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Perbandingan Kadar 25-(OH)-Vitamin D3 pada Serum Kelompok Mioma Uteri dan Non-Mioma Uteri Aria Prasetya Masoem; Tono Djuwantono; Mulyanusa A. Ritonga; Jusuf Sulaeman Effendi; Wiryawan Permadi; Tita Husnitawati Madjid
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakTujuan: Penelitian ini bertujuan untuk membandingkan perbedaan kadar 25-hidroksi-vitamin D3 pada serum kelompok mioma uteri dan non-mioma uteri. Metode: Penelitian ini merupakan penelitian analitik observasional dengan rancangan komparatif cross sectional. Subjek penelitian adalah wanita usia reproduksi yang menjalani prosedur laparatomi/laparaskopi yang memenuhi kriteria inklusi penelitian (n=42). Subjek penelitian dibagi menjadi dua kelompok, yakni kelompok mioma uteri (n=21) dan non-mioma uteri (n=21). Pada kedua kelompok dilakukan pemeriksaan kadar serum 25-hidroksi-vitamin D3 kemudian diperiksa dengan metode Electro-chemiluminescence Immunoassay (ECLIA). Penelitian ini dilakukan di RSUP Dr. Hasan Sadikin Bandung pada bulan Juni−Agustus 2017. Hasil: Hasil penelitian menunjukkan kadar 25-hidroksi-vitamin D3 rata-rata pada kelompok mioma uteri adalah 6,70 (3,29) ng/ml, sementara pada kelompok non-mioma uteri 10,34 (2,79) ng/ml. Perbedaan kadar rata-rata 25-hidroksi-vitamin D3 pada kedua kelompok tersebut bermakna dengan nilai p<0,001. Namun, tidak didapatkan korelasi antara kadar 25-hidroksi-vitamin D3 dengan berat massa mioma uteri. Kesimpulan : Kadar 25-hidroksi-vitamin D3 pada kelompok mioma uteri lebih rendah dibandingkan dengan kelompok non-mioma uteri. Comparison Serum Level OF 25-Hydroxy-Vitamin D3 in Uterine Fibroid Group and Non-Uterine Fibroid GroupAbstract Objective: The aim of this study was to determine if there is any significant difference between serum levels of 25-hydroxy-vitamin D3 of uterine fibroid group and non-uterine fibroid group. Method: This was an observational analytic study with comparative cross-sectional method. Subjects were women in reproductive age who underwent laparotomy / laparoscopy procedures who met the study criteria (n=42). The subjects were divided into two groups, uterine fibroid group (n=21) and non-uterine fibroid (n=21). Measurement of serum 25-hydroxy-vitamin D3 was performed using Electro-chemiluminescence Immunoassay (ECLIA) method. The study was conducted at Dr. Hasan Sadikin hospital in June−August 2017. Result: The results showed the mean level 25-hydroxy-vitamin D3 on uterine fibroid group was 6.70 (3.29) ng / ml and non-uterine fibroid group 10.34 (2.79) ng/ml. There was significant difference between serum level of 25-hydroxy-vitamin D3 in uterine fibroid group and non-uterine fibroid with p value <0.001. But, there was no correlation between serum level of 25-hydroxy-vitamin D3 content and the weight of uterine fibroid mass. Conclusions: Serum level of 25-hydroxy-vitamin D3 is lower in uterine fibroid group than non-uterine fibroid group.Key words: Uterine fibroid, vitamin D, 25-hydroxy-vitamin D3

Perbandingan Nilai Female Sexual Function Index pada Wanita Primipara Berdasarkan Metode Persalinan Rena Nurita; Andi Rinaldi; Wiryawan Permadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 4 Nomor 2 September 2021
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n2.257

