Article Per Year (5 Year)
p-Index From 2021 - 2026
3.662
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Matematika & Sains Jurnal Farmasi Klinik Indonesia Pharmacology and Clinical Pharmacy Research FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmiah Farmasi Farmasyifa Jurnal Riset Farmasi Bandung Conference Series: Pharmacy Borneo Journal of Pharmacy
Bertha Rusdi
Universitas Islam Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Mathematics Medicine & Pharmacology Public Health

Published : 30 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 30 Documents
Search

 1   2   3 
Identifikasi Struktur Pada Antibiotika Golongan Tetrasiklin Yang Memberikan Efek Toksik Dengan Uji In-Silico Susi Susilawati; Taufik M. Fakih; Bertha Rusdi
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8900

Abstract

Abstrak. Tetrasiklin adalah kelompok antibiotik yang memiliki spektrum luas dalam melawan bakteri, namun penggunaan antibiotik tetrasiklin dibatasi oleh efek samping yang ditimbulkan kelompok obat ini seperti Iritasi Lambung, demam,hingga kerusakan sel hati. Efek samping tersebut erat kaitannya dengan struktur yang dimiliki oleh senyawa sehingga pada penelitian dilakukan identifikasi gugus fungsi yang dapat menyebabkan efek samping pada golongan obat tetrasiklin serta sifat fisikokimia golongan obat tersebut. Sifat fisikokimia golongan tetrasiklin diprediksi secara insilico dengan menggunakan perangkat lunak Swiss ADME. Toksisitas golongan tersebut diidentifikasi secara in silico menggunakan perangkat lunak, prediksi PASS, Protox II dan Gauss view. Struktur yang menimbulkan efek samping diidentifikasi berdasarkan data yang diperoleh dari berbagai artikel ilmiah. Hasil penelitian menunjukan golongan tetrasiklin memenuhi aturan Lipinsky, yaitu kurang dari 500 g/mol. Kata Kunci: Struktur, efek samping, toksisitas, Fisikokimia, Tetrasiklin Abstract. Tetracyclines are a group of antibiotics that have a broad spectrum against bacteria, but the use of tetracycline antibiotics is limited by the side effects this group of drugs can cause, such as stomach irritation, fever, and liver cell damage. These side effects are closely related to the structure of the compound so that in this study the identification of functional groups that could cause side effects in the tetracycline class of drugs and the physicochemical properties of the drug class was carried out. The physicochemical properties of the tetracyclines were predicted insilico using the Swiss ADME software. The toxicity of these groups was identified in silico using software, PASS prediction, Protox II and Gauss view. Structures that cause side effects are identified based on data obtained from various scientific articles. The results showed that the tetracycline group complied with Lipinsky's rules, namely less than 500 g/mol. Keywords: Structure, side effects, toxicity, physicochemistry, tetracyclines
Uji Aktivitas Daun Sirsak (Annona Muricata L.) Pada Reseptor Beta Adrenergic Sebagai Antihipertensi Secara In Silico Galand Febrial Akbar; Taufik Muhammad Fakih; Bertha Rusdi
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.9132

