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All Journal Global Health Management Journal Manuju : Malahayati Nursing Journal Jambura Journal of Health Sciences and Research PREPOTIF : Jurnal Kesehatan Masyarakat Tunas Medika Jurnal Kedokteran & Kesehatan JPM: JURNAL PENGABDIAN MASYARAKAT PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) InaBHS (Indonesian Journal of Biomedicine and Health Science) Jurnal Pengabdian Masyarakat Inovasi Indonesia
Rama Samara Brajawikalpa
Fakultas Kedokteran Universitas Swadaya Gunung Jati
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Inhibition Test of Cassava Leaves (Manihot Esculenta Crantz) Flavonoid Nicotiflorin on Replication of Dengue Virus Serotype 1 in Vitro Yulianti, Selsa; Apriyanto, Dadan Ramadhan; Brajawikalpa, Rama Samara; Dewi, Beti Ernawati
GHMJ (Global Health Management Journal) Vol. 8 No. 2 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-821192

Abstract

Background:  Dengue fever is a disease caused by the bite of Aedes aegypti mosquitoes infected with the dengue virus. Dengue virus infection can lead to hemorrhagic fever and even death. Currently, treatment for dengue infection is supportive, as there are no commercially available antiviral drugs. Nicotiflorin, a compound found in cassava leaves (Manihot esculenta Crantz), has shown potential as an antiviral agent against dengue. Aims: This study aimed to determine the inhibitory effect of the flavonoid nicotiflorin, derived from cassava (Manihot esculenta Crantz) leaves, as an antiviral agent against dengue virus serotype 1 (DENV-1) in vitro. Methods: A post-test-only control group design was utilized in this experimental research, comprising one control group alongside thirteen treatment groups. For the cytotoxicity assessment, the treatment groups were exposed to seven varying concentrations (1.25 µg/mL, 2.5 µg/mL, 5 µg/mL, 10 µg/mL, 20 µg/mL, 40 µg/mL, and 80 µg/mL), while six different concentration levels (1.5 µg/mL, 3.125 µg/mL, 6.25 µg/mL, 12.5 µg/mL, 25 µg/mL, and 50 µg/mL) were employed in the inhibition assay. The control group received 0.2% DMSO as a negative control. Antiviral inhibition was assessed using the Focus Forming Unit (FFU) Assay, while cytotoxicity was evaluated using the Microtiter Tetrazolium Assay (MTT Assay). Statistical analyses included the Shapiro-Wilk test for normality, the Kruskal-Wallis test for hypothesis testing, and post-hoc analysis to assess significant differences among treatment groups. Results: The CC₅₀ and IC₅₀ values of nicotiflorin from cassava leaves were determined to be 19.24 μg/mL and 0.9550 μg/mL, respectively, yielding a Selectivity Index (SI) of 20.14. These findings indicate that the flavonoid nicotiflorin from cassava leaves exhibits selective antiviral activity against DENV-1 replication. Statistical analysis revealed a non-normal data distribution (P < 0.05), a significant difference among groups based on the Kruskal-Wallis test (P < 0.05), and no statistically significant differences among specific concentrations in the post-hoc test. Conclusion: Nicotiflorin from cassava leaf (Manihot esculenta Crantz) has inhibitory activity on the replication of dengue virus serotype 1 strain in vitro.
Dampak Optimalisasi Kesehatan Remaja dengan Edukasi Bijak Dalam Penggunaan Obat Kepada Siswa SMP Marfuati, Sri; Weni, Mustika; Brajawikalpa, Rama Samara; Emallia Fitriani
JPM: Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2025): July 2025
Publisher : Forum Kerjasama Pendidikan Tinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jpm.v6i1.2444

