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All Journal Majalah Kedokteran Bandung Althea Medical Journal Health Notions Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Kesehatan Indonesian Journal of Cancer Journal Research Midwifery Politeknik Tegal Media Penelitian dan Pengembangan Kesehatan

Wiryawan Permadi

Departemen Obstetri Dan Ginekologi Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung

Author-ID : 341837

Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Correlation between Sperm Motility and Morphology in the Success Rate of in Vitro Fertilization Procedure Ramadhan, Praditya Virza; Rezano, Andri; Permadi, Wiryawan
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.062 KB)

Background: In vitro fertilization (IVF) is one of the assisted reproductive technology that has been used in treating infertility. Unfortunately, not every IVF procedure achieves 100% success in fertilizing the oocyte. It has been studied that the percentage of normal motile sperm and percentage of normal sperm morphology play a key role in this process. This study was conducted to evaluate correlation between sperm motility and morphology in the success rate of IVF. Methods: This study was an observational analytic involving medical records of infertile couples who were treated by IVF procedure in Dr.Hasan Sadikin General Hospital Bandung in 2009â2014. The variables that were used in this study were percentage of sperm motility, percentage of sperm morphology and fertilization rate.The collected data was analyzed using nonparametric Mann Whitney test and Spearman correlation test.Result: This study showed that there was a significant difference between the fertilization rate group and sperm motility (p=0,048) but there was no significant correlation between motility and the entire fertilization rate (p=0,319). This study also indicated that there was no significant difference between fertilization rate group and sperm morphology (p=0,232) and there was no significant correlation between sperm morphology and fertilization rate (p=0,720).Conclusions: Motility might has a role in determining the success rate of in vitro fertilization; meanwhile morphology does not have any role in determining the success rate of in vitro fertilization. [AMJ.2016;3(4):520â5]Â DOI:Â 10.15850/amj.v3n4.957

Total Serum Level of Calcium and Ion Calcium is Lower in Hypotonic Uterine Inertia Wattimury, Josef; Permadi, Wiryawan; Armawan, Edwin
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To know the correlation between total and ion serum calcium level with the uterine contractility of laboring patient. Methods: This is a cross-sectional analytic correlative study measuring the strength of correlation of total and ion calcium serum level between groups with hypotonic uterine inertia - and normal labor. Each group consists of 20 subjects who met inclusion criteria and presented to Dr. Hasan Sadikin Hospital in August - September 2012. Statistical analysis was performed by using Eta (η) coefficient. Results: Mean total calcium serum level on hypotonic uterine inertia is 6.66 mg/dl, while mean of total calcium serum level on normal labor is 8.56 mg/dl, with Eta (η) correlation coefficient 0.721. Mean ion calcium serum level on hypotonic uterine inertia is 4.14 mg/dl, while mean of total calcium serum level on normal labor is 4.92 mg/dl, with Eta (η) correlation coefficient 0.802. Conclusion: Total serum level of calcium and ion calcium in hypotonic uterine inertia is lower than the level of which in normal labor. There is a strong correlation between total and ion serum calcium level with uterine contractility, the Eta (η) correlation coefficient are 0.721 and 0.802 respectively. [Indones J Obstet Gynecol 2013; 1-3: 145-8] Keywords: hypotonic uterine inertia, ion serum calcium level, normal labor, total serum calcium level

Analysis of Maternal Mortality Due to Hypertension in Pregnancy in West Bandung Karwati, Karwati; Permadi, Wiryawan; Herawati, Dewi M D
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Hypertension in pregnancy is one of causes in maternal mortality in West Bandung District in 2017 and there are 11 mothers (39.28%) of 28 mortality cases, which is in the highest rank. Moreover, this research aimed at analyzing maternal mortality due to hypertension in pregnancy in West Bandung District. This research was qualitative research by utilizing grounded theory approach with constructivism paradigm. Sample of this research was the closest family and health personnels who knew the cronology of maternal mortality and there were 21 people from 8 mortality cases. The sample collection utilized purposive sampling technique. Meanwhile, the instruments of this research were researchers, interview guidance, stationery, and voice recorder. Validity test utilized triangulation technique. Technique of data collection was by in depth interview and the analysis process were by transcription, reduction, coding, categorization, and theme. The result of this research was known that factors, which had contribution against maternal mortality, was such as poor access of health service and it was caused by several things: PONED function that had not been optimal in handling hypertension in pregnancy, poor quality of health service, guidance in handling hypertension in pregnancy that had not been optimal, less optimal information from health service, health personnel?s poor knowledge about hypertension in pregnancy, and delay in referring to hospital. The next factor was unhealthy living behavior, such as mother who had risk of hypertension in pregnancy did not use long-term contraception, underwent quite high failure level in the use of long-term contraception, the mother was a missing patient from the referral, and not sensitive against emergency situation. Besides that, unknown or unexpected factors also became contribution against mortality, such as unclear demographic status; undesirable pregnancy; assuming that dying in pregnancy, having birth, and in postpartum period was martyred. In conclusion, factors that contributed against maternal mortality due to hypertension in pregnancy in West Bandung District were access of health service, healthy living behavior, and unknown even unexpected factors. However, the factors that really impacted against maternal mortality were access of health service and healthy living behavior. Keywords: Maternal mortality, Hypertension in pregnancy