Abstract

Abstract. Hypertension is a condition where arterial blood pressure is persistently elevated. Hypertension therapy can be treated with several groups of drugs. One of the targets of hypertension treatment is beta-1 adrenergic receptors. Phenol and acetogenin compounds in soursop leaves are reported to have antihypertensive effects in vivo. This study aims to prove in silico that phenol and acetogenin compounds in soursop leaves have potential as antihypertensives. Docking simulation of test compounds against test receptors (beta adrenergic) using MGLTools 1.5.6 software equipped with Autodock Tools version 4.2. Based on the results of the study, the docking results of goniothalamicin compounds have better affinity among the four other test compounds. The goniothalamicin compound from soursop leaves has the best free energy of bonding (ΔG) value among other test compounds which is -8.39 kcal/mol. The toxicity prediction results of goniothalamicin compounds are not classified as toxic compounds so they are safe to use. The conclusion of this study is that the test compound goniothalamicin has the potential as a candidate compound for antihypertensive treatment. Abstrak. Hipertensi merupakan suatu kondisi dimana tekanan darah arteri meningkat secara terus-menerus. Terapi hipertensi dapat diobati dengan beberapa kelompok golongan obat. Salah satu target pengobatan hipertensi adalah reseptor beta-1 adrenergik. Senyawa fenol dan asetogenin dalam daun sirsak dilaporkan memiliki efek antihipertensi secara in vivo. Penelitian ini bertujuan membuktikan secara in silico senyawa fenol dan asetogenin pada daun sirsak berpotensi sebagai antihipertensi. Simulasi docking senyawa uji terhadap reseptor uji (beta adrenergik) menggunakan software MGLTools 1.5.6 yang dilengkapi Autodock Tools versi 4.2. Berdasarkan hasil penelitian, hasil docking senyawa goniothalamicin memiliki afinitas yang lebih baik diantara keempat senyawa uji senyawa lainnya. Senyawa goniothalamicin dari daun sirsak mempunyai nilai energi bebas ikatan (ΔG) yang paling baik diantara senyawa uji lainnya yaitu sebesar -8,39 kcal/mol. Hasil prediksi toksisitas senyawa goniothalamicin tidak tergolong senyawa yang toksik sehingga aman digunakan. Maka kesimpulan dari penelitian ini yaitu senyawa uji goniothalamicin berpotensi sebagai kandidat senyawa pengobatan antihipertensi.
Prebiotic Activity of Ambon Banana (Musa acuminata (AAA Group) ‘Ambon’) Peel Starch Against Lactobacillus. acidophilus and Escherichia coli In Vitro Rusdi, Bertha; Yuniarni, Umi
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9237

Abstract

Prebiotics are compounds with the ability to specifically enhance the population of advantageous bacteria in the gastrointestinal tract. Starch is a polysaccharide which has prebiotic activity. Agricultural waste like banana peel contains prebiotic polysaccharides including starch. The prebiotic effect of starch from many varieties of banana peel has been explored by researchers. Although Ambon banana is a variety that is commonly consumed in Indonesia, the prebiotic activity of its peel, particularly the peel starch,  has not been studied yet. Thus, this study aims to research the prebiotic activity of Ambon banana peel starch against probiotic bacteria of the Lactobacillus acidophilus and the opportunistic pathogen bacteria of Eschericia coli. In this research, starch was extracted from banana peel (var. pisang Ambon) and prebiotic activity of the starch was tested on L. acidophilus and E. coli.  The number of bacteria was calculated at 0 and 24 hours of incubation using plate count methods.The result showed that at the concentration of 1% w/v, Ambon banana peel starch increases the number of L. acidophilus while inhibiting the growth of E. coli. The L. acidophilus culture in the starch-containing media had SCFAs (acetic, butyric and propionic acid) that were  known to have good impact to human health.
The Effect of Prebiotic Starch and Pectin from Ambon Banana Peel (musa acuminata aaa) on the Growth of Skin Microbiota Bacteria In Vitro Rusdi, Bertha; Aryani, Ratih; Yuniarni, Umi
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.49261

Abstract

Propionibacterium acnes is a bacteria which causes acne. This bacteria is hypothesized to be inhibited by Staphylococcus epidermidis. Prebiotics have been shown to enhance the number of S. epidermidis and decrease the growth of P. acnes. The prebiotic action of starch and pectin from diverse plant sources is known in the skin microbiome. The prebiotic activity of Ambon banana peel starch and pectin on skin microbiota has not been researched. This study aims to investigate the prebiotic activity of starch and pectin from Ambon banana peels on skin microbiota, represented by S.epidermidis and P.acnes. The results showed that starch, and pectin have a prebiotic activity because they promoted the growth of S. epidermidis while suppressing the growth of P. acnes. P. acnes inhibitor percentages were 1.62% for starch and 65.07% for pectin. Negative inhibition values were -184.95% for starch and -5.80% for pectin suggesting an increase in S. epidermidis proliferation.
Karakterisasi Pati Termodifikasi dengan Metode Hmt (Heat Moisture Treatment) Tellisa Rayasari Haryono; Bertha Rusdi
Jurnal Riset Farmasi Volume 3, No. 2, Desember 2023, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v3i2.3164