Abstract

Self-medication is increasingly common among the general public, including adolescents. However, a lack of proper understanding regarding drug use, storage, and disposal can lead to medication errors that pose serious health risks. This community service activity aimed to improve the knowledge of students at SMP regarding the proper and responsible use of medications through an educational session titled “Using Medicines Wisely.” The activity was conducted on May 24, 2025, by lecturers from the Faculty of Medicine, Universitas Swadaya Gunung Jati (UGJ), using a face-to-face method involving a pre-test, educational material delivery, interactive discussion, and a post-test. Pre-test results showed that only 22% of participants had good knowledge, which increased to 68% after the educational session with the meaning of value. These findings indicate that the activity effectively enhanced students’ understanding of responsible self-medication practices, particularly in recognizing drug types, usage instructions, proper storage, and safe disposal methods. This program is expected to foster wise medication habits from an early age and contribute to the development of a health-conscious society.
Effect of Ethyl Acetate Fraction of Avocado Peel (Persea americana Mill.) on Total Cholesterol Levels in Hypercholesterolemic Wistar Rats Putra, Ferdian Adhy Pratama; Wisandoko, Ignatius Hapsoro; Brajawikalpa, Rama Samara
GHMJ (Global Health Management Journal) Vol. 8 No. 3 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-831158

Abstract

Background: Hypercholesterolemia is a condition that can increase the risk of coronary heart disease, stroke, high blood pressure, obesity and other health problems. The ethyl acetate fraction of avocado peel offers a novel approach by isolating key bioactive compounds while separating them from other components, focusing on the desired properties of compounds such as flavonoids, saponins, and phenolics, which are well-known for their antihyperlipidemic effects. Aims: To analyze the effect of ethyl acetate fraction of avocado peel (Persea americana Mill.) on total cholesterol levels of Wistar white rats with hypercholesterolemia. Methods: This study was experimental with a pre and post test with control group design using 20 male white rats (Rattus norvegicus) of the Wistar strain that had been fed high-fat feed for 14 days and divided into 5 groups for 7 days of treatment, namely the negative control group that was given only high-fat feed, the positive control group that was given the drug simvastatin 0.18 mg/200gBW, and 3 treatment groups that were given the ethyl acetate fraction of avocado peel with a tiered dose of 100 mg/KgBW,  75 mg/KgBW, and 50 mg/kgBW. The data were analyzed using a one-way ANOVA test with a post hoc test Results: The ethyl acetate fraction of avocado fruit peel positively contains alkaloids, flavonoids, phenolics, saponins, tannins, and triterpenoids or steroids. The average reduction in total cholesterol levels is 19.5 mg/dL (p < 0.05) at a dose of 100 mg/kgBW, 17.5 mg/dL (p < 0.05) at a dose of 75 mg/kgBW, and 13 mg/dL (p < 0.05) at a dose of 50 mg/kgBW. Conclusion: The ethyl acetate fraction of avocado peel is effective in reducing total cholesterol levels with an effective dose of 100 mg/kgBW. With an effective dose of 100 mg/kg body weight that has been established, subsequent research can focus on the development of more stable and efficient formulations for clinical applications. The effect of lowering cholesterol levels is associated with the content of secondary metabolite compounds contained in the ethyl acetate fraction of avocado peels, namely flavonoids, phenolics, saponins, tannins, triterpenoids and steroids.
UJI AKTIVITAS DAYA HAMBAT FRAKSI N-HEKSAN, ETIL ASETAT, DAN BUTANOL BIJI MANGGA (MANGIFERA INDICA L.) VARIETAS GEDONG GINCU DALAM MENGHAMBAT AKTIVITAS BAKTERI STAPHYLOCOCCUS AUREUS ATCC 29213 Nasution, Aulia Ananta; Brajawikalpa, Rama Samara; Marfuati, Sri
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 3 (2025): DESEMBER 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i3.50563

