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All Journal Jurnal Respirologi Indonesia Pharmaceutical Sciences and Research (PSR) Makara Journal of Health Research Eduvest - Journal of Universal Studies Holistik Jurnal Kesehatan
Santi Purna Sari
Universitas Indonesia
Aerospace Engineering Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Profile of Drug-Resistant Tuberculosis Patients at Rumah Sakit Universitas Indonesia Depok Period October 2024 Dumiarsih, Suci Rizki; Sari, Santi Purna; Andrajati, Retnosari; Handayani, Diah
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.50269

Abstract

Indonesia has been one of the three countries in Asia that contributes to the highest case of Tuberculosis (TB) in the world. Tuberculosis itself counted as the top ten cause of death globally. Two of the challenges in controlling TB cases are the occurrence of drug-resistance strain and patients’ adherence. Drug-resistant TB has to be treated with the second line drugs of TB with higher risk of adverse events. Linezolid as one of the suggested drugs by WHO in the treatment may increase patients’ risk of cytopenia events. This study was conducted to represent the profile of drug-resistant TB obtained from Rumah Sakit Universitas Indonesia (RSUI) Depok period October 2024. Design of this study is a quantitative-descriptive where the data of patients obtained from the patients’ medical records in the period of October 2024. The findings of this study showed the total number of drug-resistant TB was 104 with 3 cases of HIV and 70 patients having Linezolid in their regimen. Most of the patients are male with mean of age 41.3 years. New cases and RR/MDR TB level are dominated while on the other hand there’s 9 cases of After Failure and 4 others are After Loss to Follow-up. Median values obtained for patients’ leukocytes, hemoglobin, and platelets are 7818.0, 11.9, 279.5 respectively.
Identification of Adverse Drug Reaction Incidents in Statin Use in Depok Hospital Inpatient Nurhikmah, Rizky; Andrajati, Retnosari; Sari, Santi Purna
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.50934

Abstract

One of the adverse drug reactions that occur in patients who receive treatment therapy is drug side effects. Statins are the first choice in cholesterol-lowering therapy. Although statins are safe and well tolerated, they have the potential for side effects. The purpose of this study is to determine the prevalence of adverse drug reactions, the incidence of adverse drug reactions that occur, and the probability score of adverse drug reactions based on the Naranjo Algorithm instrument in patients with inpatient atherosclerosis cardiovascular disease who use statin therapy at RSUI. The method used in this study is a prospective observational descriptive method with observation through patient interviews and medical record data collection as well as causality analysis using the Naranjo Algorithm. The results of this study were obtained from 116 patients who used statin therapy in the RSUI inpatient room in accordance with the inclusion and exclusion criteria. Of the 116 patients, as many as 14 patients (12.07%) experienced adverse drug reactions statins. Adverse drug reactions felt included shoulder pain (3.40%), nausea (2.60%), muscle pain (1.70%), blurred vision, difficulty sleeping, chest palpitations, joint pain, dizziness and body aches as much as 0.9% each. The total probability score of the Naranjo algorithm is a probable score of 5-8 in 7 patients (50%) and a possible score of 1-4 (50%).
Efektivitas intervensi apoteker terhadap optimalisasi terapi opioid dan manajemen nyeri pada pasien kanker: A literature review Budiastuti, Rizky Farmasita; Sari, Santi Purna; Andrajati, Retnosari; Syafhan, Nadia Farhanah
Holistik Jurnal Kesehatan Vol. 19 No. 5 (2025): Volume 19 Nomor 5
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i5.872