Abstract

Abstract. Starch is a carbohydrate which is a glucose polymer consisting of amylose and amylopectin. One source of starch is from sago plants and taro belitung. Starch in the pharmaceutical field can be used as a binder, disintegrant, filler, lubricant. The physicochemical properties of starch can be improved by modification. Modification of starch using the HMT (Heat Moisture Treatment) method is a physical modification technique involving heat treatment at 110°C for 4 hours. Unmodified natural starch still has some limited physicochemical properties, so this study aims to characterize the physicochemical properties of sago starch and Belitung Taro modified by the HMT (Heat Moisture Treatment) method. The results of the physicochemical characteristics of starch modified using the HMT (Heat Moisture Treatment) method from sago starch have a water content of  9%, 8,24%, and 8%, swelling power of 91,13%, 105%, and 94.1% while belitung taro starch has a moisture content of 1.56%, swelling power of 8.16%. Abstrak. Pati adalah karbohidrat yang merupakan polimer glukosa yang teridiri dari amilosa dan amilopektin. Salah satu sumber pati yaitu dari tumbuhan sagu dan talas belitung. Pati di bidang farmasi dapat digunakan sebagai bahan pengikat, bahan penghancur, bahan pengisi, bahan pelincir. Sifat fisikokimia pati bisa diperbaiki dengan cara modifikasi. Modifikasi pati dengan metode HMT (Heat Moisture Treatment) merupakan teknik modifikasi secara fisik yang melibatkan perlakuan panas pada suhu 110°C selama 4 jam. Pati alami yang belum termodifikasi masih memiliki beberapa keterbatasan sifat fisikokimia, maka penelitian ini bertujuan untuk mengetahui karakterisasi sifat fisikokimia dari pati sagu dan Talas Belitung yang dimodifikasi dengan metode HMT (Heat Moisture Treatment). Hasil dari karakteristik sifat fisikokimia pati yang termodifikasi menggunakan metode HMT (Heat Moisture Treatment) dari pati sagu memiliki kadar air 9%, 8,24%, dan 8%, swelling power 91,13%, 105%, dan 94,1% sedangkan pati talas belitung memiliki kadar air sebesar 1,56%, swelling power 8,16%.  
Produksi Hidrolisat Protein Maggot Black Soldier Fly (Hermetia illucens) dengan Menggunakan Enzim Tripsin Cahyaning Pertiwi; Vinda Maharani Patricia; Bertha Rusdi
Jurnal Riset Farmasi Volume 5, No. 1, Juli 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i1.6812

Abstract

Abstract. Protein hydrolysate is a protein breakdown product in the form of small peptide fragments obtained through enzymatic hydrolysis. This study aims to determine the yield of protein hydrolysate from Black Soldier Fly (BSF) maggot using trypsin enzyme. The results indicate that enzymatic hydrolysis of BSF maggot protein with trypsin produced an average yield of 37.33 mg/g. The use of trypsin did not exhibit a statistically significant difference compared to the control group, with a P-value of 0.130, which exceeds the significance threshold (α = 0.05). Abstrak. Hidrolisat protein adalah produk pemecahan protein berupa fragmen kecil peptida yang diperoleh melalui reaksi hidrolisis enzimatik. Penelitian ini bertujuan untuk memperoleh rendemen hidrolisat protein dari maggot BSF (Black Soldier Fly) dengan menggunakan enzim tripsin. Hasil penelitian menunjukkan bahwa hidrolisis enzimatik protein maggot BSF dengan menggunakan enzim tripsin mampu menghasilkan rendemen dengan rata-rata bobot sebesar 37,33 mg/g. Penggunaan enzim tripsin tidak menunjukkan perbedaan bermakna dibanding kelompok kontrol dengan P-value sebesar 0.130 yang lebih besar dari tingkat signifikansi (α = 0,05).
Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation Yuniarni, Umi; Aryani, Ratih; Rusdi, Bertha; Nabilla, Qori
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.29581

