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Alfi Muntafiah
Universitas Jenderal Soedirman
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Evaluasi Potensi Antidiabetes Sari Buah Markisa Ungu (Passiflora edulis var edulis) pada Tikus Model Diabetes Melitus yang Diinduksi Aloksan Muntafiah, Alfi; Pratama, Tisna Sendy; Ati, Viva Ratih Bening
Jurnal Kedokteran Brawijaya Vol 30, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (421.953 KB) | DOI: 10.21776/ub.jkb.2019.030.03.5

Abstract

Markisa ungu mengandung komponen nutrisi dan fitokimia non nutrisi, dan potensinya pada beberapa kondisi medis telah dilaporkan. Penelitian ini bertujuan mengeksplorasi potensi antidiabetes sari markisa ungu. Penelitian true experimental ini menggunakan 30 ekor tikus putih (Rattus norvegicus) jantan galur Wistar, dibagi 5 kelompok: I) kontrol normal,  II) kontrol DM, dan III, IV, V perlakuan sari markisa ungu dosis 1,05; 2,1; dan 4,2mL/200gBB/hari melalui sonde, selama 21 hari. Induksi diabetes dengan aloksan intraperitoneal 120mg/kgBB dosis tunggal. Sampel darah diambil sebelum induksi, setelah induksi dan setelah perlakuan, melalui vena infra orbita. Kadar GDP diukur menggunakan spektrofotometer. Uji Wilcoxon terhadap kadar GDP pasca induksi dan perlakuan, didapatkan p=0,000, menunjukkan perbedaan signifikan kadar GDP antar kelompok normal dan DM. Uji Kruskal-Wallis terhadap kadar GDP pasca perlakuan juga demikian, didapatkan p<0,05. Uji post hoc Mann-Whitney: I vs II p=0,006; I vs III p=0,006; I vs IV p=0,045; I vs V p=0,025; II vs III p=0,361; II vs IV p=0,917; II vs V p=0,584; III vs IV p=0,715; III vs V p=1,000; IV vs V p= 0,584, yang berarti perbedaan hanya antara kelompok normal dengan kelompok diabet dengan atau tanpa perlakuan sari markisa ungu, namun tidak ada perbedaan antar kelompok DM tanpa atau dengan perlakuan sari markisa ungu. Kesimpulan penelitian adalah tidak terdapat perbedaan kadar GDP antara kelompok kontrol DM dengan kelompok yang diberi perlakuan sari markisa ungu berbagai dosis. 
Endothelial Nitric Oxide Synthase 3 (eNOS3) Gene Polymorphisms and Essential Hypertension in Javanese Ethnic Group Arjadi, Fitranto; Aziz, Saefuddin; Muntafiah, Alfi
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.205 KB) | DOI: 10.21776/ub.jkb.2015.028.03.4

Abstract

Hypertension is still a major public health problem in Indonesia and in several other countries. This disease is caused by multi factorial components involving both environmental and genetic factors. eNOS3 gene is one of the enzymes related to the high prevalence of hypertension. This gene expresses the NOS enzyme which regulates the synthesis of NO. NOS enzyme causes vasodilatation which decreases peripheral resistance and lowers blood pressure. This cross sectional study compared hypertension patients to those with normal blood pressure in the age group of 40-80 years old. The main purpose of this study is to evaluate the influence of eNOS3 gene Glu298Asp allele expression in Javanese ethnic group patients with hypertension. The samples consist of 50 respondents with hypertension and 50 respondents with normotension as control. Data of eNOS3 gene polymorphisms and NO plasma levels from the respondents were analyzed using t-test and chi-square test. Glu298Asp allele genotype variation in eNOS3 gene was detected by PCR-FRLP using primers G894TF and G894TR and the PCR products were cut using Mbol restriction enzymes. Sequencing result of each polymorphism band shows a typical nucleotide sequence compared to the nucleotide sequence of eNOS3 gene in Gen Bank. The results of this study showed no connection between Glu298Asp allele polymorphism in eNOS3 gene with hypertension in Javanese. There was also no relation between eNOS3 gene polymorphisms with high levels of respondents' NO plasma. Average NO plasma level of hypertension patients is 34,53 µmol/L, whereas average NO level of normal blood pressure is 32,5 µmol/L.Keywords: Allele Glu298Asp, eNOS3 gene, G894T, hypertension, Javanese ethnic, NO plasma level 
PROGRAM SIAGA STUNTING TERINTEGRASI APLIKASI PINTAR: INOVASI PENDIDIKAN GIZI SEBAGAI UPAYA PENANGGULANGAN STUNTING DI DESA WINDUAJI KABUPATEN BREBES Elok Widyaningtyas; Salsabil Rahmadina; Rahmah Fadhilah Asrifqa; Wafa Nur Azizah; Zeha Kirana; Alfi Muntafiah
Dinamika Journal : Pengabdian Masyarakat Vol 3, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.dj.2021.3.3.1558

