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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Ceva W. Pitoyo
Divisi Respirologi Dan Penyakit Kritis, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/ RS Dr. Cipto Mangunkusumo, Jakarta
Medicine & Pharmacology

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Performance of Xpert MTB/RIF by Using Gastric Lavage Samplein The Diagnosis of Pulmonary Tuberculosis in HIV Patients withSuspected Pulmonary Tuberculosis Mboeik, Manuel Lamberto Willem; Pitoyo, Ceva Wicaksono; Karjadi, Teguh Harjono; Karuniawati, Anis; Dewiasty, Esthika
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
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Introduction. Xpert MTB/RIF test on gastric lavage sample may improve pulmonary tuberculosis (TB) case finding, but its performance as a diagnostic test for pulmonary TB in HIV-infected adults patients has not been studied widely, including in Indonesia. This study aims to determine the performance of the Xpert MTB/RIF test in diagnosing pulmonary tuberculosis 30 | Jurnal Penyakit Dalam Indonesia | Vol. 5, No. 1 | Maret 2018 Manuel Lamberto Willem Mboeik, Ceva Wicaksono Pitoyo, Teguh Harjono Karjadi, Anis Karuniawati, Esthika Dewiasty among HIV-infected adult patients with suspected pulmonary tuberculosis by using gastric lavage sample. Method. A cross-sectional study was conducted on adult HIV-infected patients with suspected pulmonary tuberculosis in Cipto Mangunkusumo hospital Jakarta between February 2016 and June 2017. Gastric lavage sample and sputum sample collection were performed for Xpert MTB/RIF test and acif fast bacilli (AFB) smear examination. Results. Among total of 117 subjects, 81 (69,2%) subjects were unable to expectorate sputum. M tuberculosis was detected on Xpert MTB/RIF using gastric lavage samples in 34 (29,1%) subjects, AFB in 4 of 36 sputum samples and 2 of 117 gastric lavage samples. The drug sensitivity test on all 34 Xpert MTB/RIF positive subjects showed no rifampicin resistance. Fifty-one (43.6%) subjects were diagnosed as clinical pulmonary tuberculosis, 26 subjects among them were positive on Xpert MTB/ RIF assay, 4 subjects were smear sputum positive and 1 subject was gastric lavage smear positive. Using clinical diagnosis of pulmonary TB as gold standard, a single Xpert MTB/RIF assay using gastric lavage sample showed sensitivity of 50.98% (95% CI: 36.6-65.25), specificity 87.88% (95% CI: 77,1-94,62), positive predictive value 76,47% (95%CI: 61,67-86,78) and negative predictive value 69,88% (95% CI: 63,36-75.68). Conclusion. Xpert MTB/RIF performed on gastric lavage samples showed sensitivity of 50.98% and specificity 87.88% in clinical diagnosis of pulmonary tuberculosis in HIV-positive patients with pulmonary tuberculosis.
Efektivitas Vaksin COVID-19 mRNA Booster Kedua pada Tenaga Kesehatan di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo dan Faktor yang Memengaruhinya Lubis, Siti Taqwa Fitria; Koesnoe, Sukamto; Yunihastuti, Evy; Shatri, Hamzah; Karjadi, Teguh Harjono; Harimurti, Kuntjoro; Pitoyo, Ceva Wicaksono; Yunir, Em
Jurnal Penyakit Dalam Indonesia
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Introduction. The emergence of the Omicron variant during the pandemic had an impact on the effectiveness of the COVID-19 vaccine. The spread of Omicron increased rapidly even in populations that had been vaccinated with booster doses, causing a high incidence of infection. This study aimed to determine the effectiveness and factors related to the effectiveness of the second mRNA booster vaccine as well as antibody levels after the second mRNA booster vaccine in healthcare workers at Cipto Mangunkusumo National General Hospital. Methods. This study used a cohort design. Total sampling of 271 healthcare workers were obtained from previous research and continued with consecutive sampling. Selected subjects were interviewed, and blood samples were taken to measure IgG sRBD antibody levels. The effectiveness of the vaccine was calculated, and bivariate and multivariate analysis was carried out to assess the factors that influenced the effectiveness of the second mRNA booster vaccine. Results. A total of 9 subjects (5.6%) were infected with COVID-19 in the second booster vaccine group and 11 subjects (9.7%) in the first vaccine group. The effectiveness of the vaccine against COVID-19 infection was 42% (CI 95% -37 – 75%), p = 0,215. Age, gender, hypertension, type 2 DM, obesity, smoking, and COVID-19 infection before booster have no relationship to the effectiveness of the second booster mRNA vaccine. In 48 subjects who had their antibody levels checked during the first and second boosters, there was an increase from 4,743 AU/ml (IQR 6,053.3) to 8,532 AU/ml (IQR 8,040.3). Conclusions. The effectiveness of the second mRNA booster vaccine against COVID-19 infection in healthcare workers was 42%. There were no factors related to the effectiveness of the second mRNA booster vaccine. The sRBD antibody levels after the second booster vaccine were higher than the first booster vaccine.
Co-Authors Adityo Susilo, Adityo Afifah Is Agnes Kurniawan Aldy Heriwardito Alvina Widhani, Alvina Andree Kurniawan Andri Sulaiman Anis Karuniawati Annisa, Firda Ardi Ardian Ardi Ardian, Ardi Ari F Syam Ari Fahrial Syam Aulia Rizka Aulia Rizka, Aulia Birry Karim Borries Foresto Buharman Bramantya Wicaksana Buharman, Borries Foresto C. Martin Rumende, C. Martin Cleopas M. Rumende Cleopas Martin Rumende Cleopas Martin Rumende Cleopas Martin Rumende Cynthia Olivia Maurine Jasirwan Diah Martina, Diah Dita Adhitianingsih Dita Adhitianingsih, Dita E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edwin Wijaya Edwin Wijaya, Edwin Eka Ginanjar Em Yunir, Em Erni J Nelwan, Erni J Erni Juwita Nelwan, Erni Juwita Esthika Dewiasty Esthika Dewiasty, Esthika Evy Yunihastuti Firda Annisa Gurmeet Singh Gurmeet Singh Herikurniawan Herikurniawan Herikurniawan, Herikurniawan Ikhwan Rinaldi Iskandar A Jasirwan, Chyntia OM Khie Chen Koesno, Soekamto Kuntjoro Harimurti Leonard Nainggolan Maksum, Maradewi Manuel Lamberto Willem Mboeik Maradewi Maksum Marcellus Simadibrata Marcellus Simadibrata Mboeik, Manuel Lamberto Willem Mira Yulianti Mira Yulianti, Mira Muhammad Alkaff Muhammad Alkaff Murdani Abdullah Murdani Abdullah Nababan, Toman Noto Dwimartutie Riahdo J. Saragih Robert Sinto Robert Sinto Rudyanto Sedono Salim Harris Salim Harris, Salim Siti Setiati Siti Setiati Siti Taqwa Fitria Lubis, Siti Taqwa Fitria Sukamto Koesnoe Sukamto Koesnoe Sukamto Koesnoe Sukamto Koesnoe Teguh Hardjono Teguh Harjono Karjadi Teguh Harjono Karjadi, Teguh Harjono Toman Nababan Tony Loho Wicaksana, Bramantya Widayat Djoko Santoso Widayat Djoko Santoso Widayat Djoko Santoso, Widayat Djoko Zulkifli Amin