Tujuan: Untuk membandingkan fungsi seksual pada wanita primipara dengan metode persalinan pervaginam dan seksio sesarea. Metode: Penelitian ini adalah penelitian observasional analitik secara cross-sectional. Penelitian ini dilakukan selama tujuh bulan di RS Hasan Sadikin dan Rumah Sakit Khusus Ibu dan Anak Kota Bandung, dimulai pada September 2019 sampai Mei 2020. kriteria inklusi primipara, berusia 18-35 tahun, 3-6 bulan postpartum sebelum pengambilan data, aktif secara seksual dalam 6 bulan setelah persalinan dan melakukan hubungan seksual dalam empat minggu terakhir. Fungsi seksual dinilai dengan Female Sexual Function Index (FSFI).Hasil: Subjek penelitian ini terdiri dari 98 subjek dengan dibagi menjadi dua kelompok, yakni persalinan pervaginam (n=56) dan seksio sesarea (n=42). Subjek penelitian mengisi kuesioner FSFI versi Bahasa Indonesia. Dari 98 subjek, disfungsi seksual didapatkan 95% pada wanita dengan persalinan pervaginam dan 90% dengan seksio sesareaKesimpulan: Tidak terdapat perbedaan yang signifikan antara persalinan pervaginam dan seksio sesarea terhadap disfungsi seksual. The Comparison of Female Sexual Function Index Score in Primiparous Women According to Delivery MethodsAbstractObjective: to compare the sexual function of primiparous woman with spontaneous delivery and cesarean section.Method: This research is an analytic observational study with cross-sectional method. This study is a 7 months study at Dr. Hasan Sadikin Central General Hospital and Rumah Sakit Khusus Ibu dan Anak Kota Bandung, started from September 2019 to May 2020. The inclusion criteria were primiparous, aged 18-35 year-old, 3-6 months postpartum before data collection, sexually active within 6 months after delivery and had sexual intercourse in the last four week. Sexual function was assessed by the Female Sexual Function Index (FSFI).Result: We obtained 98 subjects and divided them into two groups, spontaneous delivery (n = 56) and cesarean section (n = 42). Subject then filled out the Indonesian version of the FSFI questionnaire. From 98 subjects, sexual dysfunction was found in 95% subject with spontaneous delivery and 90% with cesarean section.Discussion: Using comparative chi square test (p = 0.43), there is no significant difference between each method of delivery on sexual dysfunction. Interestingly sexual dysfunction found in tremendous percentage compared to previous studies, either in spontaneous delivery (95%) or cesarean section (90%).Key word:cesarean section, Female Sexual Function Index, primiparous, sexual function, spontaneous delivery

Total Serum Level of Calcium and Ion Calcium is Lower in Hypotonic Uterine Inertia Josef Wattimury; Wiryawan Permadi; Edwin Armawan
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To know the correlation between total and ion serum calcium level with the uterine contractility of laboring patient. Methods: This is a cross-sectional analytic correlative study measuring the strength of correlation of total and ion calcium serum level between groups with hypotonic uterine inertia - and normal labor. Each group consists of 20 subjects who met inclusion criteria and presented to Dr. Hasan Sadikin Hospital in August - September 2012. Statistical analysis was performed by using Eta (Î·) coefficient. Results: Mean total calcium serum level on hypotonic uterine inertia is 6.66 mg/dl, while mean of total calcium serum level on normal labor is 8.56 mg/dl, with Eta (Î·) correlation coefficient 0.721. Mean ion calcium serum level on hypotonic uterine inertia is 4.14 mg/dl, while mean of total calcium serum level on normal labor is 4.92 mg/dl, with Eta (Î·) correlation coefficient 0.802. Conclusion: Total serum level of calcium and ion calcium in hypotonic uterine inertia is lower than the level of which in normal labor. There is a strong correlation between total and ion serum calcium level with uterine contractility, the Eta (Î·) correlation coefficient are 0.721 and 0.802 respectively. [Indones J Obstet Gynecol 2013; 1-3: 145-8] Keywords: hypotonic uterine inertia, ion serum calcium level, normal labor, total serum calcium level

