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KADAR CALPROTECTIN CAIRAN SULKUS GINGIVA PADA KEDALAMAN POKET PERIODONTAL YANG BERBEDA PENDERITA AGGRESSIVE PERIODONTITIS Desi Sandra Sari
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 7 No 3 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Aggressive Periodontitis is a form of periodontitis which is characterized with the presence of deep pocket, rapid loss of connective tissue attachment and alveolar bone. The rapid damage is caused by the dysfunction chemotaxis and phagocytosis from neutrophil.Calprotectin is a major cytosolic protein of neutrophils, monocytes and epithelial cells. The calprotectin level in gingival crevicular fluid is useful marker for evaluation the progression of inflammation in periodontitis disease. In this study, we investigated calprotectin level at different periodontal pocket depth from patient with aggressive periodontitis. This research involved twelve subjects who had been diagnosed as suffered from aggressive periodontitis. Their gingival crevicular fluid was taken from different periodontal pocket depths (slight ≤3mm, moderate 4-6mm, severe ≥ 7 mm), using sterile papperpoints. Level of calprotectin in gingival crevicular fluid were analysed by enzyme-linked immunosorbent assay (ELISA) procedures. The result showed that gingival crevicular fluids calprotectin level increased approximately in proportion to probing depth slight, moderate, and severe (p< 0,05), and showed a significant positive correlation with probing depth (R=0,776, p< 0,05). This research concluded that the calprotectin level in gingival crevicular fluid is positively related to clinical indicators (probing depth) and reflect the degree of gingival inflamation in patient with aggressive periodontitis

STATUS KESEHATAN PERIODONTAL DAN TINGKAT KEBUTUHAN PERAWATAN PASIEN YANG DATANG KE KLINIK PERIODONSIA RSGM UNIVERSITAS JEMBER TAHUN 2011 Tantin Ermawati; Desi Sandra Sari; M Melok
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 9 No 2 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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The CPITN is a screening procedure for identifying actual and potential problems posed by periodontal disease. The aim of this study was to know periodontal status and periodontal treatment needs from patient that come to RSGM department periodontia faculty of dentistry Jember University in the year 2011. The study population comprised 191 adolescences (10 – 59 years). An observational study was conducted at RSGM of Jember University. The results of the study showed that individuals with a health periodontium is 1.05 %, score (1) with bleeding on probing is 3.14 %. Periodontal pocket (4-5mm) was recorded 17.27 %. The highest periodontal score is scores 2 (calculus) 78.53% of the population need dental scaling. We conclude that prevalence periodontal disease in patients that come to periodontics department is very high and periodontal treatment need with scaling.

AKTIVITAS ANTIBAKTERI DAN KLT BIOAUTOGRAFI EKSTRAK ETANOL DAUN SISIK NAGA (Drymoglossum piloselloides) TERHADAP Streptococcus mutans Evi Umayah Ulfa; Desi Sandra Sari; Dhani Wijaya
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 1 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Sisik naga (Drymoglossum piloselloides) has been used empirically for dysentry and candidiasis. This diseases were caused by bacteria and fungi. The objective of this research was to evaluate the antibacterial effect and to find out the antimicrobial compound of sisik naga. Leaf of sisik naga was extracted with ethanol 90% by using maseration. This extract were tested for antibacterial activity against Streptococcus mutans using agar difussion. TLC Bioautography methods was used to identify the active compound. Result of antibacterial test showedf ethanolic extract of sisik naga had antibacterial effect against S. mutans. Bioautography showed one spot on Rf =0 give clear zone.

THE EFFECTIVENESS OF USING TOOTHPASTE CONTAINING ROBUSTA COFFEE BEAN EXTRACT IN INHIBITING THE FORMATION OF DENTAL PLAQUE Rina Nanda Prasasti; Desi Sandra Sari; Peni Pujiastuti
ODONTO : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.1.12-20

