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All Journal Journal of Pharmaceutics and Pharmacology Indonesian Journal of Pharmaceutical Science and Technology Pro-Life Jurnal Pengabdian UntukMu NegeRI Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Jurnal Farmanesia
Panal Sitorus
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5, Kampus USU, Medan. Sumatera Utara, Indonesia 20155.
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Phytochemical Screening of Phaleria macrocarpa (Scheff.) Boerl.) and Antibacterial Activity Test of Ethanol Extract Against Staphylococcus aureus Bacteria Muhammad Rizki; Urip Harahap; Panal Sitorus
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.781

Abstract

Phaleria macrocarpa is known as one of the medicinal plants in Indonesia. Almost all parts of the plant have chemical content that is useful for being used as medicine. The growing use of crown plants by the community for various diseases requires a series of tests to obtain traditional medicine preparations that are safe for human use. The purpose of this study was to identify the content of secondary metabolite compounds (alkaloids, flavonoids, saponins, tannins, steroids, triterpenoids, and glycosides) and the antibacterial activity of Staphylococcus aureus with the good method because the good method has the advantage that it is easier to measure the area of the inhibition zone formed because an antibacterial activity is not only on the upper surface of nutrient agar but also at the bottom. The results of phytochemical screening showed that the flesh of Phaleria macrocarpa (Scheff). The results of testing the antibacterial activity of an ethanol extract of crown Phaleria macrocarpa (Scheff) fruit flesh (Boerl) were positive for alkaloids, flavonoids, glycosides, saponins, tannins, and steroids. Boerl.) showed effective results at a concentration of 40 mg/ml against Staphylococcus aureus bacteria with an inhibition zone diameter of 14 mm; the antibacterial activity was categorized as strong.
Phytochemical Screening Of Ethanol Extract Of Temu Kunci (Boesenbergia Rotunda (L.) Mansf) Rhizome Extract And Testing Of Bilirubin Levels In Male White Mice Mawandha Sari Harahap; Urip Harahap; Panal Sitorus
International Journal of Science, Technology & Management Vol. 4 No. 3 (2023): May 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i3.819

Abstract

Liver Disease Is A Deadly Disease That Has Attacked Many People. Liver Disease Is A Disease That Occurs As A Result Of An Unhealthy Lifestyle. Usually, The Patient Will Consume Drugs With Chemical Compounds To Overcome The Problem Of This Disease. The Long-Term Use Of Chemical Drugs Will Certainly Cause Side Effects Or, Even Worse, Cause New Diseases. Therefore, The Latest Treatment Methods Must Be Developed To Minimize Side Effects, Namely The Use Of Traditional Medicines. The Purpose Of This Study Was To Determine The Use Of Temu Kunci Rhizome As An Alternative To Reduce Total Bilirubin Levels In Rats As Experimental Animals. This Study Used Rats As Experimental Animals, Which Were Divided Into 6 Test Groups, Namely Group 1 Without Treatment, Group 2 With 0.5% CMC Suspension, Group 3 With 200 Mg Acetylcysteine, Group 4 With 250 Mg/Kg BW Ethanol Extract Of Temukunci, Group 5 Treated With A 500 Mg/Kg BW Dose Of Ethanol Extract Of Temukunci, And Group 6 With A 750 Mg/Kg BW Ethanol Extract Of Temukunci. From The Results Of The Research Conducted, The Ethanol Extract Of Temu Kunci At A Dose Of 750 Mg/Kg BW Was The Best Treatment For Reducing Total Bilirubin Levels In Rats As Experimental Animals.
Uji Aktivitas ALT, AST dan Histopatologi Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia rotunda (L.) Mansf) pada Tikus Putih Jantan Mawandha Sari Harahap; Urip Harahap; Panal Sitorus
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3262

Abstract

Experimental research in the field of hepatology on the development of traditional medicine into a potential pharmacological solution to protect the liver from cirrhosis. Accordingly, this study investigated the effect of ethanol extract of temu kunci rhizome on liver cirrhosis. The rats were divided into six groups, the normal control group was given nothing but pellets and sufficient water, the negative control group was given orally CMC-Na 0.5%, 200 mg acetylcysteine (dose converted to rat) was given to the positive control group, and the treatment group was given ethanol extract of temu kunci rhizome doses of 250, 500, 750 mg/kg BW, given daily for 10 days. Then on the 10th day after 1 hour of extract administration, induction was carried out with paracetamol 800 mg/kg BW orally; 16 hours after induction, rats were sacrificed, blood was taken for ALT and AST enzyme examination, then liver organs were taken for histopathological examination. The administration of ethanol extract of temu kunci rhizome can prevent liver damage by reducing ALT and AST enzyme levels in rat blood serum. The best dose in reducing ALT and AST enzymes was produced by giving 500 mg/kg BW of temu kunci rhizome ethanol extract every day for 10 days. At a dose of 500 mg/kg BW ethanol extract of temu kunci rhizome morphologically (evaluation with H&E staining) can also repair liver tissue damaged by paracetamol induction. The development of liver damage can be interpended by using ethanol extract of temu kunci rhizome, so that the status of liver morphology, structure and function of the liver can be maintained.
Co-Authors Aida Apriani Ayu Meta Sari BR PA Ayu Vevariantina Bernadetta R. Munthe Berton Sitanggang Cintya, Henni Denny Satria Devina Chandra Dewi Pertiwi Effendy De Lux Putra, Effendy De Lux Eka Margareta Sinaga Fidayani Pasaribu Fikarwin Zuska Ihsanul Hafiz Jon Kenedy Marpaung Jon Kenedy Marpaung M. Fauzan Lubis Mahatir Muhammad Masfria Masfria Masfria Masfria Mawandha Sari Harahap Mawandha Sari Harahap Muhammad Rizki Regina Marinta Sinaga Rosidah, Rosidah Saiful Bahri Siti Samaniyah Suharyanisa Supartiningsih Supartiningsih Urip Harahap Urip Harahap Urip Harahap