Abstract

Abstrak Stunting merupakan salah satu permasalahan gizi kronis di Indonesia yang perlu ditangani untuk menyelamatkan perkembangan generasi bangsa. Desa Winduaji termasuk penyumbang utama kasus stunting di Indonesia dengan jumlah 245 kasus pada tahun 2018. Upaya penanggulangan stunting dapat dilakukan dengan cara promotif, preventif, dan kuratif. Metode yang dilaksanakan terdiri dari persiapan (wawancara dengan bidan desa dan pengurus Rumah Desa Sehat dan penggalian sumber referensi secara online), penyusunan media, pelaksanaan (sosialisasi, edukasi, pelatihan melalui media, dan evaluasi kegiatan). Hasil kegiatan ini menunjukkan dapat meningkatkan pengetahuan ibu terkait stunting sebesar 28,32%, pengetahuan ibu terkait gizi pra-kehamilan dan gizi kehamilan sebesar 43,69%, pengetahuan terkait ASI dan teknik menyusui sebesar 72,29%. Rata-rata peningkatan pengetahuan sebesar 48,1% setelah diberikan penyuluhan mengenai stunting. Melalui edukasi dan pelatihan, diharapkan masyarakat dapat menerapkan ilmu yang telah disampaikan. Buku serta aplikasi siaga stunting yang telah diberikan juga diharapkan dapat dimanfaatkan secara maksimal oleh masyarakat sebagai pedoman dalam mencegah dan menangani tingginya kasus stunting di Desa Winduaji.Kata-kata kunci : Aplikasi Siaga Stunting, Buku Siaga Stunting, Edukasi, Gizi, Pelatihan, Stunting, WinduajiAbstractStunting is one of the chronic nutritional problems in Indonesia that needs to be addressed to save the development of the nation's generation. Winduaji Village is one of the main contributors to stunting cases in Indonesia, with 245 cases in 2018. Stunting prevention efforts can be carried out in promotive, preventive, and curative ways. The methods implemented consisted of preparation (interviews with village midwives and the Health Village House management and online reference sources), preparation of media, implementation (socialization, education, training through media, and evaluation of activities). The results showed that this activity increased maternal knowledge regarding stunting by 28.32%, maternal knowledge related to pre-pregnancy nutrition and pregnancy nutrition by 43.69%, knowledge related to breastfeeding and breastfeeding techniques by 72.29%. The average increase in knowledge was 48.1% after being given counselling about stunting. Through education and training, it is hoped that the community can apply the knowledge that has been conveyed. The provided book and the stunting alert application are also expected to be utilized optimally by the community as a guide in preventing and dealing with the high number of stunting cases in Winduaji Village.Keywords : Stunting, Nutritional, Education, Training, stunting book, stunting application, Winduaji
Empowerment of Posyandu Cadres in Early Detection of Child Growth Problems: Optimization of KIA Books Alfi Muntafiah; Octavia Permata Sari; Nor Sri Inayati; Qodri Santosa
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 1 (2021): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (667.858 KB) | DOI: 10.22146/jpkm.41510