Background: Periodontal disease is caused by the interaction between pathogenic bacteria and plaque, without the accumulation of plaque, periodontal disease will not appear. Plaque will be visible one to two days if no oral cleaning steps are taken. The combination of antimicrobial therapy such as antibiotics and mouthwash as well as mechanical therapy such as scaling and root plain gives more effective results. However, if done in the long term it will cause resistance. To overcome this, alternative materials are needed that are used to inhibit bacterial growth, one of which is robusta coffee beans. The content of robusta coffee bean extract contains phenolic and flavonoid compounds that function as antibacterials that work by disrupting the function of the cytoplasmic and cytoplasmic membranes of bacteria.Method: In this study, 6 groups were used, namely KN, K-, K+, KP 25%, KP 50%, and KP 75%. The gingivitis model was made with wire using ligation technique for 3 days, then toothpaste was applied, brushing process, and disclosing agent was given, and the plaque index calculation was PHP (Personal Hygiene Performance). The data obtained were then analyzed using the Kruskall-Wallis test followed by the Mann-Whitney test.Result: The Robusta coffee bean extract toothpaste group at a concentration of 75% experienced a significant reduction in plaque compared to the negative control group and the 25% treatment group (p<0.05), but there were no significant differences or had the same ability when compared to the experimental group. 50% treatment group, normal control group and positive control group.Conclusion: The 75% concentration of Robusta coffee bean extract found in toothpaste is proven to be effective in inhibiting the formation of dental plaque.

The potential of toothpaste containing Robusta coffee bean extract in reducing gingival inflammation and dental plaque formation Peni Pujiastuti; Neira Najatus Sakinah; Yuliana Mahdiyah Da’at Arina; Melok Aris Wahyukundari; Depi Praharani; Desi Sandra Sari
Dental Journal Vol. 56 No. 2 (2023): June 2023
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i2.p109-114

Background: The prevention of gingivitis using chemicals containing antibiotics and chlorhexidine can disrupt the balance of the oral microbiota and have side effects in long-term use. A recent development in the prevention of gingivitis is the use of natural ingredients. Coffee is a natural ingredient that compounds several antibacterial and anti-inflammation properties. Purpose: The study aimed to determine the potential of toothpaste containing Robusta coffee bean extract in reducing gingival inflammation and inhibiting the formation of dental plaque. Methods: Twenty male Rattus norvegicus were divided into four groups, namely the control group and treatment groups (TG) TG25%, TG50%, and TG75%. All groups were fitted with ligature wire on the first left molar to accumulate dental plaque. After the fourth day, the ligature wire was removed, and the TG25%, TG50%, and TG75% groups were brushed once a day using toothpaste containing various concentrations of Robusta coffee extract, while the control group was brushed without using toothpaste. Plaque index, gingival index, and interleukin-1 (IL-1) expression were observed on the fifth day. The data was statistically tested using a one-way analysis of variance and post hoc least significant difference. Results: The statistical test showed that the TG75% group had the lowest value of plaque, gingival index, and IL-1 expression, while the control group had the highest (p < 0.05). Conclusion: Robusta coffee bean extract toothpaste has the potential to reduce gingival inflammation and dental plaque formation in a rat with gingivitis. The most effective concentration of Robusta coffee bean extract toothpaste in reducing gingival inflammation and dental plaque formation was 75%.

NUMBER OF BLACK-PIGMENTED ANAEROBIC BACTERIA CONTAINED IN THE GINGIVAL CREVICULAR FLUID (GCF) OF PATIENTS SUFFERING FROM THE CHRONIC PERIODONTITIS AND AGGRESSIVE PERIODONTITIS Depi Praharani; Peni Pujiastuti; Melok Aris Wahyukundari; Yuliana Mahdiyah Daat Arina; Desi Sandra Sari
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

THE EFFECTIVENESS OF USING TOOTHPASTE CONTAINING ROBUSTA COFFEE BEAN EXTRACT IN INHIBITING THE FORMATION OF DENTAL PLAQUE Rina Nanda Prasasti; Desi Sandra Sari; Peni Pujiastuti
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Periodontal disease is caused by the interaction between pathogenic bacteria and plaque, without the accumulation of plaque, periodontal disease will not appear. Plaque will be visible one to two days if no oral cleaning steps are taken. The combination of antimicrobial therapy such as antibiotics and mouthwash as well as mechanical therapy such as scaling and root plain gives more effective results. However, if done in the long term it will cause resistance. To overcome this, alternative materials are needed that are used to inhibit bacterial growth, one of which is robusta coffee beans. The content of robusta coffee bean extract contains phenolic and flavonoid compounds that function as antibacterials that work by disrupting the function of the cytoplasmic and cytoplasmic membranes of bacteria.Method: In this study, 6 groups were used, namely KN, K-, K+, KP 25%, KP 50%, and KP 75%. The gingivitis model was made with wire using ligation technique for 3 days, then toothpaste was applied, brushing process, and disclosing agent was given, and the plaque index calculation was PHP (Personal Hygiene Performance). The data obtained were then analyzed using the Kruskall-Wallis test followed by the Mann-Whitney test.Result: The Robusta coffee bean extract toothpaste group at a concentration of 75% experienced a significant reduction in plaque compared to the negative control group and the 25% treatment group (p<0.05), but there were no significant differences or had the same ability when compared to the experimental group. 50% treatment group, normal control group and positive control group.Conclusion: The 75% concentration of Robusta coffee bean extract found in toothpaste is proven to be effective in inhibiting the formation of dental plaque.

