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All Journal The Journal of Pure and Applied Chemistry Research Pharmacon Indonesian Journal of Chemistry Jambura Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Acta Chimica Asiana Hydrogen: Jurnal Kependidikan Kimia Empowerment: Jurnal Pengabdian Masyarakat Jurnal ADAM : Jurnal Pengabdian Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Komunitas Farmasi Nasional
Ihsanul Arief
Akademi Farmasi Yarsi Pontianak
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Journal : Pharmacon

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Virtual Screening to Identification The Active Compounds from Kratom (Mitragyna speciosa) as Analgetics Arief, Ihsanul; Inderiyani, Inderiyani
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.19911

Abstract

Kratom (Mytragina speciosa) is one of the endemic plants in Southeast Asia in general and Kalimantan in particular which is proven to have activities as an analgesic, sedative (antidepressant), and, antiobesity, breast anticancer, antinociceptive, CYP450 induction, anti-inflammatory, opiate, antimicrobial, and antioxidant. However, no report states the active compounds from kratom leaves that have these activities. Therefore, this study will identify the active compounds contained in kratom leaves with a virtual screening process responsible for analgesic activity along with the prediction of adsorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. The virtual screening process was performed based on molecular tethering, while the prediction of ADMET properties was done with the help of a web server. The results obtained showed that the compound (-)-epicatechin was most responsible for the analgesic activity of kratom leaves. The ADMET profile of this compound predicts that it has good bioavailability and is non-toxic.
Co-Authors . Asmirah Athiah Masykuroh Bambang Setiaji Bambang Setiaji Bambang WIJIANTO Buannata, Jordi Dian Oktavianti, Dian Hairunnisa Hairunnisa Herdaningsih, Sulastri Herlina Rasyid Husnani, Husnani Inderiyani, Inderiyani Kurnianto, Erwan Masriani . Muhammad Fachrie Nunuk Hariani Soekamto Rasyid, Herlina Ria Armunanto Ria Armunanto Riska Mardiyanti Syadza Firdausiah Syahrul Khairi Tobing, Aldi Wahyu Dita Saputri