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All Journal HAYATI Journal of Biosciences INDONESIAN JOURNAL OF PHARMACY FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceuticals and Natural Sciences Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan
Fadlina Chany Saputri
Fakultas Farmasi, Universitas Indonesia, Depok, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Microscopical Evaluation and TLC Analysis of Pluchea indica (L.) Less: Leaf, Stem, and Root Ni Putu Ermi Hikmawanti; Fadlina Chany Saputri; Arry Yanuar; Ratih Asmana Ningrum; Abdul Mun'im; Hayati Hayati
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.71-81

Abstract

Pluchea indica (L.) Less is traditionally utilized to treat postpartum women in Indonesia. The plant has many pharmacological properties, so that it can be further developed as herbal medicine. In that development process, plant authentication is needed to ensure the quality of raw materials. A simple microscopical and thin-layer chromatography (TLC) analysis might be a way to authenticate the plant, but it has never been reported. So, this study evaluates the microscopical and TLC analysis for P. indica authentication in standardized herbal medicines production. Plant microscopic observation, fluorescence analysis, and polyphenol screening were conducted. n-Hexane, ethyl acetate, and methanol extracts of plant organs were then analyzed by TLC. Here, we reported that in microscopical analysis the simplicia of P. indica contains trichomes and tannin-containing cells. In addition, chlorogenic acid as a marker was present in TLC analysis by ethyl acetate-water-formic acid-acetic acid (8.5:1.5:1:1, v/v). The results of this evaluation might provide additional information in the identification, authentication, and quality control of P. indica as a raw material for herbal medicine.
Current Update of Clinical Therapeutic Strategies for Colon-Targeted Delivery Systems Widiani Batubara, Risa; Chany Saputri, Fadlina; Iswandana, Raditya
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Oral colon-targeted drug delivery systems represent a significant advancement offering both systemic and local therapeutic effects for a range of intestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, colonic bacterial infections, and colorectal cancer. These systems facilitate the delivery of both small molecules and macromolecular compounds such as peptides, proteins, antibodies, oligonucleotides, RNA, and probiotics. This review provides an up-to-date exploration of the critical factors crucial for the effective design and development of drug delivery systems targeting the colon. The chosen strategy takes into account various aspects of colon physiology that influences the profile of drug release, absorption, dissolution, and stability in the colon, including pH, retention time, presence of enzymes, pressure, presence of reactive oxygen species due to inflammation, and specific receptors. Site-targeted drug release allows for high concentrations in the colon while minimizing systemic adverse effects by reducing or preventing drug absorption in the small intestine.
Formulasi Emulgel yang Mengandung Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten.) Steenis) dan Uji Aktivitasnya terhadap Propionibacterium acnes secara In Vitro Yani, Tri Nofi; Anwar, Effionora; Saputri, Fadlina Chany
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2923

Abstract

Binahong (Anredera cordifolia (Ten.) Steenis) leaves have been known to have antibacterial activity but the activity against Propionibacterium acnes as one of the bacteria that play a role in acne’s pathogenesis is still unknown. Binahong leaves ethanolic extract containing 1,28% of ursolic acid in this study were tested by in vitro against Propionibacterium acnes giving result minimum bactericidal concentration of 0,05%. Emulgel of binahong leaves ethanolic extract in this study had physical stability for 12 weeks. Inhibition zone of binahong leaves ethanolic extract emulgel is larger than clindamycin phosphate 1,2% against Propionibacterium acnes, which is in formula 1 (extract equivalen with MIC 0,05%) is 19,67±1,25 mm and formula 2 (extract equivalen double MIC 0,05%) is 20,67±0,47 mm, while inhibition zone of clindamycin phosphate 1,2% is 16,3±0,47 mm.
Natural deep eutectic solvents (NaDES) improves extraction and antioxidant activity of stem bark of Garcinia cowa Roxb. Fahleni, Fahleni; Mun'im, Abdul; Saputri, Fadlina Chany; Surini, Silvia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1722

