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All Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana Jurnal Veteriner ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan
I Gusti Nyoman Sri Wiryawan
Departemen Histologi, Fakultas Kedokteran, Universitas Udayana, Denpasar, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Veterinary

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Journal : Neurologico Spinale Medico Chirurgico

 1 
Java plum (Syzygium cumini) extract cream effect on decreasing the number of sunburn cell on the dorsal skin of male Wistar rat (Rattus norvegicus) exposed to UV-radiation Dinesh Tanabbal; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; I Gusti Kamasan Nyoman Arijana; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.89

Abstract

Background: The primary acute damage due to UV radiation is keratinocyte apoptosis or sunburn cell. Previous studies showed that antioxidants inhibit UV damage. Java plum (Syzygium cumini) which is found in Indonesia, was known to have a high concentration of antioxidants. This study was aimed to assess the Java plum ethanol extract cream effects on the number of sunburn cells on the dorsal skin of male Wistar rats that exposed to UV-B. Methods This experimental research was a post-test only control group design that was conducted on 30 male rats. Groups were divided into control, placebo, 5%, 10%, and 20% ethanol extract cream concentrations (P1, P2, P3, P4, and P5, respectively). The number of sunburn cell were then observed and recorded based on visual evaluation of the skin biopsy under a light microscope. Results: The mean results of P1, P2, P3, P4, and P5 were 132.67, 98.67, 118.67, 104.00, and 54.67 respectively. The control, placebo, 5%, and 10% ethanol extract cream showed no significant result (p>0.05). In contrast, 20% ethanol extract cream showed a protective effect (p<0.05). Conclusion: Java plum ethanol extract cream with 20% dose could decrease the number of sunburn cells in the skin.
Red dragon fruit (Hylocereus polyrhizhus) in preventing collagen decrease in menopause induced rats skin Eswariy Chandramogan; I Wayan Sugiritama; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.90

Abstract

Background: Skin aging in menopause women was due to fewer collagen numbers in cells and antioxidants are necessary for inhibiting the process of skin aging due to oxidative stress. Red dragon fruits which plant in Indonesia was known to have a high concentration of antioxidants. This study aimed to assess the ethanol extract of red dragon fruit skin effects on the number of collagens on the skin of female Wistar rats which has been ovariectomized. Methods: This experimental research was a post-test only control group design that was conducted on 30 female Wistar rats. Groups were divided into control (P0), 5% ethanol extract (P1), and 15% ethanol extract concentrations (P2). The dosage was given orally to the 30 female rats and left for observation for 30 days. The number of collagens was observed and calculated on visual evaluation of the skin biopsy under a light microscope. Results: The result showed a significant difference between treatment groups and control (p<0.05). The number of collagen are higher in P2 (83.03 ±4.84) and P1 (77.26 ±5.06) than P0 (57.73 ±5.04). Conclusion: Ethanol extract of red dragon fruit skin could increase the number of collagen in rat skin.
Co-Authors Andwi Ari Sumiwi Arijana, I Gusti Nyoman Kamasan Dewa Ayu Agus Sri Laksmi Dewi Wijayanti, Ni Putu Ayu Dinesh Tanabbal Dyta Putri Aryo Eswariy Chandramogan Fedik Abdul Ratam GAP Ratih Pradnyandari Gede Reynaldi Wahyu Sanjaya Gede Wirata I Dewa Ayu Inten Primayanti I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Made Perdana I Nyoman Wande I Wayan Sugiritama I. G. A. D. Ratnayanthi Ida Ayu Ika Wahyuniari Ida Ayu Ika Wahyuniari Linawati N.M Luh Made Mas Rusyati Marsetyawan HNE Soesatyo Mayun G.N Melita Soares Cristovao Muhammad Ghufron N. M. Linawati Ni Made Linawati Ni Made Linawati Ni Made Mertaniasih Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Sriwidyani Putu Diah Pratiwi Raditya Pradipta Ratnayanthi, I Gusti Ayu Dewi Raymond Elbert Budianto Riezky Januar Pramitha Ruthirar Kalaichelvam Yustina -