Oxytocin 10 IU as Prophylactic for Uterine Atony : a Randomized Clinical Trial: Oksitosin 10 IU sebagai Profilaksis Atonia Uteri : suatu Uji Coba Klinis Acak Ridwan A. Putra; Iskandar Zulqarnain; Zaimursyaf Azis; Jusuf S. Effendi; Wiryawan Permadi; Ria Bandiara
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 3 July 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective : To compare the effectiveness of oxytocin dose of 10 IU and 20 IU for preventing uterine atony in women undergoing cesarean section. Methods : This was a double-blind, randomized clinical trial with good matching selection with randomization block of patients who had risk factors for the occurrence of uterine atony such as preeclampsia, patients were receiving MgSO4, oxytocin intrapartum and chorioamnionitis who performed stratified randomization prospectively with two kinds of oxytocin doses which are 10 IU and 20 IU as a prophylaxis for uterine atony in women who performed emergency cesarean section with transverse incision and were using a general anesthesia. Results : This study found no any significant differences between the use of 10 IU and 20 IU as prophylaxis for uterine atony during cesarean section either in its action at the time or while in recovery room, especially on the cases without chorioamnionitis thus using oxytocin 10 IU regimen can be considered, besides the effectiveness did no differ, it will cost cheaper than oxytocin 20 IU regimen which frequently used. Conclusions : There were no significant differences in the incidence of blood loss during the cesarean section between the treatment of oxytocin 10 IU group and oxytocin 20 IU group. The additional uterotonic was using during the action of the cesarean section between the treatment of oxytocin 10 IU group, and oxytocin 20 IU group gave no significant differences. The side effects in this study at least form of chills and vomiting found no significant differences between both of groups despite the side effects that arise in oxytocin 20 IU group was higher at 23.08% than oxytocin 10 IU group at 15.19%. Chorioamnionitis would be a risk factor for the occurrence of uterine atony during the action of the cesarean section if it associated with the use of additional uterotonic in oxytocin 10 IU group if compared with oxytocin 20 IU group. Keywords : cesarean section, oxytocin, uterine atony. Abstrak Tujuan : Untuk membandingkan efektifitas penggunaan dosis 10 IU dan 20 IU sebagai profilaksis atonia uteri pada saat seksio sesarea. Metode : Penelitian ini menggunakan uji klinis acak ganda dengan seleksi yang sesuai dengan blok acak pada pasien-pasien yang memiliki faktor risiko terjadinya atonia uteri seperti preeklamsia, pasien yang diberikana MgSO4 dan oxytocin intrapartum sebelumnya serta chorioamnionitis yang dilakukan pengacakan secara prosfektif bertingkat yang diberikan dua jenis dosis oksitosin yaitu 10 IU dan 20 IU sebagai profilaksis atonia uteri pada perempuan yang dilakukan seksio sesarea darurat dengan insisi transversal dan menggunakan anestesi umum. Hasil : Penelitian ini menemukan tidak adanya perbedaan yang bermakna antara penggunaan dosis oksitosin 10 IU dan 20 IU sebagai profilaksis atonia uteri pada seksio sesarea baik saat tindakan operasi maupun saat berada di ruang pemulihan, terutama pada kasus-kasus tanpa khorioamnionitis dimana memerlukan oksitosin tambahan pada kelompok 10 IU, selain efektifitasnya tidak berbeda, akan lebih murah dari pada rejimen oksitosin 20 IU yang sering digunakan saat ini. Kesimpulan : Berdasarkan hasil penelitian ini, tidak ada perbedaan yang bermakna dalam kejadian kehilangan darah selama operasi seksio sesarea antara perlakuan kelompok oksitosin 10 IU dan kelompok oksitosin 20 IU. Penggunaan uterotonik tambahan selama tindakan seksio sesarea antara perlakuan kelompok oksitosin 10 IU dan kelompok oksitosin 20 IU tidak memberikan perbedaan yang signifikan. Efek samping dalam penelitian ini yakni menggigil dan muntah, tidak ditemukan perbedaan yang bermakna antara kedua kelompok meskipun efek samping yang muncul pada kelompok oksitosin 20 IU lebih tinggi 23,08% dibandingkan kelompok oksitosin 10 IU pada 15,19%. Khorioamnionitis merupakan faktor risiko terjadinya atonia uteri selama tindakan seksio sesarea jika dikaitkan dengan penggunaan uterotonika tambahan pada kelompok oksitosin 10 IU jika dibandingkan dengan kelompok oksitosin 20 IU. Kata kunci : atonia uteri, oksitosin, seksio sesarea.