Abstract

Garcinia cowa Roxb. ex DC. is a plant belonging to the Clusiaceae family, and commonly dicovered in Southeast and South Asia. This study aimed to assess the efficiency of eight natural deep eutectic solvents (NaDES) in extracting total xanthones and phenolic compounds from the stem bark using ultrasound-assisted extraction as there is limited research on the use of NaDES in this plant extraction process. The study also examined their antioxidant properties. The NaDES were synthesized with choline chloride and betaine as hydrogen-bond acceptors, accompanied by various acids, alcohols, and glucose as hydrogen-bond donors. In comparison, ethanol was used as standard solvent. The NaDES exhibited higher densities than water, ranging from 1.059 to 1.244 g/cm³, with density increasing according to the number of hydroxyl groups present in the constituents. The total phenolic content (TPC) varied from 22.82 to 28.73 mg GAE/g extract, with NaDES1 (a combination of choline chloride, 1,2-propanediol, and water in a ratio of 1:3:1) showing the highest TPC at 28.73±0.18 mg GAE/g extract. It also exhibited significant antioxidant activities, as demonstrated by DPPH (28.98±0.03 µg/mL) and FRAP assays (43.66±1.51 mmol trolox/g dw). A significant negative correlation was observed between total xanthone, total phenolic content, and IC50 values. These findings suggest that NaDES, particularly NaDES1, have considerable advantages in extracting phenolic compounds and xanthones from G. cowa stem bark, resulting in enhanced antioxidant properties.This highlights the potential of NaDES as eco-friendly and effective solvents for the extraction of bioactive compounds from plant materials.
Roselle and Red Ginger: A Potential Combination of Medicinal Plants for Hypertension Therapy Yunas, Ranum Wanudya; Rahmawati, Siti Irma; Saputri, Fadlina Chany; Bayu, Asep; Chianese, Giuseppina; Putra, Masteria Yunovilsa
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

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Abstract

Hypertension is a prevalent cardiovascular condition that significantly increases the risk of heart disease and stroke. Effective management is essential to prevent severe complications. Roselle (Hibiscus sabdariffa L.) and red ginger (Zingiber officinale var. rubrum) are two medicinal plants known for their antihypertensive properties. Roselle contains bioactive compounds such as anthocyanins that exhibit vasodilatory and angiotensin-converting enzyme (ACE) inhibition, while red ginger is rich in gingerols and shogaols, which possess anti-inflammatory and vasodilatory properties. The complementary mechanisms of action of these two plants, including ACE inhibition, antioxidant activity, and modulation of vascular tone, result in a more pronounced antihypertensive effect when used together. By targeting multiple pathways, the combination allows for more effective blood pressure control, which could lead to improved patient outcomes. The purpose of this study is to provide a detailed review of the evidence supporting the use of roselle and red ginger in combination as a potential therapeutic approach for hypertension. This review aims to identify gaps in the existing research and suggest directions for future studies. Understanding the synergistic effects of these plants can help in developing more effective herbal therapies that leverage their combined benefits. Further research is needed to confirm these findings through more in-depth preclinical and clinical studies. Investigations should focus on optimizing dosages, understanding long-term safety, and establishing standardized protocols for combination therapy. This review serves as a foundation for future research and encourages the integration of traditional herbal medicine into modern hypertensive management strategies, promoting a holistic approach to cardiovascular health.
Review of Antihypertensive Activity of Purslane (Portulaca oleracea L.) Azizah, Rizqi Nur; Putra, Bayu; Suhaenah, Asriani; Saputri, Fadlina Chany; Ahmad, Aktsar Roskiana; Malik, Abdul
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 2 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i2.5461

Abstract

Hypertension is a chronic disease in which blood pressure in the arteries increases. Hypertension is a health problem that has a risk of causing other diseases such as coronary heart disease, kidney failure, nerve dysfunction and stroke. Plants such as purslane (Portulaca oleracea L.) are one of the plants that have benefits in treating disease. The purpose of the review article is to determine the potential of Portulaca oleracea L. as an anti-hypertensive. This research is a Review Journal. The subject of this review is national and international articles indexed nationally and internationally in the last 10 years which discuss the antihypertensive ability of Portulaca oleracea L. by classifying them based on the type of study and test model used in-vivo, the potential of the plant in lowering blood pressure, mechanism of action in treating hypertension, and specific chemical constituents responsible for anti-hypertensive activity. Based on the results of studies conducted on several journal articles, it can be concluded that Portulaca oleracea L. : 1. exhibits promising antihypertensive properties through various mechanisms, including vasodilation, reduction of heart rate, and improvement of endothelial function; 2. Clinical trials and comparative studies indicate that it can significantly reduce systolic blood pressure, making it a potential natural adjunct in managing hypertension; 3. exhibits multiple mechanisms that can help manage hypertension, primarily through its antioxidant, anti-inflammatory, and lipid-regulating properties, 4. contains several bioactive compounds that contribute to its antihypertensive effects such as Asperglaucide (ASP), Oleracein E and Oleracein L, Omega-3 Fatty Acids, Quercetin, and Rutin.
Uji Antihipertensi Ekstrak Bawang Dayak (E.palmifolia (L.)Merr) dan Ciplukan (P.angulata. L) Terhadap Tekanan Darah Tikus Sari, Atika Mutiara; Syafi'i, Imam; Saputri, Fadlina Chany; Elya, Berna
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia Special Issue for 18th Mulawarman Pharmaceu
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.364

