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Mesenchymal Stem Cells and Clinical Application in Chronic Lung Diseases Isti Mardiana Soetartio; Triya Damayanti
Jurnal Respirasi Vol. 7 No. 3 (2021): September 2021
Publisher : Faculty of Medicine Universitas Airlangga

Mesenchymal stem cells are a multipotent mature non hematopoietic stem cells, with characteristics such as ability to self-renew and differentiate in mesodermal, ectodermal, and endodermal pathway. Mesenchymal stem cells also secrete cytokine and immunoreceptor which regulate micro environment in host tissues and angiogenic mediators which are able to improve damaged tissues. Mesenchymal stem cells are obtained from the human body by isolation, culture, proliferation, characterization, and/or differentiation originating from fat cells (adipose), periosteum tissue, and other tissues from the body. Mesenchymal stem cells can be obtained by autologous and allogenic way. Stem cell processing includes isolation, proliferation, differentiation, and temporary storage for clinical application adhering to good drug manufacturing practice. Approach to cell therapy and bioengineering in lung disease is rapidly developing in the last 10 years. In the current era of cell therapy and transplantation, a lot of research has been done to understand and develop mesenchymal stem cells as a therapeutic alternative, particularly in respiratory area.

The Proportion of Lung Hyperinflation In Patients With Persistent Asthma In Persahabatan Hospital Jakarta Using Multiple Breath N2-Washout Marisa Afifudin; Faisal Yunus; Triya Damayanti
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.20

Background: In asthma, small airway dysfunction and inflammation may induce significant lung hyperinflation. The aim of the study is to discover the proportion of lung hyperinflation in patient with persistent asthma in Persahabatan Hospital Jakarta. Method: A cross sectional study with descriptive analysis was done in Asthma clinic Persahabatan Hospital from September-November 2016. Forty-five subjects were recruited consecutively. Interview, physical examination, chest x-ray (CXR), spirometry and multiple breath N2-washout (MBW) were performed. Lung hyperinflation was defined as a residual volume /total lung capacity (RV/TLC%) above the upper limit of normal. Results: The proportion of lung hyperinflation in patients with persistent asthma was 17,8% (8 of 45 subjects). Median RV in milliliter was 1230 (570-2860). Median functional residual capacity (FRC) in milliliter was 1730 (970-3990). Median TLC in milliliter was 3310 (2490-6350). Mean RV/TLC ratio was 36,39% (SD±8,86). Mean FRC/TLC ratio was 52,86% (SD ±6,85). There was a significant correlation between forced expiratory volume in 1 second (FEV1%) value with lung hyperinflation with the decline of FEV1 <60% increased the risk of lung hyperinflation by 8,46 (95%CI=1,155-61,98; p=0,036). There were no significant correlation between age, gender, smoking habit, body mass index (BMI), ACT score, the severity of persistent asthma, duration of asthma, duration of steroid inhalation use, exacerbation history in the last 12-months and emphysematous in CXR with lung hyperinflation (p>0,05). Conclusions: The proportion of lung hyperinflation in patient with persistent asthma in Persahabatan Hospital Jakarta is 17,8%. Lung hyperinflation in persistent asthma is associated with the degree of airway obstruction.

Role of Mesenchymal Stem Cells In Chronic Obstructive Lung Disease Fatmi Andari; Triya Damayanti
Respiratory Science Vol. 1 No. 3 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i3.26

Therapy for Chronic Obstructive Pulmonary Disease (COPD) is currently still not giving effect to tissue repair and regeneration. Chronic Obstructive Pulmonary Disease is still a progressive degenerative disease. Stem cells through their regenerative ability offer a new promising alternative therapy for the management of degenerative diseases including COPD. There have been many studies conducted to determine the safety and efficacy of stem cells in COPD. Published research about stem cells on COPD is still in phase II. Further research is needed on a larger scale before stem cells can be widely applied in the management of COPD. Stem cells are a very promising alternative therapy and are a big leap in the medical world for degenerative diseases including COPD.

Proportions of Hypertension in Stable COPD Patients at the National Respiratory Center Persahabatan Hospital Dewantoro, Luhur; Wiyono, Wiwien Heru; Yunus, Faisal; Agustin, Heidy; Damayanti, Triya; Antariksa, Budhi; Fachrucha, Fanny; Samoedro, Erlang; Elhidsi, Mia
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.774

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most of these deaths are related to cardiovascular disease. This is due to systemic inflammation that causes increased vascular stiffness and hypertension. These comorbidities lead to poor quality of life, low exercise tolerance, and an increased risk of hospitalization. This study aims to report the proportion of hypertension among stable COPD patients in the Indonesian population.Methods: This cross-sectional study was conducted at the National Respiratory Center Persahabatan Hospital between February and March 2023. Stable COPD patients admitted to the Asthma and COPD Polyclinic who met the criteria were enrolled. Clinical information, vital signs, spirometry results, and DLCO measurements were collected.Results: There were 84 subjects participating in this study. The result of this study shows a 60.7% proportion of hypertension in stable COPD patients. Hypertension has a significant correlation with pulmonary functional values (P=0.021), severity degree of clinical COPD (P=0.004), Brinkman index (P=0.008), and age (P=0.0001). However, hypertension association with COPD duration (P=0.505) and DLCO (P=0.122) were not significant.Conclusion: The hypertension proportion in stable COPD Indonesian patients is 60.7%. Hypertension shows a significant association with pulmonary function values, severity degree of clinical COPD, Brinkman index, and age.

