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XGBoost and Network Analysis for Prediction of Proteins Affecting Insulin based on Protein Protein Interactions Mohammad Hamim Zajuli Al Faroby; Mohammad Isa Irawan; Ni Nyoman Tri Puspaningsih
Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control Vol. 5, No. 4, November 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/kinetik.v5i4.1076

Abstract

Protein Interaction Analysis (PPI) can be used to identify proteins that have a supporting function on the main protein, especially in the synthesis process. Insulin is synthesized by proteins that have the same molecular function covering different but mutually supportive roles. To identify this function, the translation of Gene Ontology (GO) gives certain characteristics to each protein. This study purpose to predict proteins that interact with insulin using the centrality method as a feature extractor and extreme gradient boosting as a classification algorithm. Characteristics using the centralized method produces  features as a central function of protein. Classification results are measured using measurements, precision, recall and ROC scores. Optimizing the model by finding the right parameters produces an accuracy of  and a ROC score of . The prediction model produced by XGBoost has capabilities above the average of other machine learning methods.
XGB-Hybrid Fingerprint Classification Model for Virtual Screening of Meningitis Drug Compounds Candidate Mohammad Hamim Zajuli Al Faroby; Helisyah Nur Fadhilah; Siti Amiroch; Rahmat Sigit Hidayat
Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control Vol. 7, No. 2, May 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/kinetik.v7i2.1424

Abstract

Meningitis is an infection of the lining of the brain caused by diffuse inflammation, and this condition is caused by viruses or bacteria that cause Meningitis. Prevention for this disease is still in the form of strengthening antibodies with vaccines. There is no significant compound to relieve or treat Meningitis patients. In previous studies, they got seven proteins vital to Meningitis. We continued to investigate the compounds associated with the seven proteins. We chose the in-silico process by utilizing data in an open database. We use several databases for the data collection process. After that, the compound data were extracted for bonding features and chemical elements using molecular fingerprints. We use two fingerprint methods, where both we combine with three types of combinations. The combined results produce three types of datasets with different matrix sizes. We establish the Extreme Gradient Boosting (XGB) method to form the classification model for the three datasets, select the best classification model, and compare it with other classification algorithms. The XGB model has better quality than the classification model of other algorithms. We used this model to predict and quantify compounds that strongly bind to seven vital meningitis proteins. The compound with the highest predictive score (we found more than 0.99) became a drug candidate to inhibit or neutralize Meningitis.
Regression Analysis of CAR, NPL-Net, LDR on Increasing Return on Asset (Case Study on Banking Companies Listed on IDX in 2018-2020) Mohammad Hamim Zajuli Al Faroby
Internasional Journal of Data Science, Engineering, and Anaylitics Vol. 2 No. 1 (2022): International Journal of Data Science, Engineering, and Analytics Vol 2, No 1,
Publisher : International Journal of Data Science, Engineering, and Analytics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/ijdasea.v2i1.24

Abstract

Banking is a financial institution tasked with collecting funds from the public and then channeling them back to obtain income. The bank's performance can be seen by comparing the ratio figures in the annual financial statements that the bank has achieved. Therefore, this study aims to determine the CAR, NPL-Net, and LDR, which affect bank profitability or Return on Assets. This research method uses Multiple Linear Regression Analysis with secondary data and a ratio measurement scale, and the number of samples is 90 samples from 30 banking companies during the 2018-2020 period. This data is sourced from the Indonesia Stock Exchange, with the Judgment Sampling technique. The sample was reduced to 84 by the outlier test due to abnormal data. Based on the results of the analysis, it is known that CAR and LDR have no significant effect on Return on Assets, otherwise, NPL-Net has a significant effect on Return on Assets, and CAR, NPL-Net, LDR simultaneously have a significant effect on Return on Assets.
Classification of IGF1R ligand compounds for Identification of herbal extracts using extreme gradient boosting Mohammad Hamim Zajuli Al Faroby; Siti Amiroch; Bernadus Anggo Seno Aji; Avriono Aritonang
Jurnal Informatika Vol 16, No 3 (2022): September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26555/jifo.v16i3.a23286