Abstract

Purple sweet potatoes are recognized for their prebiotic properties including againts Lactobacillus casei and L. bulgaricus bacteria. This prebiotic effect is due to the high starch content in purple sweet potatoes. The amylose content in starch which is difficult to digest in gastointestinal tract, functions as a prebiotic. To enhance the prebiotic effect of purple sweet potato starch, modification into resistant starch can be performed. Resistant starch exhibits a higher prebiotic effect compared to regular starch because it cannot be broken down by digestive enzymes, allowing it to reach the large intestine in significant amounts. Additionally, the prebiotic effect can be further enhanced by creating mucoadhesive granule formulations that increase the contact time of a substance on the mucosa of the digestive tract. This study aims to evaluate the prebiotic effect of resistant starch from purple sweet potatoes and to develop its mucoadhesive granule formulation. The resistant starch from purple sweet potatoes was prepared using the heat moisture treatment method. The prebiotic activity of resistant starch was tested against Lactobacillus acidophilus and Escherichia coli. The granule formulation was prepared by varying the concentration of polymers used, namely a combination of HPMC and carbopol as mucoadhesive polymers. The results showed that resistant starch from purple sweet potatoes had a prebiotic index of 0.930. The granule formulation F3 with an HPMC and Carbopol polymer ratio of 1:2 was identified as a good mucoadhesive granule formulation. It met pharmaceutical evaluation with a mucoadhesive percentage value of 40%.
In Vitro Evaluation of Prebiotic Potential of Red Ginger (Zingiber officinale var. rubrum) Rhizome Ethanol Extract on Lactobacillus acidophilus and Escherichia coli Gumelar, Fadil Rido; Suarantika, Farendina; Rusdi, Bertha
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6029

Abstract

Prebiotics, including carbohydrates and phenols, promote beneficial gut bacteria (probiotics). Red ginger (Zingiber officinale var. rubrum) rhizomes, rich in these compounds, have been traditionally used in medicine but their prebiotic potential remains unexplored. This study investigated the in vitro prebiotic effects of Z. officinale var. rubrum rhizomes on Lactobacillus acidophilus (beneficial) and Escherichia coli (opportunistic) bacteria. Prebiotic activity was assessed using a turbidimetric method, measuring bacterial growth via UV-Vis spectrophotometry at 600 nm. The prebiotic index and percentage inhibition were calculated to evaluate the impact on bacterial growth. Additionally, total phenol content was determined using the Folin-Ciocalteu method. Results indicate that Z. officinale var. rubrum rhizomes exhibit prebiotic properties, stimulating L. acidophilus growth (prebiotic index of 156.035 and percentage inhibition value of -153.128%) while inhibiting E. coli growth (54.343% inhibition). The rhizomes contained 31.15 mg GAE/g extract of total phenols and 23.55% carbohydrates. These findings suggest that Z. officinale var. rubrum rhizomes possess prebiotic potential, warranting further investigation for potential applications in gut health management.
Uji In Silico Aktivitas Senyawa Kumarin Turunannya Terhadap Enzim Alfa Glukosidase Antidiabetes Syifa Prahayati; Bertha Rusdi
Jurnal Riset Farmasi Volume 3, No. 1, Juli 2023, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v3i1.2343

