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All Journal Emerging Science Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Pengabdian kepada Masyarakat Journal of Innovation Research and Knowledge Proceeding ISETH (International Summit on Science, Technology, and Humanity) Borneo Journal of Pharmacy Jurnal Riset Multidisiplin Edukasi Jurnal Farmasi Udayana
Triadisti, Nita
Universitas Muhammadiyah Banjarmasin
Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Antidiabetic Properties of Uncaria sclerophylla Roxb: In Vitro, Metabolite Profiling, and Molecular Docking Triadisti, Nita; Hanafi, Muhammad; Mohd Hashim, Najihah; Berna Elya
Emerging Science Journal Vol. 10 No. 1 (2026): February
Publisher : Ital Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28991/ESJ-2026-010-01-019

Abstract

Uncaria sclerophylla Roxb is a traditional medicinal plant used to treat diabetes mellitus in Kalimantan, Indonesia, and the antidiabetic properties of its stem bark have not been previously investigated. This research will focus on investigating the potential of U. sclerophylla stem bark as an antidiabetic with the mechanism of inhibiting dipeptidyl peptidase-4, α-glucosidase, and antioxidants from extracts to chromatographic fractions, including the exploration of the major compounds contained in the most active chromatographic fraction. Extraction using a four-grade maceration technique, bioassays were carried out using spectrophotometric methods, fractionation using gradient column chromatography, and compound profiling using UHPLC-Q-ToF-MS/MS. The profiled compounds were predicted for their bioactivity in silico. The stem bark of U. sclerophylla demonstrated antidiabetic potential, and the methanol extract showed superior antidiabetic potential compared with the other extracts. From the extract, the most active chromatographic fraction, FUS2, was successfully obtained, which had the best activity with DPP-4 inhibition IC50 of 83.07 ± 6.3393 µg/mL, α-glucosidase inhibition IC50 of 58.06 ± 1.6226 µg/mL, and antioxidant IC50 of 8.47 ± 0.0443 (DPPH method) and 8.47 ± 0.0234 µg/mL (FRAP method). Compound profiling of FUS2 and in silico bioassays revealed potential antidiabetic compounds, including rhynchophyllic acid, arecatannin A2, silydianin, and procyanidin A2.
Co-Authors Anhar Muflih Annisa Salsabela Berna Elya Heldawati Heldawati Irfan Zamzani Irfan Zamzani Islan Nor Mi’rajunnisa, Mi’rajunnisa Mohd Hashim, Najihah Muhammad Chaidir Hafidz Muhammad Hanafi Nadia Safitri Nurul Fajeriyati Risa Ahdyani Riska Hidayah Rizka Mulya Miranti Tuty Mulyani Yulianita Pratiwi Indah Lestari Zamzani, Irfan Zamzani, Irfan