Expiratory Carbon Monoxide Levels of Cigarette Smokers in College Environment Sumarsudi, Karel Handito Syafi; Damayanti, Triya
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.642

Background: The impact of smoking is still a huge problem in the world. The use of cigarettes is one of the biggest causes of death that can be prevented. One of the harmful substances of smoking is carbon monoxide (CO). Unfortunately, research comparing CO levels in white and Kretek cigarette smokers among college students in Indonesia has not been conducted. This study aims to determine the relationship of expiratory CO levels in male students who smoke white or Kretek cigarettes at a university in Depok using a CO analyzer and questionnaire.Methods: This is a cross-sectional study design with 108 samples divided into two groups of white cigarette smokers and Kretek cigarette smokers with consecutive sampling techniques. Subjects took the expiratory CO test using a CO analyzer and filled out questionnaires related to smoking and other factors.Results: The study found expiratory CO results in white cigarette smokers at 13.9±8.36 ppm and Kretek cigarette at 13.18±8.79 ppm with no significant relation statistically. The factor that influences the subject's CO expiration is the Brinkman Index (P<0.001) with a weak correlation result and factors that influence the choice of cigarette type, namely pocket money (P=0.023) and age (P=0.015).Conclusion: There was no statistically significant relationship between the average of white cigarette smokers or Kretek cigarette smokers with expiratory CO levels in subjects. This might be due to a more significant effect on the number of cigarettes consumed. Seeing the trend in Indonesia that Kretek cigarettes are relatively cheaper than white cigarettes, money allowance is one of the factors that determine the choice of white or Kretek cigarettes for college students in Depok.

Biological Activity of Der p 1 and Der f 1 in Allergic Asthma and Their Contribution in Inflammation and the Role of Anti-inflammation in Allergic Asthma Julian; Rozaliyani, Anna; Wibowo, Heri; Damayanti, Triya
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 04 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss04/463

Asthma is a disease marked by chronic inflammation of the airways, with indications including wheezing, shortness of breath, and/or cough. As reported by GINA, the global prevalence of asthma is 1-18%. One type of asthma is Allergic asthma which is triggered by allergens, like Der p 1 and Der f 1 which upregulate type II immune response to secret IL-4 and IL-13 to upregulate IgE secretion. IgE binds to FcÎµRI in mast cells to release mediators that cause hypercontraction, this condition leads to asthma. Meanwhile, anti-inflammatory IL-10 manages IgE production by reducing inflammatory cytokine production and changing isotype switching. IgE Production is a crucial step. Therefore, it is essential to explore the cellular and molecular factors that trigger the regulated isotype-switching IgE and its suppressed mechanism, so this review will explore the biological activity of Der p 1 and Der f I and their contribution to inflammation and the role of anti-inflammation in allergic asthma especially isotype switching IgE We used PRISMA approaches, and tools (RSCB PDB, Uniprot, and SMART). The result appeared Der p 1, and Der f 1 activity have impacts on IL-4, IL-13, IL-10, and IgE secretion.

Exercise to Improve Asthma Control and Lung Function in Stable Asthma: An Evidence-based Case Report Romdhon, Abdul Rois; Abraham, Andre Thadeo; Damayanti, Triya
Kesmas Vol. 19, No. 5
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Asthma is a heterogeneous disease with respiratory symptoms that vary over time and intensity. Exercise-induced asthma patients are advised to avoid strenuous physical activity, which can trigger bronchospasm. However, appropriate exercise can improve asthma control and lung function in stable asthma patients. A literature search was conducted on PubMed, COCHRANE, and EMBASE databases using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines according to the specified eligibility criteria. Those studies were critically appraised using the Oxford Critical Appraisal Tool 4.0. Four articles were selected based on the PRISMA search strategy flowchart to assess their validity, importance, and applicability. There was a significant effect of aerobic exercise on lung function (p-value = 0.05) and asthma control (p-value = 0.004). There was a significant effect of breathing exercise on the quality-of-life outcome group (p-value <0.05) and Forced Expiratory Volume in 1 second (FEV1)% predicted (p-value <0.001). Physical exercise for 30 minutes two to three times per week or yoga exercise for 60 minutes per day for 3-5 days improves lung function and asthma control in stable asthma patients.