EFEK OLIVE OIL DAN VIRGIN COCONUT OIL TERHADAP STRIAE GRAVIDARUM Pratami, Evi; Permadi, Wiryawan; Gondodiputro, Sharon
Majalah Kedokteran Bandung Vol 46, No 1 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Prevalensi striae gravidarum (SG) pada ibu hamil berkisar 50% sampai 90%. Efek SG menyebabkan rasa gatal, panas, dan kering serta gangguan emosional sehingga menimbulkan masalah kosmetik pada sebagian besar ibu. Saat ini banyak ibu hamil menggunakan olive oil untuk mencegah SG, namun minyak ini relatif sukar didapat dan harganya mahal. Di Indonesia dikenal minyak lain yaitu virgin coconut oil (VCO) yang memiliki kandungan efektif untuk menjaga elastisitas kulit, minyak ini mudah didapat dan murah. Penelitian ini bertujuan menganalisis perbedaan dan korelasi efek olive oil dan VCO terhadap SG. Penelitian ini dilaksanakan pada bulan Maret?Juli 2012. Rancangan penelitian ini merupakan penelitian klinis melalui pendekatan eksperimental. Subjek penelitian adalah 80 ibu hamil di wilayah Dinas Kesehatan Kota Surabaya dan dikelompokkan menjadi 2 kelompok dengan menggunakan random permuted blocks. Hasil penelitian menunjukkan tidak terdapat perbedaan SG berdasarkan jumlah garis dan tingkat eritema antara kelompok yang menggunakan olive oil dan VCO (p=0,156 dan 1,00). Selanjutnya terdapat korelasi kuat antara kelompok olive oil dan VCO dengan jumlah garis (r=-0,576 dan -0,560) dan tingkat eritema (r=-0,699 dan -0,586). Simpulan, tidak ada perbedaan efek olive oil dengan VCO terhadap SG. [MKB. 2014;46(1):1?5]Kata kunci: Olive oil, striae gravidarum, virgin coconut oilEffects of Olive Oil and Virgin Coconut Oil against Striae GravidarumThe prevalence of striae gravidarum (SG) in pregnant women ranges from 50% to 90%. Effects of SG include itchy and hot feeling as well as dry skin. This situation also causes emotional disturbances that poses a cosmetic problem for most pregnant women. Nowadays, many pregnant women use olive oil to prevent SG, but it is relatively difficult to find and costly. In Indonesia, a similar oil, virgin coconut oil (VCO), has been used by many pregnant women for the same reason. The aim of this study was to analyze the differences and correlation between effects of olive oil and VCO against SG. The study was conducted in March?July 2012. An experimental study was performed on 80 pregnant women in Surabaya Municipality and they were divided into 2 groups using random permuted blocks. The results of this study showed that there was no difference in SG appearance based on the number of lines and levels of erythema between groups (p=0.156 and 1.00). Furthermore, there was a strong negative correlation between the effect of olive oil or VCO on the number of lines (r=-0.576 and -0.560) and the level of erythema (r=-0.699 and -0.586). In conclusion, there is no difference in the effect of olive oil and VCO against SG. [MKB. 2014;46(1):1?5]Key words: Olive oil, striae gravidarum, virgin coconut oil DOI: 10.15395/mkb.v46n1.220

Correlation between Sperm Motility and Morphology in the Success Rate of in Vitro Fertilization Procedure Praditya Virza Ramadhan; Andri Rezano; Wiryawan Permadi
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.062 KB)