Abstract

Bawang Dayak (Eleutherine palmifolia (L.) Merr) secara empiris digunakan untuk menyembuhkan penyakit diabetes melitus, hipertensi, menurunkan kolesterol, dan stroke. Ciplukan (Physalis angulata L.) telah banyak digunakan masyarakat dalam bentuk jamu tunggal atau kombinasi ramuan sebagai obat radang saluran napas, radang gusi, radang testis, hipertensi, dan diabetes. Penelitian ini bertujuan untuk mengetahui kandungan kimia ekstrak etanol 96% bawang dayak dan ciplukan dan aktivitas sebagai antihipertensi terhadap tikus jantan sprague dawley yang diinduksi NaCl dan deksametason. Tikus dibagi ke dalam 6 kelompok terdiri dari kelompok normal, negatif, positif, dan kelompok perlakuan ekstrak bawang dayak, ekstrak ciplukan serta kombinasi bawang dayak-ciplukan. Tikus diinduksi selama 28 hari dengan parameter yang diukur adalah tekanan darah sistoel-diastol dan berat badan. Hasil skrining kandungan kimia ekstrak bawang dayak adalah flavonoid, tanin dan kuinon. Kandungan ekstrak ciplukan adalah alkaloid, Falvonoid, tanin, terpenoid/steroid dan saponin. Hasil pengujian aktivitas antihipertensi menunjukkan bahwa kombinasi ekstrak bawang Dayak dan ciplukan dengan dosis 81 mg/Kg BB dan 155 mg/Kg BB memberikan efek penurunan tekanan darah diastole dan sistol serta profil bobot badan dari hewan uji tikus. Hasil uji secara in vivo dari kombinasi ekstrak perlu dilakukan pengkajian lebih lanjut agar dapat dikembangkan sebagai kandidat bahan aktif dalam penanganan hipertensi.
Stabilitas Kimia Nanoemulsi Gel Kombinasi Eugenol dan Sitronellal: Chemical Stability of Gel Nano Emulsion Combination of Eugenol and Sitronellal Fitria, Wahda; Saputri, Fadlina Chany; Jufri, Mahdi
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2355

Abstract

Clove oil and lemongrass essential oil can be formulated into Nanoemulsion Gel preparations as topical preparations for the skin. This Nanoemulsion Gel preparation is formulated by first making a nanoemulsion preparation, which is then made into a Nanoemulsion Gel preparation by dispersing the nanoemulsion into a gel that has been made with active ingredients from clove oil and lemongrass essential oil. The gel nanoemulsion preparation was then analyzed for the stability of its chemical components using GC-MS. The results of analysis using GC-MS obtained that a Nanoemulsion Gel preparation formulated from clove oil and lemongrass oil was chemically stable.   Keywords:          Nanoemulsion gel preparation, Chemical stability, GC-MS   Abstrak Minyak atsiri cengkeh dan minyak atsiri sereh dapat diformulasikan menjadi sediaan nanoemulsi gel sebagai sediaan topikal pada kulit. Sediaan nanoemulsi gel ini diformulasikan dengan terlebih dahulu membuat sediaan nanoemulsi, yang selanjutnya dibuat menjadi sediaan nanoemulsi gel dengan mendispersikan nanoemulsi ke dalam gel yang telah dibuat dengan bahan aktif dari minyak atsiri cengkeh dan minyak atsiri sereh. Sediaan nanoemulsi gel kemudian dianalisis stabilitas komponen kimianya dengan menggunakan GC-MS. Hasil analisis menggunakan GC-MS diperoleh sediaan nanoemulsi gel yang diformulasikan dari minyak cengkeh dan minyak sereh cukup stabil secara kimia.   Kata Kunci:         sediaan Nanoemulsi Gel, stabilitas Kimia, GC-MS
Co-Authors Abdul Malik Abdul Mun'ím Abdul Mun'im Abdul Munim Abdul Mun’im Ahmad, Aktsar Roskiana Arry Yanuar Asriani Suhaenah Bayu Putra, Bayu Bayu, Asep Berna Elya Chianese, Giuseppina Dewi Sriyani Dewi Sriyani, Dewi Dimas Thoriq Muhammad Iqbal Effionora Anwar Effionora Anwar Fahleni Fahleni Fitria, Wahda Hariyanti Hariyanti Hayati Hayati Hayun, Hayun Iis Irawatty Dewi Imam Syafi'i Mahdi Jufri Muhammad Hanafi Mun'im, Abdul Ni Putu Ermi Hikmawanti Noorwati Sutandyo Nur Rahmawati Putra, Masteria Yunovilsa Raditya Iswandana Rahmawati, Siti Irma Ratih Asmana Ningrum Rita Zahara Rita Zahara, Rita Rizqi Nur Azizah Santi Purna Sari Santi Purna Sari Sari, Atika Mutiara Silvia Surini SITI MARDIYANTI Sri Wardatun Suswidiantoro, Vicko Syafi'i, Imam Tri Nofi Yani Wahda Fitria Widiani Batubara, Risa Yahdiana Harahap Yani, Tri Nofi Yesi Desmiaty, Yesi Yunas, Ranum Wanudya