Perbandingan Kepadatan Mineral Tulang Antar Pemakai Kontrasepsi Hormonal Progestin dan Kontrasepsi Non Hormonal pada Wanita Usia Subur Aprilina Aprilina; Wiryawan Permadi; Elsa Pudji Setyawati; Farid Husin; Johanes C. Mose; Yudi Mulyana Hidayat
Jurnal Kesehatan Vol 11, No 1 (2020): Jurnal Kesehatan
Publisher : Politeknik Kesehatan Tanjung Karang

The decrease of bone mineral density will result in reducing bone strength tend to bone brittle so osteoporosis occurred. Osteoporosis affects 44 million people in the United States, 80% are women. It was assumed that progestin contraceptive acceptors decreased bone mineral density and increased the risk of osteoporotic fractures. The study used a comparative analytical method by using a cross-sectional study. The population was all acceptors progestin hormonal contraceptives (implants or injections) and acceptors of non-hormonal contraception (IUD or MOW) who came to the Public health center of Sekip Palembang and public health center of Basuki Rahmat in Palembang. The total sample was 200 respondents. The sample used purposive sampling, by using a consecutive sampling technique. The results were analyzed by using the Mann Whitney test and two ways ANOVA test directions with post hoc test and profile analysis. The results showed a significant difference in bone mineral density between the acceptors of progestin hormonal contraceptives and the acceptors of non- hormonal contraceptives to eligible women with ρ-value=0.001. There was a significant difference between acceptor of progestin hormonal contraceptives and non- hormonal contraceptives to eligible women referred to the duration of use, p-value of 1-2 years old was p-value=0.109, >2-3 years, p-value 0.039, and ≥3 years, p-value=0.033. Conclusion: there are differences in bone mineral density between acceptors of progestin hormonal contraceptives and acceptors of non-hormonal contraceptives to eligible women.

Pengaruh Pijat Punggung dan Memerah ASI terhadap Produksi ASI pada Ibu Postpartum dengan Seksio Sesarea Retno Puji Astuti; Kusnandi Rusmil; Wiryawan Permadi; Johanes C Mose; Jusuf Sulaeman Effendi; Dewi M.D Herawati
Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care Vol 2, No 1 (2015): Maret
Publisher : Program Studi Magister Kebidanan FK UNPAD

Produksi ASI yang sedikit pada hari-hari pertama setelah melahirkan menjadi kendala dalampemberian ASI secara dini pada tindakan seksio sesarea. Pengaruh anestesi pada ibu pasca seksio sesarea menyebabkan terhambatnya pengeluaran hormon oksitosin. Perlu dilakukan stimulasi reflek oksitosin dengan pijat punggung dan memerah ASI. Tujuan penelitian ini untuk menganalisis pengaruh pijat punggung dan memerah ASI terhadap produksi ASI pada ibu Postpartum dengan seksio sesarea. Penelitian ini menggunakan metode quasi experiment dengan rancangan posttest only design with nonequivalent groups. Populasi penelitian ini adalah ibu Postpartum dengan seksio sesarea di RSIA Buah Hati Pamulang, Tangerang Selatan. Pengambilan sampel ini dilakukan dengan teknik non- random sampling dengan metode consecutive sampling. Jumlah sampel 60 responden yang dibagi menjadi 30 responden kelompok intervensi dan 30 responden kelompok kontrol. Pengolahan dan analisis data menggunakan uji chi-Square dan uji exact fisher. Hasil penelitian ini menunjukkan adanya pengaruh pijat punggung dan memerah ASI terhadap produksi ASI pada ibu postpartum dengan seksio sesarea dengan nilai Number Needed to Treat (NNT) = 3,3 dan nilai RR sebesar 2,8 serta nilai p = 0,012 menunjukkan adanya perbedaan yang signifikan produksi ASI antara kelompok intervensi dan kelompok kontrol. Besarnya pengaruh pijat punggung dan memerah ASI berdasarkan karakteristik Ibu, ditinjau dari usia 20-34 tahun pada kelompok intervensi dengan produksi ASI yang lancar nilai p = 0,011. Paritas dengan multiparitas nilai p = 0,013. Pendidikan dengan tamat SMA nilai p = 0,016. Pekerjaan dengan status tidak bekerja nilai p = 0,023. Simpulan dalam penelitian ini adalahtindakan pijat punggung dan memerah ASI berpengaruh baik terhadap produksi ASI yang lancar pada ibu postpartum dengan seksio sesarea. Selain itu, usia 20 – 34 tahun, paritas dengan multiparitas, pendidikan tamat SMA dan ibu yang tidak bekerja berpengaruh baik pada produksi ASI yang lancar. Saran untuk bidan dapat melakukan pijat punggung dan memerah ASI pada ibu postpartum dengan seksio sesarea maupun spontan dalam meningkatkan produksi ASI

