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All Journal Dentika Dental Journal Jurnal Kesehatan Masyarakat (IKESMA) Jurnal Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students Odonto dental journal Dental Agromedis
Desi Sandra Sari
Faculty Of Dentistry, Jember University, Jember, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Analisis kandungan logam timbal (Pb) pada pasta gigi dengan ekstrak biji kopi robusta (Coffea canephora L.) Putri, Puspita Nabila; Pujiastuti, Peni; Sari, Desi Sandra
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 11, No 2 (2025)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.104299

Abstract

Pasta gigi dengan ekstrak biji kopi robusta merupakan produk alternatif untuk mencegah penyakit periodontal yang mengandung bahan alami dengan sifat antibakteri, antiinflamasi, dan antioksidan. Pengembangan pasta gigi memerlukan pengujian untuk mendapatkan formula yang baik dan sesuai dengan Standar Nasional Indonesia (SNI). Salah satu pengujian yang perlu dilakukan adalah uji kandungan logam berat timbal (Pb). Tujuan penelitian ini adalah untuk mengetahui apakah kandungan Pb dalam pasta gigi dengan ekstrak biji kopi robusta sesuai dengan standar SNI. Ekstrak biji kopi robusta dibuat menggunakan metode maserasi dengan pelarut etanol 96%. Pasta gigi diformulasikan dengan mencampur pasta plasebo dan ekstrak biji kopi robusta pada konsentrasi 0,0625%, 0,125%, 0,25%, dan 0,5%. Pengujian kontaminasi Pb dilakukan menggunakan Spektrofotometer Serapan Atom (AAS) dengan hasil dinyatakan dalam mg/kg. Hasil penelitian menunjukkan bahwa ekstrak biji kopi robusta tidak mengandung Pb yang terdeteksi, dengan hasil tercatat sebagai "nd" atau "not detected", namun kandungan Pb sebesar 1,382mg/kg ditemukan pada pasta plasebo. Pada pasta gigi dengan ekstrak biji kopi robusta dengan berbagai konsentrasi, kandungan Pb berkisar antara 1,626 hingga 1,866mg/kg. Dari hasil penelitian ini dapat disimpulkan bahwa kandungan Pb dalam pasta gigi dengan ekstrak biji kopi robusta lebih rendah dari batas maksimum Pb yang ditetapkan SNI, yaitu kurang dari 20 mg/kg.
Karakterisasi bovine tooth scaffold dalam bentuk nanopartikel dengan uji x-ray diffraction (XRD) untuk terapi periodontitis Adisty, Anggi Salwa; Sari, Desi Sandra; Wahyukundari, Melok Aris
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 11, No 2 (2025)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.104301