Abstract

Kandungan metabolit sekunder didalam biji mangga (Mangifera indica L.) varietas gedong gincu memiliki banyak potensi yang belum diteliti secara maksimal, salah satunya sebagai antibakteri yang berpotensi menjadi salah satu alternatif pengobatan antibakteri Sehingga, diperlukan skrining fitokimia dan mengetahui efektivitas dari fraksi n-heksan, etil asetat, dan butanol biji mangga (Mangifera indica L.) varietas gedong gincu dalam menghambat pertumbuhan bakteri Staphylococcus aureus ATCC 29213. Penelitian eksperimental dengan rancangan post-test only control group design. Pembuatan konsentrasi dari fraksi n-heksan, etil asetat, dan butanol biji mangga (Mangifera indica L.) varietas Gedong Gincu (0,5%, 1%, 2%, 4%, dan 6%) diuji ke bakteri Staphylococcus aureus ATCC 29213 menggunakan metode pourplate untuk mengetahui daya hambat bakteri, yang kemudian dilakukan analisis statistik menggunakan uji normalitas Shapiro Wilk, uji parametrik One Way ANOVA, dan uji lanjutan PosHoc LSD. Senyawa metabolit sekunder yang terdapat pada fraksi n-heksan, etil asetat, dan butanol yaitu, flavonoid, alkaloid, tanin, steroid, saponin. Konsentrasi 6% dari masing-masing fraksi biji mangga (Mangifera indica L.) varietas gedong gincu memiliki rerata hasil pourplate yang signifikan dalam menghambat pertumbuhan bakteri (p<0,05). Fraksi etil asetat biji mangga (Mangifera indica L.) varietas gedong gincu konsentrasi 6% memiliki daya hambat paling efektif dibandingkan dengan fraksi lainnya dalam menghambat pertumbuhan bakteri Staphylococcus aureus ATCC 29213.
UJI EFEKTIVITAS FRAKSI N-HEKSAN, ETIL ASETAT, BUTANOL KULIT MANGGA GEDONG GINCU TERHADAP PERTUMBUHAN JAMUR Candida Albicans ATCC 10231 Safitri, Diah; Apriyanto, Dadan Ramadhan; Brajawikalpa, Rama Samara
Jambura Journal of Health Sciences and Research Vol 7, No 1 (2025): JANUARI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v7i1.27451

Abstract

Candida albicans adalah jamur flora normal pada manusia yang dapat menyebabkan kandidiasis. Menurut laporan Global Burden Fungal Disease 2017, terdapat 159.253 kasus kandidiasis di 39 negara. Penggunaan obat anti jamur yang umum sering menghadapi kendala, seperti efek samping serius dan resistensi jamur, sehingga diperlukan alternatif obat alami. Salah satunya adalah kulit mangga yang mengandung senyawa antijamur. Kebaruan Penelitian yaitu Penelitian ini mengkaji potensi ekstrak dari fraksi-fraksi tersebut sebagai agen antijamur, dengan fokus pada efektivitas masing-masing fraksi dalam menghambat pertumbuhan jamur patogen. Penelitian ini bertujuan untuk mengevaluasi efektivitas fraksi n-heksan, etil asetat, dan butanol dari kulit mangga Gedong Gincu (Mangifera indica var. gedong gincu) terhadap pertumbuhan Candida albicans ATCC 10231. Metode penelitian menggunakan Rancangan penelitian eksperimental menggunakan metode post-test only control group design, dengan sampel Candida albicans ATCC 10231. Fraksi n-heksan mengandung alkaloid, saponin, dan steroid, sedangkan etil asetat dan butanol memiliki alkaloid, tanin, fenol, flavonoid, dan triterpenoid. Hasil penelitian yaitu daya hambat terbesar ditemukan pada fraksi etil asetat dengan konsentrasi 50%, menunjukkan bahwa ketiga fraksi dapat menghambat pertumbuhan Candida albicans ATCC 10231. Kesimpulan penelitian ini memberikan wawasan penting tentang pemanfaatan kulit mangga sebagai sumber senyawa bioaktif untuk pengendalian infeksi jamur dan membuka peluang untuk penelitian lebih lanjut terkait mekanisme kerja serta komponen aktif dalam fraksi tersebut.
PERBEDAAN PENGARUH PEMBERIAN EKSTRAK SELEDRI (Apium graveolens L) DAN EKSTRAK JAHE GAJAH (Zingiber officinale Roscoe) TERHADAP KADAR PROFIL LIPID TIKUS PUTIH JANTAN HIPERKOLESTEROLEMIA Ayudithiya, Vhirna Fitri; Brajawikalpa, Rama Samara; Primanagara, Risnandya
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 1 No 1 (2022)
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v1i1.7386