Abstract

Abstract. Alpha glucosidase enzyme is one of the treatment targets for diabetes mellitus. Coumarin compounds contained in the avocado plant (Persea americana Mill.). known to have antidiabetic effects in vitro. These compounds are thought to have antidiabetic effects in vitro. This compound is thought to have an antidiabetic effect by inhibiting the alpha glucosidase enzyme, but this hypothesis has not been proven. Therefore, this study tested coumarin compounds and their derivatives, namely umbelliferone, scoparon, scopaletin, fraxetin, esculin, osthole, psoralen, rutamarin, decursinol, decursidin, edgeworin, daphnoretin, and edgeworoside c, against the alpha-glucosidase enzyme receptor using molecular docking. in silico. This study aims to determine the physicochemical parameters, affinity, and toxicity of compounds with the most potential as antidiabetics. Parameters carried out identified the physicochemical properties of the test compounds using SwissADME software and Scibio-iitd.res.in. Then macromolecular preparation was carried out using the BIOVIA Discovery Studio 2021 software. Next, the docking method was validated and the docking method simulated using the MGLTools 1.5.6 software with AutoDock Tools 4.2. The results obtained using molecular docking were then visualized using the BIOVIA Discovery Studio 2021 software. The toxicity test was carried out using Toxtree version 3.1.0. The physico-chemical parameters show that the lipophilicity, molecular weight, molar reactivity, and hydrogen bonds show that coumarin compounds and their derivatives meet the requirements of Lipinski's Rule of Five, which means that these compounds are predicted to be absorbed and can bind to target receptors. The results of molecular docking of coumarin compounds and their derivatives have an affinity for alpha glucosidase receptors. The compound that has the best affinity is edgeworoside c with a bond free energy value of -8.91 kcal/mol and an inhibition constant of 0.29255 μmolar. The toxicity results obtained were that all the tested compounds were included in the toxicity class III, which means that at high concentrations safety in use is not guaranteed. Then all coumarin test compounds and their derivatives were neither carcinogenic nor mutagenic. Abstrak. Enzim alfa glukosidase adalah salah satu target pengobatan diabetes mellitus. Senyawa Kumarin yang terkandung dalam tanaman alpukat (Persea americana Mill.). diketahuo memiliki efek antidiabetes secara in vitro. Senyawa ini diperkirakan memiliki efek antidiabetes secara in vitro. Senyawa ini diperkirakan memiliki efek antidiabetes dengan menghambat enzim alfa glukosidase, namun hipotesa ini belum dibuktikan. Maka, penelitian ini dilakukan pengujian senyawa kumarin dan turunannya yaitu senyawa umbelliferone, scoparon, scopaletin, fraxetin, esculin, osthole, psoralen, rutamarin, decursinol, decursidin, edgeworin, daphnoretin, dan edgeworoside c, terhadap reseptor ezim alfa gkukosidase dengan menggunakan molecular docking secara in silico. Peneltian ini bertujuan untuk mengetahui parameter fisikokimia, afinitas, dan toksisitas senyawa yang paling berpotensi sebagai antidiabetes. Parameter yang dilakukan mengidentifikasi sifat fisikokimia senyawa uji menggunakan software SwissADME dan Scibio-iitd.res.in. kemudian dilakukan Preparasi makromolekul menggunakan software BIOVIA Discovery Studio 2021. Selanjutnya, dilakukan validasi metode docking dan simulasi metode docking dengan software MGLTools 1.5.6 dengan AutoDock Tools 4.2. Hasil yang diperoleh menggunakan molecular docking kemudian divisualisasikan dengan menggunakan software BIOVIA Discovery Studio 2021. Uji toksisitas dilakukan menggunakan Toxtree versi 3.1.0. Pada parameter fisiko kimia menunjukan bahwa lipofilisitas, berat molekul, reaktivitas molar, dan ikatan hidrogen bahwa senyawa kumarin dan turunanya memenuhi persyaratan Lipinski’s Rule of Five yang artinya senyawa tersebut diprediksi dapat diabsorpsi dan dapat berikatan dengan reseptor target. Hasil penambatan molekular dari senyawa kumarin dan turunannya memiliki afinitas terhadap reseptor alfa glukosidase. Senyawa yang memiliki afinitas paling baik yaitu senyawa edgeworoside c dengan nilai energi bebas ikatan -8,91 kkal/mol dan konstanta inhibisi 0,29255 μmolar. Hasil toksisitas yang diperoleh adalah seluruh senyawa uji termasuk ke dalam toksisitas kelas III yang artinya pada konsentrasi yang tinggi tidak dijamin keamanan dalam penggunaannya. Kemudian seluruh senyawa uji kumarin dan turunnya tidak bersifat karsinogenik maupun mutagenik.
Studi Literatur Efek Farmakologi Rimpang Temu Kunyit Putih (Curcuma zedoaria) Nurul Azizah Rahmawati; Bertha Rusdi
Jurnal Riset Farmasi Volume 3, No. 1, Juli 2023, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v3i1.2692