Abstract

Kerusakan tulang alveolar akibat periodontitis memiliki prevalensi tertinggi di Indonesia. Pencegahan kerusakan tulang alveolar dapat dilakukan dengan terapi regenerasi periodontal. Desain scaffold telah menjadi fokus utama untuk regenerasi jaringan tulang. Bovine teeth scaffold berukuran nanopartikel saat ini sedang dikembangkan sebagai solusi untuk mengatasi keterbatasan scaffold berukuran mikro. Scaffold harus memiliki karakteristik tertentu yang mendukung pertumbuhan dan diferensiasi sel untuk regenerasi jaringan periodontal yang dapat diketahui melalui uji karakterisasi X-ray diffraction. Penelitian ini bertujuan untuk mengetahui karakterisasi bovine teeth scaffold dalam bentuk nanopartikel melalui uji X-ray diffraction (XRD) untuk terapi periodontitis. Metode yang digunakan dalam penelitian ini adalah penelitian deskriptif kuantitatif untuk mendeskripsikan karakterisasi bovine teeth scaffold dalam bentuk nanopartikel dan data dianalisis secara deskriptif dengan tabel, kurva, dan nilai persentase. Hasil uji XRD menunjukkan bahwa terdapat dua fasa yang terdeteksi, yaitu hidroksiapatit dan whitlockite. Puncak-puncak difraksi hidroksiapatit muncul pada sudut difraksi 2θ sebesar 25,82˚; 31,67˚; 33,91˚; 49,33˚; 50,30˚ dengan puncak tertinggi pada sudut difraksi 31,67˚. Puncak-puncak difraksi whitlockite muncul pada sudut difraksi 2θ sebesar 28,86˚; 32,72˚; 39,58˚; 46,56˚ dengan puncak tertinggi pada sudut difraksi 32,72˚. Grafik menunjukkan pola difraksi sempit, tinggi, dan tajam yang mengindikasikan bahwa bovine teeth scaffold memiliki struktur kristal. Bovine teeth scaffold dalam bentuk nanopartikel mengandung 65% Hidroksiapatit (Ca10(PO4)6OH) dan 35% Whitlockite (Ca10NaMg(PO4)6(CO3) (OH)3). Karakterisasi bovine teeth scaffold dalam bentuk nanopartikel dengan menggunakan uji XRD diperoleh fasa hidroksiapatit sebesar 65% dan fasa whitlockite sebesar 35%.
EFFECTIVENESS OF ROBUSTA COFFEE BEAN EXTRACT GEL (Coffea canephora) ON THE THICKNESS OF COLLAGEN FIBERS AFTER WISTAR RAT TOOTH EXTRACTION Sari, Desi Sandra; Aisyah, Siti; Rachmawati, Dessy; Sutjiati, Rina; Yuwono, Budi
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Tooth extraction causes injury to the alveolar bone and oral mucosa which is followed by the body ’s natural response through wound healing. One of the important parameters and indicators of wound healing is collagen density. Collagen is synthesised by fibroblasts in the proliferative phase, which was formed from day 3 and reached its peak on day 7. Robusta coffee beans have active compounds in the form of anti-inflammatory and antioxidants that are effective in accelerating wound healing. Objective: To determine the effectiveness of robusta coffee bean extract gel (Coffea canephora) at concentrations of 12,5%, 25%, and 50% in increasing the thickness of collagen fibres in socket wound healing after tooth extraction in Wistar rats. Method: This type of research is laboratory experimental. The samples used were 40 male Wistar rats divided into 5 groups: negative control, positive control, 12.5% robusta coffee bean extract gel treatment, 25% robusta coffee bean extract gel treatment, and 50% robusta coffee bean extract gel treatment. The sample group was decapitated on the 3rd and 7th day after tooth extraction. Socket tissues were taken to make histological preparations stained with trichrome mallory and then measured using Adobe Photoshop CS 6.0 software. Results: The average thickness of collagen fibres in the Robusta coffee bean extract gel treatment group was higher than that in the control group (p
EFFECTIVENESS OF ROBUSTA COFFEE BEAN EXTRACT GEL (Coffea canephora) ON THE THICKNESS OF COLLAGEN FIBERS AFTER WISTAR RAT TOOTH EXTRACTION Sari, Desi Sandra; Aisyah, Siti; Rachmawati, Dessy; Sutjiati, Rina; Yuwono, Budi
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Tooth extraction causes injury to the alveolar bone and oral mucosa which is followed by the body ’s natural response through wound healing. One of the important parameters and indicators of wound healing is collagen density. Collagen is synthesised by fibroblasts in the proliferative phase, which was formed from day 3 and reached its peak on day 7. Robusta coffee beans have active compounds in the form of anti-inflammatory and antioxidants that are effective in accelerating wound healing. Objective: To determine the effectiveness of robusta coffee bean extract gel (Coffea canephora) at concentrations of 12,5%, 25%, and 50% in increasing the thickness of collagen fibres in socket wound healing after tooth extraction in Wistar rats. Method: This type of research is laboratory experimental. The samples used were 40 male Wistar rats divided into 5 groups: negative control, positive control, 12.5% robusta coffee bean extract gel treatment, 25% robusta coffee bean extract gel treatment, and 50% robusta coffee bean extract gel treatment. The sample group was decapitated on the 3rd and 7th day after tooth extraction. Socket tissues were taken to make histological preparations stained with trichrome mallory and then measured using Adobe Photoshop CS 6.0 software. Results: The average thickness of collagen fibres in the Robusta coffee bean extract gel treatment group was higher than that in the control group (p
The effect of supernatants of Lactobacillus casei against Porphyromonas gingivalis Zainina, Iris Amelinda; Kusumawardani, Banun; Sari, Desi Sandra
Majalah Kedokteran Gigi Indonesia Vol 11, No 2 (2025): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.101506

Abstract

Periodontitis is an inflammatory disease of the periodontal tissues primarily caused by Porphyromonas gingivalis (P. gingivalis). In recent years, probiotics have been proposed as a potential bacteriotherapeutic approach for periodontitis. Probiotic bacteria such as Lactobacillus casei (L. casei) are known to produce antibacterial compounds, which can be found in their culture supernatants. The ability of L. casei to grow and synthesize these substances depends on environmental factors, including pH. Based on preliminary findings, a pH of 6.5 was used in this study. This study aimed to evaluate the antibacterial activity of L. casei supernatant against P. gingivalis in vitro. The research employed an experimental post-test-only group design. Two control groups were included: a negative control (aquadest) and a positive control (0.2% chlorhexidine). The treatment groups received L. casei supernatant at volumes of 20 µl, 50 µl, and 80 µl, with incubation periods of 6, 12, and 24 hours. The results demonstrated that the L. casei supernatant exhibited the highest antibacterial activity against P. gingivalis at a volume of 80 µl after 12 hours of incubation. The Shapiro–Wilk test indicated that the data were normally distributed, while Levene’s test revealed a lack of homogeneity. Post hoc analysis showed significant differences among all treatment groups at the 12-hour incubation point. In conclusion, the supernatant of L. casei exhibits in vitro antibacterial activity against P. gingivalis.
THE EFFECTIVENESS OF USING TOOTHPASTE CONTAINING ROBUSTA COFFEE BEAN EXTRACT IN INHIBITING THE FORMATION OF DENTAL PLAQUE Prasasti, Rina Nanda; Sari, Desi Sandra; Pujiastuti, Peni
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.412 KB) | DOI: 10.30659/odj.9.1.12-20