Abstract

Diabetes Mellitus is a serious disease that requires serious treatment. The cause of this disease is due to malfunctions in insulin and insulin-producing organs. One of the proteins that become insulin signaling receptors is IGF1R, which has an important role in activating and maximizing insulin performance. In this study, we aimed to obtain herbal compounds that can activate the function of the IGF1R protein by utilizing compound data in an open database and modeling it using the ensemble method, namely extreme gradient boosting. We found that this method produces the best classification model than with other algorithms. We predicted 844 data for herbal compounds, but only 15 data met the threshold of 0.6. We got one plant from the fifteen herbal compounds, namely Zostera Marine, which was confirmed to have compounds that bind to IGF1R. These compounds have the highest probability value in the classification model that we formed compared to others.
Pendampingan Perizinan Usaha Melalui Online Single Submission Risk-Based Approach Untuk Pelaku Usaha Perempuan Sekitar Desa Pangkahwetan Kecamatan Ujungpangkah Rifdatun Ni'mah; Mohammad Hamim Zajuli Al Faroby; Bernadus Anggo Seno Aji
Humanism : Jurnal Pengabdian Masyarakat Vol 4 No 1 (2023): April
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/hm.v4i1.15720

Abstract

Kelompok perempuan merupakan pilar utama dalam pertumbuhan Usaha Mikro, Kecil dan Menengah (UMKM). Pemerintah telah melakukan sejumlah kebijakan untuk mendukung sektor UMKM dalam mengembangkan usaha diantaranya kemudahan perizinan usaha melalui Undang-Undang (UU) Nomor 11 Tahun 2020 tentang Cipta Kerja (Ciptaker). Undang-undang tersebut mendorong reformasi perizinan berusaha, salah satunya adalah bukti perizinan berusaha. Pelaku usaha dapat membuat Nomor Induk Berusaha (NIB) melalui sistem Online Single Submission Risk Based Approach (OSS-RBA). KPI Balai Perempuan Pangkahwetan sebagai kesatuan kelompok kepentingan perempuan di tingkat desa dan sekitarnya berupaya agar kelompok perempuan pelaku UMK di wilayah sekitar dapat mengurus perizinan berusaha supaya dapat meningkatkan kegiatan usaha mereka. Namun, sebagian besar dari kelompok perempuan ini berasal dari kelompok kurang mampu, usia lanjut, tingkat pendidikan dan literasi digital rendah. Kondisi tersebut membuat kelompok perempuan tersebut enggan mengurus perizinan usaha secara mandiri. Pengabdian masyarakat dilakukan agar mitra mendapatkan peningkatan pemberdayaan berupa pengetahuan terbaru terkait perizinan berusaha berbasis risiko melalui kegiatan penyuluhan dan pendampingan. Sebanyak 23 pelaku usaha telah berhasil terdaftar dalam sistem OSS-RBA dan mendapatkan dokumen NIB versi cetak secara gratis. Bukti legalitas usaha dapat dimanfaatkan untuk membantu dalam mengembangkan kapasitas usaha mereka.
Leaf Health Identification on Melon Plants Using Convolutional Neural Network Farah Zakiyah Rahmanti; Bernadus Anggo Seno Aji; Oktavia Ayu Permata; Berliana Amelia; M. Hamim Zajuli Al Faroby
Jurnal Nasional Pendidikan Teknik Informatika : JANAPATI Vol. 12 No. 1 (2023)
Publisher : Prodi Pendidikan Teknik Informatika Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/janapati.v12i1.58492