Abstract

Posyandu (integrated health center) as a health information center for the community is expected to be the spearhead of early detection of developmental disorders in children under five. Posyandu activities are driven by cadres. Cadres monitor the growth of children under five through anthropometric measurements: body weight, height, head circumference and development milestones. Knowing how to measure anthropometric parameters, data plotting on a growth chart in the Maternal and Child Health (Kesehatan Ibu dan Anak=KIA) book, and interpret the results are very important. Cadres with good understanding and skills will greatly assist in monitoring child growth and development. This activity is expected to increase the knowledge and skills of cadres in monitoring child development. This activity was carried out through counseling, training, case study, and discussion. Pre-tests and post-tests were conducted to evaluate this activity. The mean pre-test was 40.00 ± 11.69, with the lowest value being 10.00 and the highest value being 60.00. The mean post-test was 54.10 ± 12.08, the lowest value was 30.00 and the highest was 90.00. The Wilcoxon test found p=000, where 20.5% participants' knowledge did not change while 69.23% had better knowledge compared to before the activity. Conclusion: This training can significantly improve cadres' knowledge and skills about the use of the KIA book.
Evaluasi Penggunaan Fototerapi Konvensional dalam Tata laksana Hiperbilirubinemia Neonatal: Efektif, tetapi Tidak Efisien Qodri Santosa; Muhammad Mukhson; Alfi Muntafiah
Sari Pediatri Vol 21, No 6 (2020)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp21.6.2020.377-85

Abstract

Latar belakang. Hiperbilirubinemia merupakan masalah umum yang sering dijumpai pada bayi baru lahir. Tata laksana hiperbilirubinemia neonatal dilakukan untuk mencegah timbulnya komplikasi dan fototerapi merupakan metode yang paling sering digunakan. Fototerapi konvensional menurunkan kadar bilirubin lebih lama dibanding fototerapi intensif sehingga berpotensi menyebabkan inefisiensi. Saat penelitian ini dilakukan, RSUD Prof.dr. Margono Soekarjo (RSMS) Purwokerto hanya memiliki alat fototerapi konvensional.Tujuan. Mengevaluasi pengelolaan hiperbilirubinemia neonatal dengan fototerapi konvensional. Metode. Penelitian crossectional melibatkan 157 subjek dengan kiteria inklusi adalah hiperbilirubinemia neonatal, yang dirawat inap pada Januari–September 2018 di RSMS Purwokerto, dengan menggunakan data sekunder rekam medis. Analisis data dan statistik digunakan SPSS dan uji Wilcoxon digunakan untuk mengalisis perbedaan antara kadar bilirubin serum total (BST) pra dan pascafototerapi. Hasil. Sebanyak 157 bayi (13,08 %) dirawat dengan hiperbilirubinemia, dengan usia tersering 3 hari. Rerata lama fototerapi 60,27 jam. Analisis komparatif antara kadar BST pra dan pascafototerapi, terdapat penurunan BST yang signifikan (p <0,001) dari 17.23±5.04 mg/dL (prafototerapi) menjadi 10,18±2,02 mg/dL (pascafototerapi). Rerata lama rawat inap 4,48±4,47 hari. Kecepatan penurunan kadar bilirubin 0,12 mg/dL per jam. Kesimpulan. Fototerapi konvensional efektif menurunkan kadar BST hiperbilirubinemia neonatal, tetapi tidak efisien.
Metalloproteinase-9 gene variants and risk for hypertension among ethnic Javanese Fitranto Arjadi; Saefuddin Aziz; Alfi Muntafiah
Universa Medicina Vol. 33 No. 3 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.213-220

Abstract

BackgroundHypertension is associated with endothelial-dependent vasodilation disorders, due to reduced nitric oxide (NO) availability and excessive angiotensin II (ANG-II) activation. The objective of this study was to determine the association between matrix metallopeptidase 9 (MMP-9) gene polymorphism and hypertension in ethnic Javanese in the 40-80 year age group. MethodsThis was a case-control study on 50 PROLANIS patients of family doctors meeting the inclusion criteria and 50 controls without hypertension. Subjects were hypertensive patients with constant systolic arterial pressure of >140 mmHg and diastolic arterial pressure of >90 mmHg, confirmed in three successive measurements The observed parameters were degree of MMP-9 polymorphism, and NO and ANG-II levels. Matrix metallopeptidase 9 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using the SmaI restriction enzyme. MMP-9 polymorphisms were indicated by variation in band patterns. Degree of polymorphism in cases and controls were compared with NO and ANG-II levels in both groups. Data analysis was done using independent t-test.ResultsThe heterozygous (3 band) to normal (2 band) MMP-9 genotype ratio was 3:1 in hypertensives, but balanced in controls. In hypertensives, heterozygous GA and homozygous AA genotype frequencies were respectively 3.198 and 1.548 times higher than that of the GG genotype (p=0.008 and p=0.726). There was a statistically significant differences of NO and Ang-II levels between cases and controls (p=0.000 and p=0.000; respectively). ConclusionMatrix metallopeptidase 9 gene polymorphisms in hypertensive ethnic Javanese are associated with NO and angiotensin II levels.
PENGARUH EKSTRAK JAHE MERAH (Zingiber officinale) DAN MADU TERHADAP KADAR KOLESTEROL TOTAL TIKUS MODEL DIABETES MELITUS Alfi Muntafiah; Dita Yulianti; Aulia Husna Cahyaningtyas; Hani Ismi Damayanti
Scripta Biologica Vol 4, No 1 (2017)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (730.829 KB) | DOI: 10.20884/1.sb.2017.4.1.329

