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All Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan
I Gusti Nyoman Sri Wiryawan
Departemen Histologi, Fakultas Kedokteran, Universitas Udayana, Denpasar, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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PENGEMBANGAN POLA HIDUP BERSIH DAN SEHAT (PHBS) PADA ANAK SEKOLAH MELALUI METODE PENYULUHAN I. W. Sugiritama; I. G. N. S. Wiryawan; I. G. A. D. Ratnayanthi; I. G. K. K. Arijana; N. M. Linawati; I. A. I. Wahyuniari
Buletin Udayana Mengabdi Vol 20 No 1 (2021): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4650.153 KB) | DOI: 10.24843/BUM.2021.v20.i01.p11

Abstract

Perilaku hidup bersih dan sehat (PHBS) merupakan salah satu strategi penting untuk meningkatkan derajat kesehatan, karena banyak penyakit yang bisa dicegah jika masyarakat menerapkan perilaku hidup sehat. Anak sekolah merupakan kelompok usia yang rentan untuk mengalami masalah kesehatan karena sebagian waktunya dihabiskan diluar lingkungan rumah dan diluar pengawasan orang tua. Saat anak berada di lingkungan sekolah bisa mengalami penularan penyakit dari teman sebaya, dari lingkungan sekolah atau bisa saja mengkonsumsi makanan yang tidak memenuhi syarat kesehatan. Anak sekolah juga merupakan kelompok usia yang mudah untuk diberikan pengetahuan tentang PHBS untuk membentuk perilaku yang sehat. Sekolah Dasar 2 Demulih berlokasi dilingkungan padat penduduk dan belum tersedia kantin yang memenuhi syarat kesehatan. Karena hal tersebut maka sangat tepat jika dilakukan pemberian pengetahuan tentang PHBS melalui metode ceramah yang menarik dengan media gambar dan video yang kemudian dilanjutkan dengan tanya jawab. Pelaksanaan penyuluhan berlangsung dengan baik, anak-anak sekolah sangat antusias saat mendengarkan paparan dan sangat aktif saat diskusi. Anak-anak sekolah terlihat sudah memahami konsep PHBS dan sudah mengerti bagaimana cara melaksanakannya.
DETEKSI DINI DAN PENANGANAN FAKTOR RISIKO PENYAKIT KARDIOVASKULAR PADA PENDUDUK USIA 45 TAHUN KE ATAS DI DESA PEGAYAMAN BULELENG Ika Wahyuniari I.A; Dewi Ratnayanti I.G.A; Mayun G.N; Sri Wiryawan G.N; Linawati N.M; Sugiritama W
Buletin Udayana Mengabdi Vol 9 No 2 (2010): Volume 9 No.2 – September 2010
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