Abstract

Background: Periodontal disease is caused by the interaction between pathogenic bacteria and plaque, without the accumulation of plaque, periodontal disease will not appear. Plaque will be visible one to two days if no oral cleaning steps are taken. The combination of antimicrobial therapy such as antibiotics and mouthwash as well as mechanical therapy such as scaling and root plain gives more effective results. However, if done in the long term it will cause resistance. To overcome this, alternative materials are needed that are used to inhibit bacterial growth, one of which is robusta coffee beans. The content of robusta coffee bean extract contains phenolic and flavonoid compounds that function as antibacterials that work by disrupting the function of the cytoplasmic and cytoplasmic membranes of bacteria.Method: In this study, 6 groups were used, namely KN, K-, K+, KP 25%, KP 50%, and KP 75%. The gingivitis model was made with wire using ligation technique for 3 days, then toothpaste was applied, brushing process, and disclosing agent was given, and the plaque index calculation was PHP (Personal Hygiene Performance). The data obtained were then analyzed using the Kruskall-Wallis test followed by the Mann-Whitney test.Result: The Robusta coffee bean extract toothpaste group at a concentration of 75% experienced a significant reduction in plaque compared to the negative control group and the 25% treatment group (p<0.05), but there were no significant differences or had the same ability when compared to the experimental group. 50% treatment group, normal control group and positive control group.Conclusion: The 75% concentration of Robusta coffee bean extract found in toothpaste is proven to be effective in inhibiting the formation of dental plaque.
NUMBER OF BLACK-PIGMENTED ANAEROBIC BACTERIA CONTAINED IN THE GINGIVAL CREVICULAR FLUID (GCF) OF PATIENTS SUFFERING FROM THE CHRONIC PERIODONTITIS AND AGGRESSIVE PERIODONTITIS Praharani, Depi; Pujiastuti, Peni; Wahyukundari, Melok Aris; Daat Arina, Yuliana Mahdiyah; Sari, Desi Sandra
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (574.238 KB) | DOI: 10.30659/odj.8.1.101-107

Abstract

Analisis cemaran logam berat dalam pasta gigi ekstrak biji kopi robusta Pujiastuti, Peni; Arina, Yuliana Mahdiyah Da'at; Praharani, Depi; Wahyukundari, Melok Aris; Sakinah, Neira Najatus; Sari, Desi Sandra
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 37, No 3 (2025): Desember 2025
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v37i3.61265