Abstract

Background: Cancer pain remains a significant clinical challenge, with a high prevalence across various disease stages. Opioids are the mainstay for moderate to severe pain management but carry risks of dependence, tolerance, and serious side effects, necessitating careful supervision. Purpose: To review the effectiveness of pharmacist interventions in managing opioid use among cancer pain patients. Method: A literature search was conducted using two approaches: keyword-based searches through electronic databases (Google Scholar and Scopus) and the snowballing technique. Keywords included "cancer pain," "opioid," "pharmacist intervention," and "breakthrough pain," combined with Boolean operators. After identifying primary articles, backward and forward snowballing was performed to find additional relevant studies. All articles were screened based on predefined inclusion and exclusion criteria. Results: The review demonstrates that pharmacist interventions can improve pain control by up to 40%, reduce opioid-related side effects such as constipation by up to 50%, and enhance patient adherence to therapy. In Indonesia, however, barriers such as limited access to strong opioids, low patient education levels, and minimal pharmacist involvement in multidisciplinary teams remain significant challenges. Conclusion: Pharmacists play a strategic role in cancer pain management, particularly in optimizing pain control, minimizing opioid dependence, and managing adverse effects. Their active involvement in multidisciplinary teams enhances patients' quality of life and reduces inappropriate opioid use. Strengthening policies, providing continuous professional development, and conducting context-specific research are essential to optimize pharmacist contributions in Indonesia.   Keywords: Cancer Pain; Opioids; Pain Management; Pharmacist Intervention.   Pendahuluan: Nyeri kanker merupakan tantangan klinis utama dengan prevalensi tinggi pada berbagai tahap penyakit kanker, dan opioid menjadi terapi lini utama untuk nyeri sedang hingga berat. Namun, penggunaannya memiliki risiko ketergantungan, toleransi, serta efek samping serius, sehingga diperlukan pengawasan ketat. Tujuan: Untuk meninjau literatur terkait efektivitas intervensi apoteker dalam pengelolaan penggunaan opioid pada pasien nyeri kanker. Metode: Pencarian literatur dilakukan dengan dua pendekatan, yaitu pencarian menggunakan kata kunci melalui basis data elektronik (Google scholar dan Scopus) serta teknik snowballing. Kata kunci yang digunakan meliputi: "cancer pain", "opioid", "pharmacist intervention", dan "breakthrough pain", yang dikombinasikan menggunakan operator Boolean. Setelah diperoleh artikel utama, dilakukan teknik snowballing secara backward dan forward untuk menemukan studi relevan. Semua artikel yang diperoleh diseleksi berdasarkan kriteria inklusi dan eksklusi. Hasil: Tinjauan menunjukkan bahwa intervensi apoteker dapat meningkatkan efektivitas terapi nyeri hingga 40%, menurunkan kejadian konstipasi sebagai efek samping hingga 50%, serta meningkatkan kepatuhan pasien terhadap regimen terapi. Namun, di Indonesia, implementasi peran apoteker masih menghadapi hambatan seperti keterbatasan akses opioid kuat, kurangnya edukasi pasien, dan rendahnya keterlibatan apoteker dalam tim multidisiplin. Simpulan: Dari tinjauan ini menunjukan bahwa intervensi apoteker terbukti memiliki kontribusi strategis dalam pengelolaan nyeri kanker, khususnya melalui pengendalian nyeri yang lebih efektif, pencegahan ketergantungan opioid, dan manajemen efek samping yang lebih terstruktur. Keterlibatan apoteker dalam tim multidisiplin dapat meningkatkan kualitas hidup pasien dan menurunkan risiko penggunaan opioid yang tidak tepat. Namun, untuk mengoptimalkan peran ini, diperlukan dukungan kebijakan, pelatihan berkelanjutan, serta riset lebih lanjut dalam konteks lokal untuk menjawab tantangan implementasi di Indonesia.   Kata Kunci: Intervensi Apoteker; Nyeri Kanker; Opioid; Pengelolaan Nyeri.
The Factor Affecting Medication Adherence in Tuberculosis Patients: A Literature Review Harahap, Daimah Wirdatus Sanaun; Andrajati, Retnosari; Sari, Santi Purna; Handayani, Diah
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.1541

Abstract

Medication adherence is crucial for the successful treatment of tuberculosis (TB), a persistent global health issue that demands prolonged and rigorous therapy to achieve cure, prevent drug resistance, and reduce transmission rates within communities. Recent studies highlight predictors of effective treatment outcomes such as being a new TB case and being HIV-negative. There is a significant relationship between various psychosocial factors that influence treatment adherence, particularly among elderly TB patients, where adherence is characterized by complexity and multidimensionality. Factors like depression, anxiety, income levels, social support, patient status, and TB classification play critical roles in adherence. Understanding these factors is essential for optimizing treatment strategies and improving outcomes in TB management.
Medication Adherence among Drug-Resistant Tuberculosis (DR-TB) Patients at Universitas Indonesia Hospital Harahap, Daimah Wirdatus Sanaun; Andrajati, Retnosari; Sari, Santi Purna; Handayani, Diah
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.775

Abstract

Background: Drug-resistant tuberculosis (TB-DR) is a deadly disease caused by infectious agents. Indonesia is one of the countries with the highest drug-resistant tuberculosis (TB-DR) rates in the world. The prevalence of tuberculosis cases in Depok City between 2019-2022 showed an increase in cases every year. This study aims to measure the level of adherence of drug-resistant tuberculosis (TB-DR) patients to their treatment using the Eight-Item Morisky Medication Adherence Scale (MMAS-8) questionnaire.Methods: This study is an observational study using a cross-sectional study design, conducted from February 2024 to March 2024 at the University of Indonesia Hospital. Eighty-seven respondents participated in this study. Respondents completed the validated Indonesian version of the MMAS-8 questionnaire after signing informed consent forms.Results: The results of the study showed that 50.6% of respondents had low adherence levels, 47.1% had moderate adherence levels, and 2.3% had high adherence levels. The data was then statistically analyzed using the SPSS version 29 statistical package with Chi-Square analysis, which resulted in a significant correlation (P<0.05) between adherence levels and gender.Conclusion: There was a significant correlation between gender and respondent adherence. More than 50% of drug-resistant tuberculosis (TB-DR) patients at the University of Indonesia Hospital still have low adherence levels to their treatment.
Co-Authors Abdul Munim Ardi Findyartini, Ardi Ari Estuningtyas, Ari Ariesa Oktamauri Diah Handayani Dian Ayubi Diandra Andina Ratimanjari, Diandra Andina Diantha Soemantri Dumiarsih, Suci Rizki Evi Martha Fadlina Chany S Fadlina Chany Saputri Farmasita Budiastuti, Rizky Handayani, Raden Rara Diah Hanny Handiyani Harahap, Daimah Wirdatus Sanaun HJ Freisleben, HJ Isra, Nur Juheini Amin K.J, Wahyu Atmaja MARIA BINTANG Nadia Farhanah Syafhan Nurhikmah, Rizky Retnosari Andrajati Sari, Rusmalita Pebriana Sri Wulandah Fitriani, Sri Wulandah tri wahyuni Yahdiana Harahap