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Abstract

Cardiovascular diseases such as heart attacks and strokes, are the main cause of death in Indonesia. Information about risk factors of these disease (like hypertension, diabetes mellitus, obesity) are required in order to control and prevent the disorders. The aim of this program was at early detection and managing the relevant risk factors. The program commenced by providing information about risk factors of cardiovascular disease and by examining the level of blood pressure, blood sugar, body weight, body height, and waist circumference. Participants that have risk factors of cardiovascular disease in Pagayaman were 52,94%. Most of them had abnormal waist circumference (59,26%), particularly in woman. The next and most prevalent risk factors were Body Mass Index (40,74%), hypertension (18,52%), and hyperglycemia (3,70%).
THE ROLE OF ESTROGEN IN WOMEN WITH ANDROGENETIC ALOPECIA Putu Diah Pratiwi; IGN Sri Wiryawan; Ni Made Linawati; Ni Luh Mas Rusyati
E-Jurnal Medika Udayana vol 2 no 8 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Hair loss may accured in both male and female population. Hair loss usually accured in Telogenic phase, meanwhile in Anagenic phase hair loss due to chemotherapy or radiation. Female pattern hair loss (FPHL) is regarded as hair fall type which is accured in women in common and known as female androgenetic alopecia. Almost 40%, 50 years old female shown hair fall sign, which is developed progressive fibrosing alopecia of central scalp, especially in frontal and parietal area. There are two common treatment for Female pattern Hair Loss are Minoxidil for topical use, and Fenesteride by oral. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs), in turn increase anagenic phase and represed telogenic phase.
EKSTRAK ETANOL UBI JALAR UNGU (IPOMOEA BATATAS L.) MENURUNKAN DEGENERASI LEMAK JARINGAN HATI TIKUS YANG DI https://ojs.unud.ac.id/index.php/eum OVARIEKTOMI Ni Putu Candra Paramita; I Wayan Sugiritama; Ni Made Linawati; IGA Dewi Ratnayanti; Ida Ayu Ika Wahyuniari; IGK Nyoman Arijana; IGN Sri Wiryawan
E-Jurnal Medika Udayana Vol 8 No 5 (2019): Vol 8 No 5 (2019): Vol 8 No 5 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Menopause didefinisikan sebagai 1 tahun tanpa menstruasi. Wanita menopausekemungkinan berisiko mengalami Nonalcoholic Fatty Liver Disease(NAFLD). Efekmenguntungkan dari antosianin telah dibuktikan dalam penelitian hewan,sehubungan denganstres oksidatif dan steatosis hati. Ubi jalar ungu mengandung antosianin yang berfungsi sebagaiantioksidan. Penelitian ini dilakukan dengan menggunakan sampel tikus yang sudah diovariektomi, kemudian diberikan ekstrak etanol ubi jalar ungu pada tikus secara oral selama 30hari. Pada hari pertama dilakukan randomisasi dibagi menjadi empat kelompok yaitu kelompokkontrol negatif (P0), kelompok perlakuan pemberian ekstrak etanol ubi jalar ungu dosis 1ml(P1), dosis 2 ml (P2), dan dosis 4ml (P3). Pada hari ke-31 dilakukan terminasi untuk di ambiljaringan hati dan pembuatan preparat histologi, kemudian dilakukan pengamatan pada preparatdengan pembesaran 10x10 pada 2 lapang pandang. Dari 28 sampel hati tikus yang diperiksa,didapatkan semua sel hati tikus mengalami degenerasi lemak atau steatosis sebanyak >5% yangmerupakan kunci dari penyakit hati berlemak nonalkohol (NAFLD), namun jumlahnya berbedabeda. Rerata perlemakan kelompok kontrol negatif didapatkan hasil perlemakan paling tinggiyaitu 49,1%, kelompok perlakuan pemberian dosis 1ml, 2ml, dan 4ml didapatkan hasil 39,48%,31,62%, dan 29,14%. Setelah diuji secara statistik didapatkan perbedaan yang signifikan(p<0,05) terhadap pengaruh pemberian ekstrak etanol ubi jalar ungu.Berdasarkan hasilpenelitian yang telah dilakukan, maka dapat disimpulkan bahwa pemberianekstrak etanol ubijalar ungu selama 30 hari dapat menurunkan degenerasi lemak pada hati tikus yang mengalamipenyakit hati berlemak nonalkohol (NAFLD). Kata Kunci: Ekstrak etanol ubi jalar ungu, menopause, fatty liver
ROLE OF OLIVE OIL IN CANCER PREVENTION GAP Ratih Pradnyandari; IGN Sri Wiryawan
E-Jurnal Medika Udayana vol 3 no 2 (2014):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Cancer is the second leading cause of death in the United States. From this fact showshow ferociously the disease if not treated well. The emergence of this disease is causedby various factors, but often caused by damage to the structure of DNA and othermolecular structures by a reactive oxygen species (ROS). Early prevention that can beimplemented, is to improve the lifestyle and diet that contains a substance that canprotect our body cells from damage caused by ROS. These molecules calledantioxidants. Therefore, antioxidants are often called reducing agents (thiol orpolyphenols). Olive oil is the one of the exogenous antioxidants have many benefitsespecially polyphenols that have chemo preventive effects on several types of cancer,and can inhibit the process of carcinogenesis by several mechanisms such as inhibitionof DNA synthesis in the process, reducing the production of ROS, regulate cell cycle,regulate proliferation and survival mechanisms of cells.
KORELASI TINGKAT PENGETAHUAN DAN SIKAP MASYARAKAT USIA 17-30 TAHUN DESA TIGAWASA KECAMATAN BANJAR KABUPATEN BULELENG TERHADAP PEROKOK PASIF I Made Perdana; IGN Sri Wiryawan
E-Jurnal Medika Udayana Vol 9 No 9 (2020): Vol 9 No 09(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2020.V09.i9.P08