Abstract

Pendahuluan: Pasta gigi bermanfaat dalam upaya kontrol plak secara mekanis sehingga berperan dalam mencegah penyakit periodontal. Produk pasta gigi ekstrak biji kopi robusta dalam pasta gigi harus memenuhi Standar Nasional Indonesia (SNI) 8861:2020, diantaranya cemaran logam berat, Timbal (Pb), Cadmium (Cd), Raksa (Hg) dan Arsen (As)  dapat mengganggu kesehatan tubuh manusia. Belum ada informasi tentang adanya cemaran logam berat dalam pasta gigi ekstrak biji kopi robusta. Tujuan penelitian mengkaji kesesuaian cemaran Pb, Cd, Hg dan As dalam pasta gigi ekstrak biji kopi robusta dengan standar SNI 8861:2020. Metode: Jenis penelitian ini eksperimental laboratoris dengan sampel pasta gigi ekstrak biji kopi robusta dengan konsentrasi 0,0625%, 0,125%, 0,25%, dan 0,5% serta plasebo. Pembuatan ekstrak biji kopi robusta menggunakan metode maserasi. Pembuatan pasta gigi plasebo dengan kandungan magnesium karbonat, kalsium karbonat, gliserin, propilen glikol, trietanolamin, oleum menthae piperithae, dan aquades steril. Pembuatan pasta gigi ekstrak biji kopi robusta dengan cara mencampur bahan pasta gigi plasebo dengan ekstrak biji kopi robusta 0,0625%, 0,125%, 0,25%, dan 0,5%. Selanjutnya dilakukan uji Pb, Cd, Hg dan As dengan menggunakan metode spektrofotometri serapan atom. Hasil: Kadar Pb pada kontrol negatif 1,382 dan  perlakuan 1,687–1,846. Kadar Cd pada kontrol negatif 0,240 dan perlakuan 0,216–0,239. Kadar Hg dan As pada semua kelompok 0. Seluruh kadar logam masih di bawah batas cemaran. Simpulan: Terdapat cemaran logam berat Pb dan Cd pada pasta gigi ekstrak biji kopi robusta dibawah batas maksimal berdasarkan SNI 8861:2020.Analysis of the compliance of heavy metal contamination in robusta coffee bean extract toothpaste based on the Indonesian National Standard (SNI) 8861:2020: an experimental laboratory studyIntroduction: Toothpaste plays an important role in mechanical plaque control and in preventing periodontal disease. Natural ingredients, including robusta coffee beans, have been used in toothpaste formulations. Toothpaste products containing robusta coffee bean extract must meet the Indonesian National Standard (SNI) 8861:2020, which includes provisions on heavy metal contamination (Pb, Cd, Hg, and As) that can affect human health. To date, there is no information available regarding the presence of heavy metal contamination in robusta coffee bean extract toothpaste. The purpose of the study was to evaluate the compliance of Pb, Cd, Hg and As contamination levels in robusta coffee bean extract toothpaste with the SNI 8861:2020 standard. Method: This study employed an experimental laboratory design using samples of robusta coffee bean extract toothpaste with concentrations of 0.0625%, 0.125%, 0.25%, and 0.5%, as well as a placebo. The robusta coffee bean extract was prepared using the maceration method. The placebo toothpaste was composed of magnesium carbonate, calcium carbonate, glycerin, propylene glycol, triethanolamine, oleum menthae piperitae, and sterile distilled water. The robusta coffee bean extract toothpaste was made by mixing the placebo base with the extract at concentrations of 0.0625%, 0.125%, 0.25%, and 0.5%. Subsequently, tests for Pb, Cd, Hg, and As contamination were carried out using atomic absorption spectrophotometry (AAS). Result: Pb levels in the negative control  group were 1.382,  while those in treatment groups ranged from 1.687 to 1.846. Cd levels in the negative control were 0.240, and in the treatment groups ranged from 0.216 to 0.239. Hg and As levels in all groups were 0. All measured levels of heavy metals remained below the contamination limits set by SNI 8861:2020. Conclusion: The findings showed the presence of Pb and Cd contamination in robusta coffee bean extract toothpaste. However, all concentrations were below the maximum permissible limits established in SNI 8861:2020.
NUMBER OF BLACK-PIGMENTED ANAEROBIC BACTERIA CONTAINED IN THE GINGIVAL CREVICULAR FLUID (GCF) OF PATIENTS SUFFERING FROM THE CHRONIC PERIODONTITIS AND AGGRESSIVE PERIODONTITIS Praharani, Depi; Pujiastuti, Peni; Wahyukundari, Melok Aris; Daat Arina, Yuliana Mahdiyah; Sari, Desi Sandra
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.1.101-107

Abstract

Co-Authors Adisty, Anggi Salwa Arina, Yuliana Mahdiyah Da'at Banun Kusumawardani Budi Yuwono Candra Bumi Daat Arina, Yuliana Mahdiyah Depi Praharani Dessy Rachmawati Dhani Wijaya Dhani Wijaya, Dhani Ernie Maduratna Evi Umayah Ulfa Evi Umayah Ulfa Fany, Manta Farahdila, Nihla Adinda Fedik Abdul Rantam Ferdiansyah Mahyudin Happy Harmono Leersia Yusi M Melok M Melok, M M. Nurul Amin Melok Aris Wahyukundari Melok Aris Wahyukundari, Melok Aris Muhammad Nurul Amin Neira Najatus Sakinah Nulend, Jenneke Klein Peni Pujiastuti Perdana, Mohammad Daffa Duta Prasasti, Rina Nanda Prasetya, Rendra C. Prastifa, Febi Zulaikha Pudjiastuti, Peni Putri, Puspita Nabila Rahmawati, Iis Rina Nanda Prasasti Rina Sutjiati S.Pd. M Kes I Ketut Sudiana . Sakinah, Neira Najatus Siti Aisyah Suryono Suryono Tantin Ermawati Utha, Maria Fransisca Wanodyo, Ari Tri Yuliana Mahdiyah DA Yuliana Mahdiyah DA Yuliana Mahdiyah Daat Arina Yuliana Mahdiyah Da’at Arina Zahara Meilawaty Zainina, Iris Amelinda