Daya antibakteri pasta gigi yang mengandung ekstrak biji kopi robusta (Coffea canephora) terhadap Treponema denticola: eksperimental laboratoris Perdana, Mohammad Daffa Duta; Praharani, Depi; Sari, Desi Sandra
Padjadjaran Journal of Dental Researchers and Students Vol 8, No 1 (2024): Februari 2024
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v8i1.52979

ABSTRAK Pendahuluan: Treponema denticola merupakan bakteri anaerob Gram negatif penyebab penyakit periodontal dan dominan pada plak subgingiva. Penyakit periodontal dapat dicegah dengan pengendalian plak secara mekanis, seperti menyikat gigi dengan pasta gigi. Salah satu bahan herbal yang dapat dimanfaatkan sebagai bahan tambahan pasta gigi adalah biji kopi robusta yang mengandung senyawa aktif antibakteri. Tujuan penelitian ini adalah untuk menganalisis daya antibakteri pasta gigi yang mengandung ekstrak biji kopi robusta pada konsentrasi 12,5%, 25%, dan 50% terhadap T. denticola. Metode: Jenis penelitian yang digunakan yaitu eksperimental laboratorium dengan rancangan penelitian menggunakan the post test only control group design. Biji kopi robusta diekstraksi menggunakan metode maserasi, dan diformulasi menjadi pasta gigi dengan konsentrasi 12,5, 25 dan 50%. Uji antibakteri menggunakan metode difusi sumuran dengan media Mueller-Hinton Agar (MHA) yang telah diinokulasi T. denticola. Kelompok penelitian terdiri dari kelompok pasta gigi dengan ekstrak biji kopi robusta konsentrasi 12,5, 25, dan 50%, kontrol positif, dan kontrol negatif. Hasil: Terbentuk zona hambat pada kelompok pasta gigi yang mengandung ekstrak biji kopi robusta konsentrasi 12,5, 25, dan 50%, dan kontrol positif terhadap pertumbuhan T. denticola. Rata-rata diameter zona hambat yang dihasilkan berturut-turut dari konsentrasi ekstrak biji kopi robusta terendah hingga tertinggi adalah 11,02 mm; 12,81 mm; dan 15,95 mm dengan perbedaan yang signifikan di antara tiap konsentrasi (p<0,05). Simpulan: Pasta gigi yang mengandung ekstrak biji kopi robusta konsentrasi 12,5, 25, dan 50% memiliki daya antibakteri terhadap T. denticola. Pasta gigi dengan konsentrasi ekstrak 50% memperlihatkan daya antibakteri yang paling besar.KATA KUNCI: biji kopi robusta, antibakteri, pasta gigi, treponema denticola, penyakit periodontalAntibacterial activity of toothpaste containing robusta coffee bean (Coffea canephora)extract towards Treponema denticola: a laboratory experimental studyABSTRACT Introduction: Treponema denticola is a Gram-negative anaerobic bacterium that causes periodontal disease and is dominant in subgingival plaque. Periodontal disease can be prevented by mechanical plaque control, such as brushing teeth with toothpaste. One of the herbal ingredients that can be used as an additional ingredient for toothpaste is robusta coffee beans which contain active antibacterial compounds. The aim of this research was to analyze the antibacterial activity of toothpaste containing Robusta coffee bean extract at concentrations of 12.5, 25, and 50% against T. denticola. Methods: The type of research used is experimental with a research design using a posttest only control group design. Robusta coffee beans were extracted using the maceration method, and formulated into toothpaste with concentrations of 12.5, 25, and 50%. The well diffusion method with Mueller-Hinton Agar (MHA) media which had been inoculated with T. denticola was used for the antibacterial activity test. The research group consisted of toothpaste with 12.5% robusta coffee bean extract group, 25% group, and 50% group, as well as the positive control and negative control groups. Results: The inhibitory zone was formed in the toothpaste with 12.5% robusta coffee bean extract group, 25% group, 50%, and positive control group against the growth of T. denticola. The average diameter of the inhibition zone produced respectively from the lowest to the highest concentration of robusta coffee bean extract were 11.02 mm, 12.81 mm, and 15.95 mm, with significant differences between concentrations (p<0,05). Conclusion: Toothpaste containing robusta coffee bean extract at concentrations of 12.5, 25, and 50% showed the antibacterial activity against T. denticola. Toothpaste containing 50% of the robusta coffee bean extract showed the greatest antibacterial activity.KEY WORDS: robusta coffee bean, antibacterial, toothpaste, treponema denticola, periodontal disease