Abstract

Plants require complete nutrients to grow well and produce good-quality products. Some examples of symptoms in plants that lack nutrients such as wrinkled leaves and slow ripening of fruit, so plants are less productive. Plants that lack nutrients are unhealthy plants. This research aims to identify healthy and unhealthy leaves on melon plants so that immediate action can be taken to deal with them. This research will be useful for melon farmers everywhere. The dataset used is data taken directly using a digital camera with the help of melon farmers to label each data, both healthy and unhealthy leaves. This research has two main works, they are the training process and the testing process. The proposed research uses the Convolutional Neural Network (CNN) method with 10 epochs. The test results on the 20-test data achieve 100% accuracy. We used accuracy, precision, recall, and f1-score to evaluate the classification method.
Identifikasi Interaksi Protein-Protein Meningitis Menggunakan ClusterONE dan Analisis Jaringan Al Faroby, Mohammad Hamim Zajuli; Nur Fadhilah, Helisyah; Hartanta Sembiring, Fikri
Journal of Advances in Information and Industrial Technology Vol. 4 No. 1 (2022): May
Publisher : LPPM Telkom University Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52435/jaiit.v4i1.180

Abstract

Patogen penyebab Meningitis menyebabkan peradangan pada selaput otak. Kondisi ini menyebabkan kondisi kronis jika dibiarkan dalam jangka waktu lama. Patogen Meningitis menyerang protein tertentu yang berkaitan langsung dengan fungsional selaput otak. Dengan mendeteksi protein signifikan dari Meningitis dapat kita dapat menganalisis lebih jauh untuk menemukan inhibitor dari patogen tersebut. Menemukan protein yang signifikan dengan menganalisis jaringan interaksi protein yang terlibat ketika meningitis menginfeksi. Data jaringan protein diolah untuk mendapatkan klaster protein yang signifikan. Data jaringan pada klaster terbaik digunakan untuk mencari protein tertentu yang memiliki pengaruh signifikan. Skor sigifikansi protein berdasarkan nilai karakterisktik simpul pada jaringan graf dengan mendapatkan nilai eigen dan vektor eigen. Nilai keseluruhan karakteristik diperoleh dari hasil perkalian vektor eigen dengan vektor karakteristik simpul yang menghasilkan nilai skalar. Kami menemukan protein yang paling signifikan terhadap Meningitis adalah TLR2, hal ini diketahui dari nilai keseluruhan karakteristiknya yang paling tinggi dibandingkan protein lainnya.
Modality-based Modeling with Data Balancing and Dimensionality Reduction for Early Stunting Detection Setiawan, Yohanes; Al Faroby, Mohammad Hamim Zajuli; Ma’ady, Mochamad Nizar Palefi; Sanjaya, I Made Wisnu Adi; Ramadhani, Cisa Valentino Cahya
JOIN (Jurnal Online Informatika) Vol 10 No 1 (2025)
Publisher : Department of Informatics, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/join.v10i1.1495

Abstract

In Indonesia, the stunting rate has reached 36%, significantly higher than the World Health Organization's (WHO) standard of 20%. This high prevalence underscores the urgent need for effective early detection methods. Traditional data mining approaches for stunting detection have primarily focused on unimodal data, either tabular or image data alone, limiting the comprehensiveness and accuracy of the detection models. Modality-based modeling, which integrates image and tabular data, can provide a more holistic view and improve detection accuracy. This research aims to analyze modality-based modeling for the early detection of stunting. Two modalities, unimodal and multimodal, are used in this study. The main contributions of this research are the development of a comprehensive framework for modality-based analysis, the application of advanced data preprocessing techniques, and the comparison of various machine learning algorithms to identify the best model for stunting detection. The dataset, comprising images and tabular data, is sourced from Posyandu in Sidoarjo, Indonesia. Image data undergoes preprocessing, including background segmentation and feature extraction using the Gray Level Co-occurrence Matrix (GLCM), while tabular data is processed through categorical encoding. The Synthetic Minority Oversampling Technique (SMOTE) addresses class imbalance, and Principal Component Analysis (PCA) is used for dimensionality reduction. Unimodal modeling uses tabular or image data alone, while multimodal modeling combines both before classification. The study achieves the best F1 scores of 0.96, 0.91, and 0.90 for tabular-only, image-only, and image-tabular modalities, respectively, demonstrating the effectiveness of data balancing and dimensionality reduction techniques.
Digitalisasi Bimbingan Konseling pada Sekolah Menengah Atas Muhammad Dzulfikar Fauzi; Maulana, Rizky Fenaldo; Wicaksono, Ardian Yusuf; Hajar, Granita; Al Faroby, Mohammad Hamim Zajuli
PaKMas: Jurnal Pengabdian Kepada Masyarakat Vol 5 No 1 (2025): Mei 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/pakmas.v5i1.4100

