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All Journal HAYATI Journal of Biosciences ILMU KELAUTAN: Indonesian Journal of Marine Sciences BULETIN OSEANOGRAFI MARINA Journal of Marine Research Jurnal Kelautan Tropis JURNAL ENGGANO Journal of Fisheries & Marine
Rini Pramesti
Department Of Marine Sciences, Faculty Of Fisheries And Marine Sciences, Diponegoro University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Other

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Journal : HAYATI Journal of Biosciences

 1 
The Potential of Fucoxanthin from Sargassum polycystum: Antioxidant, Antibacterial, and Photoprotective Properties Pramesti, Rini; Setyati, Wilis Ari; Subagiyo; Anjani, Devi Oktavia
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.466-474

Abstract

Sargassum is a genus of seaweed that is known to contain fucoxanthin. The increasing incidence of health issues related to antimicrobial resistance (AMR), free radicals, and ultraviolet (UV) radiation has prompted the exploration of natural compounds as alternative sources of pharmaceutical agents. Fucoxanthin possesses the ability to protect cells from oxidative damage and offers a wide range of health benefits. This study aimed to evaluate the potential of fucoxanthin derived from Sargassum polycystum as an antioxidant, antifungal, antibacterial, and photoprotective (sunscreen) agent. The research methods included the extraction and isolation of fucoxanthin using Open Column Chromatography (OCC), phytochemical screening, thin-layer chromatography (TLC), antibacterial and antifungal assays, antioxidant activity assessment using the DPPH method, and determination of the Sun Protection Factor (SPF). The results showed that the extract of Sargassum polycystum contains secondary metabolites such as flavonoids, alkaloids, tannins, steroids, and saponins. The fucoxanthin fraction was successfully isolated, characterized by a distinct absorption peak at 447.5 nm and a retention factor (Rf) value of 0.93. The fucoxanthin fraction showed antibacterial activity against Staphylococcus aureus, as well as antifungal activity against Trichoderma sp. and Candida albicans. The antioxidant activity of the fucoxanthin fraction was categorized as strong, with an IC50 value of 67 ppm. Its photoprotective ability was classified as maximal, with a Sun Protection Factor value of 13.71. The fucoxanthin fraction derived from Sargassum polycystum exhibits promising potential as an antibacterial, antifungal, antioxidant, and photoprotective agent, and may serve as a valuable natural resource in pharmaceutical and cosmeceutical applications.
Seaweed Diversity and Bioactive Compounds in Panjang Islands, Central Java, Indonesia Setyati, Wilis Ari; Pramesti, Rini; Putri, Angela Salsalina; Risandhi, Danendra Aquila Azfa; Firdaus, Syifa Shafira; Lumban Gaol, Josua Gabriel
HAYATI Journal of Biosciences Vol. 33 No. 3 (2026): May 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.3.669-680

Abstract

The biodiversity of seaweed encompasses a wide array of potential bioactive compounds applicable to various industries, particularly pharmaceuticals. This study aimed to collect seaweed diversity data from Panjang Island, Jepara, Central Java, Indonesia, and to identify the bioactive compounds and biological activity of each seaweed species for preliminary screening. Random sampling was used to collect the sample. Qualitative identification of bioactive compounds was performed using the maceration method for extraction, phytochemical screening tests, and pigment identification based on Rf values on TLC. Antibacterial screening tests were performed against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, followed by testing against pathogenic fungi (C. albicans) using the disk diffusion method, and an antioxidant test using the DPPH method. The results showed that six species from three phyla (Chlorophyta, Phaeophyta, and Rhodophyta) exhibited distinct morphological characteristics, and the types of bioactive compounds produced by each species differed. The biological activity test results showed a low inhibitory activity. Antibacterial and antifungal biological activities were at the value of (<5 mm), and antioxidant biological activity was (>750 ppm). However, the active compounds and pigments with potential antibacterial, antifungal, and antioxidant properties can be optimized in various fields of bioindustry in the future.
Co-Authors A. B. Susanto A.B. Susanto A.B. Susanto A.B. Susanto AB Susanto AB. Susanto Adam Sojuangon Pasaribu Adi Santoso Agus Sabdono Ahmad Fadhil Muzaki Ahmad Saddam Habibi Akbar, Muhamad Rahadian Akmal Nasrulloh Alfi Satriadi Ali Djunaedi Ali Ridlo Ananta, Raditya Rizki Andiska, Prismabella Wilis Anisah Harahap Anjani, Devi Oktavia Antonius Budi Susanto Ardiawan Pandu Romenda Ardiawan Pandu Romenda Bambang Yulianto C. Wiencke Chrisna Adhi Suryono Dafit Ariyanto Dara Ramadhania Istiqomahani Delianis Pringgenies Desni Elfrida Samosir Dini, Puti Sukma Rahma Edi Wibowo Kushartono Ega Hagita Testi Eldita Amalia Elfonso Robby Sitorus Endang Supriyantini Errizal Machmud Putra Faishal Islami, Faishal Feri Setiawan Firdaus, Syifa Shafira G. O. Kirst Galih S. Adiguna Gandang Herdananto Nugroho Ghofari, Miftahul Akhyar Gunawan Widi Santosa Ihsan Mahfudh Ika Asri Desanti Intan Budi Setiasih Irwani Irwani Istiqomahani, Dara Ramadhania Jelita Rahma Hidayati Karla Lutfia Rahmadanti Koesoemadji Koesoemadji Lovensia Zukruff Albasit Lumban Gaol, Josua Gabriel Mahfudh, Ihsan Marhaeny, Annisa Maya Puspita Meli Ayu Pangestika Miftahul Akhyar Ghofari Mohamad Mirza Mohamad Mirza Muhamad Ihsan Muhamad Rahadian Akbar Muhammad Abdul Zaky Muhammad Zainuddin Muhammad Zainuddin Nasrulloh, Akmal Nirwani Nirwani Nirwani Soenardjo Nursiana Suci Wulandari Panjaitan, Kristina Venza Pasaribu, Adam Sojuangon Pramastuti, Fransisca Ria Prayudha, Muhammad Rifky Prismabella Wilis Andiska Puti Sukma Rahma Dini Putra, Errizal Machmud Putri, Angela Salsalina Raden Ario Radhian Wikanarto Widodo Raditya Rizki Ananta Risandhi, Danendra Aquila Azfa Rozi Hamdani Rudhi Pribadi Satria Sakti Budi Leksono, Satria Sakti Budi Sebastian Margino Setia Devi Kurniasih, Setia Devi Setiasih, Intan Budi Siti Rudiyanti Sitorus, Elfonso Robby Sri Sedjati Subagiyo Subagiyo Subagiyo Subagiyo Subagiyo Sunaryo Sunaryo Suryono Suryono Susanto, AB. Tarida Tarida Tarida, Tarida Testi, Ega Hagita Titis Buana Tiurma S Triyanto Triyanto Wahid Agung Saputra Wahyu Bagio Leksono Wakhid Indra Kusuma Widodo, Radhian Wikanarto Wilis A Setyati Wilis Ari Setyati Wulandari, Nursiana Suci Yohanes Oktaviaris Yulandaris Marsa Zaky, Muhammad Abdul