Abstract

Latar Belakang: Hiperlipidemia disebabkan oleh peningkatan kadar profil lipid. Untuk menurunkan kadar kolesterol dalam darah digunakan obat golongan statin yang mempunyai efek jika dikonsumsi jangka panjang. Tanaman seledri dan jahe gajah dapat  digunakan sebagai alternatif pengobatan hiperkolesterolemia.Tujuan: Mengetahui perbedaan pengaruh pemberian ES, EJG, dan ESJ terhadap kadar profil lipid tikus putih jantan yang hiperkolesterolemia. Metode: Penelitian eksperimental menggunakan rancangan Pre and Post Test with Control Group Design dengan tikus putih jantan sebanyak 30 ekor dibagi menjadi 6 kelompok. KN (kontrol normal), K-, K+, kelompok dengan perlakuan ES (ekstrak seledri 200mg/kgbb), EJG (ekstrak jahe gajah 200mg/kgbb) dan ESJ (kombinasi seledri dan jahe 200mg/kgbb). Pengambilan sampel dilakukan secara simple random sampling. Hasil: Rerata penurunan kadar kolesterol total sebesar 84,97mg/dl (ES), 78,48mg/dl (EJG) dan 84,29 mg/dl (ESJ) dengan nilai (P<0,05). Penurunan kadar LDL sebesar 38,43mg/dl (ES), 28,01mg/dl (EJG), dan 32,84mg/dl (ESJ) dengan nilai (P<0,05). Penurunan kadar trigliserida sebesar 30,68mg/dl (ES), 20,99mg/dl (EJG) dan 21,20mg/dl (ESJ) dengan nilai (P<0,05). Peningkatan kadar HDL sebesar 38,17mg/dl (ES), 29,31mg/dl (EJG), 32,04mg/dl (ESJ) dengan nilai (P<0,05). Simpulan: Ekstrak seledri lebih efektif dibandingkan dengan ekstrak jahe gajah dan kombinasi keduanya pada tikus putih jantan yang hiperkolesterolemia.Keywords: hiperkolesterolemia, seledri, jahe gajah.ABSTRACTBackground: Hyperlipidemia is caused by an increase in lipid profile levels. To reduce cholesterol levels in the blood used statin drugs that have an effect if consumed long term. Celery and ginger can be used as an alternative treatment for hypercholesterolemia. Aim: Knowing the difference in the effect of ES, EJG, and ESJ administration on the lipid profile level of hypercholesterolemic white male rats. Method: The experimental study used the Pre and Post Test with Control Group Design with 30 male white rats divided into 6 groups. KN (normal control), K-, K +, groups treated with ES (celery extract 200mg / kgbb), EJG (ginger extract 200mg / kgbb) and ESJ (combination of celery and ginger 200mg / kgbb). Sampling by simple random sampling. Results: The mean reduction in total cholesterol levels was 84.97 mg / dl (ES), 78.48 mg / dl (EJG) and 84.29 mg / dl (ESJ) with values (P <0.05). Reduction in LDL levels by 38.43 mg / dl (ES), 28.01 mg / dl (EJG), and 32.84 mg / dl (ESJ) with values (P <0.05). Decreased triglyceride levels by 30.68 mg / dl (ES), 20.99 mg / dl (EJG) and 21.20 mg / dl (ESJ) with values (P <0.05). Increased HDL levels of 38.17 mg / dl (ES), 29.31 mg / dl (EJG), 32.04 mg / dl (ESJ) with values (P <0.05). Conclusions: Celery extract was more effective than ginger extract and a combination of both in male white hypercholesterolemia rats.Keywords: hypercholesterolemia, celery, ginger.
PENGARUH EKSTRAK BIJI KACANG POLONG (Pisum sativum L.) TERHADAP KADAR LDL TIKUS PUTIH YANG HIPERKOLESTEROLEMIA Azizah, Hana; Brajawikalpa, Rama Samara; Sulistiyana, Catur Setiya
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 2 No 1 (2023)
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v2i1.9257