Abstract

Diabetes mellitus (DM) is a disease characterized by elevated blood glucose levels (hyperglycemia) caused by deficiency of insulin, and insulin resistance or both. This chronic disease prevalence is increasing nationally and globally. This study aimed to determine the effect of ginger extract and honey various doses on levels of total cholesterol in the Wistar diabetic rat model induced by alloxan. This research is true experimental post-test only with control group design. Subject of the study 30 male Wistar rats weight 150-200 grams, divided into 6 groups: A) healthy controls (K1), B) DM control (K2), C) Treatment with red ginger extract 1000 mg / kg and honey 1 ml / kg (K3), D) Treatment with ginger extract red 1000 mg / kg and honey 2 ml / kg (K4), E) Treatment with red ginger extract 500 mg / kg and honey 1 ml / kg (K5), F) Treatment with red ginger extract 500 mg / kg and honey 2 ml / kg (K6). DM induction by alloxan 160 mg / kg intraperitoneally for 5 days, and the provision of treatment for 14 days. Total cholesterol levels were measured by CHOD-PAP method. Results: The mean total cholesterol levels of healthy control group vs the diabetic control 58.20 ± 8.76 vs. 87.80 ± 5.81 mg / dL. Based on one way ANOVA test, red ginger extract and honey various doses significantly lower total cholesterol level (p <0.05). The mean total cholesterol levels between the group K3 to K4 was not statistically different, as well as K5 with K6. However, mean total cholesterol levels at K3 and K4 differ significantly from the K5 and K6. Conclusion: Combination of red ginger extract and honey can lower total cholesterol levels in diabetic rat model induced by alloxan.
Promosi Kesehatan Untuk Mencegah Miopi dan Komplikasinya Pada Murid SDN 2 Berkoh, Purwokerto Alfi Muntafiah; Afifah Afifah; Octavia Permata Sari; Ika Murti Harini; Qodri Santosa
Jurnal Pengabdian Pada Masyarakat Vol 3 No 1 (2018)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (704.867 KB) | DOI: 10.30653/002.201831.48

Abstract

HEALTH PROMOTION FOR PREVENTING AND COMPLICATIONS MYOPIA IN STUDENTS OF SDN 2 BERKOH, PURWOKERTO. Myopia is the most common refractive disorder in school-aged children. These visual disorders need attention, because they can interfere with life and daily work, and also their intellectual development. This health promotion activity is conducted to improve knowledge and understanding about myopia and the efforts that must be done to maintain eye health. This activity was conducted on 140 students of 4th, 5th, and 6th grade of SDN 2 Berkoh Purwokerto, through counseling, training, giving module, leaflet and poster. Based on the T-test of the pre-post and post-test in each class, the p values obtained in grades 4,5 and 6 respectively p = 0.058; 0.588; and 0.074. Conclusion: this activity can increase students' knowledge of myopia, although the increase is not significant.
Pelatihan Manajemen Laktasi untuk Ibu Hamil dan Ibu Menyusui: Upaya Optimalisasi Tumbuh Kembang Anak Qodri Santosa; Miko Ferrine; Muhammad Fakih; Alfi Muntafiah
Jurnal Pengabdian Pada Masyarakat Vol 4 No 1 (2019)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.566 KB) | DOI: 10.30653/002.201941.94

