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All Journal Journal of Pharmaceutics and Pharmacology Indonesian Journal of Pharmaceutical Science and Technology Pro-Life Jurnal Pengabdian UntukMu NegeRI Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Jurnal Ners Journal of Pharmaceutical and Health Research Jurnal Farmanesia Indonesian Journal of Global Health Research
Panal Sitorus
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5, Kampus USU, Medan. Sumatera Utara, Indonesia 20155.
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Formulation and Evaluation of Lantana camara L. Leaf Extract Hair Tonic as an Anti-Dandruff and Hair Growth Agent Nurul Husna; Sumaiyah Sumaiyah; Panal Sitorus
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.451

Abstract

Hair problems like loss and dandruff (Pityrosporum ovale) are common, fueling the search for natural alternatives. Lantana camara L. leaves, rich in flavonoids, saponins, and tannins, were selected for their antifungal and hair-growth promoting potential. This study formulated and evaluated a Lantana camara L. leaf ethanol extract hair tonic as an anti-dandruff agent (in vitro) and a hair growth promoter (in vivo). The extract was obtained via maceration and phytochemically screened. Hair tonic formulations (15%, 20%, 25%) underwent evaluation for physical stability, pH, viscosity, and microbial contamination, all meeting SNI standards. In vitro anti-dandruff tests against P. ovale used the disc diffusion method, while in vivo hair growth promotion was tested on mice for 30 days. Results confirmed the extract contained alkaloids, flavonoids, saponins, tannins, steroids, and triterpenoids. All formulas were stable and met SNI. The 25% formula (F3) showed superior microbial safety and strong in vitro antifungal activity (10.7 mm inhibition zone, comparable to positive control). In vivo, F3 significantly increased mouse hair length, comparable to commercial tonic by day 20. Flavonoids and saponins are suspected to contribute to hair growth stimulation. In conclusion, the Lantana camara L. leaf ethanol extract hair tonic 25% (F3) is safe, stable, effective as an anti-dandruff agent in vitro, and a hair growth promoter in vivo, positioning it as a promising natural alternative.  
Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride Meiva Amelia Lubis; Aminah Dalimunthe; Panal Sitorus; Denny Satria; Arga Lubis
Viva Medika Vol 17 No 3 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i3.1490

Abstract

This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Additionally, liver macropathology observations indicated improved liver conditions in the treatment group. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended to validate these findings and explore the extract's therapeutic applications.
Co-Authors Aminah Dalimunthe Arga Lubis Ayu Vevariantina Bernadetta R. Munthe Berton Sitanggang Cintya, Henni Denny Satria Devina Chandra Dewi Pertiwi Effendy De Lux Putra, Effendy De Lux Eka Margareta Sinaga Fidayani Pasaribu Fikarwin Zuska Ihsanul Hafiz Jon Kenedy Marpaung Jon Kenedy Marpaung M. Fauzan Lubis Mahatir Muhammad Masfria Masfria Mawandha Sari Harahap Meiva Amelia Lubis Nadya Ulfa Safitri Nurul Husna Regina Marinta Sinaga Rosidah, Rosidah Saiful Bahri Suharyanisa Sumaiyah Sumaiyah Sunariati Sunariati Supartiningsih Supartiningsih Urip Harahap