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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Journal Pharmaceutical Science and Application (JPSA) Jurnal Kimia (Journal of Chemistry) METAMORFOSA Journal of Biological Sciences Jurnal Farmasi Udayana Jurnal Farmasi Klinik Indonesia Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo Journal of Health Sciences and Medicine Pharmacy Reports Prosiding Workshop dan Seminar Nasional Farmasi (WSNF)
Ni Made Pitri Susanti
Udayana University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Potensi Penangkapan Radikal Bebas DPPH dari Ekstrak Mengkudu (Morinda citrifolia L), Kelor (Moringa oleifera) dan Kedondong Hutan (Spondias pinnata (l.f) kurz) P.R. Satriari; P.P.K. Vedawati; M. Primantara; N.K. Warditiani; I M.A. Gelgel Wirasuta; N.M.P. Susanti
Jurnal Farmasi Udayana Vol. 6 No. 1, Tahun 2017
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.279 KB) | DOI: 10.24843/JFU.2017.v06.i01.p08

Abstract

Reactive Oxygen Species (ROS) merupakan suatu produk alami yang terbentuk dari metabolisme aerobik normal dalam tubuh yang secara potensial dapat menyebabkan kerusakan. Penelitian bertujuan untuk mengetahui potensi antioksidan yang paling kuat dari ekstrak buah mengkudu (Morinda citrifolia L), ekstrak daun kelor (Moringa oleifera) dan ekstrak daun kedondong hutan (Spondias pinnata (l.f) kurz). Pengujian aktivitas antioksidan dari ketiga tanaman ini yaitu dilakukan dengan metode DPPH yang kemudian diamati dengan Spektro UV-Vis pada panjang gelombang maksimum 315 nm. Analisis data dilakukan dengan menghitung persen inhibisi (% inhibisi) yang kemudian dibuat persamaan regresi linear. Hasil yang diperoleh bahwa nilai IC50 ekstrak buah mengkudu yaitu 22,95 µg/mL, nilai IC50 dari ekstrak daun kelor yaitu 42,19 µg/mL sedangkan nilai IC50 dari ekstrak daun kedondong hutan yaitu 49,97 µg/mL
EKSTRAKSI LIKOPEN DARI LIMBAH BUAH TOMAT (Solanum lycopersicum L.) N. M. P. Susanti; L. P. M. K. Dewi; I N.K. Widjaja; I.M.A.G. Wirasuta; K. G. Gityarani
Jurnal Farmasi Udayana Vol. 5, No. 1, Tahun 2016
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Tomat (Solanum lycopersicum L.) merupakan salah satu buah yang identik dengan warna merah menyala. Warna merah tersebut disebabkan oleh adanya pigmen merah karotenoid. Karotenoid yang paling berlimpah dalam buah tomat adalah likopen sebesar 60-64%. Likopen memiliki aktivitas antioksidan tertinggi dibandingkan karotenoid lainnya. Berdasarkan hasil Survei Sosial Ekonomi Nasional (SUSENAS) periode 2010-2014 menunjukkan bahwa konsumsi rata-rata buah tomat di Indonesia lebih kecil bila dibandingkan dengan ketersediaan buah tomat dari Necara Bahan Makanan (NBM). Produksi buah tomat yang berlebih dan tidak dimanfaatkan secara efektif seringkali dapat menimbulkan masalah bagi lingkungan karena buah tomat yang membusuk dan akhirnya menjadi limbah. Dalam penelitian ini dilakukan ekstraksi likopen dari limbah buah tomat dengan metode ekstraksi cair-cair untuk mengetahui jumlah kadar total likopen dari limbah buah tomat. Limbah buah tomat yang digunakan adalah buah tomat yang telah mengalami penyimpanan selama 6 sampai 10 hari. Metode ekstraksi cair-cair dilakukan dengan menggunakan pelarut n-heksan:aseton:etanol 96% (50:25:25 v/v/v) dengan perbandingan ekstrak:pelarut (1:1). Metode Spektrofotometri UV-Vis dilakukan dalam pengukuran kadar total likopen pada panjang gelombang maksimum 445, 472 dan 503nm menggunakan ?503 sebesar 1.585 x 105 M-1cm-1. Kadar total likopen yang diperoleh dari limbah buah tomat sebesar 0,00042% b/b atau sekitar 0,42 mg/100 gram dengan KV sebesar 6,88%.
VALIDASI METODE UJI KONFIRMASI SENYAWA GOLONGAN BENZODIAZEPIN DENGAN HPLC-DAD Khatija Taher Ali; Ni Made Pitri Susanti; I M.A.Gelgel Wirasuta
Jurnal Farmasi Udayana Vol. 2, No. 1, Tahun 2013
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Telah dilakukan validasi metode uji konfirmasi senyawa golongan benzodiazepin, yang meliputi spesifisitas, selektivitas, presisi, ketahanan (robustness), serta sensitivitas dengan HPLC-DAD. Penelitian ini bertujuan untuk memperoleh metode uji konfirmasi yang telah tervalidasi untuk senyawa golongan benzodiazepin. Penelitian dilakukan terhadap senyawa nitrazepam, bromazepam, flurazepam, klordiazepoksida, dan diazepam. Sistem kromatografi yang digunakan adalah fase diam kolom Luna C8-strong cation exchange dengan fase gerak campuran dapar fosfat 0,05 M pH 3 dan asetonitril 90% (68,5:31,5, v/v). Sistem ini menghasilkan pemisahan yang spesifik, selektif, dan seksama untuk semua senyawa uji, namun tidak senstitif dan tidak tahan (robust).
Potensi Toksisitas Andrografolid dari Sambiloto (Andrographis paniculata (Burm.f.) Nees) pada kulit dan mata secara In Silico N. M. P. Susanti; N.K. Warditiani; C. Juwianti; I. N. T. Wisesa
Jurnal Farmasi Udayana Vol. 6 No. 1, Tahun 2017
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.915 KB) | DOI: 10.24843/JFU.2017.v06.i01.p09