Background: In vitro fertilization (IVF) is one of the assisted reproductive technology that has been used in treating infertility. Unfortunately, not every IVF procedure achieves 100% success in fertilizing the oocyte. It has been studied that the percentage of normal motile sperm and percentage of normal sperm morphology play a key role in this process. This study was conducted to evaluate correlation between sperm motility and morphology in the success rate of IVF. Methods: This study was an observational analytic involving medical records of infertile couples who were treated by IVF procedure in Dr.Hasan Sadikin General Hospital Bandung in 2009–2014. The variables that were used in this study were percentage of sperm motility, percentage of sperm morphology and fertilization rate.The collected data was analyzed using nonparametric Mann Whitney test and Spearman correlation test.Result: This study showed that there was a significant difference between the fertilization rate group and sperm motility (p=0,048) but there was no significant correlation between motility and the entire fertilization rate (p=0,319). This study also indicated that there was no significant difference between fertilization rate group and sperm morphology (p=0,232) and there was no significant correlation between sperm morphology and fertilization rate (p=0,720).Conclusions: Motility might has a role in determining the success rate of in vitro fertilization; meanwhile morphology does not have any role in determining the success rate of in vitro fertilization. [AMJ.2016;3(4):520–5] DOI: 10.15850/amj.v3n4.957

Analysis of Maternal Mortality Due to Hypertension in Pregnancy in West Bandung Karwati Karwati; Wiryawan Permadi; Dewi M.D. Herawati
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Hypertension in pregnancy is one of causes in maternal mortality in West Bandung District in 2017 and there are 11 mothers (39.28%) of 28 mortality cases, which is in the highest rank. Moreover, this research aimed at analyzing maternal mortality due to hypertension in pregnancy in West Bandung District. This research was qualitative research by utilizing grounded theory approach with constructivism paradigm. Sample of this research was the closest family and health personnels who knew the cronology of maternal mortality and there were 21 people from 8 mortality cases. The sample collection utilized purposive sampling technique. Meanwhile, the instruments of this research were researchers, interview guidance, stationery, and voice recorder. Validity test utilized triangulation technique. Technique of data collection was by in depth interview and the analysis process were by transcription, reduction, coding, categorization, and theme. The result of this research was known that factors, which had contribution against maternal mortality, was such as poor access of health service and it was caused by several things: PONED function that had not been optimal in handling hypertension in pregnancy, poor quality of health service, guidance in handling hypertension in pregnancy that had not been optimal, less optimal information from health service, health personnel’s poor knowledge about hypertension in pregnancy, and delay in referring to hospital. The next factor was unhealthy living behavior, such as mother who had risk of hypertension in pregnancy did not use long-term contraception, underwent quite high failure level in the use of long-term contraception, the mother was a missing patient from the referral, and not sensitive against emergency situation. Besides that, unknown or unexpected factors also became contribution against mortality, such as unclear demographic status; undesirable pregnancy; assuming that dying in pregnancy, having birth, and in postpartum period was martyred. In conclusion, factors that contributed against maternal mortality due to hypertension in pregnancy in West Bandung District were access of health service, healthy living behavior, and unknown even unexpected factors. However, the factors that really impacted against maternal mortality were access of health service and healthy living behavior. Keywords: Maternal mortality, Hypertension in pregnancy

Correlation between Estrogen Receptorβ (ERβ), Neurofilament Protein (NF), and Protein Gene Product 9.5 (PGP9.5) Expressions as a Marker of Pain on Adenomyosis Etiopathogenesis Arief Setiawan; Ruswana Anwar; Tita Husnitawati; Tono Djuwantono; Wiryawan Permadi
Majalah Kedokteran Bandung Vol 53, No 4 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n4.2363

Adenomyosis is a pathological condition characterized by the presence of endometrial glands and stroma within the myometrium. Endometrial like cells development was influenced by local inflammatory reactions, increases local estradiol due to asynchromatized estrogen synthesis (ERβ) and then stimulated to proliferation and fibrosis, are also irritation on small nerve fibers in women with painful characterized symptoms on adenomyosis. There are expressions of neurofilament protein (NF) and protein gene product 9.5 (PGP 9.5) is a highly specific pan-neuronal marker for microfilament nerve fibers and is related to presenting pain with adenomyosis symptoms. A retrospective immunohistochemical study of thirty samples histopathological of adenomyosis as study groups and 30 with control groups between 25–49 ages which were established at Dr. Hasan Sadikin General Hospital and the satellites in April 2014–May 2015. This case-control analyzed ERβ, NF, and PGP 9.5 expressions compared and correlation between study groups and controls. The results showed there were significant differences in expression of ERβ, NF, and PGP 9.5 on adenomyosis higher than the control study (p<0.05). The intensity was higher and very strong into the study groups (p<0,001). Cut off point of ERβ was more than>6(sensitivity 66.7%; specificity 70%), NF>3 (sensitivity 93%; specificity 46%), PGP 9.5>4 (sensitivity 90%; specificity 67%). Odds Ratio (CI 95%) ERβ>6= 4.67; NF >3=12.25; PGP 9.5 >4=24.75 (p<0.001). The value of histoscore of ERβ and PGP9.5 have correlates to adenomyosis, the differences were statistically significant (p<0.05). The conclusion were that the adenomyosis had higher ERβ, NF, and PGP 9.5 expressions. There are simultant correlates and positive values between ERβ, NF, and PGP9.5 based on etiophatogenesis of pain on adenomyosis.