Korelasi antara Kadar Vitamin D dengan Kejadian Preeklamsi Ekadewi Retnosari; Wiryawan Permadi; Elsa Pudji Setiawati; Farid Husin; Johanes Cornellius Mose; Udin Sabarudin
Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care Vol 2, No 4 (2015): Desember
Publisher : Program Studi Magister Kebidanan FK UNPAD

Program Pembangunan Kesehatan di Indonesia dewasa ini masih diprioritaskan pada upaya peningkatan derajat kesehatan ibu dan anak, terutama pada kelompok yang paling rentan kesehatannya yaitu ibu hamil, ibu bersalin dan bayi pada masa perinatal. Hal ini ditandai dengan tingginya Angka Kematian Ibu (AKI). Menurut Survei Demografi Kesehatan Indonesia (SDKI) tahun 2012, AKI tahun 2007 sebesar 228/100.000 Kelahiran Hidup (KH) meningkat menjadi 359 /100.000 KH. Penyebab langsung kematian ibu adalah faktor yang berhubungan dengan komplikasi kehamilan, persalinan dan nifas seperti perdarahan, preeklamsi/eklamsi dan infeksi. Preeklamsi merupakan gangguan multifaktorial. Beberapa penelitian memperlihatkan adanya bukti yang mendukung tentang kadar vitamin D yang berperan untuk terjadinya komplikasi kehamilan. Sumber vitamin D berasal dari sintesis endogen (matahari) dan sintesis eksogen (makanan). Sinar ultraviolet dapat mengubah pre vitamin D menjadi vitamin D3. Indonesia terletak didaerah tropis yang kaya akan sinar ultraviolet, tetapi masih banyak ibu hamil yang menderita preeklamsi, sehingga tujuan dari penelitian ini adalah menganalis hubungan antara kadar vitamin D dengan kejadian preeklamsi. Populasi dalam penelitian ini adalah semua ibu hamil yang di diagnosis preeklamsi dan di diagnosis hamil normal yang melakukan pemeriksaan di RSUD H.M. Rabain dan empat puskesmas di wilayah kabupaten Muara Enim. Total sampel 76 orang yang terdiri dari 38 orang kelompok kasus dan 38 orang kelompok kontrol. Rancangan penelitian dengan metode analitik yang dilakukan secara cross sectional. Analisis hasil dengan uji korelasi Point Biserial. Hasil penelitian dengan uji korelasi Point Biserial menunjukkan bahwa tidak terdapat hubungan antara kadar vitamin D dengan kejadian preeklamsi dengan nilai p 0,052. Simpulan dalam penelitian ini adalah tidak terdapat hubungan antara kadar vitamin D dengan kejadian preeklamsi awitan dini. Kadar vitamin D berkaitan dengan awitan lanjut pada kejadian preeklamsi yang merupakan bagian dari faktor maternal, disamping itu kejadian preeklamsi sampai saat ini dipengaruhi oleh etiopatogenesis yang kompleks.

FACTORS CONTRIBUTING TO MATERNAL MORTALITY IN TASIKMALAYA CITY Dewi Andariya Ningsih; Wiryawan Permadi; Dinan S. Bratakoesoema; Hadi Susiarno; Henni Djuhaeni; Polar Silumi
Siklus : Journal Research Midwifery Politeknik Tegal Vol 9, No 2 (2020)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/siklus.v9i2.1789

Maternal deaths reflect the risks faced by mothers during pregnancy, childbirth, and postpartum were affected by maternal nutritional status, state of ill health during pregnancy, the incidence of various complications in pregnancy, childbirth, and postpartum. Moreover, the availability and use of healthcare facilities, including prenatal and obstetric services, were also very affecting. So it is necessary to minimize the occurrence of maternal deaths. The government had made various efforts to reduce maternal mortality, but the results were still not optimal yet. If maternal mortality could be prevented as early as possible with appropriate identification, it could significantly reduce maternal mortality. The research aims to analyze the cause of maternal death in Tasikmalaya city in 2015. The research design used a quantitative approach in the form of observation. The population was all maternal deaths in Tasikmalaya City Health department in 2015. The study's affordable population was all maternal mortality data with a precise address and recorded in the OVM as many as 20 cases of death. Factors associated with maternal mortality were the problem relating to patients, health professionals, health infrastructure, and referrals. Moreover recording and reporting of maternal mortality also influenced the determination of proper diagnosis to decrease the number of maternal mortality. Maternal mortality was a problem that has never finished with the complexity of the cause. It requires efforts that involve many parties, not only the health authorities alone, but all stakeholders were supported by government regulation. This study could be the basis for further research on maternal mortality and can be used to enhance the knowledge of researchers, health professionals, and stakeholders about the factors that cause maternal deaths. This study's results are expected to know the causes of maternal mortality and used as guidelines in making policy to reduce maternal mortality.Keywords: Maternal mortality, related factors