Abstract

Andrografolid adalah kandungan kimia utama yang terdapat dalam tanaman sambiloto (Andrographis paniculata). Andrografolid memiliki banyak aktivitas farmakologi antara lain sebagai antiaterosklerosis, antiinflamasi, antioksidan, antihiperglikemik, dan antimalaria. Tujuan dari penelitian ini adalah untuk mengetahui toksisitas dari senyawa andrografolid dalam tanaman sambiloto secara in silico menggunakan software Toxtree v2.6.13. Uji toksisitas dilakukan menggunakan software Toxtree dengan menginput struktur 2 dimensi dari senyawa andrografolid dan diujikan terhadap 2 parameter uji yaitu Skin Irritation/Corrosion dan Eye Irritation and Corrosion. Hasil penelitian menunjukkan bahwa senyawa andrografolid tidak berpotensi menyebabkan korosi maupun iritasi pada kulit dan tidak berpotensi menyebabkan luka bakar dan luka bakar yang parah pada mata.
IDENTIFIKASI KANDUNGAN CANNABINOID DALAM EKSTRAK BATANG GANJA DENGAN METODE Al-TLC DAN HPTLC SPECTROPHOTODENSITOMETRY Ni Made Pitri Susanti
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 2 (2012): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

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Abstract

A research of identification of cannabinoid compounds of stems of cannabis sp was conducted. The aim of thisresearch was identified cannabinodes using TLC and HPTLC spectrophotodensitometry and confirmed by colortest. Cannabinoides of stems cannabis sp was extracted by maceration method by using ether as solvent.Concentrated extract was spotted on AL-TLC Si 60 G F 254 and also HPTLC Si 60 G F 254. Plates were elutedwith hexane-diethyl ether (80:20, v/v) in ascending on twin chember. Each peak was scanned on Camag TLCScannerIII, Identification of each insitu spectra were based on Rf and library spectra and confirmed by colortestby Fast Blue B salt.. The result showed that method can be used to identify the CBN, THC and CBD contentof marijuana stems.
PRAKTEK PELAYANAN KEFARMASIAN PADA RAWAT INAP-PT ASKES DI UNIT LOKET ASKES -IFRS -RS WANGAYA I Made Agus Gelgel Wirasuta; Made Gede Praditya Putra; Ni Made Pitri Susanti
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 3 (2013): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