Hubungan Kadar Vitamin D Serum dengan Konsentrasi, Motilitas dan Morfologi Sperma pada Pria Subfertil di Klinik Teknologi Reproduksi Berbantu Aster Rumah Sakit Dr. Hasan Sadikin Bandung Magnadi Yogi Rahma; Wiryawan Permadi; Anita Rachmawati; Jusuf Sulaeman Effendi; Tono Djuwantono; Budi Handono
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: Untuk menganalisis hubungan kadar vitamin D dengan kualitas sperma pada pria subfertil, serta membandingkan kualitas sperma berdasarkan klasifikasi kadar vitamin D serum pada pria normospermia dan pria oligoasthenoteratospermia.Metode: Penelitian ini merupakan penelitian yang bersifat observasional analitik dengan rancangan studi potong lintang. Subjek penelitian adalah pria subfertil yang berusia 20-50 tahun, dibagi menjadi 2 kelompok, yaitu 30 pasien normospermia dan 16 pasien oligoasthenoteratospermia berdasarkan berdasarkan kriteria World Health Organization 2010. Penelitian dilakukan di Klinik Teknologi Reproduksi Berbantu Aster, RSUP Dr. Hasan Sadikin Bandung. Analisis data menggunakan analisis korelasi rank SpearmanHasil: Pada penelitian ini didapatkan korelasi positif antara kadar vitamin D dan motilitas sperma ( r = 0,639, p = < 0,001), tetapi tidak didapatkan korelasi pada konsentrasi dan morfologi sperma ( p>0,05). Perbedaan yang bermakna didapatkan antara kadar vitamin D pada kelompok normospermia dan oligoasthenoteratospermia dengan nilai p<0,05. Pada perbandingan kualitas sperma berdasarkan klasifikasi kadar vitamin D hanya motilitas sperma saja yang memiliki perbedaan bermakna dengan nilai p<0,05.Simpulan: Terdapat hubungan yang bermakna antara kadar vitamin D serum dan motilitas sperma.Correlation Of Vitamin D Serum Level With Concentration, Motility, And Morphology Of Spermatozoa Subfertil In Assisted Reproductive Technology Aster Clinic Hasan Sadikin Hospital BandungAbstractObjective: This study aims to analyze the relationship of vitamin D levels with sperm quality in subfertile men, as well as comparing sperm quality based on vitamin D serum levels classification in normospermic men and oligoasthenoteratospermia men.Method: This study is an analytic observasional with cross sectional design. Research subjects were subfertile men aged 20-50 years divided into 2 groups, consisting of 30 patients with normospermic and 16 patients with oligoasthenoteratospermia based on World Health Organization 2010 criteria. The research was conducted at Assisted Reproductive Technology Aster, RSUP Dr. Hasan Sadikin Bandung. Data analysis was using Spearman’s rank correlation analytic.Result: We found a positive correlation between vitamin D levels and sperm motility (r = 0.639, p = <0.001), but no correlation was found on sperm concentration and morphology (p> 0.05). There was a significant difference between vitamin D levels in normospermic and oligoasthenoteratospermia group with p <0,05. In the sperm quality comparison based on vitamin D serum classification, only sperm motility alone had a significant difference with the value of p <0.05. It was concluded that level of vitamin D serum has positive correlation with sperm motility.Key word: subfertile, vitamin D, sperm quality