Abstract

Abstract. Lime (Citrus aurantifolia) is one of the plants known to have anticancer effects. The use of lime as an anticancer has been scientifically researched, but has not been presented holistically. Therefore, this research was conducted in a Systematic Literature Review (SLR) so that it can be used as a reference in the development of new anticancer drugs. This literature research aims to recognize the potential and mechanism of lime plants in inhibiting cancer cell proliferation and determine the IC50 value that can inhibit cancer cell poliferation where data retrieval is carried out on Google Scholar, PubMed and Science Direct portals so that seven articles are obtained that meet the criteria of this study. The results of the analysis show that lime peel plant (Citrus aurantifolia) has the ability as an anticancer through mechanism such as induction of apoptosis and has potential in the IC50 values range of 2,18 µg/mL – 320 µg/mL where in that range lime plants are said to have very strong, moderately active to low as anticancer. The best anticancer activity of lime plants is found in lime peel extract againts colorectal cancer cells lim 1863 with IC50 values in the range of 2,18 µg/mL. Abstrak. Jeruk nipis (Citrus aurantifolia) ialah salah satu tumbuhan yang dikenal mempunyai efek sebagai antikanker. Pemakaian jeruk nipis sebagai antikanker sudah banyak dilakukan riset secara ilmiah, tetapi belum tersajikan secara holistik. Oleh sebab itu, penelitian ini dilakukan secara Sistematic Literature Review (SLR) sehingga bisa dijadikan rujukan dalam pengembangan obat baru antikanker. Riset literatur ini bertujuan untuk mengenali potensi dan mekanisme tanaman jeruk nipis dalam menghambat poliferasi sel kanker serta mengetahui nilai IC50 yang dapat menghambat poliferasi sel kanker dimana pengambilan data dilakukan pada portal Google Scholar, PubMed serta Science Direct sehingga diperoleh sebanyak tujuh artikel yang memenuhi kriteria penelitian ini. Hasil analisis menunjukkan bahwa tanaman jeruk nipis (Citrus aurantifolia) mempunyai kemampuan sebagai antikanker melalui mekanisme seperti induksi apoptosis serta memiliki potensi pada rentang nilai IC50 sebesar 2,18 µg/mL – 320 µg/mL dimana pada rentang tersebut tanaman jeruk nipis dikatakan memiliki aktivitas yang sangat kuat, moderat aktif hingga rendah sebagai antikanker. Aktivitas antikanker tanaman jeruk nipis yang paling baik terdapat pada ekstrak kulit jeruk nipis terhadap sel kanker kolorektal lim 1863 dengan nilai IC50 pada rentang 2,18 µg/mL.
Co-Authors Ai Nurlaela Anggi Arumsari Aulia Lairanisa Cahyaning Pertiwi Diar Herawati Diena Elisa Cahyani Fadil Rido Gumelar Farendina Suarantika Fattah, Miswar Febriani Saputri Fika Nurul Hafidzoh Galand Febrial Akbar Gumelar, Fadil Rido Helen Caterina Simorangkir Hilda Aprilia W Hilda Aprilia, Hilda Indra Topik Maulana Kiki Mulkiya Yuliawati Lanny Mulqie Marwah Mayang Fitriani Sukma Dewi Miski A. Khairinisa Miswar Fattah Miswar Fattah Muhammad Ilham Hardian Muhammad Khalid Anshari Muhammad Rafii Akbar Nabilla, Qori Netty Kurniaty Nurul Azizah Rahmawati Onoy Rohaeni Ratih Aryani Ratih Aryani, Ratih Reisya Nabila REZA ABDUL KODIR, REZA ABDUL Shifa Fudjayanti Susi Susilawati Suwendar Suwendar Syifa Prahayati Syifa Prahayati Taufik M. Fakih Taufik Muhammad Fakih Tellisa Rayasari Haryono Tutus Gusdinar TUTUS GUSDINAR Umi Yuniarni Vinda Maharani Patricia