Abstract

ABSTRAK Merokok menjadi gaya hidup sebagian orang dikarenakan zat adiktif yang terkandung didalamnya membawa efek kecanduan. Asap rokok dihirup oleh perokok pasif. Kurang pengetahuan masyarakat di pedesaan mengakibatkan sikap terhadap perokok masih kurang. Adapun tujuan dari penelitian ini adalah untuk mengetahui tingkat pengetahuan warga Desa Tigawasa Kecamatan Banjar Kabupaten Buleleng terhadap perokok pasif dan untuk mengetahui korelasi tingkat pengetahuan dan sikap warga terhadap perokok pasif. Perokok pasif adalah yang terpapar asap rokok secara tidak sadar. Secara teori orang dengan tingkat pengetahuan yang lebih akan mengambil keputusan dengan logika dalam pengambilan sikap. Penelitian ini merupakan cross-sectional dengan populasi warga Desa Tigawasa. Dengan menggunakan simple random sampling, didapatkan 96 sampel. Teknik pengumpulan data dilakukan dengan kuisioner dan analisis data dengan SPSS. Berdasarkan hasil penelitian didapatkan bahwa 69 (62,5%) warga memiliki tingkat pengetahuan berada pada kategori baik, meskipun sikapnya dikategorikan kurang (50,0%). Terdapat korelasi antara tingkat pengetahuan dan sikap warga (r= -0,306; p=0,002). Dapat disimpulkan bahwa tingkat pengetahuan masyarakat usia 17-30 tahun Desa Tigawasa Kecamatan Banjar Kabupaten Buleleng terhadap perokok pasif termasuk kategori baik meskipun dengan sikap yang kurang. Terdapat korelasi negatif lemah antara tingkat pengetahuan dan sikap masyarakat terhadap perokok pasif. Disarankan agar penelitian selanjutnya membandingkan populasi di pedesaan dengan perkotaan. Kata kunci: Perokok pasif, tingkat pengetahuan, sikap
PHARMACOTHERAPY ALOPECIA ANDROGENETIC IN MEN Riezky Januar Pramitha; I.G.N Sri Wiryawan; Ni Made Linawati
E-Jurnal Medika Udayana vol 2 no3 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Androgenetic alopecia is hair thinning due to the stimulation of hair follicles to androgens. Incidence in men is higher than in women, it is because men have a degree higher 5? reductase. This condition can cause both physical and psychological effects to the patient. Physical effects due to baldness cause hair loss as a function of protection against heat, cold and trauma. While psychologically can affect self-esteem and self-perception of the patient. Androgenetic alopecia in men influenced by the androgen dihydrotestosterone and genetic predisposition, although the physiology remains unclear. Modality in the management of androgenetic alopecia in males patients including pharmacotherapy, hair transplants and cosmetic approach. According to the Food and Drug Administration (FDA), there are two main drugs are safe and effective in the long term given to men with androgenetic alopecia are minoxidil and finasteride. Although the mechanism of action and route of administration are different, but both drugs have similar effectiveness in stopping the progression of androgenetic alopecia in men.
Effects of red dragon fruit (Hylocereus polyrhizus) peel on low-density lipoprotein levels in menopause wistar rats Dyta Putri Aryo; I Wayan Sugiritama; I Gusti Nyoman Sri Wiryawan; I Gusti Ayu Dewi Ratnayanti
Bali Anatomy Journal Vol 3 No 1 (2020): Bali Anatomy Journal (BAJ)
Publisher : Department of Anatomy, Medical Faculty, Universitas Udayana, Bali-Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/baj.v3i1.37

