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All Journal Global Health Management Journal Manuju : Malahayati Nursing Journal Jambura Journal of Health Sciences and Research PREPOTIF : Jurnal Kesehatan Masyarakat Tunas Medika Jurnal Kedokteran & Kesehatan Indonesian Journal of Applied Research (IJAR) JPM: JURNAL PENGABDIAN MASYARAKAT PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) InaBHS (Indonesian Journal of Biomedicine and Health Science) Jurnal Pengabdian Masyarakat Inovasi Indonesia
Rama Samara Brajawikalpa
Fakultas Kedokteran Universitas Swadaya Gunung Jati
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Other

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Antibiotic Prescription Patterns in Children with Pneumonia at the Waled Regional General Hospital in Cirebon Regency, West Java, 2023 Istiharah, Sherin Nadia; Marfuati, Sri; Brajawikalpa, Rama Samara
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 5 No. 1 (2026): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v5i1.1940

Abstract

Irrational antibiotic use and inappropriate prescribing in pneumonia remain major public health concerns, as they contribute significantly to the development of antimicrobial resistance worldwide. This study aimed to describe the pattern of antibiotic prescribing for pneumonia patients under five years old treated at Waled Hospital, Cirebon Regency, in 2023. A descriptive study design was employed using medical record data, with total sampling applied to all eligible cases. Data were analyzed using univariate analysis and presented as frequencies and percentages. A total of 193 pediatric pneumonia cases were included, consisting of both inpatients and outpatients. Lobular pneumonia was the most common diagnosis in both groups. The majority of patients were one year of age. Third-generation cephalosporins were the most frequently prescribed antibiotic class for inpatients (62.3%) and outpatients (89.1%). Parenteral antibiotic formulations were predominantly administered to inpatients, whereas oral antibiotics were used for all outpatients. The duration of antibiotic therapy was appropriate in all cases. Adverse drug reactions were observed in a small proportion of inpatients and were not reported among outpatients. The predominant use of third-generation cephalosporins, particularly in outpatient settings, suggests a potential overreliance on broad-spectrum antibiotics and may reflect deviation from standard first-line treatment recommendations for pediatric pneumonia. These findings highlight the need for regular evaluation of prescribing practices and the implementation of antimicrobial stewardship programs to promote rational antibiotic use and reduce the risk of resistance.
Antibacterial Activity of Mango Gedong Gincu Peel Fraction in Inhibiting the Growth of Staphylococcus aureus Brajawikalpa, Rama Samara; 'Adawiyah, Robi'atul
Indonesian Journal of Applied Research (IJAR) Vol. 6 No. 3 (2025): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v6i3.773

Abstract

Gedong Gincu Mango peel (Mangifera indica L.) contains a variety of secondary metabolites, including flavonoids, tannins, saponins, alkaloids, and terpenoids. These compounds play a crucial role in self-defence and exhibit significant pharmacological activity, particularly as antibacterial agents. The purpose of this study is to identify the content of secondary metabolite compounds of each fraction based on its polarity properties, and to determine the inhibitory power of Staphylococcus aureus ATCC 25293 bacteria. This study is experimental research with a post-test only control group. This study used 2 control groups and 12 treatment groups consisting of n-hexane, ethyl acetate, and butanol fractions with concentrations of 6.25%, 12.5%, 25%, 50% respectively and repeated 3 times. The antibacterial test was carried out by the well diffusion method, which was repeated 3 times on the MHA medium, and the inhibition zone was measured. The study showed that the n-hexane fraction contained alkaloids, steroids, and saponins, while the ethyl acetate and butanol fractions contained flavonoids, alkaloids, tannins, triterpenoids, and phenolics. A 50% concentration produced the greatest inhibition zone in all fractions, with mean values of 8.05 mm (moderate) for n-hexane, 15.41 mm (strong) for ethyl acetate, and 12.16 mm (strong) for butanol. The 50% ethyl acetate fraction was the most effective in inhibiting the growth of Staphylococcus aureus ATCC 25923.
Co-Authors 'Adawiyah, Robi'atul Aditya Naufal Ramzy Albab, Arthur Ulil Amanah Amanah Apriyanto, Dadan Ramadhan Ayudithiya, Vhirna Fitri Azizah B, Nur Alma Azizah, Hana Beti Ernawati Dewi Catur Setiya Sulistiyana Cindyyani Eka Putri Diah Safitri Emallia Fitriani Herdwiyanti, Menik Istiharah, Sherin Nadia Maelina, Maelina Marfuati, Sri Mirella Gresyalli Kautama Mulyaningsih, Ruri Eka Maryam Nasution, Aulia Ananta Nia Hernanti Novianti Dwi Puspitasari Nugraha, Prendy Prasetya Nurdianti, Helma Nuria Nirmala Pahmi Budiman S. Basyir Pamungkas, Try Yogi Damar Pitaloka, Amalia Dwi Ayu Putra, Ferdian Adhy Pratama Raden Mohamad Herdian Bhakti Rahayu, Esa Giri Rayasari, Husnaya Ricardi Wicaksono Alibasjah Risnandya Primanagara Ruri Eka Maryam Mulyaningsih Siskanti, Alvina Waly, Tuswandi Ahmad Weni, Mustika Wisandoko, Ignatius Hapsoro Yulianti, Selsa ‘Adawiyah, Robi’atul