informatics Journal of Mathematics, Computation and Statistics (JMATHCOS) Advance Sustainable Science, Engineering and Technology (ASSET) Indonesian Journal of Statistics and Its Applications Journal on Mathematics Education
Kusman Sadik
Departemen Statistika, IPB University
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Neuroscience Physics Social Sciences Transportation Other

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Journal : Parameter: Jurnal Matematika, Statistika dan Terapannya

 1 
Comparison of LASSO, Ridge, and Elastic Net Regularization with Balanced Bagging Classifier Nisrina Az-Zahra, Putri; Sadik, Kusman; Suhaeni, Cici; Mohamad Soleh, Agus
Parameter: Jurnal Matematika, Statistika dan Terapannya Vol 4 No 2 (2025): Parameter: Jurnal Matematika, Statistika dan Terapannya
Publisher : Jurusan Matematika FMIPA Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/parameterv4i2pp287-296

Abstract

Predicting Drug-Induced Autoimmunity (DIA) is crucial in pharmaceutical safety assessment, as early identification of compounds with autoimmune risk can prevent adverse drug reactions and improve patient outcomes. Classification analysis often faces challenges when the number of predictor variables exceeds the number of observations or when high correlations among predictors lead to multicollinearity and overfitting. Regularization methods, such as Ridge Regression, Least Absolute Shrinkage and Selection Operator (LASSO), and Elastic-Net, help stabilize parameter estimation and improve model interpretability. This study focuses on building a binary classification model to predict the risk of DIA using 196 molecular descriptors derived from chemical compound structures. To address class imbalance in the response variable, the Balanced Bagging Classifier (BBC) is combined with regularized logistic regression models. Elastic Net + BBC outperforms other models with the highest accuracy (0.825), followed closely by LASSO + BBC and Ridge + BBC (both 0.816). This integration not only improves classification accuracy but also enhances generalization and the reliable detection of minority class instances, supporting the early identification of autoimmune risks in drug discovery.
Co-Authors . Erfiani . Indahwati A.Tuti Rumiati Aam Alamudi Abdullah, Adib Roisilmi Achmad Fauzan Agus Mohamad Soleh Ahmad Rifai Nasution Aji Hamim Wigena Akbar Rizki Akbar Rizki Akbar Rizki Akmala Firdausi Amalia, Rahmatin Nur Anadra, Rahmi Ananda Shafira Anang Kurnia Andespa, Reyuli Andi Okta Fengki ASEP SAEFUDDIN Astari, Reka Agustia Astari, Reka Agustia Aulya Permatasari Azka Ubaidillah Bagus Sartono Budi Susetyo Budi Susetyo Cici Suhaeni Cici Suhaeni Dito, Gerry Alfa Dwi Agustin Nuriani Sirodj Efriwati Efriwati Embay Rohaeti Eminita, Viarti EVITA PURNANINGRUM FARDILLA RAHMAWATI Farit Mochamad Afendi Fitrianto, Anwar Haikal, Husnul Aris Hari Wijayanto Hasnataeni, Yunia Hazan Azhari Zainuddin Hermawati, Neni I Gusti Ngurah, Sentana Putra I Made Sumertajaya I Wayan Mangku Indahwati Indahwati Indahwati Intan Arassah, Fradha Iqbal, Teuku Achmad Isnanda, Eriski Khairi A N Khairil Anwar Notodiputro Khikmah, Khusnia Nurul Khusnul Khotimah Kusni Rohani Rumahorbo Latifah, Leli Lili Puspita Rahayu Logananta Puja Kusuma M Soleh, Agus Mochamad Ridwan Mochamad Ridwan, Mochamad Mohammad Masjkur Muh Nur Fiqri Adham Muhammad Yusran Mulianto Raharjo Naima Rakhsyanda Nisrina Az-Zahra, Putri Nur Khamidah NURADILLA, SITI Nusar Hajarisman Pangestika, Dhita Elsha Parwati Sofan, Parwati Purnama Sari Rifqi Aulya Rahman Rizki, Akbar Rizqi, Tasya Anisah ROCHYATI ROCHYATI Sahamony, Nur Fitriyani Saleh, Agus Muhammad Satriyo Wibowo Siregar, Jodi jhouranda Siti Raudlah Sitti Nurhaliza Soleh, Agus M Suhaeni, Cici Supriatin, Febriyani Eka Tendi Ferdian Diputra Titin Suhartini Titin Suhartini, Titin Tri Wahyuni Uswatun Hasanah Utami Dyah Syafitri Viarti Eminita Widhiyanti Nugraheni Yenni Angraini Yenni Kurniawati Yuli Eka Putri