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Abstract

Pharmaceutical care takes an essential role in order to realize the patient safety caring with effective medication cost. It was studied the pharmaceutical caring in pharmacy-clinic-Unit of Wangaye Hospital-Denpasar, which provided to the hospitalization patients of PT. Askes (Persero)-Cabang Denpasar and the role of  the health insurance verification.  Aim of the study was to observe the role of pharmacist and health insurance verification in order to realize the patient safety caring with effective medication cost. The pharmacist in this unit has strived for a pharmaceutical praxis according to the pharmaceutical regulation but not yet optimal utilized his praxis to obtain a rational use of drugs and effective medical cost. There was not a pharmacist, which was employed by PT ASKES to verify the pharmaceutical praxis, which provided pharmaceutical care to the ASKES patients.
ANTIOXIDANT ACTIVITY TEST OF ANDROGRAPHOLIDE IN BITTER HERBS USING DPPH SCAVENGING Ni Made Pitri Susanti; Ni Kadek Warditian; I Made Agus Gelgel Wirasuta
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.435 KB) | DOI: 10.24843/JHSM.2017.v01.i01.p03

Abstract

Abstract Bitter herbs (Sambiloto) have many pharmacological activities including antioxidant, antidiabetic, anticancer, antihyperlipidemic and anti-inflammation. Andrographolide is a diterpene compounds contained in bitter herbs. It is known that andrographolide compound responsible for the pharmacological activity of the bitter herbs. This study investigated DPPH free radical scavenging activity from andrographolide diterpene lactone. This study was initiated with the isolation of andrographolide compound from bitter herbs and then testing their DPPH free radical scavenging. The results suggested that andrographolide had IC50 value of 5.45 mg. This means andrographolide has 50% DPPH inhibition effect, i.e 5.45 mg.
Exploring the binding affinity of rutin, catechin, and epicatechin to ALK and caspase-3: implications for colorectal cancer treatment Adhyaksa, I Nyoman Mahesa Praba; Pramesti, Ni Luh Putu Cintya; Susanti, Ni Made Pitri; Laksmiani, Ni Putu Linda
Pharmacy Reports Vol. 2 No. 2 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.56

Abstract

This study explores the interaction of rutin, catechins, and epicatechins with anaplastic lymphoma kinase (ALK) and caspase-3, focusing on their potential role in modulating the apoptotic mechanisms in colorectal cancer cells. The experimental approach included the preparation of ALK (PDB ID: 5USQ) and caspase-3 (PDB ID: 2XZT), validation of the docking process, optimization of the test compounds, and docking analyses. The molecular docking methodology was validated with an RMSD value of ≤ 3 Å. The docking outcomes revealed that rutin, catechins, and epicatechin exhibited lower binding affinity to ALK, with binding energies of -8.58 kcal/mol, -8.41 kcal/mol, and -7.82 kcal/mol, respectively, compared to ALK's native ligand (-10.27 kcal/mol). Conversely, these compounds demonstrated higher affinity to caspase-3 than its native ligand (-2.54 kcal/mol), with binding energies of -6.03 kcal/mol for rutin, -5.28 kcal/mol for catechins, and -4.95 kcal/mol for epicatechin. These findings suggest that rutin, catechins, and epicatechins hold promise as colorectal anticancer agents by potentially modulating the activity of ALK and caspase-3 through inhibition and activation mechanisms, respectively.
The activity of of vitexicarpin and artemetin in inhibiting hyperpigmentation: an in silico study Riswana, I Kadek Rizki; Anjani, Ni Luh Ari Krisma; Susanti, Ni Made Pitri; Laksmiani, Ni Made Linda
Pharmacy Reports Vol. 3 No. 1 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.57