Determining Factors for Smoking Habits and FeNO Levels in Male College Student Smokers Tadjoedin, Irfan Hasyim; Wibowo, Adityo; Damayanti, Triya
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.130-136

Introduction: Smoking remains a pervasive and persistent health issue in Indonesia. Numerous studies have explored the impact of smoking and fractional exhaled nitric oxide (FeNO) levels on college students. However, none have been conducted in Indonesia. With a substantial number of smokers and teenage smokers in the country, there is a critical need to understand the implications of smoking. This study aimed to enhance the comprehension of the motivations behind smoking habits and, consequently, to devise more effective smoking cessation programs. It specifically sought to elucidate the relationship between smoking habits and exhaled nitric oxide (NO) levels among college students and to explore the reasons why students smoke. Methods: This study employed analytical and descriptive cross-sectional approaches. We interviewed 124 participants, 30 of whom were randomly selected for FeNO-level testing. Results: The mean age of the subjects was 20.1 ± 1.54 years. Of these, 48 (38.7%) were enrolled in science and technology programs and 76 (61.3%) in social sciences. The Brinkman index predominantly indicated a mild level of smoking (96.8%), with a moderate level observed in 3.2% of the subjects. The median FeNO level was 12 ppb. According to the Horn questionnaire, the most cited reasons for smoking were pleasure (71%), followed by stress relief (66.1%) and stimulation (38.7%). No significant correlation was found between the Brinkman index and FeNO levels. Conclusion: The primary factors influencing smoking habits among the subjects were stress relief and the pleasure derived from smoking. No correlation was observed between smoking habits and exhaled NO levels.

Expiratory Carbon Monoxide Levels of Cigarette Smokers in College Environment Sumarsudi, Karel Handito Syafi; Damayanti, Triya
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.642

Background: The impact of smoking is still a huge problem in the world. The use of cigarettes is one of the biggest causes of death that can be prevented. One of the harmful substances of smoking is carbon monoxide (CO). Unfortunately, research comparing CO levels in white and Kretek cigarette smokers among college students in Indonesia has not been conducted. This study aims to determine the relationship of expiratory CO levels in male students who smoke white or Kretek cigarettes at a university in Depok using a CO analyzer and questionnaire.Methods: This is a cross-sectional study design with 108 samples divided into two groups of white cigarette smokers and Kretek cigarette smokers with consecutive sampling techniques. Subjects took the expiratory CO test using a CO analyzer and filled out questionnaires related to smoking and other factors.Results: The study found expiratory CO results in white cigarette smokers at 13.9±8.36 ppm and Kretek cigarette at 13.18±8.79 ppm with no significant relation statistically. The factor that influences the subject's CO expiration is the Brinkman Index (P<0.001) with a weak correlation result and factors that influence the choice of cigarette type, namely pocket money (P=0.023) and age (P=0.015).Conclusion: There was no statistically significant relationship between the average of white cigarette smokers or Kretek cigarette smokers with expiratory CO levels in subjects. This might be due to a more significant effect on the number of cigarettes consumed. Seeing the trend in Indonesia that Kretek cigarettes are relatively cheaper than white cigarettes, money allowance is one of the factors that determine the choice of white or Kretek cigarettes for college students in Depok.

Proportions of Hypertension in Stable COPD Patients at the National Respiratory Center Persahabatan Hospital Dewantoro, Luhur; Wiyono, Wiwien Heru; Yunus, Faisal; Agustin, Heidy; Damayanti, Triya; Antariksa, Budhi; Fachrucha, Fanny; Samoedro, Erlang; Elhidsi, Mia
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.774

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most of these deaths are related to cardiovascular disease. This is due to systemic inflammation that causes increased vascular stiffness and hypertension. These comorbidities lead to poor quality of life, low exercise tolerance, and an increased risk of hospitalization. This study aims to report the proportion of hypertension among stable COPD patients in the Indonesian population.Methods: This cross-sectional study was conducted at the National Respiratory Center Persahabatan Hospital between February and March 2023. Stable COPD patients admitted to the Asthma and COPD Polyclinic who met the criteria were enrolled. Clinical information, vital signs, spirometry results, and DLCO measurements were collected.Results: There were 84 subjects participating in this study. The result of this study shows a 60.7% proportion of hypertension in stable COPD patients. Hypertension has a significant correlation with pulmonary functional values (P=0.021), severity degree of clinical COPD (P=0.004), Brinkman index (P=0.008), and age (P=0.0001). However, hypertension association with COPD duration (P=0.505) and DLCO (P=0.122) were not significant.Conclusion: The hypertension proportion in stable COPD Indonesian patients is 60.7%. Hypertension shows a significant association with pulmonary function values, severity degree of clinical COPD, Brinkman index, and age.

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