Apakah Kadar β-hCG Praevakuasi dan Gambaran Proliferasi Sel Trofoblas secara Mikroskopik dapat digunakan untuk Prediksi Transformasi Keganasan pada Mola Hidatidosa? Kemala Isnainiasih Mantilidewi; Zulvayanti Zulvayanti; Wiryawan Permadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 1 Maret 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakTujuan: Meneliti perbedaan karakteristik umur, paritas, besar uterus, kadar β-hCG, dan hiperproliferasi pada mola hidatidosa (MH) dengan regresi spontan dan pada MH dengan transformasi keganasan di RS Dr.Hasan Sadikin Bandung. Metode: Penelitian cross sectional deskriptif restrospektif mengambil data umur, paritas, besar uterus, kadar β-hCG pre-evakuasi, dan hiperproliferasi dari rekam medis pasien MH periode 2007-2016. Data diolah menggunakan program SPSS versi 20.0 for Windows. Nilai p<0,05 dianggap signifikan. Hasil: Dari 400 rekam medis yang dianalisis, 233 dengan data lengkap dapat dianalisis. Mayoritas pasien usia reproduktif 20-35(53,6%) tahun, paritas 1-2 (n=90, 38,6%), dan besar uterus rata-rata 19,12±4,633 (~minggu kehamilan). Kadar β-hCG <100000 mIU/mL sebanyak 78(33,5%), ≥100000 mIU/mL sebanyak 155(66,5%). Pasien dengan hiperproliferasi sebanyak 83(35,6%) sedangkan pasien tanpa hiperproliferasi sebanyak 150(64,4%). Terdapat 219(94,0%) dengan komplit MH, dan 14(6,0%) HM parsial (tidak dipublikasi). Pasien kemudian dikategorikan menjadi kelompok transformasi keganasan dan kelompok remisi spontan. Tidak terdapat perbedaan umur, paritas, dan besar uterus diantara dua kelompok (p>0,05). Perbedaan kadar βhCG (mIU/mL) dan tingkat proliferasi menunjukkan hasil signifikan (p<0.05). Kesimpulan: Kadar β-hCG preevakuasi dan status hiperproliferasi dapat digunakan sebagai prediktor transformasi keganasan pasien MH. Can Preevacuation Level β-hCG and Microscopic Trophoblast Proliferation Predict Malignant Transformation in Hydatidiform Mole?AbstractObjective: To describe differences among age, parity, size of uterus, level of β-hCG, and hyperproliferation state in HM with spontaneous remission and in that with malignancy transformation at dr.Hasan Sadikin General Hospital Bandung. Methods: This a cross sectional descriptive restrospective study of HM cases analyzing data on age, parity, size of uterus, pre-evacuation level of β-hCG, and hyperproliferation state taken from medical record of HM patients between 2007-2016. Data were statistically analyzed using SPSS version 20.0 for Windows. Result p<0.05 was considered significant. Results: Out of 400 cases, 233 cases were selected. Those with incomplete data were not included in the analysis. Majority of patients were in reproductive age 20-35(53.6%) years old, has parity 1-2(n=90, 38.6%), and the size of uterus has mean 19.12±4.633 (~week of pregnancy). The level of β-hCG <100000 mIU/mL was 78(33.5%), ≥100000 mIU/mL was 155(66.5%). Patients with hyperproliferation were 83(35.6%) while without hyperproliferation were 150(64.4%). There were 219(94.0%) with complete HM, and 14(6.0%) partial HM (unpublished data). There were no significant differences in age, parity, size of uterus between the two groups (p>0.05). Differences on level of βhCG (mIU/mL) and proliferation state showed significant result (p<0.05). Conclusion: Preevacuation level of β-hCG and histopatology (proliferation state) may predict malignancy transformation in HM.Keywords: Hydatidiform mole, risk factors, remission, malignancy transformation