Abstract

Latar Belakang: Hiperkolesterolemia merupakan permasalahan yang menjadi perhatian bagi tenaga kesehatan, karena merupakan faktor risiko utama berkembangnya penyakit kardiovaskular, seperti aterosklerosis dan penyakit komplikasi, infark akut miokardium atau hipertensi. Ekstrak biji kacang polong (Pisum sativum L.) memiliki kandungan yang bersifat anti-hiperkolesterol. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak biji kacang polong terhadap LDL (Low Density Lipoprotein) pada tikus putih yang telah diinduksi hiperkolesterolemia. Metode: Metode penelitian yang digunakan adalah pre and post test with control group design. Tikus dibagi menjadi 6 kelompok, yaitu 3 kelompok kontrol dan 3 kelompok perlakuan. K+ menggunakan simvastatin dengan dosis sebesar 0,18 mg/200 grBB. Kelompok perlakuan, yaitu EBKP 1, EBKP 2, dan EBKP 3 secara berturut diberikan dosis ekstrak sebesar 200-400-600 mg/200 grBB. Hasil: Terjadi penurunan kadar LDL sebesar 41,17mg/dL dengan nilai P (<0,05). Ekstrak biji kacang polong dengan dosis 600 mg/200 grBB sama efektifnya dengan K+ dalam menurunkan kadar LDL. Kesimpulan: Ekstrak biji kacang polong dapat mempengaruhi kadar LDL tikus putih yang telah diinduksi hiperkolesterolemia.
AKTIVITAS ANTIJAMUR EKSTRAK ETANOL DAUN ALPUKAT (Persea americana Mill.) TERHADAP Malassezia furfur Nurdianti, Helma; Brajawikalpa, Rama Samara; Mulyaningsih, Ruri Eka Maryam
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 3 No 2 (2024): Indonesian Journal of Biomedicine and Health Science
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v3i2.10525