Abstract

LACTATION MANAGEMENT TRAINING FOR PREGNANT WOMEN AND BREASTFEEDING MOTHERS: EFFORTS TO OPTIMIZE CHILD GROWTH. The key person for making quality generation lies on mother, through breast milk. Breastfeeding, besides providing the best nutrition for optimal baby growth and development, it is also a form of love to a baby. Ironically, not all mothers realize and many mothers do not breastfeed their babies exclusively. The low level of knowledge and working mothers is often an obstacle for mothers to give exclusive breastfeeding. In Indonesia, almost 9 of 10 mothers give breast milk, but only 49.8% give exclusive breastfeeding for 6 months. Lactation management health promotion activities are carried out in accordance with WHO recommendations and the Indonesian government in promoting breastfeeding, especially increasing the achievement of the rate of early breastfeeding initiation and exclusive breastfeeding. The activities carried out using several methods: counseling, demonstration, video and discussion. We found that 54.1% of participants gave exclusive breastfeeding for 6 months, 27% for 4 months, and others 2-3 months. Wilcoxon Rank Test showed a significant difference (p = 0,000) between the score of pre-test and post-test, with a mean pre-test of 49.02 ± 19.74, and a mean post-test of 68.53 ± 20.00. Conclution: This activity increased participants' knowledge regarding lactation management.
The effect of purple passion fruit juice on superoxide dismutase and malondialdehyde levels in hypercholesterolemic rats Alfi Muntafiah; Johanes Hasian Siahaan; Sofyan Hardi; Dody Novrial; Hernayanti Hernayanti
Universa Medicina Vol. 41 No. 2 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.139-148

Abstract

BackgroundHypercholesterolemia due to a high cholesterol diet can increase free radicals resulting in oxidative stress. Superoxide dismutase (SOD) and malondialdehyde (MDA) have been used as the study markers of oxidative stress in cases of hypercholesterolemia. Purple passion fruit contains various compounds that may reduce free radicals. This study aimed to determine the effect of purple passion fruit juice on SOD and MDA levels in hypercholesterolemic rats. MethodsAn experimental analysis with post-test only control group design involving 28 male Wistar rats. They were divided into 4 groups: normal control (K1), hypercholesterolemic control (K2), purple passion fruit juice treatment at 4.2 mL/200 gBW/day (K3), and simvastatin treatment at 0.018 mg/200 gBW/day (K4). The purple passion fruit juice at 4.2 mL/200 gBW/day was administered for 14 days. SOD levels were examined by enzymatic colorimetric methods using the Ransod kit and MDA levels by the TBARS method. ResultsThe Kruskal-Wallis test showed a significant difference in SOD levels between the tested groups (p<0.05). One-way ANOVA test for MDA levels showed a significant difference (p<0.05). Post Hoc test (Mann-Whitney for SOD and LSD for MDA levels) also showed significant differences: K1 vs. K2, K2 vs. K3, K2 vs. K4, and K3 vs. K4 (p<0.05). ConclusionThis study demonstrated that purple passion fruit juice significantly increases the SOD and lowers the MDA level in hypercholesterolemic male Wistar rats. Consumption of purple passion fruit juice may help to modulate oxidative stress caused by hypercholesterolemia in rats.
Co-Authors Afifah Afifah Arfi Nurul Hidayah Ariadne Tiara Hapsari Aris Dwi Susilarto Aulia Husna Cahyaningtyas Aulia Okhid Ariza Dita Yulianti Dody Novrial, Dody Edy Priyanto Elok Widyaningtyas Fajar Windiya Fitranto Arjadi Hani Ismi Damayanti Hernayanti Hernayanti Ika Murti Harini Irwan Nuryadin Johanes Hasian Siahaan Lantip Rujito Lily Burkon Miko Ferrine Muhamad Rifqy Setyanto Muhammad Fakih Muhammad Mukhson Naluri Widyaningsih Syamsiedi Nenden Nursyamsi Agustina Nia Krisniawati Nor Sri Inayati Nor Sri Inayati Nor Sri Inayati Octavia Permata Sari Octavia Permata Sari Pratama, Tisna Sendy Prihatno, M. Mukhlis Rudi Qodri Santosa Qodri Santosa Rahmah Fadhilah Asrifqa Saefuddin Aziz Saefuddin Aziz Salsabil Rahmadina Setiawati Setiawati Setya Dian Kartika Sofyan Hardi Synta Haqqul Fadlilah Synta Haqqul Fadlilah Tirta Wardana Viva Ratih Bening Ati Wafa Nur Azizah Wahyudin Wahyudin Windy Oliviany Wiwiek Fatchurrohmah Zeha Kirana