Maturation of Vaginal Epithelium and Dyspareunia Symptoms in Equol Producing and Non-Producing Menopausal Women Tita Husnitawati Madjid; Nurlina Juniar; Dian Tjahyadi; Birgitta M. Dewayani; Wiryawan Permadi; Benny Hasan Purwara; Hadi Susiarno
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Introduction: Equol is a metabolite of soy isoflavon called daidzein which is produced by gastrointestinal tract bacteria. This research aims to analyze the maturation of vaginal epithelium and dyspareunia symptoms in producing and non-producing equol menopausal women.Method: This is a cross sectional research. Subject was a community of menopausal women who fulfilled inclusion criteria. Subjects were asked to sign a written informed consent. Subjects underwent vaginal epithelium maturation assessment and were asked whether she experienced dyspareunia. Research was conducted in January 2017.Result: There was a significant difference on the maturation of vaginal epithelium and dyspareunia symptoms between equol producing and non-producing women (p < 0.05). This research found that in equol producing menopausal women, there was a shift-to-the-right vaginal epithelium maturation with more superficial cells compared to parabasal cells produced and less dyspareunia. Meanwhile, in women who did not produce equol, there was a shift-to-the-left vaginal epithelium maturation with more parabasal cells compared to superficial cells produced and more dyspareunia.Conclusion: In equol producing menopausal women, vaginal epithelium will undergo a shift-to-the-right maturation, with more superficial cells produced compared to women who did not produce equol.Maturasi Epitel Vagina dan Gejala Dispareunia pada Wanita Menopause yang Menghasilkan Equol dan Wanita yang Tidak Menghasilkan EquolAbstrakPendahuluan: Equol adalah metabolit isoflavon kedelai yang disebut daidzein yang diproduksi oleh bakteri saluran pencernaan. Penelitian ini bertujuan untuk menganalisis maturasi epitel vagina dan gejala dispareunia pada wanita menopause yang memproduksi dan tidak memproduksi equol.Metode: Penelitian ini merupakan penelitian cross sectional. Subjek penelitian adalah sekelompok wanita menopause yang memenuhi kriteria inklusi. Subjek diminta untuk menandatangani persetujuan tertulis dan menjalani penilaian maturasi epitel vagina dan ditanya apakah mengalami dispareunia. Penelitian dilakukan pada Januari 2017.Hasil: Terdapat perbedaan yang signifikan pada maturasi epitel vagina dan gejala dispareunia antara wanita yang memproduksi equol dan yang tidak memproduksi (p <0,05). Pada wanita menopause yang memproduksi equol, terjadi pematangan epitel vagina shift-to-the-right disertai produksi sel superfisial yang lebih banyak dibandingkan sel parabasal dan lebih sedikit gejala dispareunia. Sementara itu, pada wanita yang tidak menghasilkan equol, terjadi pergeseran shift-to-the-left maturasi epitel vagina dengan produksi sel parabasal lebih banyak dibandingkan sel superfisial dan lebih sering gejala dispareunia.Kesimpulan: Wanita menopause yang memproduksi equol mengalami maturasi epitel vagina shift-to-the-right disertai produksi sel superfisial yang lebih banyak dibandingkan dengan wanita menopause yang tidak memproduksi equol.Kata kunci: Dyspareunia; equol; maturasi epitel vagina

Co-Authors ahmad rizal Andi Kurniadi, Andi Andi Rinaldi Andri Rezano Anita Deborah Anwar Anita Rachmawati Aprilina Aprilina Aria Prasetya Masoem Arief Setiawan Benny Hasan Purwara Birgitta M. Dewayani Budi Handono Dani Setiawan Dany Hilmanto Dewi Andariya Ningsih Dewi M.D Herawati Dewi M.D. Herawati Dian Tjahyadi Dinan S. Bratakoesoema Disastra, Yuda Putra Edwin Armawan Ekadewi Retnosari Elsa Pudji Setiawati Elsa Pudji Setyawati Evi Pratami Farid Husin Farid Husin Gatot Nyarumenteng Adhipurnawan Winarno Harsono, Ali Budi Henni Djuhaeni Herawati, Dewi M D Iskandar Zulqarnain Johanes C Mose Josef Wattimury Josef Wattimury Jusuf S. Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Karwati Karwati Karwati, Karwati Kemala Isnainiasih Mantilidewi Kireina, Jessica Kusnandi Rusmil Kusuma, Aria Yusti M. Rizkar Arev Sukarsa Magnadi Yogi Rahma Mulyanusa A. Ritonga Nurlina Juniar Polar Silumi Praditya Virza Ramadhan Prianto, Adi Setyawan Qorinah Estiningtyas Sakilah Adnani Raden Tina Dewi Judistiani Ramadhan, Praditya Virza Ratnasari, Eka Rena Nurita Retno Puji Astuti Ria Bandiara Ridwan A. Putra Rosalina, Phang Ruswana Anwar Setiawan, Nurhayati Setyorini Irianti Sharon Gondodiputro Shilvia, Shilvia Supriyatin, Dedeh Susiarno, Hadi Sutrisno, Sutrisno Tita Husnitawati Tita Husnitawati Madjid Tita Husnitawati Madjid Tono Djuwantono Tono Djuwantono Tono Djuwantono Udin Sabarudin Windi Nurdiawan Yudi Mulyana Hidayat Yunas, Aisya Astri Zaimursyaf Azis Zulvayanti Zulvayanti

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