Abstract

Latar Belakang: Pertumbuhan Malassezia furfur secara berlebihan dapat menyebabkan penyakit ketombe dan jika dibiarkan akan menjadi dermatitis seboroik di kulit kepala. Prevalensi ketombe di dunia mencapai 15-20% dan di Indonesia >70% populasi. Daun alpukat (Persea americana Mill.) memiliki senyawa bioaktif sebagai antijamur yang dapat digunakan sebagai alternatif pengobatan. Tujuan: Mengetahui efektivitas antijamur ekstrak etanol daun alpukat (Persea americana Mill.) terhadap pertumbuhan Malassezia furfur. Metode: Desain penelitian menggunakan post-test only with control group design dengan 8 kelompok terdiri dari 6 kelompok perlakuan yang diberikan ekstrak etanol daun alpukat (Persea americana Mill.) konsentrasi 6,25%, 12,5%, 25%, 50%, 75%, dan 100%, serta 2 kelompok kontrol, yaitu kelompok kontrol (+) yang diberi ketokonazol dan kontrol (-) yang diberi DMSO 10%. Pengujian menggunakan metode dilusi padat dengan media Sabouraud Dextrose Agar (SDA). Hasil: Ekstrak etanol daun alpukat (Persea americana Mill.) dengan konsentrasi 6,25%, 12,5%, 25%, 50%, 75%, dan 100% secara signifikan dapat menghambat pertumbuhan Malassezia furfur (p value < 0,05) dengan rerata TPC secara berturut-turut sebanyak 7,8 x 108 CFU/mL, 6,5 x 108 CFU/mL, 6,3 x 108 CFU/mL, 6 x 108 CFU/mL, 5,6 x 108 CFU/mL, dan 6,2 x 108 CFU/mL. Simpulan: Ekstrak etanol daun alpukat (Persea americana Mill.) memiliki aktivitas antijamur dengan Konsentrasi Hambat Minimum (KHM) pada konsentrasi 6,25% dengan jumlah TPC 7,8 x 108 CFU/mL dan konsentrasi paling efektif pada konsentrasi 75% dengan jumlah rerata TPC 5,6 x 108 CFU/mL. Kata Kunci: Antijamur, Daun alpukat, Malassezia furfur, Persea americana Mill. ABSTRACT Background: Overgrowth of Malassezia furfur can cause dandruff disease and if left untreated will become seborrheic dermatitis on the scalp. The prevalence of dandruff in the world reaches 15-20% and in Indonesia >70% of the population. Avocado leaves (Persea americana Mill.) have bioactive compounds as antifungals that can be used as alternative treatments. Aim: To determine the antifungal effectiveness of ethanol extract of avocado leaves (Persea americana Mill.) against the growth of Malassezia furfur. Methods: Laboratory experimental true research with post-test only with control group design. Using 8 groups, consisting of 6 treatment groups given ethanol extract of avocado leaves (Persea americana Mill.) concentrations of 6.25%, 12.5%, 25%, 50%, 75%, and 100%, and 2 control groups, namely the control group (+) which was given ketoconazole and control (-) which was given 10% DMSO. The test used the solid dilution method with Sabouraud Dextrose Agar (SDA) media. Results: Ethanol extract of avocado leaves (Persea americana Mill.) with concentrations of 6.25%, 12.5%, 25%, 50%, 75%, and 100% can significantly inhibit the growth of Malassezia furfur (p value <0.05) with a mean TPC of 7.8 x 108 CFU/mL, 6.5 x 108 CFU/mL, 6.3 x 108 CFU/mL, 6 x 108 CFU/mL, 5.6 x 108 CFU/mL, and 6.2 x 108 CFU/mL, respectively. Conclusion: Ethanol extract of avocado leaves (Persea americana Mill.) has antifungal activity with a Minimum Inhibitory Concentration (KHM) at a concentration of 6.25% with a TPC count of 7.8 x 108 CFU/mL and the most effective concentration at a concentration of 75% with a mean TPC count of 5.6 x 108 CFU/mL. Keywords: Antifungal, Avocado leaf, Malassezia furfur, Persea americana Mill.
Peningkatan Kapasitas Kader Kesehatan dalam Pencegahan Stunting melalui Pelatihan Berbasis Regulasi di Desa Ragawacana, Kabupaten Kuningan, Jawa Barat Azizah B, Nur Alma; Pamungkas, Try Yogi Damar; Maelina, Maelina; Nugraha, Prendy Prasetya; Brajawikalpa, Rama Samara
Jurnal Pengabdian Masyarakat Inovasi Indonesia Vol 3 No 2 (2025): JPMII - April 2025
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jpmii.753