Abstract

Hyperpigmentation, characterized by increased skin darkening, is primarily attributed to augmented melanin production, often exacerbated by UV ray exposure. Inhibiting melanogenesis enzymes, such as tyrosinase, tyrosinase-related protein 1, and d-dopachrome tautomerase, is a recognized strategy for managing hyperpigmentation. Flavonoid compounds, namely vitexicarpin and artemetin, have emerged as potential antihyperpigmentation agents. This study explores the inhibitory capabilities of vitexicarpin and artemetin on melanogenesis enzymes through in silico molecular docking. The process involved optimization of test compounds using HyperChem 8, target protein preparation with Chimera 1.11, method validation, and docking employing AutoDockTools 1.5.6, which integrates Autodock4 and Autogrid4 programs. The validity of the molecular docking method was confirmed with an RMSD value of ≤3 Å. The findings demonstrate that vitexicarpin and artemetin exhibit higher affinity towards tyrosinase, tyrosinase-related protein 1, and d-dopachrome tautomerase than the native ligands. Interaction models between the compounds and target proteins include hydrogen bonds, Van der Waals forces, hydrophobic interactions, and electrostatic bonds, with the most visually identifiable hydrogen bonds. These results suggest that vitexicarpine and artemetin have promising potential as antihyperpigmentation agents by inhibiting melanogenesis enzymes, as evidenced by the molecular docking approach.
The potency of pinostrobin and pinocembrin as antiphotoaging agents: in silico study Pradnyana, I Gusti Ngurah Agung; Putri, Ketut Yuantarisa Kartika; Susanti, Ni Made Pitri; Laksmiani, Ni Putu Linda
Pharmacy Reports Vol. 2 No. 2 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.58

Abstract

Photoaging occurs when the skin ages due to ultraviolet light exposure. Phenolic compounds generally possess antioxidant activity, which helps prevent the formation of free radicals caused by sunlight exposure. This study explores the potential of pinostrobin and pinocembrin as antiphotoaging agents through molecular docking against matrix metalloproteinases (MMPs): MMP-1, MMP-3, and MMP-9. We utilized Hyperchem 8 to prepare and optimize the test compound and Chimera 1.11.1 for protein preparation. Validation and docking procedures were conducted using the AutoDockTools 1.5.6 application, with validation confirming that the method was valid with an RMSD value ≤ 3 Å. Both pinostrobin and pinocembrin exhibited an affinity for the target protein, although their affinity was slightly less than that of the native ligand and retinol. In conclusion, pinostrobin and pinocembrin demonstrate an affinity for MMP-1, MMP-3, and MMP-9, indicating their potential as anti-photoaging agents by obstructing the mechanisms of MMP-1, MMP-3, and MMP-9.
Co-Authors Adhyaksa, I Nyoman Mahesa Praba Amir Musadad Anjani, Ni Luh Ari Krisma Bhadreswara, I Gede Rheza Wisnu C. Juwianti D. P.D. Saputra Daryono H. Tjahjono Dewa Ayu Swastini Dewi K. A. S. Dewi, A.A.R.P. Dewi, Luh Putu Mirah Kusuma Dewi, N. M. A. P. Diajeng Putri Dwinda Saputra Febriani, Ni Kadek Dwi G. A. K. Amarawati G. A.K. Amarawati Harlina Setiawati Manurung I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I K. Duantara I K. N. S. Sanjaya I Made Agus Gelgel Wirasuta I N.K. Widjaja I. N. T. Wisesa I. P.D.N. I. P. D. N. Parahyangan K. G. Gityarani K. M. Arianti Khatija Taher Ali L. P. M. K. Dewi Laksmiani, Ni Made Linda Luh Gede Winda Kusuma Dewi Luh Putu Febryana Larasanty Luh Putu Mirah Kusuma Dewi M. D. Widyastuti M. Primantara Made Gede Praditya Putra Meilinayanti, Ni Made L. Milawati Milawati N. K. M. Noviyanti N. K. M. Noviyanti N. L. P. V. Paramita Ni Kadek Dwi Candra Sasmita Yanti Ni Kadek Warditian Ni Kadek Warditiani Ni Putu Arista Dewi Ni Putu Linda Laksmiani Nyunda, Ricky Putra Banyim Oka M. P. L. Hendrayati P. V. P. Putri P.P.K. Vedawati P.R. Satriari Pinangkaan, C. Pradnyana, I Gusti Ngurah Agung Pramesti, Ni Luh Putu Cintya Primadewi C. Putri, Ketut Yuantarisa Kartika Putri, Lucienne Agatha Larasati Nugraha Putu Ayu Asri Damayanti Putu Oka Samirana Rahmana E. Kartasasmita Rismayanti, A. A. M. I. Riswana, I Kadek Rizki Sri Laksemi, Dewa Ayu Agus Sunariyani, P. E. A. Surudarma, I Wayan W. A. Wijaya Wiantini, Ni Made Rita Widhiastuti, K.A.P. Widjaja I N.K. Widjaja, I N. K Widjaja, I. N. K.