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All Journal Journal of Pharmaceutics and Pharmacology Indonesian Journal of Pharmaceutical Science and Technology Pro-Life Jurnal Pengabdian UntukMu NegeRI Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Jurnal Ners Journal of Pharmaceutical and Health Research Jurnal Farmanesia Journal of Pharmaceutical and Sciences. Indonesian Journal of Global Health Research
Panal Sitorus
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5, Kampus USU, Medan. Sumatera Utara, Indonesia 20155.
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Formulation and Evaluation of Lantana camara L. Leaf Extract Hair Tonic as an Anti-Dandruff and Hair Growth Agent Nurul Husna; Sumaiyah Sumaiyah; Panal Sitorus
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.451

Abstract

Hair problems like loss and dandruff (Pityrosporum ovale) are common, fueling the search for natural alternatives. Lantana camara L. leaves, rich in flavonoids, saponins, and tannins, were selected for their antifungal and hair-growth promoting potential. This study formulated and evaluated a Lantana camara L. leaf ethanol extract hair tonic as an anti-dandruff agent (in vitro) and a hair growth promoter (in vivo). The extract was obtained via maceration and phytochemically screened. Hair tonic formulations (15%, 20%, 25%) underwent evaluation for physical stability, pH, viscosity, and microbial contamination, all meeting SNI standards. In vitro anti-dandruff tests against P. ovale used the disc diffusion method, while in vivo hair growth promotion was tested on mice for 30 days. Results confirmed the extract contained alkaloids, flavonoids, saponins, tannins, steroids, and triterpenoids. All formulas were stable and met SNI. The 25% formula (F3) showed superior microbial safety and strong in vitro antifungal activity (10.7 mm inhibition zone, comparable to positive control). In vivo, F3 significantly increased mouse hair length, comparable to commercial tonic by day 20. Flavonoids and saponins are suspected to contribute to hair growth stimulation. In conclusion, the Lantana camara L. leaf ethanol extract hair tonic 25% (F3) is safe, stable, effective as an anti-dandruff agent in vitro, and a hair growth promoter in vivo, positioning it as a promising natural alternative.  
Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride Meiva Amelia Lubis; Aminah Dalimunthe; Panal Sitorus; Denny Satria; Arga Lubis
Viva Medika Vol 17 No 3 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i3.1490

Abstract

This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Additionally, liver macropathology observations indicated improved liver conditions in the treatment group. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended to validate these findings and explore the extract's therapeutic applications.
Efek Ekstrak Etanol Daun Mobe (Artocarpus lacucha Buch-Ham.) terhadap Histopatologi Hati Tikus Diinduksi Karbon Tetraklorida Meiva Amelia Lubis; Aminah Dalimunthe; Panal Sitorus; Denny Satria; Indah Pertiwi; Damayanti S Damayanti S
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1432

Abstract

Background: Liver injury due to exposure to hepatotoxic chemicals remains a major problem in the medical and pharmaceutical fields. Carbon tetrachloride (CCl₄) is a classic hepatotoxic agent that induces oxidative stress, lipid peroxidation, and hepatocyte necrosis through free radical formation. Mobe leaves (Artocarpus lacucha Buch-Ham.) contain bioactive compounds, particularly flavonoids and phenolics, which possess antioxidant and anti-inflammatory properties with potential hepatoprotective effects. Objective: This study aimed to evaluate the effect of ethanol extract of mobe leaves (EEML) on the liver histopathology of rats induced with carbon tetrachloride. Methods: This experimental study used a post-test only control group design. Twenty-five male rats were divided into five groups: negative control (CMC-Na 1% + CCl₄), positive control (silymarin 100 mg/kgBW + CCl₄), and three treatment groups receiving EEML at doses of 50, 100, and 200 mg/kgBW + CCl₄. Hepatotoxicity was induced by intraperitoneal injection of CCl₄ (1 mL/kgBW) twice weekly for 14 days. Liver tissue was processed for hematoxylin-eosin staining, and histopathological changes (hepatocyte degeneration, necrosis, and inflammatory cell infiltration) were assessed semi-quantitatively using a scoring system (0-3). Results: CCl₄ induction caused severe liver damage in the negative control group, characterized by diffuse hydropic degeneration, extensive necrosis, and marked inflammatory infiltration (score 3 for all parameters). EEML administration significantly reduced liver injury in a dose-dependent manner. The 200 mg/kgBW dose showed the most pronounced hepatoprotective effect, with degeneration score 2, necrosis score 1, and inflammation score 2, approaching the protective effect of silymarin (score 1 for all parameters). Conclusion: Ethanol extract of mobe leaves demonstrated hepatoprotective activity against CCl₄-induced liver damage in rats, with the optimal effect at 200 mg/kgBW. These findings support the potential of mobe leaves as a natural hepatoprotective agent.
Co-Authors Aminah Dalimunthe Arga Lubis Ayu Vevariantina Bernadetta R. Munthe Berton Sitanggang Cintya, Henni Damayanti S Damayanti S Denny Satria Denny Satria Devina Chandra Dewi Pertiwi Effendy De Lux Putra, Effendy De Lux Eka Margareta Sinaga Fidayani Pasaribu Fikarwin Zuska Ihsanul Hafiz Indah Pertiwi Jon Kenedy Marpaung Jon Kenedy Marpaung M. Fauzan Lubis Mahatir Muhammad Masfria Masfria Mawandha Sari Harahap Meiva Amelia Lubis Nadya Ulfa Safitri Nurul Husna Regina Marinta Sinaga Rosidah, Rosidah Saiful Bahri Suharyanisa Sumaiyah Sumaiyah Sunariati Sunariati Supartiningsih Supartiningsih Urip Harahap