Abstract

Permasalahan kesehatan yang masih menjadi tantangan di Indonesia yaitu Stunting, termasuk di Desa Ragawacana. Upaya pencegahan stunting tidak hanya memerlukan intervensi gizi tetapi juga penguatan regulasi serta optimalisasi peran kader kesehatan sebagai garda terdepan dalam edukasi dan intervensi gizi masyarakat. Meskipun berbagai regulasi telah diterbitkan, implementasi di tingkat desa masih menghadapi kendala, seperti kurangnya pemahaman kader kesehatan terhadap kebijakan yang ada. Oleh karena itu, kegiatan pengabdian ini bertujuan untuk meningkatkan kapasitas kader kesehatan dalam memahami regulasi dan pelaksanaan pencegahan stunting melalui pelatihan partisipatif di Desa Ragawacana. Pengabdian masyarakat ini menggunakan metode normatif yuridis dengan pendekatan langsung kepada pihak yang terlibat. Teknik pengumpulan data dilakukan melalui studi kepustakaan yang mencakup analisis peraturan perundang-undangan, jurnal ilmiah, serta laporan terkait pencegahan stunting.  Selain itu, Pengabdian ini juga melakukan observasi terhadap kegiatan pelatihan kader kesehatan di Desa Ragawacana dan wawancara dengan kader serta pemerintah desa untuk mengevaluasi efektivitas pelatihan yang diberikan. Hasil Pengabdian menunjukkan bahwa meskipun regulasi terkait pencegahan stunting telah tersedia, implementasi di tingkat desa belum optimal akibat kurangnya pemahaman hukum di kalangan kader kesehatan serta keterbatasan fasilitas dalam mendukung program pelatihan. Pelatihan kader kesehatan terbukti meningkatkan pemahaman mereka terhadap kebijakan yang ada serta memperkuat peran mereka dalam mendampingi masyarakat. Oleh karena itu, diperlukan penguatan regulasi, peningkatan kualitas pelatihan, serta sinergi antara pemerintah dan kader kesehatan dalam upaya pencegahan stunting agar hak anak atas gizi seimbang dapat terpenuhi secara optimal.
Antibiotic Prescription Patterns in Children with Pneumonia at the Waled Regional General Hospital in Cirebon Regency, West Java, 2023 Istiharah, Sherin Nadia; Marfuati, Sri; Brajawikalpa, Rama Samara
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 5 No. 1 (2026): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v5i1.1940

Abstract

Irrational antibiotic use and inappropriate prescribing in pneumonia remain major public health concerns, as they contribute significantly to the development of antimicrobial resistance worldwide. This study aimed to describe the pattern of antibiotic prescribing for pneumonia patients under five years old treated at Waled Hospital, Cirebon Regency, in 2023. A descriptive study design was employed using medical record data, with total sampling applied to all eligible cases. Data were analyzed using univariate analysis and presented as frequencies and percentages. A total of 193 pediatric pneumonia cases were included, consisting of both inpatients and outpatients. Lobular pneumonia was the most common diagnosis in both groups. The majority of patients were one year of age. Third-generation cephalosporins were the most frequently prescribed antibiotic class for inpatients (62.3%) and outpatients (89.1%). Parenteral antibiotic formulations were predominantly administered to inpatients, whereas oral antibiotics were used for all outpatients. The duration of antibiotic therapy was appropriate in all cases. Adverse drug reactions were observed in a small proportion of inpatients and were not reported among outpatients. The predominant use of third-generation cephalosporins, particularly in outpatient settings, suggests a potential overreliance on broad-spectrum antibiotics and may reflect deviation from standard first-line treatment recommendations for pediatric pneumonia. These findings highlight the need for regular evaluation of prescribing practices and the implementation of antimicrobial stewardship programs to promote rational antibiotic use and reduce the risk of resistance.
Co-Authors Aditya Naufal Ramzy Amanah Amanah Apriyanto, Dadan Ramadhan Aurora Nurfauziyyah Nabiilah Fatimatuzah Ayudithiya, Vhirna Fitri Azizah B, Nur Alma Azizah, Hana Beti Ernawati Dewi Catur Setiya Sulistiyana Cindyyani Eka Putri Diah Safitri Emallia Fitriani Istiharah, Sherin Nadia Maelina, Maelina Marfuati, Sri Mirella Gresyalli Kautama Mulyaningsih, Ruri Eka Maryam Nasution, Aulia Ananta Nia Hernanti Novianti Dwi Puspitasari Nugraha, Prendy Prasetya Nurdianti, Helma Nuria Nirmala Pahmi Budiman S. Basyir Pamungkas, Try Yogi Damar Putra, Ferdian Adhy Pratama Raden Mohamad Herdian Bhakti Rayasari, Husnaya Ricardi Wicaksono Alibasjah Risnandya Primanagara Ruri Eka Maryam Mulyaningsih Siskanti, Alvina Waly, Tuswandi Ahmad Weni, Mustika Wisandoko, Ignatius Hapsoro Yukke Nilla Permata Yulianti, Selsa ‘Adawiyah, Robi’atul