Abstract

Guidance and Counseling (BK) has an important role in supporting the academic, social and emotional development of students in high school. However, recording and managing guidance and counseling services which are still done manually often creates obstacles, such as limitations in data retrieval, lack of privacy, and difficulties in maintaining student development on an ongoing basis. To overcome this problem, the use of digital systems in BK services is an effective solution. The BK digital system allows for more structured student data recording, faster access, as well as features such as counseling scheduling and student progress reports. This community service aims to build an application-based counseling guidance system that makes it easier to record counseling and violations committed by students. So far, counseling has been carried out by recording it in a counseling book, or if a customer commits it, it will be recorded on a violation card, which over time will fill the storage locker and it is also difficult to make mass data changes when a class changes guidance and counseling teachers. The counseling guidance application that has been created can meet the needs of guidance and counseling teachers for scheduling counseling and can see a brief description of the number of counseling activities in a particular month and can also print the results of the counseling
Sistem Pendukung Keputusan untuk Identifikasi Protein Kunci pada Kanker Darah: Integrasi MCDM, KMeans, dan Topologi Jaringan Al Faroby, Mohammad Hamim Zajuli; Fauzi, Muhammad Dzulfikar
Reputasi: Jurnal Rekayasa Perangkat Lunak Vol. 6 No. 1 (2025): Mei 2025
Publisher : LPPM Universitas Bina Sarana Informatika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31294/reputasi.v6i1.8959

Abstract

Kanker darah merupakan salah satu penyakit kompleks yang dipicu oleh gangguan pada regulasi jalur pensinyalan seluler, salah satunya melibatkan mutasi pada protein JAK2. Mengingat pentingnya JAK2 dalam patogenesis kanker hematologi, diperlukan pendekatan sistemik berbasis data untuk mengidentifikasi protein-protein yang memiliki asosiasi fungsional dengannya secara menyeluruh. Penelitian ini bertujuan mengembangkan sistem pendukung keputusan (SPK) untuk mengidentifikasi protein kunci dalam jaringan interaksi protein (PPI) terkait JAK2, melalui integrasi algoritma KMeans clustering, fitur topologi graf, dan metode Multi-Criteria Decision Making (MCDM). Data PPI diperoleh dari STRING-DB dan divisualisasikan menggunakan Cytoscape. Delapan fitur topologi jaringan diekstraksi sebagai dasar analisis, di antaranya degree, stress, dan neighborhood connectivity. Proses klasterisasi menghasilkan tiga kelompok optimal yang divalidasi menggunakan Silhouette Score dan Davies-Bouldin Index. Selanjutnya, model MCDM diterapkan untuk mengevaluasi kontribusi masing-masing klaster secara agregat terhadap kestabilan jaringan. Hasil penelitian menunjukkan bahwa Cluster 2 memiliki skor MCDM tertinggi (0,6667), ditopang oleh nilai stress dan degree yang sangat tinggi, mengindikasikan peran strategis protein dalam klaster tersebut sebagai hub utama dalam jaringan. Temuan ini memberikan landasan kuat untuk eksplorasi kandidat target terapi baru yang potensial dalam konteks kanker darah, serta menegaskan efektivitas integrasi teknik analisis graf dan SPK berbasis MCDM dalam studi jaringan molekuler.