Daya Hambat Pasta Gigi yang Mengandung Ekstrak Biji Kopi Robusta (Coffea canephora) Terhadap Pertumbuhan Bakteri Aggregatibacter actinomycetemcomitans Secara In Vitro Farahdila, Nihla Adinda; Pujiastuti, Peni; Sari, Desi Sandra
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 21 No 1 (2024)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v21i1.47335

Periodontitis is caused by bacteria in plaque, namely Aggregatibacter actinomycetemcomitans. Prevention of periodontal disease can be done by controlling plaque, namely brushing teeth using toothpaste to remove plaque and prevent plaque maturation. Alternative ingredients (herbs) that can be used to make toothpaste are robusta coffee beans which contain caffeine, flavonoids, trigonelin, and chlorogenic acid as antibacterial. The purpose of this study was to analyze the inhibition of toothpaste containing robusta coffee bean extract at concentrations of 6.25%, 12.5%, 25%, and 50% against the growth of A. actinomycetemcomitans. This type of research is experimental laboratory with posttest only control group design. This study was divided into 6 groups, namely positive control (Arabica coffee toothpaste), negative control (placebo paste), Robusta coffee bean extract toothpaste 6.25%, 12.5%, 25%, and 50%. Inhibition test using well diffusion method by making holes in the media. The diameter of the inhibition zone was measured using a caliper. The results showed that the control (-) group and the 6.25% group had no inhibitory power against the growth of A. actinomycetemcomitans. The robusta coffee bean extract toothpaste at concentrations of the 50% group (18.69 mm) had the greatest inhibition, but K (+) had greater inhibition than the 50% (22.89 mm) group. The conclusion of this study is that the robusta coffee bean extract toothpaste at concentrations of 12.5%, 25%, and 50% had inhibitory power against the growth of A. actinomycetemcomitans, but the greatest inhibitory power was at a concentration of 50%.

GAMBARAN STATUS KEBERSIHAN RONGGA MULUT DAN KESEHATAN JARINGAN PERIODONTAL PADA IBU HAMIL DI WILAYAH PERKEBUNAN GLANTANGAN, KABUPATEN JEMBER Prastifa, Febi Zulaikha; Sari, Desi Sandra; Praharani, Depi
Jurnal Kesehatan Vol 17 No 1 (2024): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v17i1.35720

Introduction: During pregnancy, there are changes in hormone levels that can affect the condition of the oral cavity. An increase in hormones leads to gingival changes and a decrease in salivary flow that can affect the hygiene of the oral cavity and periodontal tissues leading to the occurrence of local inflammation and increased plaque accumulation. A sustained increase in plaque accumulation leads to periodontal disease. The purpose of this study was to determine the hygiene status of the oral cavity and the health of the periodontal tissue of pregnant women. Method: This type of research is descriptive observational with a total sampling data collection technique involving 51 pregnant women in 8 posyandu Pondokrejo Village, Glantangan Plantation area. Data collection was obtained through the oral hygiene index simplified (OHI-S), Community Periodontal Index of Treatment Needs (CPITN), and questionnaires. Results: The results of the OHI-S examination of pregnant women were obtained at 58.8% including moderate criteria, 35.3% bad, and 5.9% good. CPITN results are healthy periodontal 0%; bleeding when probing 0%; calculus and other retentive factors 86.3%; pathological pocket 4-5 mm 11.8%; pathological pocket 6 mm 2%. Pregnant women were most in the age of 26-35 years (58.82%), 3rd trimester (41.18%), last primary education (43.14%), had one-sided chewing habits (56.86%), never visited the dentist (92.16%), never scaling (90.20%), and brushed their teeth every bath (68.63%). Conclusion: The most common oral health status in pregnant women in the glantangan plantation area is moderate. The most common periodontal tissue health status in pregnant women is the condition that it is supragingival or subgingival calculus or there are debris retentive factors such as crowns and restorations that are not adapted properly.

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