Abstract

Background: Estrogen has major role to control LDL levels in woman’s body, therefore if a woman experienced hypoestrogen condition usually during menopause phase, there is an increase of the LDL levels. Anthocyanin has similar structure with isoflavones, which have been widely studied and proven to be estrogenic. One of the food ingredients that is rich in anthocyanin is the peel of red dragon fruit (Hylocereus polyrhizus), so it is hoped that this red dragon fruit peels can be a source of phytoestrogens that can play a role in improving LDL levels in menopausal women. Aim: To determine the effect of red dragon fruit peel (Hylocereus polyrhizus) on Low Density Lipoprotein levels in menopause wistar rats. Method: This study was a purely experimental study with a randomized post-test only control group design with a sample of 27 female wistar rats that had fulfilled the inclusion and exclusion criteria. The study sample was divided into 3 (three) groups with each group consisting of 9 female wistar rats, namely the control group (P0), the ethanol extract of red dragon fruit peels at a dose of 60mg / 200grBB group (P1), and dose 90mg / 200grBB group (P2).Result: There was a significant difference between P0 and P1 so that between P0 and P2, meanwhile comparison between P1 and P2 showed only slight difference. Conclusion: The red dragon peel extract can control LDL levels, therefore it is possible to be a substitute of estrogen endogen in menopausal women.
Java plum (Syzygium cumini) extract cream effect on decreasing the number of sunburn cell on the dorsal skin of male Wistar rat (Rattus norvegicus) exposed to UV-radiation Dinesh Tanabbal; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; I Gusti Kamasan Nyoman Arijana; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.89

Abstract

Background: The primary acute damage due to UV radiation is keratinocyte apoptosis or sunburn cell. Previous studies showed that antioxidants inhibit UV damage. Java plum (Syzygium cumini) which is found in Indonesia, was known to have a high concentration of antioxidants. This study was aimed to assess the Java plum ethanol extract cream effects on the number of sunburn cells on the dorsal skin of male Wistar rats that exposed to UV-B. Methods This experimental research was a post-test only control group design that was conducted on 30 male rats. Groups were divided into control, placebo, 5%, 10%, and 20% ethanol extract cream concentrations (P1, P2, P3, P4, and P5, respectively). The number of sunburn cell were then observed and recorded based on visual evaluation of the skin biopsy under a light microscope. Results: The mean results of P1, P2, P3, P4, and P5 were 132.67, 98.67, 118.67, 104.00, and 54.67 respectively. The control, placebo, 5%, and 10% ethanol extract cream showed no significant result (p>0.05). In contrast, 20% ethanol extract cream showed a protective effect (p<0.05). Conclusion: Java plum ethanol extract cream with 20% dose could decrease the number of sunburn cells in the skin.
Red dragon fruit (Hylocereus polyrhizhus) in preventing collagen decrease in menopause induced rats skin Eswariy Chandramogan; I Wayan Sugiritama; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.90

Abstract

Background: Skin aging in menopause women was due to fewer collagen numbers in cells and antioxidants are necessary for inhibiting the process of skin aging due to oxidative stress. Red dragon fruits which plant in Indonesia was known to have a high concentration of antioxidants. This study aimed to assess the ethanol extract of red dragon fruit skin effects on the number of collagens on the skin of female Wistar rats which has been ovariectomized. Methods: This experimental research was a post-test only control group design that was conducted on 30 female Wistar rats. Groups were divided into control (P0), 5% ethanol extract (P1), and 15% ethanol extract concentrations (P2). The dosage was given orally to the 30 female rats and left for observation for 30 days. The number of collagens was observed and calculated on visual evaluation of the skin biopsy under a light microscope. Results: The result showed a significant difference between treatment groups and control (p<0.05). The number of collagen are higher in P2 (83.03 ±4.84) and P1 (77.26 ±5.06) than P0 (57.73 ±5.04). Conclusion: Ethanol extract of red dragon fruit skin could increase the number of collagen in rat skin.
Co-Authors Andwi Ari Sumiwi Arijana, I Gusti Nyoman Kamasan Dewa Ayu Agus Sri Laksmi Dewi Wijayanti, Ni Putu Ayu Dinesh Tanabbal Dyta Putri Aryo Eswariy Chandramogan Fedik Abdul Ratam GAP Ratih Pradnyandari Gede Reynaldi Wahyu Sanjaya Gede Wirata I Dewa Ayu Inten Primayanti I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Made Perdana I Nyoman Wande I Wayan Sugiritama I. G. A. D. Ratnayanthi Ida Ayu Ika Wahyuniari Ida Ayu Ika Wahyuniari Linawati N.M Luh Made Mas Rusyati Marsetyawan HNE Soesatyo Mayun G.N Melita Soares Cristovao Muhammad Ghufron N. M. Linawati Ni Made Linawati Ni Made Linawati Ni Made Mertaniasih Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Sriwidyani Putu Diah Pratiwi Raditya Pradipta Ratnayanthi, I Gusti Ayu Dewi Raymond Elbert Budianto Riezky Januar Pramitha Ruthirar Kalaichelvam Yustina -