FACTORS CONTRIBUTING TO MATERNAL MORTALITY IN TASIKMALAYA CITY Dewi Andariya Ningsih; Wiryawan Permadi; Dinan S. Bratakoesoema; Hadi Susiarno; Henni Djuhaeni; Polar Silumi
Siklus : Journal Research Midwifery Politeknik Tegal Vol 9, No 2 (2020)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/siklus.v9i2.1789

Maternal deaths reflect the risks faced by mothers during pregnancy, childbirth, and postpartum were affected by maternal nutritional status, state of ill health during pregnancy, the incidence of various complications in pregnancy, childbirth, and postpartum. Moreover, the availability and use of healthcare facilities, including prenatal and obstetric services, were also very affecting. So it is necessary to minimize the occurrence of maternal deaths. The government had made various efforts to reduce maternal mortality, but the results were still not optimal yet. If maternal mortality could be prevented as early as possible with appropriate identification, it could significantly reduce maternal mortality. The research aims to analyze the cause of maternal death in Tasikmalaya city in 2015. The research design used a quantitative approach in the form of observation. The population was all maternal deaths in Tasikmalaya City Health department in 2015. The study's affordable population was all maternal mortality data with a precise address and recorded in the OVM as many as 20 cases of death. Factors associated with maternal mortality were the problem relating to patients, health professionals, health infrastructure, and referrals. Moreover recording and reporting of maternal mortality also influenced the determination of proper diagnosis to decrease the number of maternal mortality. Maternal mortality was a problem that has never finished with the complexity of the cause. It requires efforts that involve many parties, not only the health authorities alone, but all stakeholders were supported by government regulation. This study could be the basis for further research on maternal mortality and can be used to enhance the knowledge of researchers, health professionals, and stakeholders about the factors that cause maternal deaths. This study's results are expected to know the causes of maternal mortality and used as guidelines in making policy to reduce maternal mortality.Keywords: Maternal mortality, related factors

Performance of Pre-Operative IOTA Three-Step Algorithm in Detecting Ovarian Carcinoma in a Referral Center in Indonesia Kurniadi, Andi; Permadi, Wiryawan; Kusuma, Aria Yusti; Kireina, Jessica; Andarini, Mia Yasmina; Winarno, Gatot Nyarumenteng Adhipurnawan; Harsono, Ali Budi
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1044

Background: To assess the diagnostic performance of a three-step algorithm using the International Ovarian Tumor Analysis (IOTA) Group ‘simple rules’, ‘simple descriptors’, and Assessment of Different NEoplasias in the adneXa (ADNEX) model for discriminating benign and malignant adnexal masses. Methods: This was a retrospective observational study, performed at a tertiary-care university hospital, on women diagnosed with adnexal mass on ultrasonography from January 2021 and February 2022. The examiner first classified the mass using ‘simple descriptors’ (first step) and, if not possible, using ‘simple rules’ (second step). For inconclusive masses, an assessment using the ADNEX model was done as the third step. All masses were managed surgically. Histopathology results were used as the reference standard.Results: One hundred and forty-one women were included (median age of 48 years). Histopathology results showed 104 (73.76%) mass to be malignant, and 37 (26.24%) mass to be benign. Twelve (8.51%) of 141 masses could be classified using simple descriptors, 89 (63.12%) masses were classified using simple rules, and 40 (28.37%) masses were classified using the ADNEX model. Overall accuracy, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of the three-step algorithm were 89.36%, 94.23%, 75.68%, 91.59%, 82.35%, 3.87, and 0.08 respectively.Conclusions: The IOTA three-step algorithm, based on the sequential use of simple descriptors, simple rules, and ADNEX model, performs well for classifying adnexal masses as benign or malignant

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